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The HIV-1 antisense protein ASP is a transmembrane protein of the cell surface and an integral protein of the HIV-1 viral envelope.

Affram Y, Zapata JC, Gholizadeh Z, Tolbert WD, Zhou W, Iglesias-Ussel MD, Pazgier M, Ray K, Latinovic OS, Romerio F.

J Virol. 2019 Aug 21. pii: JVI.00574-19. doi: 10.1128/JVI.00574-19. [Epub ahead of print]


Concurrent Exposure of Neutralizing and Non-neutralizing Epitopes on a Single HIV-1 Envelope Structure.

Ray K, Mengistu M, Orlandi C, Pazgier M, Lewis GK, DeVico AL.

Front Immunol. 2019 Jul 5;10:1512. doi: 10.3389/fimmu.2019.01512. eCollection 2019.


Induction of Fc-Mediated Effector Functions Against a Stabilized Inner Domain of HIV-1 gp120 Designed to Selectively Harbor the A32 Epitope Region.

Visciano ML, Gohain N, Sherburn R, Orlandi C, Flinko R, Dashti A, Lewis GK, Tolbert WD, Pazgier M.

Front Immunol. 2019 Apr 2;10:677. doi: 10.3389/fimmu.2019.00677. eCollection 2019.


An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity.

Alsahafi N, Bakouche N, Kazemi M, Richard J, Ding S, Bhattacharyya S, Das D, Anand SP, Prévost J, Tolbert WD, Lu H, Medjahed H, Gendron-Lepage G, Ortega Delgado GG, Kirk S, Melillo B, Mothes W, Sodroski J, Smith AB 3rd, Kaufmann DE, Wu X, Pazgier M, Rouiller I, Finzi A, Munro JB.

Cell Host Microbe. 2019 Apr 10;25(4):578-587.e5. doi: 10.1016/j.chom.2019.03.002.


From Rhesus macaque to human: structural evolutionary pathways for immunoglobulin G subclasses.

Tolbert WD, Subedi GP, Gohain N, Lewis GK, Patel KR, Barb AW, Pazgier M.

MAbs. 2019 May/Jun;11(4):709-724. doi: 10.1080/19420862.2019.1589852. Epub 2019 Apr 2.


Antibody-Induced Internalization of HIV-1 Env Proteins Limits Surface Expression of the Closed Conformation of Env.

Anand SP, Grover JR, Tolbert WD, Prévost J, Richard J, Ding S, Baril S, Medjahed H, Evans DT, Pazgier M, Mothes W, Finzi A.

J Virol. 2019 May 15;93(11). pii: e00293-19. doi: 10.1128/JVI.00293-19. Print 2019 Jun 1.


CD4- and Time-Dependent Susceptibility of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity.

Lee WS, Prévost J, Richard J, van der Sluis RM, Lewin SR, Pazgier M, Finzi A, Parsons MS, Kent SJ.

J Virol. 2019 May 1;93(10). pii: e01901-18. doi: 10.1128/JVI.01901-18. Print 2019 May 15.


Dithiocarbamate-inspired side chain stapling chemistry for peptide drug design.

Li X, Tolbert WD, Hu HG, Gohain N, Zou Y, Niu F, He WX, Yuan W, Su JC, Pazgier M, Lu W.

Chem Sci. 2018 Nov 30;10(5):1522-1530. doi: 10.1039/c8sc03275k. eCollection 2019 Feb 7.


Systematic mutational analysis of human neutrophil α-defensin HNP4.

Hu H, Di B, Tolbert WD, Gohain N, Yuan W, Gao P, Ma B, He Q, Pazgier M, Zhao L, Lu W.

Biochim Biophys Acta Biomembr. 2019 Apr 1;1861(4):835-844. doi: 10.1016/j.bbamem.2019.01.007. Epub 2019 Jan 15.


Structural Basis for Epitopes in the gp120 Cluster A Region that Invokes Potent Effector Cell Activity.

