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Neurocognitive Decline Following Radiotherapy: Mechanisms and Therapeutic Implications.

Pazzaglia S, Briganti G, Mancuso M, Saran A.

Cancers (Basel). 2020 Jan 8;12(1). pii: E146. doi: 10.3390/cancers12010146. Review.


ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP.

Bufalieri F, Infante P, Bernardi F, Caimano M, Romania P, Moretti M, Lospinoso Severini L, Talbot J, Melaiu O, Tanori M, Di Magno L, Bellavia D, Capalbo C, Puget S, De Smaele E, Canettieri G, Guardavaccaro D, Busino L, Peschiaroli A, Pazzaglia S, Giannini G, Melino G, Locatelli F, Gulino A, Ayrault O, Fruci D, Di Marcotullio L.

Nat Commun. 2019 Jul 24;10(1):3304. doi: 10.1038/s41467-019-11093-0.


Cancer risk from low dose radiation in Ptch1+/- mice with inactive DNA repair systems: Therapeutic implications for medulloblastoma.

Tanori M, Pannicelli A, Pasquali E, Casciati A, Antonelli F, Giardullo P, Leonardi S, Tanno B, De Stefano I, Saran A, Mancuso M, Pazzaglia S.

DNA Repair (Amst). 2019 Feb;74:70-79. doi: 10.1016/j.dnarep.2018.12.003. Epub 2018 Dec 16.


Sonic hedgehog signaling controls dentate gyrus patterning and adult neurogenesis in the hippocampus.

Antonelli F, Casciati A, Pazzaglia S.

Neural Regen Res. 2019 Jan;14(1):59-61. doi: 10.4103/1673-5374.243703. No abstract available.


Alterations in Morphology and Adult Neurogenesis in the Dentate Gyrus of Patched1 Heterozygous Mice.

Antonelli F, Casciati A, Tanori M, Tanno B, Linares-Vidal MV, Serra N, Bellés M, Pannicelli A, Saran A, Pazzaglia S.

Front Mol Neurosci. 2018 May 23;11:168. doi: 10.3389/fnmol.2018.00168. eCollection 2018.


[Education, motivations and working conditions of a cohort of nurses attending to an open-competition].

Accardi R, Pazzaglia S, Demarchi A, Sappa B, Laquintana D.

Assist Inferm Ric. 2018 Jan-Mar;37(1):5-11. doi: 10.1702/2890.29147. Italian.


Multidisciplinary European Low Dose Initiative (MELODI): strategic research agenda for low dose radiation risk research.

Kreuzer M, Auvinen A, Cardis E, Durante M, Harms-Ringdahl M, Jourdain JR, Madas BG, Ottolenghi A, Pazzaglia S, Prise KM, Quintens R, Sabatier L, Bouffler S.

Radiat Environ Biophys. 2018 Mar;57(1):5-15. doi: 10.1007/s00411-017-0726-1. Epub 2017 Dec 15. Review.


[The new methods to define the staffing requirements for doctors,<BR>nurses and nurses aides: an example of their implementation in an Italian hospital].

Laquintana D, Pazzaglia S, Demarchi A.

Assist Inferm Ric. 2017 Jul-Sep;36(3):123-134. doi: 10.1702/2786.28221. Italian.


Synthetic lethal genetic interactions between Rad54 and PARP-1 in mouse development and oncogenesis.

Tanori M, Casciati A, Berardinelli F, Leonardi S, Pasquali E, Antonelli F, Tanno B, Giardullo P, Pannicelli A, Babini G, De Stefano I, Sgura A, Mancuso M, Saran A, Pazzaglia S.

Oncotarget. 2016 Jul 7;8(60):100958-100974. doi: 10.18632/oncotarget.10479. eCollection 2017 Nov 24.


Brain Radiation Information Data Exchange (BRIDE): integration of experimental data from low-dose ionising radiation research for pathway discovery.

