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Molecular Classification of Hepatocellular Carcinoma Using Wnt-Hippo Signaling Pathway-Related Genes.
Chang YS, Chou YP, Chung CC, Lee YT, Yen JC, Jeng LB, Chang JG. Chang YS, et al. Cancers (Basel). 2022 Sep 21;14(19):4580. doi: 10.3390/cancers14194580. Cancers (Basel). 2022. PMID: 36230503 Free PMC article.
Subclass HCCW4 was associated with a poor prognosis, the highest PCDHB2 and PCDHB6 expression, a relatively high abundance of Th1 cells, NKT and class-switched memory B cells, relatively low enrichment of cDC, iDC, and CD4+ memory T cells, and high Edmondson-Steiner grades …
Subclass HCCW4 was associated with a poor prognosis, the highest PCDHB2 and PCDHB6 expression, a relatively high abundance of Th1 cel …
Sex-Specific Whole-Transcriptome Analysis in the Cerebral Cortex of FAE Offspring.
Mishra NK, Shrinath P, Rao R, Shukla PK. Mishra NK, et al. Cells. 2023 Jan 15;12(2):328. doi: 10.3390/cells12020328. Cells. 2023. PMID: 36672262 Free PMC article.
FAE female mouse brain sequencing data also show an increased expression of Eno1, Tpm3, and Pcdhb2 compared to male offspring. We performed a pathway analysis using a commercial software package (Ingenuity Pathway Analysis). ...
FAE female mouse brain sequencing data also show an increased expression of Eno1, Tpm3, and Pcdhb2 compared to male offspring. We per …
Genomic characterization of cervical cancer based on human papillomavirus status.
Zhang L, Jiang Y, Lu X, Zhao H, Chen C, Wang Y, Hu W, Zhu Y, Yan H, Yan F. Zhang L, et al. Gynecol Oncol. 2019 Mar;152(3):629-637. doi: 10.1016/j.ygyno.2018.12.017. Epub 2018 Dec 20. Gynecol Oncol. 2019. PMID: 30581036
TP53, ARID5B, ARID1A, CTNNB1 and PTEN were significantly differentially mutated between HPV+ and HPV- tumors. Results of radiotherapy analyses demonstrated that CDO1, PCDHB2 and MYOD1 were different between the two subsets. In addition, RP11-299 L17.3, SLC14A2, FGF18 and O …
TP53, ARID5B, ARID1A, CTNNB1 and PTEN were significantly differentially mutated between HPV+ and HPV- tumors. Results of radiotherapy analys …
Identification of m6A-Related Biomarkers Associated with Prognosis of Colorectal Cancer.
Zhang Z, Zhang X. Zhang Z, et al. Med Sci Monit. 2021 Aug 10;27:e932370. doi: 10.12659/MSM.932370. Med Sci Monit. 2021. PMID: 34373442 Free PMC article.
CONCLUSIONS Nine candidate m6A-related mRNA biomarkers (LRRC17, NFKB1, NOS2, PCDHB2, RAB7A, RPS6KA1, RRNAD1, TLE6, and UBE2H) were found to be closely related to the clinicopathology and prognosis of colorectal cancer, indicating that they could be potential prognostic bio …
CONCLUSIONS Nine candidate m6A-related mRNA biomarkers (LRRC17, NFKB1, NOS2, PCDHB2, RAB7A, RPS6KA1, RRNAD1, TLE6, and UBE2H) were fo …
Identification and Prognostic Value Exploration of Cyclophosphamide (Cytoxan)-Centered Chemotherapy Response-Associated Genes in Breast Cancer.
Du J, Dong Y, Li Y. Du J, et al. DNA Cell Biol. 2021 Nov;40(11):1356-1368. doi: 10.1089/dna.2021.0077. Epub 2021 Oct 26. DNA Cell Biol. 2021. PMID: 34704810
Ten genes were further selected to be related to the prognosis of BRCA patients, including PCDHB2, GRIK2, FRMD7, CCSER1, PCDHGA1, PCDHA1, LRRC37A6P, PCDHGA12, ZNF486, and PCDHGB5, based on the Risk Score model. ...
