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Items: 1 to 50 of 57

1.

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.

Flannick J, Mercader JM, Fuchsberger C, Udler MS, Mahajan A, Wessel J, Teslovich TM, Caulkins L, Koesterer R, Barajas-Olmos F, Blackwell TW, Boerwinkle E, Brody JA, Centeno-Cruz F, Chen L, Chen S, Contreras-Cubas C, Córdova E, Correa A, Cortes M, DeFronzo RA, Dolan L, Drews KL, Elliott A, Floyd JS, Gabriel S, Garay-Sevilla ME, García-Ortiz H, Gross M, Han S, Heard-Costa NL, Jackson AU, Jørgensen ME, Kang HM, Kelsey M, Kim BJ, Koistinen HA, Kuusisto J, Leader JB, Linneberg A, Liu CT, Liu J, Lyssenko V, Manning AK, Marcketta A, Malacara-Hernandez JM, Martínez-Hernández A, Matsuo K, Mayer-Davis E, Mendoza-Caamal E, Mohlke KL, Morrison AC, Ndungu A, Ng MCY, O'Dushlaine C, Payne AJ, Pihoker C; Broad Genomics Platform, Post WS, Preuss M, Psaty BM, Vasan RS, Rayner NW, Reiner AP, Revilla-Monsalve C, Robertson NR, Santoro N, Schurmann C, So WY, Soberón X, Stringham HM, Strom TM, Tam CHT, Thameem F, Tomlinson B, Torres JM, Tracy RP, van Dam RM, Vujkovic M, Wang S, Welch RP, Witte DR, Wong TY, Atzmon G, Barzilai N, Blangero J, Bonnycastle LL, Bowden DW, Chambers JC, Chan E, Cheng CY, Cho YS, Collins FS, de Vries PS, Duggirala R, Glaser B, Gonzalez C, Gonzalez ME, Groop L, Kooner JS, Kwak SH, Laakso M, Lehman DM, Nilsson P, Spector TD, Tai ES, Tuomi T, Tuomilehto J, Wilson JG, Aguilar-Salinas CA, Bottinger E, Burke B, Carey DJ, Chan JCN, Dupuis J, Frossard P, Heckbert SR, Hwang MY, Kim YJ, Kirchner HL, Lee JY, Lee J, Loos RJF, Ma RCW, Morris AD, O'Donnell CJ, Palmer CNA, Pankow J, Park KS, Rasheed A, Saleheen D, Sim X, Small KS, Teo YY, Haiman C, Hanis CL, Henderson BE, Orozco L, Tusié-Luna T, Dewey FE, Baras A, Gieger C, Meitinger T, Strauch K, Lange L, Grarup N, Hansen T, Pedersen O, Zeitler P, Dabelea D, Abecasis G, Bell GI, Cox NJ, Seielstad M, Sladek R, Meigs JB, Rich SS, Rotter JI; DiscovEHR Collaboration; CHARGE; LuCamp; ProDiGY; GoT2D; ESP; SIGMA-T2D; T2D-GENES; AMP-T2D-GENES, Altshuler D, Burtt NP, Scott LJ, Morris AP, Florez JC, McCarthy MI, Boehnke M.

Nature. 2019 Jun;570(7759):71-76. doi: 10.1038/s41586-019-1231-2. Epub 2019 May 22.

2.

Revisiting Antarctic ice loss due to marine ice-cliff instability.

Edwards TL, Brandon MA, Durand G, Edwards NR, Golledge NR, Holden PB, Nias IJ, Payne AJ, Ritz C, Wernecke A.

Nature. 2019 Feb;566(7742):58-64. doi: 10.1038/s41586-019-0901-4. Epub 2019 Feb 6.

PMID:
30728522
3.

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.