Karapiperis C, Kempf SJ, Quintens R, Azimzadeh O, Vidal VL, Pazzaglia S, Bazyka D, Mastroberardino PG, Scouras ZG, Tapio S, Benotmane MA, Ouzounis CA.

BMC Bioinformatics. 2016 May 11;17(1):212. doi: 10.1186/s12859-016-1068-8.


Age-related effects of X-ray irradiation on mouse hippocampus.

Casciati A, Dobos K, Antonelli F, Benedek A, Kempf SJ, Bellés M, Balogh A, Tanori M, Heredia L, Atkinson MJ, von Toerne C, Azimzadeh O, Saran A, Sáfrány G, Benotmane MA, Linares-Vidal MV, Tapio S, Lumniczky K, Pazzaglia S.

Oncotarget. 2016 May 10;7(19):28040-58. doi: 10.18632/oncotarget.8575.


MK-4101, a Potent Inhibitor of the Hedgehog Pathway, Is Highly Active against Medulloblastoma and Basal Cell Carcinoma.

Filocamo G, Brunetti M, Colaceci F, Sasso R, Tanori M, Pasquali E, Alfonsi R, Mancuso M, Saran A, Lahm A, Di Marcotullio L, Steinkühler C, Pazzaglia S.

Mol Cancer Ther. 2016 Jun;15(6):1177-89. doi: 10.1158/1535-7163.MCT-15-0371. Epub 2016 Mar 9.


Acceleration of atherogenesis in ApoE-/- mice exposed to acute or low-dose-rate ionizing radiation.

Mancuso M, Pasquali E, Braga-Tanaka I 3rd, Tanaka S, Pannicelli A, Giardullo P, Pazzaglia S, Tapio S, Atkinson MJ, Saran A.

Oncotarget. 2015 Oct 13;6(31):31263-71. doi: 10.18632/oncotarget.5075.


A multidisciplinary approach unravels early and persistent effects of X-ray exposure at the onset of prenatal neurogenesis.

Verreet T, Quintens R, Van Dam D, Verslegers M, Tanori M, Casciati A, Neefs M, Leysen L, Michaux A, Janssen A, D'Agostino E, Vande Velde G, Baatout S, Moons L, Pazzaglia S, Saran A, Himmelreich U, De Deyn PP, Benotmane MA.

J Neurodev Disord. 2015;7(1):3. doi: 10.1186/1866-1955-7-3. Epub 2015 Jan 9.


The cognitive defects of neonatally irradiated mice are accompanied by changed synaptic plasticity, adult neurogenesis and neuroinflammation.

Kempf SJ, Casciati A, Buratovic S, Janik D, von Toerne C, Ueffing M, Neff F, Moertl S, Stenerlöw B, Saran A, Atkinson MJ, Eriksson P, Pazzaglia S, Tapio S.

Mol Neurodegener. 2014 Dec 16;9:57. doi: 10.1186/1750-1326-9-57.


The Patched 1 tumor-suppressor gene protects the mouse lens from spontaneous and radiation-induced cataract.

De Stefano I, Tanno B, Giardullo P, Leonardi S, Pasquali E, Antonelli F, Tanori M, Casciati A, Pazzaglia S, Saran A, Mancuso M.

Am J Pathol. 2015 Jan;185(1):85-95. doi: 10.1016/j.ajpath.2014.09.019. Epub 2014 Nov 15.


Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells.

Spina R, Filocamo G, Iaccino E, Scicchitano S, Lupia M, Chiarella E, Mega T, Bernaudo F, Pelaggi D, Mesuraca M, Pazzaglia S, Semenkow S, Bar EE, Kool M, Pfister S, Bond HM, Eberhart CG, Steinkühler C, Morrone G.

Oncotarget. 2013 Aug;4(8):1280-92.


Developmental and oncogenic radiation effects on neural stem cells and their differentiating progeny in mouse cerebellum.

Tanori M, Pasquali E, Leonardi S, Casciati A, Giardullo P, De Stefano I, Mancuso M, Saran A, Pazzaglia S.

