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Items: 1 to 50 of 206

1.

APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin.

Uzureau S, Lecordier L, Uzureau P, Hennig D, Graversen JH, Homblé F, Mfutu PE, Oliveira Arcolino F, Ramos AR, La Rovere RM, Luyten T, Vermeersch M, Tebabi P, Dieu M, Cuypers B, Deborggraeve S, Rabant M, Legendre C, Moestrup SK, Levtchenko E, Bultynck G, Erneux C, Pérez-Morga D, Pays E.

Cell Rep. 2020 Mar 17;30(11):3821-3836.e13. doi: 10.1016/j.celrep.2020.02.064.

2.

Identification and preliminary characterization of a putative C-type lectin receptor-like protein in the T. cruzi tomato lectin endocytic-enriched proteome.

Brosson S, Bottu G, Pays E, Bousbata S, Salmon D.

Microbiol Res. 2017 Dec;205:73-79. doi: 10.1016/j.micres.2017.07.001. Epub 2017 Jul 12.

3.

APOLs with low pH dependence can kill all African trypanosomes.

Fontaine F, Lecordier L, Vanwalleghem G, Uzureau P, Van Reet N, Fontaine M, Tebabi P, Vanhollebeke B, Büscher P, Pérez-Morga D, Pays E.

Nat Microbiol. 2017 Nov;2(11):1500-1506. doi: 10.1038/s41564-017-0034-1. Epub 2017 Sep 18.

4.

Trypanosoma musculi Infection in Mice Critically Relies on Mannose Receptor-Mediated Arginase Induction by a TbKHC1 Kinesin H Chain Homolog.

Nzoumbou-Boko R, De Muylder G, Semballa S, Lecordier L, Dauchy FA, Gobert AP, Holzmuller P, Lemesre JL, Bras-Gonçalves R, Barnabé C, Courtois P, Daulouède S, Beschin A, Pays E, Vincendeau P.

J Immunol. 2017 Sep 1;199(5):1762-1771. doi: 10.4049/jimmunol.1700179. Epub 2017 Jul 24.

5.

Trypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine.

Vanwalleghem G, Morias Y, Beschin A, Szymkowski DE, Pays E.

Sci Rep. 2017 Jul 21;7(1):6165. doi: 10.1038/s41598-017-06496-2.

6.

Specific Endocytosis Blockade of Trypanosoma cruzi Exposed to a Poly-LAcNAc Binding Lectin Suggests that Lectin-Sugar Interactions Participate to Receptor-Mediated Endocytosis.

Brosson S, Fontaine F, Vermeersch M, Perez-Morga D, Pays E, Bousbata S, Salmon D.

PLoS One. 2016 Sep 29;11(9):e0163302. doi: 10.1371/journal.pone.0163302. eCollection 2016.

7.

Apolipoproteins L control cell death triggered by TLR3/TRIF signaling in dendritic cells.

Uzureau S, Coquerelle C, Vermeiren C, Uzureau P, Van Acker A, Pilotte L, Monteyne D, Acolty V, Vanhollebeke B, Van den Eynde B, Pérez-Morga D, Moser M, Pays E.

Eur J Immunol. 2016 Aug;46(8):1854-66. doi: 10.1002/eji.201546252. Epub 2016 Jun 8.

8.

Apolipoprotein L1 Variant Associated with Increased Susceptibility to Trypanosome Infection.

Cuypers B, Lecordier L, Meehan CJ, Van den Broeck F, Imamura H, Büscher P, Dujardin JC, Laukens K, Schnaufer A, Dewar C, Lewis M, Balmer O, Azurago T, Kyei-Faried S, Ohene SA, Duah B, Homiah P, Mensah EK, Anleah F, Franco JR, Pays E, Deborggraeve S.

mBio. 2016 Apr 12;7(2):e02198-15. doi: 10.1128/mBio.02198-15.

9.

Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1.

Vanwalleghem G, Fontaine F, Lecordier L, Tebabi P, Klewe K, Nolan DP, Yamaryo-Botté Y, Botté C, Kremer A, Burkard GS, Rassow J, Roditi I, Pérez-Morga D, Pays E.

Nat Commun. 2015 Aug 26;6:8078. doi: 10.1038/ncomms9078.

10.

Sequencing rare and common APOL1 coding variants to determine kidney disease risk.

Limou S, Nelson GW, Lecordier L, An P, O'hUigin CS, David VA, Binns-Roemer EA, Guiblet WM, Oleksyk TK, Pays E, Kopp JB, Winkler CA.

Kidney Int. 2015 Oct;88(4):754-63. doi: 10.1038/ki.2015.151. Epub 2015 May 20.

11.

