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Items: 1 to 50 of 59

1.

Prostaglandin D2 generation from human lung mast cells is catalysed exclusively by cyclooxygenase-1.

Baothman BK, Smith J, Kay LJ, Suvarna SK, Peachell PT.

Eur J Pharmacol. 2018 Jan 15;819:225-232. doi: 10.1016/j.ejphar.2017.12.005. Epub 2017 Dec 7.

PMID:
29225187
2.

Orai and TRPC channel characterization in FcεRI-mediated calcium signaling and mediator secretion in human mast cells.

Wajdner HE, Farrington J, Barnard C, Peachell PT, Schnackenberg CG, Marino JP Jr, Xu X, Affleck K, Begg M, Seward EP.

Physiol Rep. 2017 Mar;5(5). pii: e13166. doi: 10.14814/phy2.13166.

3.

Recovery from desensitization of IgE-dependent responses in human lung mast cells.

Lewis A, MacGlashan DW Jr, Suvarna SK, Peachell PT.

Clin Exp Allergy. 2017 Aug;47(8):1022-1031. doi: 10.1111/cea.12912. Epub 2017 Mar 31.

PMID:
28236656
4.

Evaluation of the anti-inflammatory effects of β-adrenoceptor agonists on human lung macrophages.

Gill SK, Marriott HM, Suvarna SK, Peachell PT.

Eur J Pharmacol. 2016 Dec 15;793:49-55. doi: 10.1016/j.ejphar.2016.11.005. Epub 2016 Nov 7.

PMID:
27832943
5.

The anti-inflammatory effects of PGE2 on human lung macrophages are mediated by the EP4 receptor.

Gill SK, Yao Y, Kay LJ, Bewley MA, Marriott HM, Peachell PT.

Br J Pharmacol. 2016 Nov;173(21):3099-3109. doi: 10.1111/bph.13565. Epub 2016 Sep 6.

6.

Cyclic nucleotide phosphodiesterase isoforms in human basophils and mast cells.

Eskandari N, Tashrifi F, Bastan R, Andalib A, Yousefi Z, Peachell PT.

Int J Immunopathol Pharmacol. 2016 Dec;29(4):654-665. Epub 2016 Jan 18.

7.

The effect of cyclic nucleotide analog drugs on the mediators release from basophils.

Eskandari N, Bastan R, Esfahani SH, Peachell PT.

Adv Biomed Res. 2015 Jun 4;4:125. doi: 10.4103/2277-9175.158040. eCollection 2015.

8.

Role of protein phosphatases inhibitors on the histamine release and the functional desensitization in human lung mast cells.

Bastan R, Eskandari N, Sabzghabaee AM, Esfahani SH, Peachell PT.

J Res Med Sci. 2014 Oct;19(10):923-7.

9.

Mast cell purification protocols.

Farrington J, Seward EP, Peachell PT.

Methods Mol Biol. 2014;1192:49-55. doi: 10.1007/978-1-4939-1173-8_3.

PMID:
25149482
10.

Evaluation of the correlation and reproducibility between histamine, IL-4, and IL-13 release from human basophils.

Eskandari N, Bastan R, Ahmadi M, Peachell PT.

Iran J Allergy Asthma Immunol. 2014 Jun;13(3):190-7.

11.

Regulation of human skin mast cell histamine release by PDE inhibitors.

Eskandari N, Bastan R, Peachell PT.

Allergol Immunopathol (Madr). 2015 Jan-Feb;43(1):37-41. doi: 10.1016/j.aller.2013.07.011. Epub 2013 Nov 11.

PMID:
24231152
12.

Characterization of the EP receptor subtype that mediates the inhibitory effects of prostaglandin E2 on IgE-dependent secretion from human lung mast cells.

Kay LJ, Gilbert M, Pullen N, Skerratt S, Farrington J, Seward EP, Peachell PT.

Clin Exp Allergy. 2013 Jul;43(7):741-51. doi: 10.1111/cea.12142.

PMID:
23786281
13.

Heterogeneity in the responses of human lung mast cells to stem cell factor.

Lewis A, Wan J, Baothman B, Monk PN, Suvarna SK, Peachell PT.

Clin Exp Allergy. 2013 Jan;43(1):50-9. doi: 10.1111/cea.12045.

PMID:
23278880
14.