Stem Cells. 2013 Nov;31(11):2506-16. doi: 10.1002/stem.1485.


Oncogenic radiation abscopal effects in vivo: interrogating mouse skin.

Mancuso M, Leonardi S, Giardullo P, Pasquali E, Tanori M, De Stefano I, Casciati A, Naus CC, Pazzaglia S, Saran A.

Int J Radiat Oncol Biol Phys. 2013 Aug 1;86(5):993-9. doi: 10.1016/j.ijrobp.2013.04.040. Epub 2013 Jun 5.


A mechanistic model for medulloblastoma induction in mice.

Heidenreich WF, Saran A, Atkinson M, Pazzaglia S.

Radiat Res. 2013 May;179(5):610-4. doi: 10.1667/RR3130.1. Epub 2013 Apr 5.


Dose and spatial effects in long-distance radiation signaling in vivo: implications for abscopal tumorigenesis.

Mancuso M, Giardullo P, Leonardi S, Pasquali E, Casciati A, De Stefano I, Tanori M, Pazzaglia S, Saran A.

Int J Radiat Oncol Biol Phys. 2013 Mar 1;85(3):813-9. doi: 10.1016/j.ijrobp.2012.07.2372. Epub 2012 Sep 11.


The Lsktm1 locus modulates lung and skin tumorigenesis in the mouse.

Galvan A, Colombo F, Noci S, Pazzaglia S, Mancuso M, Manenti G, Broman KW, Saran A, Dragani TA.

G3 (Bethesda). 2012 Sep;2(9):1041-6. doi: 10.1534/g3.112.003525. Epub 2012 Sep 1.


Hedgehog/hyaluronic acid interaction network in nonalcoholic fatty liver disease, fibrosis, and hepatocellular carcinoma.

Pazzaglia S, Cifaldi L, Saran A, Nobili V, Fruci D, Alisi A.

Hepatology. 2012 Oct;56(4):1589. doi: 10.1002/hep.25783. No abstract available.


The radiation bystander effect and its potential implications for human health.

Mancuso M, Pasquali E, Giardullo P, Leonardi S, Tanori M, Di Majo V, Pazzaglia S, Saran A.

Curr Mol Med. 2012 Jun;12(5):613-24. Review.


The estrogen receptor beta agonist diarylpropionitrile (DPN) inhibits medulloblastoma development via anti-proliferative and pro-apototic pathways.

Mancuso M, Leonardi S, Giardullo P, Pasquali E, Borra F, Stefano ID, Prisco MG, Tanori M, Scambia G, Majo VD, Pazzaglia S, Saran A, Gallo D.

Cancer Lett. 2011 Sep 28;308(2):197-202. doi: 10.1016/j.canlet.2011.05.004. Epub 2011 Jun 1.


Opposite modifying effects of HR and NHEJ deficiency on cancer risk in Ptc1 heterozygous mouse cerebellum.

Tanori M, Pasquali E, Leonardi S, Giardullo P, Di Majo V, Taccioli G, Essers J, Kanaar R, Mullenders LH, Atkinson MJ, Mancuso M, Saran A, Pazzaglia S.

Oncogene. 2011 Nov 24;30(47):4740-9. doi: 10.1038/onc.2011.178. Epub 2011 May 23.


Role of connexin43 and ATP in long-range bystander radiation damage and oncogenesis in vivo.

Mancuso M, Pasquali E, Leonardi S, Rebessi S, Tanori M, Giardullo P, Borra F, Pazzaglia S, Naus CC, Di Majo V, Saran A.

Oncogene. 2011 Nov 10;30(45):4601-8. doi: 10.1038/onc.2011.176. Epub 2011 May 23.


Protective role of 17 β-estradiol on medulloblastoma development in Patched 1 heterozygous mice.

Mancuso M, Leonardi S, Ceccarelli M, Pasquali E, De Stefano I, Prisco MG, Rebessi S, Tanori M, Scambia G, Di Majo V, Pazzaglia S, Saran A, Gallo D.

