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Items: 1 to 50 of 109

1.

Intraflagellar transport protein 74 is essential for spermatogenesis and male fertility in mice‡.

Shi L, Zhou T, Huang Q, Zhang S, Li W, Zhang L, Hess RA, Pazour GJ, Zhang Z.

Biol Reprod. 2019 Apr 20. pii: ioz071. doi: 10.1093/biolre/ioz071. [Epub ahead of print]

PMID:
31004481
2.

Hypomorphic mutations of TRIP11 cause odontochondrodysplasia.

Wehrle A, Witkos TM, Unger S, Schneider J, Follit JA, Hermann J, Welting T, Fano V, Hietala M, Vatanavicharn N, Schoner K, Spranger J, Schmidts M, Zabel B, Pazour GJ, Bloch-Zupan A, Nishimura G, Superti-Furga A, Lowe M, Lausch E.

JCI Insight. 2019 Feb 7;4(3). pii: 124701. doi: 10.1172/jci.insight.124701. [Epub ahead of print]

3.

A global analysis of IFT-A function reveals specialization for transport of membrane-associated proteins into cilia.

Picariello T, Brown JM, Hou Y, Swank G, Cochran DA, King OD, Lechtreck K, Pazour GJ, Witman GB.

J Cell Sci. 2019 Feb 11;132(3). pii: jcs220749. doi: 10.1242/jcs.220749.

PMID:
30659111
4.

Congenital Heart Defects and Ciliopathies Associated With Renal Phenotypes.

Gabriel GC, Pazour GJ, Lo CW.

Front Pediatr. 2018 Jun 15;6:175. doi: 10.3389/fped.2018.00175. eCollection 2018. Review.

5.

Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development.

Desai PB, San Agustin JT, Stuck MW, Jonassen JA, Bates CM, Pazour GJ.

Mech Dev. 2018 Jun;151:10-17. doi: 10.1016/j.mod.2018.04.001. Epub 2018 Apr 4.

6.

Intraflagellar transport is deeply integrated in hedgehog signaling.

Eguether T, Cordelieres FP, Pazour GJ.

Mol Biol Cell. 2018 May 15;29(10):1178-1189. doi: 10.1091/mbc.E17-10-0600. Epub 2018 Mar 22.

7.

Intraflagellar transporter protein 140 (IFT140), a component of IFT-A complex, is essential for male fertility and spermiogenesis in mice.

Zhang Y, Liu H, Li W, Zhang Z, Zhang S, Teves ME, Stevens C, Foster JA, Campbell GE, Windle JJ, Hess RA, Pazour GJ, Zhang Z.

Cytoskeleton (Hoboken). 2018 Feb;75(2):70-84. doi: 10.1002/cm.21427. Epub 2018 Jan 8.

8.

Erratum: Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome.

Shi X, Garcia G 3rd, Van De Weghe JC, McGorty R, Pazour GJ, Doherty D, Huang B, Reiter JF.

Nat Cell Biol. 2017 Oct 31;19(11):1379. doi: 10.1038/ncb3622.

PMID:
29087383
9.

Neurodevelopmental disease mechanisms, primary cilia, and endosomes converge on the BLOC-1 and BORC complexes.

Hartwig C, Monis WJ, Chen X, Dickman DK, Pazour GJ, Faundez V.

Dev Neurobiol. 2018 Mar;78(3):311-330. doi: 10.1002/dneu.22542. Epub 2017 Oct 13. Review.

10.

Intraflagellar transporter protein (IFT27), an IFT25 binding partner, is essential for male fertility and spermiogenesis in mice.

Zhang Y, Liu H, Li W, Zhang Z, Shang X, Zhang D, Li Y, Zhang S, Liu J, Hess RA, Pazour GJ, Zhang Z.

Dev Biol. 2017 Dec 1;432(1):125-139. doi: 10.1016/j.ydbio.2017.09.023. Epub 2017 Sep 28.

11.

Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome.

Shi X, Garcia G 3rd, Van De Weghe JC, McGorty R, Pazour GJ, Doherty D, Huang B, Reiter JF.