Preclinical evaluation of an inhibitor of cytosolic phospholipase A2α for the treatment of asthma.

Hewson CA, Patel S, Calzetta L, Campwala H, Havard S, Luscombe E, Clarke PA, Peachell PT, Matera MG, Cazzola M, Page C, Abraham WM, Williams CM, Clark JD, Liu WL, Clarke NP, Yeadon M.

J Pharmacol Exp Ther. 2012 Mar;340(3):656-65. doi: 10.1124/jpet.111.186379. Epub 2011 Dec 7.

15.

Characterization of syk expression in human lung mast cells: relationship with function.

Havard S, Scola AM, Kay LJ, Ishmael SS, MacGlashan DW Jr, Peachell PT.

Clin Exp Allergy. 2011 Mar;41(3):378-88. doi: 10.1111/j.1365-2222.2010.03667.x. Epub 2011 Jan 24.

PMID:
21255137
16.

Influence of beta2-adrenoceptor gene polymorphisms on beta2-adrenoceptor expression in human lung.

Kay LJ, Suvarna SK, Scola AM, Rostami-Hodjegan A, Chess-Williams R, Peachell PT.

Pulm Pharmacol Ther. 2010 Apr;23(2):71-7. doi: 10.1016/j.pupt.2009.10.013. Epub 2009 Nov 1.

PMID:
19887115
17.

The long-acting beta-adrenoceptor agonist, indacaterol, inhibits IgE-dependent responses of human lung mast cells.

Scola AM, Loxham M, Charlton SJ, Peachell PT.

Br J Pharmacol. 2009 Sep;158(1):267-76. doi: 10.1111/j.1476-5381.2009.00178.x. Epub 2009 Apr 9.

18.

Influence of beta2-adrenoceptor gene polymorphisms on beta2-adrenoceptor-mediated responses in human lung mast cells.

Kay LJ, Rostami-Hodjegan A, Suvarna SK, Peachell PT.

Br J Pharmacol. 2007 Oct;152(3):323-31. Epub 2007 Jul 23.

19.

Role of calcineurin in the regulation of human lung mast cell and basophil function by cyclosporine and FK506.

Harrison CA, Bastan R, Peirce MJ, Munday MR, Peachell PT.

Br J Pharmacol. 2007 Feb;150(4):509-18. Epub 2007 Jan 2.

20.

Regulation of mast cells by beta-agonists.

Peachell P.

Clin Rev Allergy Immunol. 2006 Oct-Dec;31(2-3):131-42. Review.

PMID:
17085789
21.

Prostaglandin E2 activates EP2 receptors to inhibit human lung mast cell degranulation.

Kay LJ, Yeo WW, Peachell PT.

Br J Pharmacol. 2006 Apr;147(7):707-13.

22.

Mast cell beta2-adrenoceptors.

Kay LJ, Peachell PT.

Chem Immunol Allergy. 2005;87:145-53. Review.

PMID:
16107769
23.

Targeting the mast cell in asthma.

Peachell P.

Curr Opin Pharmacol. 2005 Jun;5(3):251-6. Review.

PMID:
15907911
24.

Influence of agonist intrinsic activity on the desensitisation of beta2-adrenoceptor-mediated responses in mast cells.

Scola AM, Chong LK, Chess-Williams R, Peachell PT.

Br J Pharmacol. 2004 Sep;143(1):71-80. Epub 2004 Aug 2.

25.

Effects of phosphodiesterase inhibitors on interleukin-4 and interleukin-13 generation from human basophils.

Eskandari N, Wickramasinghe T, Peachell PT.

Br J Pharmacol. 2004 Aug;142(8):1265-72. Epub 2004 Jul 20.

26.

Desensitisation of mast cell beta2-adrenoceptor-mediated responses by salmeterol and formoterol.

Scola AM, Chong LK, Suvarna SK, Chess-Williams R, Peachell PT.

Br J Pharmacol. 2004 Jan;141(1):163-71. Epub 2003 Dec 8.

27.

Desensitization of beta2-adrenoceptor-mediated responses by short-acting beta2-adrenoceptor agonists in human lung mast cells.

Chong LK, Suvarna K, Chess-Williams R, Peachell PT.

Br J Pharmacol. 2003 Feb;138(3):512-20.

28.

Influence of the thr164ile polymorphism in the beta2-adrenoceptor on the effects of beta-adrenoceptor agonists on human lung mast cells.