Mahajan A, Taliun D, Thurner M, Robertson NR, Torres JM, Rayner NW, Payne AJ, Steinthorsdottir V, Scott RA, Grarup N, Cook JP, Schmidt EM, Wuttke M, Sarnowski C, Mägi R, Nano J, Gieger C, Trompet S, Lecoeur C, Preuss MH, Prins BP, Guo X, Bielak LF, Below JE, Bowden DW, Chambers JC, Kim YJ, Ng MCY, Petty LE, Sim X, Zhang W, Bennett AJ, Bork-Jensen J, Brummett CM, Canouil M, Ec Kardt KU, Fischer K, Kardia SLR, Kronenberg F, Läll K, Liu CT, Locke AE, Luan J, Ntalla I, Nylander V, Schönherr S, Schurmann C, Yengo L, Bottinger EP, Brandslund I, Christensen C, Dedoussis G, Florez JC, Ford I, Franco OH, Frayling TM, Giedraitis V, Hackinger S, Hattersley AT, Herder C, Ikram MA, Ingelsson M, Jørgensen ME, Jørgensen T, Kriebel J, Kuusisto J, Ligthart S, Lindgren CM, Linneberg A, Lyssenko V, Mamakou V, Meitinger T, Mohlke KL, Morris AD, Nadkarni G, Pankow JS, Peters A, Sattar N, Stančáková A, Strauch K, Taylor KD, Thorand B, Thorleifsson G, Thorsteinsdottir U, Tuomilehto J, Witte DR, Dupuis J, Peyser PA, Zeggini E, Loos RJF, Froguel P, Ingelsson E, Lind L, Groop L, Laakso M, Collins FS, Jukema JW, Palmer CNA, Grallert H, Metspalu A, Dehghan A, Köttgen A, Abecasis GR, Meigs JB, Rotter JI, Marchini J, Pedersen O, Hansen T, Langenberg C, Wareham NJ, Stefansson K, Gloyn AL, Morris AP, Boehnke M, McCarthy MI.

Nat Genet. 2018 Nov;50(11):1505-1513. doi: 10.1038/s41588-018-0241-6. Epub 2018 Oct 8.

4.

A tetrameric perylene diimide non-fullerene acceptor via unprecedented direct (hetero)arylation cross-coupling reactions.

Payne AJ, Song J, Sun Y, Welch GC.

Chem Commun (Camb). 2018 Oct 9;54(81):11443-11446. doi: 10.1039/c8cc06446f.

PMID:
30250948
5.

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells.

Thomsen SK, Raimondo A, Hastoy B, Sengupta S, Dai XQ, Bautista A, Censin J, Payne AJ, Umapathysivam MM, Spigelman AF, Barrett A, Groves CJ, Beer NL, Manning Fox JE, McCarthy MI, Clark A, Mahajan A, Rorsman P, MacDonald PE, Gloyn AL.

Nat Genet. 2018 Aug;50(8):1122-1131. doi: 10.1038/s41588-018-0173-1. Epub 2018 Jul 27.

6.

The many possible climates from the Paris Agreement's aim of 1.5 °C warming.

Seneviratne SI, Rogelj J, Séférian R, Wartenburger R, Allen MR, Cain M, Millar RJ, Ebi KL, Ellis N, Hoegh-Guldberg O, Payne AJ, Schleussner CF, Tschakert P, Warren RF.

Nature. 2018 Jun;558(7708):41-49. doi: 10.1038/s41586-018-0181-4. Epub 2018 Jun 6.

PMID:
29875489
7.

Ventral Tegmental Area GABA Neurons Are Resistant to GABA(A) Receptor-Mediated Inhibition During Ethanol Withdrawal.

Nelson AC, Williams SB, Pistorius SS, Park HJ, Woodward TJ, Payne AJ, Obray JD, Shin SI, Mabey JK, Steffensen SC.

Front Neurosci. 2018 Mar 5;12:131. doi: 10.3389/fnins.2018.00131. eCollection 2018.

8.

Correction: An unsymmetrical non-fullerene acceptor: synthesis via direct heteroarylation, self-assembly, and utility as a low energy absorber in organic photovoltaic cells.

Payne AJ, Li S, Dayneko SV, Risko C, Welch GC.

Chem Commun (Camb). 2017 Sep 21;53(76):10608. doi: 10.1039/c7cc90360j.

PMID:
28901352
9.

An unsymmetrical non-fullerene acceptor: synthesis via direct heteroarylation, self-assembly, and utility as a low energy absorber in organic photovoltaic cells.

Payne AJ, Li S, Dayneko SV, Risko C, Welch GC.

Chem Commun (Camb). 2017 Sep 12;53(73):10168-10171. doi: 10.1039/c7cc05836e. Erratum in: Chem Commun (Camb). 2017 Sep 21;53(76):10608.

PMID:
28852753
10.

Regional transport, source apportionment and health impact of PM10 bound polycyclic aromatic hydrocarbons in Singapore's atmosphere.

Urbančok D, Payne AJR, Webster RD.

Environ Pollut. 2017 Oct;229:984-993. doi: 10.1016/j.envpol.2017.07.086. Epub 2017 Aug 4.