Nat Cell Biol. 2017 Oct;19(10):1178-1188. doi: 10.1038/ncb3599. Epub 2017 Aug 28. Erratum in: Nat Cell Biol. 2017 Oct 31;19(11):1379.

12.

BLOC-1 is required for selective membrane protein trafficking from endosomes to primary cilia.

Monis WJ, Faundez V, Pazour GJ.

J Cell Biol. 2017 Jul 3;216(7):2131-2150. doi: 10.1083/jcb.201611138. Epub 2017 Jun 2.

13.

INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma.

Yang N, Leung EL, Liu C, Li L, Eguether T, Jun Yao XJ, Jones EC, Norris DA, Liu A, Clark RA, Roop DR, Pazour GJ, Shroyer KR, Chen J.

Oncogene. 2017 Aug 31;36(35):4997-5005. doi: 10.1038/onc.2017.117. Epub 2017 May 1.

14.

IFT25, an intraflagellar transporter protein dispensable for ciliogenesis in somatic cells, is essential for sperm flagella formation.

Liu H, Li W, Zhang Y, Zhang Z, Shang X, Zhang L, Zhang S, Li Y, Somoza AV, Delpi B, Gerton GL, Foster JA, Hess RA, Pazour GJ, Zhang Z.

Biol Reprod. 2017 May 1;96(5):993-1006. doi: 10.1093/biolre/iox029.

15.

Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration.

Pearring JN, San Agustin JT, Lobanova ES, Gabriel CJ, Lieu EC, Monis WJ, Stuck MW, Strittmatter L, Jaber SM, Arshavsky VY, Pazour GJ.

PLoS Genet. 2017 Apr 14;13(4):e1006740. doi: 10.1371/journal.pgen.1006740. eCollection 2017 Apr.

16.

Fifteen years of research on oral-facial-digital syndromes: from 1 to 16 causal genes.

Bruel AL, Franco B, Duffourd Y, Thevenon J, Jego L, Lopez E, Deleuze JF, Doummar D, Giles RH, Johnson CA, Huynen MA, Chevrier V, Burglen L, Morleo M, Desguerres I, Pierquin G, Doray B, Gilbert-Dussardier B, Reversade B, Steichen-Gersdorf E, Baumann C, Panigrahi I, Fargeot-Espaliat A, Dieux A, David A, Goldenberg A, Bongers E, Gaillard D, Argente J, Aral B, Gigot N, St-Onge J, Birnbaum D, Phadke SR, Cormier-Daire V, Eguether T, Pazour GJ, Herranz-Pérez V, Goldstein JS, Pasquier L, Loget P, Saunier S, Mégarbané A, Rosnet O, Leroux MR, Wallingford JB, Blacque OE, Nachury MV, Attie-Bitach T, Rivière JB, Faivre L, Thauvin-Robinet C.

J Med Genet. 2017 Jun;54(6):371-380. doi: 10.1136/jmedgenet-2016-104436. Epub 2017 Mar 13. Review.

17.

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness.

Nishita M, Park SY, Nishio T, Kamizaki K, Wang Z, Tamada K, Takumi T, Hashimoto R, Otani H, Pazour GJ, Hsu VW, Minami Y.

Sci Rep. 2017 Jan 26;7(1):1. doi: 10.1038/s41598-016-0028-x.

18.

Intraflagellar transport protein IFT20 is essential for male fertility and spermiogenesis in mice.

Zhang Z, Li W, Zhang Y, Zhang L, Teves ME, Liu H, Strauss JF 3rd, Pazour GJ, Foster JA, Hess RA, Zhang Z.

Mol Biol Cell. 2016 Sep 28. pii: mbc.E16-05-0318. [Epub ahead of print]

19.

Erratum: Genetic link between renal birth defects and congenital heart disease.

San Agustin JT, Klena N, Granath K, Panigrahy A, Stewart E, Devine W, Strittmatter L, Jonassen JA, Liu X, Lo CW, Pazour GJ.

Nat Commun. 2016 Jun 8;7:11910. doi: 10.1038/ncomms11910. No abstract available.

20.