Int J Cancer. 2010 Dec 15;127(12):2749-57. doi: 10.1002/ijc.25293.


Microsatellite instability in radiation-induced murine tumours; influence of tumour type and radiation quality.

Haines J, Bacher J, Coster M, Huiskamp R, Meijne E, Mancuso M, Pazzaglia S, Bouffler S.

Int J Radiat Biol. 2010 Jul;86(7):555-68. doi: 10.3109/09553001003734600.


Anterior chamber depth measurement in pseudophakic eyes: a comparison of Pentacam and ultrasound.

Savini G, Olsen T, Carbonara C, Pazzaglia S, Barboni P, Carbonelli M, Hoffer KJ.

J Refract Surg. 2010 May;26(5):341-7. doi: 10.3928/1081597X-20090617-02. Epub 2010 May 19.


Genetic heterogeneity of inflammatory response and skin tumorigenesis in phenotypically selected mouse lines.

Galvan A, Vorraro F, Cabrera WH, Ribeiro OG, Pazzaglia S, Mancuso M, Zolin A, Milani S, Saran A, Ibañez OM, Dragani TA.

Cancer Lett. 2010 Sep 1;295(1):54-8. doi: 10.1016/j.canlet.2010.02.013. Epub 2010 Mar 21.


Developmental and oncogenic effects of insulin-like growth factor-I in Ptc1+/- mouse cerebellum.

Tanori M, Santone M, Mancuso M, Pasquali E, Leonardi S, Di Majo V, Rebessi S, Saran A, Pazzaglia S.

Mol Cancer. 2010 Mar 9;9:53. doi: 10.1186/1476-4598-9-53.


Smoothened antagonists: a promising new class of antitumor agents.

Gallinari P, Filocamo G, Jones P, Pazzaglia S, Steinkühler C.

Expert Opin Drug Discov. 2009 May;4(5):525-44. doi: 10.1517/17460440902852686.


Physical, heritable and age-related factors as modifiers of radiation cancer risk in patched heterozygous mice.

Pazzaglia S, Pasquali E, Tanori M, Mancuso M, Leonardi S, di Majo V, Rebessi S, Saran A.

Int J Radiat Oncol Biol Phys. 2009 Mar 15;73(4):1203-10. doi: 10.1016/j.ijrobp.2008.10.068. Epub 2009 Feb 7.


Genetic background modulates gene expression profile induced by skin irradiation in ptch1 mice.

Galvan A, Noci S, Mancuso M, Pazzaglia S, Saran A, Dragani TA.

Int J Radiat Oncol Biol Phys. 2008 Dec 1;72(5):1582-6. doi: 10.1016/j.ijrobp.2008.08.008.


Two-stage study (1990-2002) of North African immigrants in Italy.

Toselli S, Galletti L, Pazzaglia S, Gualdi-Russo E.

Homo. 2008;59(6):439-52. doi: 10.1016/j.jchb.2006.08.009. Epub 2008 Nov 7.


Modulation of basal and squamous cell carcinoma by endogenous estrogen in mouse models of skin cancer.

Mancuso M, Gallo D, Leonardi S, Pierdomenico M, Pasquali E, De Stefano I, Rebessi S, Tanori M, Scambia G, Di Majo V, Covelli V, Pazzaglia S, Saran A.

Carcinogenesis. 2009 Feb;30(2):340-7. doi: 10.1093/carcin/bgn243. Epub 2008 Oct 24.


Oncogenic bystander radiation effects in Patched heterozygous mouse cerebellum.

Mancuso M, Pasquali E, Leonardi S, Tanori M, Rebessi S, Di Majo V, Pazzaglia S, Toni MP, Pimpinella M, Covelli V, Saran A.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12445-50. doi: 10.1073/pnas.0804186105. Epub 2008 Aug 18.


PARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinoma.

Tanori M, Mancuso M, Pasquali E, Leonardi S, Rebessi S, Di Majo V, Guilly MN, Giangaspero F, Covelli V, Pazzaglia S, Saran A.