PMID:
28781182
11.

Quantification of Lactate Dehydrogenase for Cell Viability Testing Using Cell Lines and Primary Cultured Astrocytes.

Kaja S, Payne AJ, Naumchuk Y, Koulen P.

Curr Protoc Toxicol. 2017 May 2;72:2.26.1-2.26.10. doi: 10.1002/cptx.21.

12.
13.

HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor.

Bareja A, Hodgkinson CP, Payne AJ, Pratt RE, Dzau VJ.

Biochem J. 2017 Feb 20;474(5):771-780. doi: 10.1042/BCJ20160976.

PMID:
28096202
14.

Caspase-3-Dependent Proteolytic Cleavage of Tau Causes Neurofibrillary Tangles and Results in Cognitive Impairment During Normal Aging.

Means JC, Gerdes BC, Kaja S, Sumien N, Payne AJ, Stark DA, Borden PK, Price JL, Koulen P.

Neurochem Res. 2016 Sep;41(9):2278-88. doi: 10.1007/s11064-016-1942-9. Epub 2016 May 25.

15.

Synthesis and structure-property relationships of phthalimide and naphthalimide based organic π-conjugated small molecules.

Payne AJ, Hendsbee AD, McAfee SM, Paul DK, Karan K, Welch GC.

Phys Chem Chem Phys. 2016 Jun 7;18(21):14709-19. doi: 10.1039/c6cp01596d. Epub 2016 May 17.

PMID:
27185588
16.

A Qualitative Analysis of Substance Use among Liberian Youth: Understanding Behaviors, Consequences, and Protective Factors Involving School Youth and the School Milieu.

Pullen SJ, Petruzzi L, Lange BC, Parnarouskis L, Dominguez S, Harris B, Quiterio N, Durham MP, Lekpeh G, Manobah B, Slopadoe SP, Diandy VC, Payne AJ, Henderson DC, Borba CP.

Int J Ment Health Psychiatry. 2016 Feb;2(1). pii: 116. Epub 2016 Feb 19.

17.

Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog.

Wang X, Hodgkinson CP, Lu K, Payne AJ, Pratt RE, Dzau VJ.

Sci Rep. 2016 Mar 15;6:23017. doi: 10.1038/srep23017.

18.

Potential sea-level rise from Antarctic ice-sheet instability constrained by observations.

Ritz C, Edwards TL, Durand G, Payne AJ, Peyaud V, Hindmarsh RC.

Nature. 2015 Dec 3;528(7580):115-8. doi: 10.1038/nature16147. Epub 2015 Nov 18.

PMID:
26580020
19.

Differential cerebellar GABAA receptor expression in mice with mutations in CaV2.1 (P/Q-type) calcium channels.

Kaja S, Payne AJ, Nielsen EØ, Thompson CL, van den Maagdenberg AM, Koulen P, Snutch TP.

Neuroscience. 2015 Sep 24;304:198-208. doi: 10.1016/j.neuroscience.2015.07.044. Epub 2015 Jul 21.

20.

Plate reader-based cell viability assays for glioprotection using primary rat optic nerve head astrocytes.

Kaja S, Payne AJ, Naumchuk Y, Levy D, Zaidi DH, Altman AM, Nawazish S, Ghuman JK, Gerdes BC, Moore MA, Koulen P.

Exp Eye Res. 2015 Sep;138:159-66. doi: 10.1016/j.exer.2015.05.023. Epub 2015 Jun 3.

21.

An optimized lactate dehydrogenase release assay for screening of drug candidates in neuroscience.

Kaja S, Payne AJ, Singh T, Ghuman JK, Sieck EG, Koulen P.

J Pharmacol Toxicol Methods. 2015 May-Jun;73:1-6. doi: 10.1016/j.vascn.2015.02.001. Epub 2015 Feb 12.

22.

Regulation of ryanodine receptor-mediated calcium signaling by presenilins.

Payne AJ, Kaja S, Koulen P.

Receptors Clin Investig. 2015;2(1):e449. No abstract available.

23.

Differential subcellular Ca2+ signaling in a highly specialized subpopulation of astrocytes.

Kaja S, Payne AJ, Patel KR, Naumchuk Y, Koulen P.

Exp Neurol. 2015 Mar;265:59-68. doi: 10.1016/j.expneurol.2014.12.014. Epub 2014 Dec 24.

24.

An electron-deficient small molecule accessible from sustainable synthesis and building blocks for use as a fullerene alternative in organic photovoltaics.