A novel ICK mutation causes ciliary disruption and lethal endocrine-cerebro-osteodysplasia syndrome.

Oud MM, Bonnard C, Mans DA, Altunoglu U, Tohari S, Ng AYJ, Eskin A, Lee H, Rupar CA, de Wagenaar NP, Wu KM, Lahiry P, Pazour GJ, Nelson SF, Hegele RA, Roepman R, Kayserili H, Venkatesh B, Siu VM, Reversade B, Arts HH.

Cilia. 2016 Apr 11;5:8. doi: 10.1186/s13630-016-0029-1. eCollection 2016.

21.

Autosomal recessive IFT57 hypomorphic mutation cause ciliary transport defect in unclassified oral-facial-digital syndrome with short stature and brachymesophalangia.

Thevenon J, Duplomb L, Phadke S, Eguether T, Saunier A, Avila M, Carmignac V, Bruel AL, St-Onge J, Duffourd Y, Pazour GJ, Franco B, Attie-Bitach T, Masurel-Paulet A, Rivière JB, Cormier-Daire V, Philippe C, Faivre L, Thauvin-Robinet C.

Clin Genet. 2016 Dec;90(6):509-517. doi: 10.1111/cge.12785. Epub 2016 Apr 29.

22.

Genetic link between renal birth defects and congenital heart disease.

San Agustin JT, Klena N, Granath K, Panigrahy A, Stewart E, Devine W, Strittmatter L, Jonassen JA, Liu X, Lo CW, Pazour GJ.

Nat Commun. 2016 Mar 22;7:11103. doi: 10.1038/ncomms11103. Erratum in: Nat Commun. 2016 Jun 08;7:11910.

23.

DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia.

Li Y, Yagi H, Onuoha EO, Damerla RR, Francis R, Furutani Y, Tariq M, King SM, Hendricks G, Cui C, Saydmohammed M, Lee DM, Zahid M, Sami I, Leatherbury L, Pazour GJ, Ware SM, Nakanishi T, Goldmuntz E, Tsang M, Lo CW.

PLoS Genet. 2016 Feb 26;12(2):e1005821. doi: 10.1371/journal.pgen.1005821. eCollection 2016 Feb.

24.

IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo.

Vivar OI, Masi G, Carpier JM, Magalhaes JG, Galgano D, Pazour GJ, Amigorena S, Hivroz C, Baldari CT.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):386-91. doi: 10.1073/pnas.1513601113. Epub 2015 Dec 29.

25.

Intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm.

San Agustin JT, Pazour GJ, Witman GB.

Mol Biol Cell. 2015 Dec 1;26(24):4358-72. doi: 10.1091/mbc.E15-08-0578. Epub 2015 Sep 30.

26.

Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis.

Yang N, Li L, Eguether T, Sundberg JP, Pazour GJ, Chen J.

Development. 2015 Aug 15;142(16):2860. doi: 10.1242/dev.128751. No abstract available.

27.

The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling T-cell receptors to the immune synapse.

Finetti F, Patrussi L, Galgano D, Cassioli C, Perinetti G, Pazour GJ, Baldari CT.

J Cell Sci. 2015 Jul 15;128(14):2541-52. doi: 10.1242/jcs.171652. Epub 2015 Jun 1.

28.

Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis.

Yang N, Li L, Eguether T, Sundberg JP, Pazour GJ, Chen J.

Development. 2015 Jun 15;142(12):2194-202. doi: 10.1242/dev.115261. Epub 2015 May 28. Erratum in: Development. 2015 Aug 15;142(16):2860.

29.

Novel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomalies.

Damerla RR, Cui C, Gabriel GC, Liu X, Craige B, Gibbs BC, Francis R, Li Y, Chatterjee B, San Agustin JT, Eguether T, Subramanian R, Witman GB, Michaud JL, Pazour GJ, Lo CW.

Hum Mol Genet. 2015 Jul 15;24(14):3994-4005. doi: 10.1093/hmg/ddv137. Epub 2015 Apr 15.

30.

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.