Adaptation of Trypanosoma rhodesiense to hypohaptoglobinaemic serum requires transcription of the APOL1 resistance gene in a RNA polymerase I locus.

Lecordier L, Uzureau P, Tebabi P, Brauner J, Benghiat FS, Vanhollebeke B, Pays E.

Mol Microbiol. 2015 Aug;97(3):397-407. doi: 10.1111/mmi.13036. Epub 2015 May 15.

12.

Resistance to normal human serum reveals Trypanosoma lewisi as an underestimated human pathogen.

Lun ZR, Wen YZ, Uzureau P, Lecordier L, Lai DH, Lan YG, Desquesnes M, Geng GQ, Yang TB, Zhou WL, Jannin JG, Simarro PP, Truc P, Vincendeau P, Pays E.

Mol Biochem Parasitol. 2015 Jan-Feb;199(1-2):58-61. doi: 10.1016/j.molbiopara.2015.03.007. Epub 2015 Apr 6.

PMID:
25858024
13.

Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cells.

Dhainaut M, Coquerelle C, Uzureau S, Denoeud J, Acolty V, Oldenhove G, Galuppo A, Sparwasser T, Thielemans K, Pays E, Yagita H, Borst J, Moser M.

EMBO J. 2015 May 12;34(10):1336-48. doi: 10.15252/embj.201490312. Epub 2015 Mar 18.

14.

Identification of Trypanosoma brucei components involved in trypanolysis by normal human serum.

Lecordier L, Uzureau P, Tebabi P, Pérez-Morga D, Nolan D, Schumann Burkard G, Roditi I, Pays E.

Mol Microbiol. 2014 Nov;94(3):625-36. doi: 10.1111/mmi.12783. Epub 2014 Sep 25.

15.

African trypanosome control in the insect vector and mammalian host.

Beschin A, Van Den Abbeele J, De Baetselier P, Pays E.

Trends Parasitol. 2014 Nov;30(11):538-47. doi: 10.1016/j.pt.2014.08.006. Epub 2014 Sep 19. Review.

PMID:
25246021
16.

The molecular arms race between African trypanosomes and humans.

Pays E, Vanhollebeke B, Uzureau P, Lecordier L, Pérez-Morga D.

Nat Rev Microbiol. 2014 Aug;12(8):575-84. doi: 10.1038/nrmicro3298. Epub 2014 Jun 30. Review.

PMID:
24975321
17.

Transcription is initiated on silent variant surface glycoprotein expression sites despite monoallelic expression in Trypanosoma brucei.

Kassem A, Pays E, Vanhamme L.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8943-8. doi: 10.1073/pnas.1404873111. Epub 2014 Jun 2.

18.

A Trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity.

De Muylder G, Daulouède S, Lecordier L, Uzureau P, Morias Y, Van Den Abbeele J, Caljon G, Hérin M, Holzmuller P, Semballa S, Courtois P, Vanhamme L, Stijlemans B, De Baetselier P, Barrett MP, Barlow JL, McKenzie AN, Barron L, Wynn TA, Beschin A, Vincendeau P, Pays E.

PLoS Pathog. 2013 Oct;9(10):e1003731. doi: 10.1371/journal.ppat.1003731. Epub 2013 Oct 31.

19.

Atypical human infections by animal trypanosomes.

Truc P, Büscher P, Cuny G, Gonzatti MI, Jannin J, Joshi P, Juyal P, Lun ZR, Mattioli R, Pays E, Simarro PP, Teixeira MM, Touratier L, Vincendeau P, Desquesnes M.

PLoS Negl Trop Dis. 2013 Sep 12;7(9):e2256. doi: 10.1371/journal.pntd.0002256. eCollection 2013. Review.

20.

Mechanism of Trypanosoma brucei gambiense resistance to human serum.

Uzureau P, Uzureau S, Lecordier L, Fontaine F, Tebabi P, Homblé F, Grélard A, Zhendre V, Nolan DP, Lins L, Crowet JM, Pays A, Felu C, Poelvoorde P, Vanhollebeke B, Moestrup SK, Lyngsø J, Pedersen JS, Mottram JC, Dufourc EJ, Pérez-Morga D, Pays E.

Nature. 2013 Sep 19;501(7467):430-4. doi: 10.1038/nature12516. Epub 2013 Aug 21.

PMID:
23965626
21.

Trypanosoma brucei FKBP12 differentially controls motility and cytokinesis in procyclic and bloodstream forms.

Brasseur A, Rotureau B, Vermeersch M, Blisnick T, Salmon D, Bastin P, Pays E, Vanhamme L, Pérez-Morga D.