Tolbert WD, Sherburn RT, Van V, Pazgier M.

Viruses. 2019 Jan 16;11(1). pii: E69. doi: 10.3390/v11010069. Review.


Two Families of Env Antibodies Efficiently Engage Fc-Gamma Receptors and Eliminate HIV-1-Infected Cells.

Anand SP, Prévost J, Baril S, Richard J, Medjahed H, Chapleau JP, Tolbert WD, Kirk S, Smith AB 3rd, Wines BD, Kent SJ, Hogarth PM, Parsons MS, Pazgier M, Finzi A.

J Virol. 2019 Jan 17;93(3). pii: e01823-18. doi: 10.1128/JVI.01823-18. Print 2019 Feb 1.


Human Enteric α-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion.

Xu D, Liao C, Zhang B, Tolbert WD, He W, Dai Z, Zhang W, Yuan W, Pazgier M, Liu J, Yu J, Sansonetti PJ, Bevins CL, Shao Y, Lu W.

Immunity. 2018 Jun 19;48(6):1233-1244.e6. doi: 10.1016/j.immuni.2018.04.014. Epub 2018 May 29.


Identification of Near-Pan-neutralizing Antibodies against HIV-1 by Deconvolution of Plasma Humoral Responses.

Sajadi MM, Dashti A, Rikhtegaran Tehrani Z, Tolbert WD, Seaman MS, Ouyang X, Gohain N, Pazgier M, Kim D, Cavet G, Yared J, Redfield RR, Lewis GK, DeVico AL.

Cell. 2018 Jun 14;173(7):1783-1795.e14. doi: 10.1016/j.cell.2018.03.061. Epub 2018 May 3.


Targeting the Late Stage of HIV-1 Entry for Antibody-Dependent Cellular Cytotoxicity: Structural Basis for Env Epitopes in the C11 Region.

Tolbert WD, Gohain N, Alsahafi N, Van V, Orlandi C, Ding S, Martin L, Finzi A, Lewis GK, Ray K, Pazgier M.

Structure. 2017 Nov 7;25(11):1719-1731.e4. doi: 10.1016/j.str.2017.09.009. Epub 2017 Oct 19.


Survivors Remorse: antibody-mediated protection against HIV-1.

Lewis GK, Pazgier M, DeVico AL.

Immunol Rev. 2017 Jan;275(1):271-284. doi: 10.1111/imr.12510. Review.


Human β-defensin 4 - defensin without the "twist".

Prahl A, Pazgier M, Alexandratos J, Lubkowski J.

Postepy Biochem. 2016;62(3):349-361.


Beyond Viral Neutralization.

Lewis GK, Pazgier M, Evans DT, Ferrari G, Bournazos S, Parsons MS, Bernard NF, Finzi A.

AIDS Res Hum Retroviruses. 2017 Aug;33(8):760-764. doi: 10.1089/AID.2016.0299. Epub 2017 Feb 16. Review.


Molecular basis for epitope recognition by non-neutralizing anti-gp41 antibody F240.

Gohain N, Tolbert WD, Orlandi C, Richard J, Ding S, Chen X, Bonsor DA, Sundberg EJ, Lu W, Ray K, Finzi A, Lewis GK, Pazgier M.

Sci Rep. 2016 Nov 9;6:36685. doi: 10.1038/srep36685.


Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins.

Richard J, Pacheco B, Gohain N, Veillette M, Ding S, Alsahafi N, Tolbert WD, Prévost J, Chapleau JP, Coutu M, Jia M, Brassard N, Park J, Courter JR, Melillo B, Martin L, Tremblay C, Hahn BH, Kaufmann DE, Wu X, Smith AB 3rd, Sodroski J, Pazgier M, Finzi A.

EBioMedicine. 2016 Oct;12:208-218. doi: 10.1016/j.ebiom.2016.09.004. Epub 2016 Sep 9.


A Highly Conserved gp120 Inner Domain Residue Modulates Env Conformation and Trimer Stability.