McAfee SM, Topple JM, Payne AJ, Sun JP, Hill IG, Welch GC.

Chemphyschem. 2015 Apr 27;16(6):1190-202. doi: 10.1002/cphc.201402662. Epub 2014 Nov 21.

PMID:
25418978
25.

Topography's crucial role in Heinrich Events.

Roberts WH, Valdes PJ, Payne AJ.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16688-93. doi: 10.1073/pnas.1414882111. Epub 2014 Nov 3.

26.

Abi3bp regulates cardiac progenitor cell proliferation and differentiation.

Hodgkinson CP, Gomez JA, Payne AJ, Zhang L, Wang X, Dal-Pra S, Pratt RE, Dzau VJ.

Circ Res. 2014 Dec 5;115(12):1007-16. doi: 10.1161/CIRCRESAHA.115.304216. Epub 2014 Oct 8.

27.

Loss of Spatial Memory, Learning, and Motor Function During Normal Aging Is Accompanied by Changes in Brain Presenilin 1 and 2 Expression Levels.

Kaja S, Sumien N, Shah VV, Puthawala I, Maynard AN, Khullar N, Payne AJ, Forster MJ, Koulen P.

Mol Neurobiol. 2015 Aug;52(1):545-54. doi: 10.1007/s12035-014-8877-4. Epub 2014 Sep 10.

28.

Resveratrol and calcium signaling: molecular mechanisms and clinical relevance.

McCalley AE, Kaja S, Payne AJ, Koulen P.

Molecules. 2014 Jun 5;19(6):7327-40. doi: 10.3390/molecules19067327. Review.

29.

Antioxidant drug therapy approaches for neuroprotection in chronic diseases of the retina.

Payne AJ, Kaja S, Naumchuk Y, Kunjukunju N, Koulen P.

Int J Mol Sci. 2014 Jan 27;15(2):1865-86. doi: 10.3390/ijms15021865. Review.

30.

Insert sequence length determines transfection efficiency and gene expression levels in bicistronic mammalian expression vectors.

Payne AJ, Gerdes BC, Kaja S, Koulen P.

Int J Biochem Mol Biol. 2013 Dec 15;4(4):201-8. eCollection 2013.

31.

Sea-level rise by 2100.

Church JA, Clark PU, Cazenave A, Gregory JM, Jevrejeva S, Levermann A, Merrifield MA, Milne GA, Nerem RS, Nunn PD, Payne AJ, Pfeffer WT, Stammer D, Unnikrishnan AS.

Science. 2013 Dec 20;342(6165):1445. doi: 10.1126/science.342.6165.1445-a. No abstract available.

PMID:
24357297
32.

A case for neuroprotection in ophthalmology: developments in translational research.

Payne AJ, Kaja S, Sabates NR, Koulen P.

Mo Med. 2013 Sep-Oct;110(5):429-36. Review.

33.

Presenilins regulate the cellular activity of ryanodine receptors differentially through isotype-specific N-terminal cysteines.

Payne AJ, Gerdes BC, Naumchuk Y, McCalley AE, Kaja S, Koulen P.

Exp Neurol. 2013 Dec;250:143-50. doi: 10.1016/j.expneurol.2013.09.001. Epub 2013 Sep 9.

34.

Fusidic acid is an effective treatment against Toxoplasma gondii and Listeria monocytogenes in vitro, but not in mice.

Payne AJ, Neal LM, Knoll LJ.

Parasitol Res. 2013 Nov;112(11):3859-63. doi: 10.1007/s00436-013-3574-1. Epub 2013 Aug 16.

35.

Enhanced basal lubrication and the contribution of the Greenland ice sheet to future sea-level rise.

Shannon SR, Payne AJ, Bartholomew ID, van den Broeke MR, Edwards TL, Fettweis X, Gagliardini O, Gillet-Chaulet F, Goelzer H, Hoffman MJ, Huybrechts P, Mair DW, Nienow PW, Perego M, Price SF, Smeets CJ, Sole AJ, van de Wal RS, Zwinger T.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14156-61. doi: 10.1073/pnas.1212647110. Epub 2013 Aug 12.

36.

A reconciled estimate of ice-sheet mass balance.

