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Items: 34


Covalent Aurora A regulation by the metabolic integrator coenzyme A.

Tsuchiya Y, Byrne DP, Burgess SG, Bormann J, Baković J, Huang Y, Zhyvoloup A, Yu BYK, Peak-Chew S, Tran T, Bellany F, Tabor AB, Chan AE, Guruprasad L, Garifulin O, Filonenko V, Vonderach M, Ferries S, Eyers CE, Carroll J, Skehel M, Bayliss R, Eyers PA, Gout I.

Redox Biol. 2019 Sep 5;28:101318. doi: 10.1016/j.redox.2019.101318. [Epub ahead of print]


A synthetic genetic polymer with an uncharged backbone chemistry based on alkyl phosphonate nucleic acids.

Arangundy-Franklin S, Taylor AI, Porebski BT, Genna V, Peak-Chew S, Vaisman A, Woodgate R, Orozco M, Holliger P.

Nat Chem. 2019 Jun;11(6):533-542. doi: 10.1038/s41557-019-0255-4. Epub 2019 Apr 22.


Akt and SGK protein kinases are required for efficient feeding by macropinocytosis.

Williams TD, Peak-Chew SY, Paschke P, Kay RR.

J Cell Sci. 2019 Jan 24;132(2). pii: jcs224998. doi: 10.1242/jcs.224998.


The Atypical MAP Kinase ErkB Transmits Distinct Chemotactic Signals through a Core Signaling Module.

Nichols JME, Paschke P, Peak-Chew S, Williams TD, Tweedy L, Skehel M, Stephens E, Chubb JR, Kay RR.

Dev Cell. 2019 Feb 25;48(4):491-505.e9. doi: 10.1016/j.devcel.2018.12.001. Epub 2019 Jan 3.


Protein CoAlation and antioxidant function of coenzyme A in prokaryotic cells.

Tsuchiya Y, Zhyvoloup A, Baković J, Thomas N, Yu BYK, Das S, Orengo C, Newell C, Ward J, Saladino G, Comitani F, Gervasio FL, Malanchuk OM, Khoruzhenko AI, Filonenko V, Peak-Chew SY, Skehel M, Gout I.

Biochem J. 2018 Jun 6;475(11):1909-1937. doi: 10.1042/BCJ20180043.


Protein CoAlation: a redox-regulated protein modification by coenzyme A in mammalian cells.

Tsuchiya Y, Peak-Chew SY, Newell C, Miller-Aidoo S, Mangal S, Zhyvoloup A, Bakovic J, Malanchuk O, Pereira GC, Kotiadis V, Szabadkai G, Duchen MR, Campbell M, Cuenca SR, Vidal-Puig A, James AM, Murphy MP, Filonenko V, Skehel M, Gout I.

Biochem J. 2017 Jul 11;474(14):2489-2508. doi: 10.1042/BCJ20170129.


Nanostructures from Synthetic Genetic Polymers.

Taylor AI, Beuron F, Peak-Chew SY, Morris EP, Herdewijn P, Holliger P.

Chembiochem. 2016 Jun 16;17(12):1107-10. doi: 10.1002/cbic.201600136. Epub 2016 Apr 20.


Catalysts from synthetic genetic polymers.

Taylor AI, Pinheiro VB, Smola MJ, Morgunov AS, Peak-Chew S, Cozens C, Weeks KM, Herdewijn P, Holliger P.

Nature. 2015 Feb 19;518(7539):427-30. doi: 10.1038/nature13982. Epub 2014 Dec 1.


The N-terminal acetylation of Sir3 stabilizes its binding to the nucleosome core particle.

Arnaudo N, Fernández IS, McLaughlin SH, Peak-Chew SY, Rhodes D, Martino F.

Nat Struct Mol Biol. 2013 Sep;20(9):1119-21. doi: 10.1038/nsmb.2641. Epub 2013 Aug 11.


Synthetic genetic polymers capable of heredity and evolution.

Pinheiro VB, Taylor AI, Cozens C, Abramov M, Renders M, Zhang S, Chaput JC, Wengel J, Peak-Chew SY, McLaughlin SH, Herdewijn P, Holliger P.

Science. 2012 Apr 20;336(6079):341-4. doi: 10.1126/science.1217622.


Identification of a eukaryotic reductive dechlorinase and characterization of its mechanism of action on its natural substrate.

Velazquez F, Peak-Chew SY, Fernández IS, Neumann CS, Kay RR.

Chem Biol. 2011 Oct 28;18(10):1252-60. doi: 10.1016/j.chembiol.2011.08.003.


The acetyltransferase activity of the bacterial toxin YopJ of Yersinia is activated by eukaryotic host cell inositol hexakisphosphate.

Mittal R, Peak-Chew SY, Sade RS, Vallis Y, McMahon HT.

J Biol Chem. 2010 Jun 25;285(26):19927-34. doi: 10.1074/jbc.M110.126581. Epub 2010 Apr 29.


N-terminal acetylation of the neuronal protein SNAP-25 is revealed by the SMI81 monoclonal antibody.

Connell E, Darios F, Peak-Chew S, Soloviev M, Davletov B.

Biochemistry. 2009 Oct 13;48(40):9582-9. doi: 10.1021/bi9012403.


Genetically encoding N(epsilon)-acetyllysine in recombinant proteins.