Ding S, Tolbert WD, Prévost J, Pacheco B, Coutu M, Debbeche O, Xiang SH, Pazgier M, Finzi A.

J Virol. 2016 Sep 12;90(19):8395-409. doi: 10.1128/JVI.01068-16. Print 2016 Oct 1.


Paring Down HIV Env: Design and Crystal Structure of a Stabilized Inner Domain of HIV-1 gp120 Displaying a Major ADCC Target of the A32 Region.

Tolbert WD, Gohain N, Veillette M, Chapleau JP, Orlandi C, Visciano ML, Ebadi M, DeVico AL, Fouts TR, Finzi A, Lewis GK, Pazgier M.

Structure. 2016 May 3;24(5):697-709. doi: 10.1016/j.str.2016.03.005. Epub 2016 Mar 31.


A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies.

Ding S, Veillette M, Coutu M, Prévost J, Scharf L, Bjorkman PJ, Ferrari G, Robinson JE, Stürzel C, Hahn BH, Sauter D, Kirchhoff F, Lewis GK, Pazgier M, Finzi A.

J Virol. 2015 Dec 4;90(4):2127-34. doi: 10.1128/JVI.02779-15. Print 2016 Feb 15.


λ Light Chain Bias Associated With Enhanced Binding and Function of Anti-HIV Env Glycoprotein Antibodies.

Sajadi MM, Farshidpour M, Brown EP, Ouyang X, Seaman MS, Pazgier M, Ackerman ME, Robinson H, Tomaras G, Parsons MS, Charurat M, DeVico AL, Redfield RR, Lewis GK.

J Infect Dis. 2016 Jan 1;213(1):156-64. doi: 10.1093/infdis/jiv448. Epub 2015 Sep 7.


Role of HIV-1 Envelope Glycoproteins Conformation and Accessory Proteins on ADCC Responses.

Veillette M, Richard J, Pazgier M, Lewis GK, Parsons MS, Finzi A.

Curr HIV Res. 2016;14(1):9-23.


Structural basis of how stress-induced MDMX phosphorylation activates p53.

Chen X, Gohain N, Zhan C, Lu WY, Pazgier M, Lu W.

Oncogene. 2016 Apr 14;35(15):1919-25. doi: 10.1038/onc.2015.255. Epub 2015 Jul 6.


Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1.

Gohain N, Tolbert WD, Acharya P, Yu L, Liu T, Zhao P, Orlandi C, Visciano ML, Kamin-Lewis R, Sajadi MM, Martin L, Robinson JE, Kwong PD, DeVico AL, Ray K, Lewis GK, Pazgier M.

J Virol. 2015 Sep;89(17):8840-54. doi: 10.1128/JVI.01232-15. Epub 2015 Jun 17.


Full Length Single Chain Fc Protein (FLSC IgG1) as a Potent Antiviral Therapy Candidate: Implications for In Vivo Studies.

Latinovic OS, Medina-Moreno S, Schneider K, Gohain N, Zapata J, Pazgier M, Reitz M, Bryant J, Redfield RR.

AIDS Res Hum Retroviruses. 2016 Feb;32(2):178-86. doi: 10.1089/AID.2015.0020. Epub 2015 Jun 22.


CD4 mimetics sensitize HIV-1-infected cells to ADCC.

Richard J, Veillette M, Brassard N, Iyer SS, Roger M, Martin L, Pazgier M, Schön A, Freire E, Routy JP, Smith AB 3rd, Park J, Jones DM, Courter JR, Melillo BN, Kaufmann DE, Hahn BH, Permar SR, Haynes BF, Madani N, Sodroski JG, Finzi A.

Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2687-94. doi: 10.1073/pnas.1506755112. Epub 2015 May 4.


Design of a potent antibiotic peptide based on the active region of human defensin 5.

Wang C, Shen M, Gohain N, Tolbert WD, Chen F, Zhang N, Yang K, Wang A, Su Y, Cheng T, Zhao J, Pazgier M, Wang J.