Carcinogenesis. 2008 Oct;29(10):1911-9. doi: 10.1093/carcin/bgn174. Epub 2008 Jul 27.


An integrated approach identifies Nhlh1 and Insm1 as Sonic Hedgehog-regulated genes in developing cerebellum and medulloblastoma.

De Smaele E, Fragomeli C, Ferretti E, Pelloni M, Po A, Canettieri G, Coni S, Di Marcotullio L, Greco A, Moretti M, Di Rocco C, Pazzaglia S, Maroder M, Screpanti I, Giannini G, Gulino A.

Neoplasia. 2008 Jan;10(1):89-98.


Effects of exposure of newborn patched1 heterozygous mice to GSM, 900 MHz.

Saran A, Pazzaglia S, Mancuso M, Rebessi S, Di Majo V, Tanori M, Lovisolo GA, Pinto R, Marino C.

Radiat Res. 2007 Dec;168(6):733-40.


Inhibition of medulloblastoma tumorigenesis by the antiproliferative and pro-differentiative gene PC3.

Farioli-Vecchioli S, Tanori M, Micheli L, Mancuso M, Leonardi L, Saran A, Ciotti MT, Ferretti E, Gulino A, Pazzaglia S, Tirone F.

FASEB J. 2007 Jul;21(9):2215-25. Epub 2007 Mar 19.


Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas.

Iacovelli L, Arcella A, Battaglia G, Pazzaglia S, Aronica E, Spinsanti P, Caruso A, De Smaele E, Saran A, Gulino A, D'Onofrio M, Giangaspero F, Nicoletti F.

J Neurosci. 2006 Aug 9;26(32):8388-97.


Alternative splicing of the ErbB-4 cytoplasmic domain and its regulation by hedgehog signaling identify distinct medulloblastoma subsets.

Ferretti E, Di Marcotullio L, Gessi M, Mattei T, Greco A, Po A, De Smaele E, Giangaspero F, Riccardi R, Di Rocco C, Pazzaglia S, Maroder M, Alimandi M, Screpanti I, Gulino A.

Oncogene. 2006 Nov 23;25(55):7267-73. Epub 2006 Jul 31.


Hair cycle-dependent basal cell carcinoma tumorigenesis in Ptc1neo67/+ mice exposed to radiation.

Mancuso M, Leonardi S, Tanori M, Pasquali E, Pierdomenico M, Rebessi S, Di Majo V, Covelli V, Pazzaglia S, Saran A.

Cancer Res. 2006 Jul 1;66(13):6606-14.


Two-hit model for progression of medulloblastoma preneoplasia in Patched heterozygous mice.

Pazzaglia S, Tanori M, Mancuso M, Gessi M, Pasquali E, Leonardi S, Oliva MA, Rebessi S, Di Majo V, Covelli V, Giangaspero F, Saran A.

Oncogene. 2006 Sep 7;25(40):5575-80. Epub 2006 Apr 24.


Linking DNA damage to medulloblastoma tumorigenesis in patched heterozygous knockout mice.

Pazzaglia S, Tanori M, Mancuso M, Rebessi S, Leonardi S, Di Majo V, Covelli V, Atkinson MJ, Hahn H, Saran A.

Oncogene. 2006 Feb 23;25(8):1165-73.


Ptc1 heterozygous knockout mice as a model of multi-organ tumorigenesis.

Pazzaglia S.

Cancer Lett. 2006 Mar 28;234(2):124-34. Epub 2005 May 31. Review.


Met proto-oncogene juxtamembrane rare variations in mouse and humans: differential effects of Arg and Cys alleles on mouse lung tumorigenesis.

Zaffaroni D, Spinola M, Galvan A, Falvella FS, Pazzaglia S, Saran A, Mancuso MT, Galbiati F, Pignatiello C, Cabrera W, Ibanez O, Manenti G, Dragani TA.

Oncogene. 2005 Feb 3;24(6):1084-90.


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