Eukaryot Cell. 2013 Feb;12(2):168-81. doi: 10.1128/EC.00077-12. Epub 2012 Oct 26.

22.

[African trypanosomes have the sense of sacrifice].

Pays E.

Med Sci (Paris). 2012 Oct;28(10):817-9. doi: 10.1051/medsci/20122810006. Epub 2012 Oct 12. French. No abstract available.

23.

Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host.

Salmon D, Vanwalleghem G, Morias Y, Denoeud J, Krumbholz C, Lhommé F, Bachmaier S, Kador M, Gossmann J, Dias FB, De Muylder G, Uzureau P, Magez S, Moser M, De Baetselier P, Van Den Abbeele J, Beschin A, Boshart M, Pays E.

Science. 2012 Jul 27;337(6093):463-6. doi: 10.1126/science.1222753. Epub 2012 Jun 14.

24.

Cytokinesis of Trypanosoma brucei bloodstream forms depends on expression of adenylyl cyclases of the ESAG4 or ESAG4-like subfamily.

Salmon D, Bachmaier S, Krumbholz C, Kador M, Gossmann JA, Uzureau P, Pays E, Boshart M.

Mol Microbiol. 2012 Apr;84(2):225-42. doi: 10.1111/j.1365-2958.2012.08013.x. Epub 2012 Mar 6.

25.

High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis.

Stijlemans B, Caljon G, Natesan SK, Saerens D, Conrath K, Pérez-Morga D, Skepper JN, Nikolaou A, Brys L, Pays E, Magez S, Field MC, De Baetselier P, Muyldermans S.

PLoS Pathog. 2011 Jun;7(6):e1002072. doi: 10.1371/journal.ppat.1002072. Epub 2011 Jun 16.

26.

[Molecular dialogue between African trypanosomes and humans].

Pays E.

Bull Mem Acad R Med Belg. 2011;166(10-12):358-63; discussion 364-5. French.

PMID:
23082501
27.

Association of trypanolytic ApoL1 variants with kidney disease in African Americans.

Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI, Bowden DW, Langefeld CD, Oleksyk TK, Uscinski Knob AL, Bernhardy AJ, Hicks PJ, Nelson GW, Vanhollebeke B, Winkler CA, Kopp JB, Pays E, Pollak MR.

Science. 2010 Aug 13;329(5993):841-5. doi: 10.1126/science.1193032. Epub 2010 Jul 15.

28.

Cellular and molecular remodeling of the endocytic pathway during differentiation of Trypanosoma brucei bloodstream forms.

Vanhollebeke B, Uzureau P, Monteyne D, Pérez-Morga D, Pays E.

Eukaryot Cell. 2010 Aug;9(8):1272-82. doi: 10.1128/EC.00076-10. Epub 2010 Jun 25.

29.

The trypanolytic factor of human serum: many ways to enter the parasite, a single way to kill.

Vanhollebeke B, Pays E.

Mol Microbiol. 2010 May;76(4):806-14. doi: 10.1111/j.1365-2958.2010.07156.x. Epub 2010 Apr 1. Review.

30.

C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense.

Lecordier L, Vanhollebeke B, Poelvoorde P, Tebabi P, Paturiaux-Hanocq F, Andris F, Lins L, Pays E.

PLoS Pathog. 2009 Dec;5(12):e1000685. doi: 10.1371/journal.ppat.1000685. Epub 2009 Dec 4.

31.

Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections.

Lepesheva GI, Park HW, Hargrove TY, Vanhollebeke B, Wawrzak Z, Harp JM, Sundaramoorthy M, Nes WD, Pays E, Chaudhuri M, Villalta F, Waterman MR.

J Biol Chem. 2010 Jan 15;285(3):1773-80. doi: 10.1074/jbc.M109.067470. Epub 2009 Nov 18.

32.

Identification of a parasitic immunomodulatory protein triggering the development of suppressive M1 macrophages during African trypanosomiasis.

Gómez-Rodríguez J, Stijlemans B, De Muylder G, Korf H, Brys L, Berberof M, Darji A, Pays E, De Baetselier P, Beschin A.

J Infect Dis. 2009 Dec 15;200(12):1849-60. doi: 10.1086/648374.

PMID:
19911988
33.

Human innate immunity against African trypanosomes.

Pays E, Vanhollebeke B.

Curr Opin Immunol. 2009 Oct;21(5):493-8. doi: 10.1016/j.coi.2009.05.024. Epub 2009 Jun 24. Review.

PMID:
19559585
34.

[The controversial story of the human trypanolytic factor].

Pays E, Vanhollebeke B.

Med Sci (Paris). 2008 Oct;24(10):792-3. doi: 10.1051/medsci/20082410792. French. No abstract available.