J Med Chem. 2015 Apr 9;58(7):3083-93. doi: 10.1021/jm501824a. Epub 2015 Mar 20.


Structural definition of an antibody-dependent cellular cytotoxicity response implicated in reduced risk for HIV-1 infection.

Acharya P, Tolbert WD, Gohain N, Wu X, Yu L, Liu T, Huang W, Huang CC, Kwon YD, Louder RK, Luongo TS, McLellan JS, Pancera M, Yang Y, Zhang B, Flinko R, Foulke JS Jr, Sajadi MM, Kamin-Lewis R, Robinson JE, Martin L, Kwong PD, Guan Y, DeVico AL, Lewis GK, Pazgier M.

J Virol. 2014 Nov;88(21):12895-906. doi: 10.1128/JVI.02194-14. Epub 2014 Aug 27.


Epitope target structures of Fc-mediated effector function during HIV-1 acquisition.

Lewis GK, Guan Y, Kamin-Lewis R, Sajadi M, Pazgier M, Devico AL.

Curr Opin HIV AIDS. 2014 May;9(3):263-70. doi: 10.1097/COH.0000000000000055. Review.


Turning defense into offense: defensin mimetics as novel antibiotics targeting lipid II.

Varney KM, Bonvin AM, Pazgier M, Malin J, Yu W, Ateh E, Oashi T, Lu W, Huang J, Diepeveen-de Buin M, Bryant J, Breukink E, Mackerell AD Jr, de Leeuw EP.

PLoS Pathog. 2013;9(11):e1003732. doi: 10.1371/journal.ppat.1003732. Epub 2013 Nov 7. Erratum in: PLoS Pathog. 2014 Dec;10(12):e1004611.


Single, double and quadruple alanine substitutions at oligomeric interfaces identify hydrophobicity as the key determinant of human neutrophil alpha defensin HNP1 function.

Zhao L, Tolbert WD, Ericksen B, Zhan C, Wu X, Yuan W, Li X, Pazgier M, Lu W.

PLoS One. 2013 Nov 13;8(11):e78937. doi: 10.1371/journal.pone.0078937. eCollection 2013.


Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses.

Pollara J, Bonsignori M, Moody MA, Pazgier M, Haynes BF, Ferrari G.

Curr HIV Res. 2013 Jul;11(5):378-87. Review.


Structural and functional analysis of the pro-domain of human cathelicidin, LL-37.

Pazgier M, Ericksen B, Ling M, Toth E, Shi J, Li X, Galliher-Beckley A, Lan L, Zou G, Zhan C, Yuan W, Pozharski E, Lu W.

Biochemistry. 2013 Mar 5;52(9):1547-58. doi: 10.1021/bi301008r. Epub 2013 Feb 21.


Diverse specificity and effector function among human antibodies to HIV-1 envelope glycoprotein epitopes exposed by CD4 binding.

Guan Y, Pazgier M, Sajadi MM, Kamin-Lewis R, Al-Darmarki S, Flinko R, Lovo E, Wu X, Robinson JE, Seaman MS, Fouts TR, Gallo RC, DeVico AL, Lewis GK.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):E69-78. doi: 10.1073/pnas.1217609110. Epub 2012 Dec 13.


Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets.

Chu H, Pazgier M, Jung G, Nuccio SP, Castillo PA, de Jong MF, Winter MG, Winter SE, Wehkamp J, Shen B, Salzman NH, Underwood MA, Tsolis RM, Young GM, Lu W, Lehrer RI, Bäumler AJ, Bevins CL.

Science. 2012 Jul 27;337(6093):477-81. doi: 10.1126/science.1218831. Epub 2012 Jun 21.


An ultrahigh affinity d-peptide antagonist Of MDM2.

Zhan C, Zhao L, Wei X, Wu X, Chen X, Yuan W, Lu WY, Pazgier M, Lu W.