Shepherd A, Ivins ER, A G, Barletta VR, Bentley MJ, Bettadpur S, Briggs KH, Bromwich DH, Forsberg R, Galin N, Horwath M, Jacobs S, Joughin I, King MA, Lenaerts JT, Li J, Ligtenberg SR, Luckman A, Luthcke SB, McMillan M, Meister R, Milne G, Mouginot J, Muir A, Nicolas JP, Paden J, Payne AJ, Pritchard H, Rignot E, Rott H, Sørensen LS, Scambos TA, Scheuchl B, Schrama EJ, Smith B, Sundal AV, van Angelen JH, van de Berg WJ, van den Broeke MR, Vaughan DG, Velicogna I, Wahr J, Whitehouse PL, Wingham DJ, Yi D, Young D, Zwally HJ.

Science. 2012 Nov 30;338(6111):1183-9. doi: 10.1126/science.1228102. Erratum in: Science. 2012 Dec 21;338(6114):1539.

37.

Deglacial rapid sea level rises caused by ice-sheet saddle collapses.

Gregoire LJ, Payne AJ, Valdes PJ.

Nature. 2012 Jul 11;487(7406):219-22. doi: 10.1038/nature11257.

38.

A Toxoplasma gondii mutant highlights the importance of translational regulation in the apicoplast during animal infection.

Payne TM, Payne AJ, Knoll LJ.

Mol Microbiol. 2011 Dec;82(5):1204-16. doi: 10.1111/j.1365-2958.2011.07879.x. Epub 2011 Nov 7.

39.

Plate reader-based assays for measuring cell viability, neuroprotection and calcium in primary neuronal cultures.

Burroughs SL, Duncan RS, Rayudu P, Kandula P, Payne AJ, Clark JL, Koulen P, Kaja S.

J Neurosci Methods. 2012 Jan 15;203(1):141-5. doi: 10.1016/j.jneumeth.2011.09.007. Epub 2011 Sep 24.

40.

Committed sea-level rise for the next century from Greenland ice sheet dynamics during the past decade.

Price SF, Payne AJ, Howat IM, Smith BE.

Proc Natl Acad Sci U S A. 2011 May 31;108(22):8978-83. doi: 10.1073/pnas.1017313108. Epub 2011 May 16.

41.

Novel mechanism of increased Ca2+ release following oxidative stress in neuronal cells involves type 2 inositol-1,4,5-trisphosphate receptors.

Kaja S, Duncan RS, Longoria S, Hilgenberg JD, Payne AJ, Desai NM, Parikh RA, Burroughs SL, Gregg EV, Goad DL, Koulen P.

Neuroscience. 2011 Feb 23;175:281-91. doi: 10.1016/j.neuroscience.2010.11.010. Epub 2010 Nov 11.

42.

Control of intracellular calcium signaling as a neuroprotective strategy.

Duncan RS, Goad DL, Grillo MA, Kaja S, Payne AJ, Koulen P.

Molecules. 2010 Mar 3;15(3):1168-95. doi: 10.3390/molecules15031168. Review.

43.

The unliganded long isoform of estrogen receptor beta stimulates brain ryanodine receptor single channel activity alongside with cytosolic Ca2+.

Rybalchenko V, Grillo MA, Gastinger MJ, Rybalchenko N, Payne AJ, Koulen P.

J Recept Signal Transduct Res. 2009 Dec;29(6):326-41. doi: 10.3109/10799890903295168.

44.

Evolution of the Antarctic ice sheet: new understanding and challenges.

Payne AJ, Hunt JC, Wingham DJ.

Philos Trans A Math Phys Eng Sci. 2006 Jul 15;364(1844):1867-72.

PMID:
16782613
45.

Numerical modelling and data assimilation of the Larsen B ice shelf, Antarctic Peninsula.

Vieli A, Payne AJ, Du Z, Shepherd A.

Philos Trans A Math Phys Eng Sci. 2006 Jul 15;364(1844):1815-39.

PMID:
16782611
46.

Ice flow direction change in interior West Antarctica.

Siegert MJ, Welch B, Morse D, Vieli A, Blankenship DD, Joughin I, King EC, Vieli GJ, Payne AJ, Jacobel R.

Science. 2004 Sep 24;305(5692):1948-51.

47.

Bilateral delayed extensor pollicis longus rupture following bilateral undisplaced distal radial fractures.

Payne AJ, Harris NJ, Kehoe NJ.

Orthopedics. 2000 Feb;23(2):163. No abstract available.

PMID:
10688293
48.

Intrapartum amnioinfusion for meconium-stained liquor in developing countries.

Moodley J, Matchaba P, Payne AJ.

Trop Doct. 1998 Jan;28(1):31-4.

PMID:
9481194
49.

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