35.

Mutual self-defence: the trypanolytic factor story.

Pays E, Vanhollebeke B.

Microbes Infect. 2008 Jul;10(9):985-9. doi: 10.1016/j.micinf.2008.07.020. Epub 2008 Jul 12. Review.

PMID:
18675374
36.

Identification and characterization of two trypanosome TFIIS proteins exhibiting particular domain architectures and differential nuclear localizations.

Uzureau P, Daniels JP, Walgraffe D, Wickstead B, Pays E, Gull K, Vanhamme L.

Mol Microbiol. 2008 Sep;69(5):1121-36. doi: 10.1111/j.1365-2958.2008.06348.x. Epub 2008 Jul 4.

37.

A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans.

Vanhollebeke B, De Muylder G, Nielsen MJ, Pays A, Tebabi P, Dieu M, Raes M, Moestrup SK, Pays E.

Science. 2008 May 2;320(5876):677-81. doi: 10.1126/science.1156296.

38.

Human serum lyses Trypanosoma brucei by triggering uncontrolled swelling of the parasite lysosome.

Vanhollebeke B, Lecordier L, Perez-Morga D, Amiguet-Vercher A, Pays E.

J Eukaryot Microbiol. 2007 Sep-Oct;54(5):448-51.

PMID:
17910690
39.

Characterization of a TFIIH homologue from Trypanosoma brucei.

Lecordier L, Devaux S, Uzureau P, Dierick JF, Walgraffe D, Poelvoorde P, Pays E, Vanhamme L.

Mol Microbiol. 2007 Jun;64(5):1164-81.

40.

Diagnostic potential of a conserved genomic rearrangement in the Trypanosoma brucei gambiense-specific TGSGP locus.

Felu C, Pasture J, Pays E, Pérez-Morga D.

Am J Trop Med Hyg. 2007 May;76(5):922-9.

PMID:
17488917
41.

G418, phleomycin and hygromycin selection of recombinant Trypanosoma brucei parasites refractory to long-term in vitro culture.

Uzureau P, Felu C, De Muylder G, Pays E, Vanhamme L.

Mol Biochem Parasitol. 2007 Jul;154(1):90-4. Epub 2007 Mar 12. No abstract available.

PMID:
17449118
42.

Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum.

Vanhollebeke B, Nielsen MJ, Watanabe Y, Truc P, Vanhamme L, Nakajima K, Moestrup SK, Pays E.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4118-23. Epub 2007 Feb 26.

43.

Diversification of function by different isoforms of conventionally shared RNA polymerase subunits.

Devaux S, Kelly S, Lecordier L, Wickstead B, Perez-Morga D, Pays E, Vanhamme L, Gull K.

Mol Biol Cell. 2007 Apr;18(4):1293-301. Epub 2007 Jan 31.

44.

Human Trypanosoma evansi infection linked to a lack of apolipoprotein L-I.

Vanhollebeke B, Truc P, Poelvoorde P, Pays A, Joshi PP, Katti R, Jannin JG, Pays E.

N Engl J Med. 2006 Dec 28;355(26):2752-6.

45.

[Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor].

Baral TN, Magez S, Stijlemans B, Conrath K, Vanhollebeke B, Pays E, Muyldermans S, De Baetselier P.

Med Sci (Paris). 2006 Nov;22(11):914-6. French. No abstract available.

46.

The function of apolipoproteins L.

Vanhollebeke B, Pays E.

Cell Mol Life Sci. 2006 Sep;63(17):1937-44. Review.

PMID:
16847577
47.

The trypanolytic factor of human serum.

Pays E, Vanhollebeke B, Vanhamme L, Paturiaux-Hanocq F, Nolan DP, Pérez-Morga D.

Nat Rev Microbiol. 2006 Jun;4(6):477-86. Review.

PMID:
16710327
48.

Characterization of RNA polymerase II subunits of Trypanosoma brucei.

Devaux S, Lecordier L, Uzureau P, Walgraffe D, Dierick JF, Poelvoorde P, Pays E, Vanhamme L.

Mol Biochem Parasitol. 2006 Jul;148(1):60-8. Epub 2006 Mar 23.

PMID:
16621069
49.

Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor.

Baral TN, Magez S, Stijlemans B, Conrath K, Vanhollebeke B, Pays E, Muyldermans S, De Baetselier P.

Nat Med. 2006 May;12(5):580-4. Epub 2006 Apr 9.

PMID:
16604085
50.

The variant surface glycoprotein as a tool for adaptation in African trypanosomes.

Pays E.

Microbes Infect. 2006 Mar;8(3):930-7. Epub 2006 Jan 11.

PMID:
16480910

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