J Med Chem. 2012 Jul 12;55(13):6237-41. doi: 10.1021/jm3005465. Epub 2012 Jun 22.


Functional determinants of human enteric α-defensin HD5: crucial role for hydrophobicity at dimer interface.

Rajabi M, Ericksen B, Wu X, de Leeuw E, Zhao L, Pazgier M, Lu W.

J Biol Chem. 2012 Jun 22;287(26):21615-27. doi: 10.1074/jbc.M112.367995. Epub 2012 May 9.


Invariant gly residue is important for α-defensin folding, dimerization, and function: a case study of the human neutrophil α-defensin HNP1.

Zhao L, Ericksen B, Wu X, Zhan C, Yuan W, Li X, Pazgier M, Lu W.

J Biol Chem. 2012 Jun 1;287(23):18900-12. doi: 10.1074/jbc.M112.355255. Epub 2012 Apr 11.


Sometimes it takes two to tango: contributions of dimerization to functions of human α-defensin HNP1 peptide.

Pazgier M, Wei G, Ericksen B, Jung G, Wu Z, de Leeuw E, Yuan W, Szmacinski H, Lu WY, Lubkowski J, Lehrer RI, Lu W.

J Biol Chem. 2012 Mar 16;287(12):8944-53. doi: 10.1074/jbc.M111.332205. Epub 2012 Jan 23.


D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms.

Liu M, Li C, Pazgier M, Li C, Mao Y, Lv Y, Gu B, Wei G, Yuan W, Zhan C, Lu WY, Lu W.

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14321-6. doi: 10.1073/pnas.1008930107. Epub 2010 Jul 26.


A left-handed solution to peptide inhibition of the p53-MDM2 interaction.

Liu M, Pazgier M, Li C, Yuan W, Li C, Lu W.

Angew Chem Int Ed Engl. 2010 May 10;49(21):3649-52. doi: 10.1002/anie.201000329. No abstract available.


Limitations of peptide retro-inverso isomerization in molecular mimicry.

Li C, Pazgier M, Li J, Li C, Liu M, Zou G, Li Z, Chen J, Tarasov SG, Lu WY, Lu W.

J Biol Chem. 2010 Jun 18;285(25):19572-81. doi: 10.1074/jbc.M110.116814. Epub 2010 Apr 9.


Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions.

Li C, Pazgier M, Li C, Yuan W, Liu M, Wei G, Lu WY, Lu W.

J Mol Biol. 2010 Apr 30;398(2):200-13. doi: 10.1016/j.jmb.2010.03.005. Epub 2010 Mar 10.


Trp-26 imparts functional versatility to human alpha-defensin HNP1.

Wei G, Pazgier M, de Leeuw E, Rajabi M, Li J, Zou G, Jung G, Yuan W, Lu WY, Lehrer RI, Lu W.

J Biol Chem. 2010 May 21;285(21):16275-85. doi: 10.1074/jbc.M110.102749. Epub 2010 Mar 10.


Apamin as a template for structure-based rational design of potent peptide activators of p53.

Li C, Pazgier M, Liu M, Lu WY, Lu W.

Angew Chem Int Ed Engl. 2009;48(46):8712-5. doi: 10.1002/anie.200904550. No abstract available.


Through the looking glass, mechanistic insights from enantiomeric human defensins.

Wei G, de Leeuw E, Pazgier M, Yuan W, Zou G, Wang J, Ericksen B, Lu WY, Lehrer RI, Lu W.

J Biol Chem. 2009 Oct 16;284(42):29180-92. doi: 10.1074/jbc.M109.018085. Epub 2009 Jul 29.


Selective arginines are important for the antibacterial activity and host cell interaction of human alpha-defensin 5.

de Leeuw E, Rajabi M, Zou G, Pazgier M, Lu W.

FEBS Lett. 2009 Aug 6;583(15):2507-12. doi: 10.1016/j.febslet.2009.06.051. Epub 2009 Jul 7.

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