Li Y, Klena NT, Gabriel GC, Liu X, Kim AJ, Lemke K, Chen Y, Chatterjee B, Devine W, Damerla RR, Chang C, Yagi H, San Agustin JT, Thahir M, Anderton S, Lawhead C, Vescovi A, Pratt H, Morgan J, Haynes L, Smith CL, Eppig JT, Reinholdt L, Francis R, Leatherbury L, Ganapathiraju MK, Tobita K, Pazour GJ, Lo CW.

Nature. 2015 May 28;521(7553):520-4. doi: 10.1038/nature14269. Epub 2015 Mar 25.

31.

Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea.

May-Simera HL, Petralia RS, Montcouquiol M, Wang YX, Szarama KB, Liu Y, Lin W, Deans MR, Pazour GJ, Kelley MW.

Development. 2015 Feb 1;142(3):555-66. doi: 10.1242/dev.113696.

32.

ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning.

Czarnecki PG, Gabriel GC, Manning DK, Sergeev M, Lemke K, Klena NT, Liu X, Chen Y, Li Y, San Agustin JT, Garnaas MK, Francis RJ, Tobita K, Goessling W, Pazour GJ, Lo CW, Beier DR, Shah JV.

Nat Commun. 2015 Jan 20;6:6023. doi: 10.1038/ncomms7023.

33.

IFT27 links the BBSome to IFT for maintenance of the ciliary signaling compartment.

Eguether T, San Agustin JT, Keady BT, Jonassen JA, Liang Y, Francis R, Tobita K, Johnson CA, Abdelhamed ZA, Lo CW, Pazour GJ.

Dev Cell. 2014 Nov 10;31(3):279-290. doi: 10.1016/j.devcel.2014.09.011. Epub 2014 Oct 30.

34.

NPHP4 controls ciliary trafficking of membrane proteins and large soluble proteins at the transition zone.

Awata J, Takada S, Standley C, Lechtreck KF, Bellvé KD, Pazour GJ, Fogarty KE, Witman GB.

J Cell Sci. 2014 Nov 1;127(Pt 21):4714-27. doi: 10.1242/jcs.155275. Epub 2014 Aug 22.

35.

Role of cilia in structural birth defects: insights from ciliopathy mutant mouse models.

Rao Damerla R, Gabriel GC, Li Y, Klena NT, Liu X, Chen Y, Cui C, Pazour GJ, Lo CW.

Birth Defects Res C Embryo Today. 2014 Jun;102(2):115-25. doi: 10.1002/bdrc.21067. Review.

PMID:
24975753
36.

Casein kinase 1δ functions at the centrosome and Golgi to promote ciliogenesis.

Greer YE, Westlake CJ, Gao B, Bharti K, Shiba Y, Xavier CP, Pazour GJ, Yang Y, Rubin JS.

Mol Biol Cell. 2014 May;25(10):1629-40. doi: 10.1091/mbc.E13-10-0598. Epub 2014 Mar 19.

37.

Distinct functions for IFT140 and IFT20 in opsin transport.

Crouse JA, Lopes VS, Sanagustin JT, Keady BT, Williams DS, Pazour GJ.

Cytoskeleton (Hoboken). 2014 May;71(5):302-10. doi: 10.1002/cm.21173. Epub 2014 Mar 25.

38.

Arf4 is required for Mammalian development but dispensable for ciliary assembly.

Follit JA, San Agustin JT, Jonassen JA, Huang T, Rivera-Perez JA, Tremblay KD, Pazour GJ.

PLoS Genet. 2014 Feb 20;10(2):e1004170. doi: 10.1371/journal.pgen.1004170. eCollection 2014 Feb.

39.

Specific recycling receptors are targeted to the immune synapse by the intraflagellar transport system.

Finetti F, Patrussi L, Masi G, Onnis A, Galgano D, Lucherini OM, Pazour GJ, Baldari CT.

J Cell Sci. 2014 May 1;127(Pt 9):1924-37. doi: 10.1242/jcs.139337. Epub 2014 Feb 19.

40.

Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton.