Neumann H, Peak-Chew SY, Chin JW.

Nat Chem Biol. 2008 Apr;4(4):232-4. doi: 10.1038/nchembio.73. Epub 2008 Feb 17.


p32 is a novel mammalian Lgl binding protein that enhances the activity of protein kinase Czeta and regulates cell polarity.

Bialucha CU, Ferber EC, Pichaud F, Peak-Chew SY, Fujita Y.

J Cell Biol. 2007 Aug 13;178(4):575-81. Epub 2007 Aug 6.


Evolved orthogonal ribosomes enhance the efficiency of synthetic genetic code expansion.

Wang K, Neumann H, Peak-Chew SY, Chin JW.

Nat Biotechnol. 2007 Jul;25(7):770-7. Epub 2007 Jun 24.


Phosphorylation of human microtubule-associated protein tau by protein kinases of the AGC subfamily.

Virdee K, Yoshida H, Peak-Chew S, Goedert M.

FEBS Lett. 2007 Jun 12;581(14):2657-62. Epub 2007 May 11.


Mechanism of arachidonic acid action on syntaxin-Munc18.

Connell E, Darios F, Broersen K, Gatsby N, Peak-Chew SY, Rickman C, Davletov B.

EMBO Rep. 2007 Apr;8(4):414-9. Epub 2007 Mar 16.


Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling.

Mittal R, Peak-Chew SY, McMahon HT.

Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18574-9. Epub 2006 Nov 20.


Control of phospholipid synthesis by phosphorylation of the yeast lipin Pah1p/Smp2p Mg2+-dependent phosphatidate phosphatase.

O'Hara L, Han GS, Peak-Chew S, Grimsey N, Carman GM, Siniossoglou S.

J Biol Chem. 2006 Nov 10;281(45):34537-48. Epub 2006 Sep 12.


Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.

Schmid EM, Ford MG, Burtey A, Praefcke GJ, Peak-Chew SY, Mills IG, Benmerah A, McMahon HT.

PLoS Biol. 2006 Sep;4(9):e262.


Promiscuous interaction of SNAP-25 with all plasma membrane syntaxins in a neuroendocrine cell.

Bajohrs M, Darios F, Peak-Chew SY, Davletov B.

Biochem J. 2005 Dec 1;392(Pt 2):283-9.


The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth.

Santos-Rosa H, Leung J, Grimsey N, Peak-Chew S, Siniossoglou S.

EMBO J. 2005 Jun 1;24(11):1931-41. Epub 2005 May 5.


Sir2 and the acetyltransferase, Pat, regulate the archaeal chromatin protein, Alba.

Marsh VL, Peak-Chew SY, Bell SD.

J Biol Chem. 2005 Jun 3;280(22):21122-8. Epub 2005 Apr 11.


Evolving nature of the AP2 alpha-appendage hub during clathrin-coated vesicle endocytosis.

Praefcke GJ, Ford MG, Schmid EM, Olesen LE, Gallop JL, Peak-Chew SY, Vallis Y, Babu MM, Mills IG, McMahon HT.

EMBO J. 2004 Nov 10;23(22):4371-83. Epub 2004 Oct 21.


The phosphorylation of subunits of complex I from bovine heart mitochondria.

Chen R, Fearnley IM, Peak-Chew SY, Walker JE.

J Biol Chem. 2004 Jun 18;279(25):26036-45. Epub 2004 Mar 31.


Interactions between centromere complexes in Saccharomyces cerevisiae.

Nekrasov VS, Smith MA, Peak-Chew S, Kilmartin JV.

Mol Biol Cell. 2003 Dec;14(12):4931-46. Epub 2003 Oct 17.


An N-acetylglucosaminyltransferase of the Golgi apparatus of the yeast Saccharomyces cerevisiae that can modify N-linked glycans.

Yoko-o T, Wiggins CA, Stolz J, Peak-Chew SY, Munro S.

Glycobiology. 2003 Aug;13(8):581-9. Epub 2003 Mar 19.


RPA is an initiation factor for human chromosomal DNA replication.

Szüts D, Kitching L, Christov C, Budd A, Peak-Chew S, Krude T.

Nucleic Acids Res. 2003 Mar 15;31(6):1725-34.


EpsinR: an ENTH domain-containing protein that interacts with AP-1.

Hirst J, Motley A, Harasaki K, Peak Chew SY, Robinson MS.

Mol Biol Cell. 2003 Feb;14(2):625-41. Erratum in: Mol Biol Cell. 2003 Apr;14(4):following 1743.


Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour.

Lee MJ, Gergely F, Jeffers K, Peak-Chew SY, Raff JW.

Nat Cell Biol. 2001 Jul;3(7):643-9.


The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation.

Clayton GM, Peak-Chew SY, Evans RM, Schwabe JW.

Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1549-54. Epub 2001 Feb 6.


Ric1p and Rgp1p form a complex that catalyses nucleotide exchange on Ypt6p.

Siniossoglou S, Peak-Chew SY, Pelham HR.

EMBO J. 2000 Sep 15;19(18):4885-94.


Resolution of the membrane domain of bovine complex I into subcomplexes: implications for the structural organization of the enzyme.

Sazanov LA, Peak-Chew SY, Fearnley IM, Walker JE.

Biochemistry. 2000 Jun 20;39(24):7229-35.


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