Ten genes were further selected to be related to the prognosis of BRCA patients, including PCDHB2, GRIK2, FRMD7, CCSER1, PCDHGA1, PCD …
Deletion of the App-Runx1 region in mice models human partial monosomy 21.
Arbogast T, Raveau M, Chevalier C, Nalesso V, Dembele D, Jacobs H, Wendling O, Roux M, Duchon A, Herault Y. Arbogast T, et al. Dis Model Mech. 2015 Jun;8(6):623-34. doi: 10.1242/dmm.017814. Epub 2015 Apr 16. Dis Model Mech. 2015. PMID: 26035870 Free PMC article.
Further studies confirmed a gene dosage effect in the Ms5Yah hippocampus, and pinpointed disruptions of pathways related to cell adhesion (involving App, Cntnap5b, Lgals3bp, Mag, Mcam, Npnt, Pcdhb2, Pcdhb3, Pcdhb4, Pcdhb6, Pcdhb7, Pcdhb8, Pcdhb16 and Vwf). ...
Further studies confirmed a gene dosage effect in the Ms5Yah hippocampus, and pinpointed disruptions of pathways related to cell adhesion (i …
A Six-Gene Prognostic and Predictive Radiotherapy-Based Signature for Early and Locally Advanced Stages in Non-Small-Cell Lung Cancer.
Peinado-Serrano J, Quintanal-Villalonga Á, Muñoz-Galvan S, Verdugo-Sivianes EM, Mateos JC, Ortiz-Gordillo MJ, Carnero A. Peinado-Serrano J, et al. Cancers (Basel). 2022 Apr 19;14(9):2054. doi: 10.3390/cancers14092054. Cancers (Basel). 2022. PMID: 35565183 Free PMC article.
We obtained a six-gene signature (APOBEC3B, GOLM1, FAM117A, KCNQ1OT1, PCDHB2, and USP43) with the ability to predict overall survival and progression-free survival (PFS), which could translate into a prediction of the response to the cancer treatment received. ...
We obtained a six-gene signature (APOBEC3B, GOLM1, FAM117A, KCNQ1OT1, PCDHB2, and USP43) with the ability to predict overall survival …
Comparison of genome-wide DNA methylation in urothelial carcinomas of patients with and without arsenic exposure.
Yang TY, Hsu LI, Chiu AW, Pu YS, Wang SH, Liao YT, Wu MM, Wang YH, Chang CH, Lee TC, Chen CJ. Yang TY, et al. Environ Res. 2014 Jan;128:57-63. doi: 10.1016/j.envres.2013.10.006. Epub 2013 Nov 22. Environ Res. 2014. PMID: 24268366
Significant associations between cumulative arsenic exposure and DNA methylation levels of 28 patients were observed in nine CpG sites of nine gens including PDGFD (Spearman rank correlation, 0.54), CTNNA2 (0.48), KCNK17 (0.52), PCDHB2 (0.57), ZNF132 (0.48), DCDC2 (0.48), …
Significant associations between cumulative arsenic exposure and DNA methylation levels of 28 patients were observed in nine CpG sites of ni …
Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM).
Carter H, Samayoa J, Hruban RH, Karchin R. Carter H, et al. Cancer Biol Ther. 2010 Sep 15;10(6):582-7. doi: 10.4161/cbt.10.6.12537. Epub 2010 Oct 1. Cancer Biol Ther. 2010. PMID: 20581473 Free PMC article.
An additional 15 genes with putative driver mutations include genes coding for kinases (PIK3CG, DGKA, STK33, TTK and PRKCG), for cell cycle related proteins (NEK8), and for proteins involved in cell adhesion (CMAS, PCDHB2). These and other mutations identified by CHASM poi …
An additional 15 genes with putative driver mutations include genes coding for kinases (PIK3CG, DGKA, STK33, TTK and PRKCG), for cell cycle …