Cui C, Chatterjee B, Lozito TP, Zhang Z, Francis RJ, Yagi H, Swanhart LM, Sanker S, Francis D, Yu Q, San Agustin JT, Puligilla C, Chatterjee T, Tansey T, Liu X, Kelley MW, Spiliotis ET, Kwiatkowski AV, Tuan R, Pazour GJ, Hukriede NA, Lo CW.

PLoS Biol. 2013 Nov;11(11):e1001720. doi: 10.1371/journal.pbio.1001720. Epub 2013 Nov 26.

41.

Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease.

Ma M, Tian X, Igarashi P, Pazour GJ, Somlo S.

Nat Genet. 2013 Sep;45(9):1004-12. doi: 10.1038/ng.2715. Epub 2013 Jul 28.

42.

Analysis of ciliary membrane protein dynamics using SNAP technology.

Follit JA, Pazour GJ.

Methods Enzymol. 2013;524:195-204. doi: 10.1016/B978-0-12-397945-2.00011-1.

43.

Combined NGS approaches identify mutations in the intraflagellar transport gene IFT140 in skeletal ciliopathies with early progressive kidney Disease.

Schmidts M, Frank V, Eisenberger T, Al Turki S, Bizet AA, Antony D, Rix S, Decker C, Bachmann N, Bald M, Vinke T, Toenshoff B, Di Donato N, Neuhann T, Hartley JL, Maher ER, Bogdanović R, Peco-Antić A, Mache C, Hurles ME, Joksić I, Guć-Šćekić M, Dobricic J, Brankovic-Magic M, Bolz HJ, Pazour GJ, Beales PL, Scambler PJ, Saunier S, Mitchison HM, Bergmann C.

Hum Mutat. 2013 May;34(5):714-24. doi: 10.1002/humu.22294.

44.

CapSeq and CIP-TAP identify Pol II start sites and reveal capped small RNAs as C. elegans piRNA precursors.

Gu W, Lee HC, Chaves D, Youngman EM, Pazour GJ, Conte D Jr, Mello CC.

Cell. 2012 Dec 21;151(7):1488-500. doi: 10.1016/j.cell.2012.11.023.

45.

The role of retrograde intraflagellar transport in flagellar assembly, maintenance, and function.

Engel BD, Ishikawa H, Wemmer KA, Geimer S, Wakabayashi K, Hirono M, Craige B, Pazour GJ, Witman GB, Kamiya R, Marshall WF.

J Cell Biol. 2012 Oct 1;199(1):151-67. doi: 10.1083/jcb.201206068.

46.

IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport.

Keady BT, Samtani R, Tobita K, Tsuchya M, San Agustin JT, Follit JA, Jonassen JA, Subramanian R, Lo CW, Pazour GJ.

Dev Cell. 2012 May 15;22(5):940-51. doi: 10.1016/j.devcel.2012.04.009.

47.

Disruption of IFT complex A causes cystic kidneys without mitotic spindle misorientation.

Jonassen JA, SanAgustin J, Baker SP, Pazour GJ.

J Am Soc Nephrol. 2012 Apr;23(4):641-51. doi: 10.1681/ASN.2011080829. Epub 2012 Jan 26.

48.

A unified taxonomy for ciliary dyneins.

Hom EF, Witman GB, Harris EH, Dutcher SK, Kamiya R, Mitchell DR, Pazour GJ, Porter ME, Sale WS, Wirschell M, Yagi T, King SM.

Cytoskeleton (Hoboken). 2011 Oct;68(10):555-65. doi: 10.1002/cm.20533.

49.

Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: implications for learning and memory.

Amador-Arjona A, Elliott J, Miller A, Ginbey A, Pazour GJ, Enikolopov G, Roberts AJ, Terskikh AV.

J Neurosci. 2011 Jul 6;31(27):9933-44. doi: 10.1523/JNEUROSCI.1062-11.2011.

50.

IFT20 is required for opsin trafficking and photoreceptor outer segment development.

Keady BT, Le YZ, Pazour GJ.

Mol Biol Cell. 2011 Apr;22(7):921-30. doi: 10.1091/mbc.E10-09-0792. Epub 2011 Feb 9.

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