Kay LJ, Chong LK, Rostami-Hodjegan A, Peachell PT.

Int Immunopharmacol. 2003 Jan;3(1):91-5.

PMID:
12538038
29.

Pharmacological characterisation of the beta-adrenoceptor expressed by human lung mast cells.

Chong LK, Chess-Williams R, Peachell PT.

Eur J Pharmacol. 2002 Feb 15;437(1-2):1-7.

PMID:
11864632
30.
31.

Vasoactive and proliferative effects of parathyroid hormone and parathyroid hormone-related peptide on human vascular smooth muscle.

Chadwick DR, Harrison BJ, Chan P, Chong L, Peachell P.

Br J Surg. 2000 Nov;87(11):1529-33.

PMID:
11091241
32.

Influence of genetic polymorphisms in the beta2-adrenoceptor on desensitization in human lung mast cells.

Chong LK, Chowdry J, Ghahramani P, Peachell PT.

Pharmacogenetics. 2000 Mar;10(2):153-62.

PMID:
10762003
33.

Role of protein phosphatases in the regulation of human mast cell and basophil function.

Peirce MJ, Munday MR, Peachell PT.

Am J Physiol. 1999 Dec;277(6 Pt 1):C1021-8. Review.

PMID:
10600752
34.

Beta-adrenoceptor reserve in human lung: a comparison between airway smooth muscle and mast cells.

Chong LK, Peachell PT.

Eur J Pharmacol. 1999 Jul 28;378(1):115-22.

PMID:
10478571
35.
36.

Regulation of human mast cell and basophil function by cAMP.

Weston MC, Peachell PT.

Gen Pharmacol. 1998 Nov;31(5):715-9. Review.

PMID:
9809467
37.

Influence of receptor reserve on beta-adrenoceptor-mediated responses in human lung mast cells.

Drury DE, Chong LK, Ghahramani P, Peachell PT.

Br J Pharmacol. 1998 Jun;124(4):711-8.

38.
39.

Effect of radiographic contrast media on histamine release from human mast cells and basophils.

Peachell PT, Morcos SK.

Br J Radiol. 1998 Jan;71(841):24-30.

PMID:
9534695
40.

Protection by dexamethasone of the functional desensitization to beta 2-adrenoceptor-mediated responses in human lung mast cells.

Chong LK, Drury DE, Dummer JF, Ghahramani P, Schleimer RP, Peachell PT.

Br J Pharmacol. 1997 Jun;121(4):717-22.

41.

Effects of phosphodiesterase inhibitors on human lung mast cell and basophil function.

Weston MC, Anderson N, Peachell PT.

Br J Pharmacol. 1997 May;121(2):287-95.

42.
43.
44.

Regulation of human basophil function by phosphatase inhibitors.

Peirce MJ, Warner JA, Munday MR, Peachell PT.

Br J Pharmacol. 1996 Sep;119(2):446-53.

45.

Functional desensitization of beta agonist responses in human lung mast cells.

Chong LK, Morice AH, Yeo WW, Schleimer RP, Peachell PT.

Am J Respir Cell Mol Biol. 1995 Nov;13(5):540-6.

PMID:
7576689
46.

Regulation of human lung mast cell function by phosphatase inhibitors.

Peachell PT, Munday MR.

J Immunol. 1993 Oct 1;151(7):3808-16.

PMID:
7690815
47.

Role of tyrosine kinases in IgE-mediated signal transduction in human lung mast cells and basophils.

Lavens SE, Peachell PT, Warner JA.

Am J Respir Cell Mol Biol. 1992 Dec;7(6):637-44.

PMID:
1280450
48.

Preliminary identification and role of phosphodiesterase isozymes in human basophils.

Peachell PT, Undem BJ, Schleimer RP, MacGlashan DW Jr, Lichtenstein LM, Cieslinski LB, Torphy TJ.

J Immunol. 1992 Apr 15;148(8):2503-10.

PMID:
1373172
49.

Differential regulation of human basophil and lung mast cell function by adenosine.

Peachell PT, Lichtenstein LM, Schleimer RP.

J Pharmacol Exp Ther. 1991 Feb;256(2):717-26. Erratum in: J Pharmacol Exp Ther 1991 Apr;257(1):539.

PMID:
1704436
50.

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