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Items: 26


Homeostatic role of transforming growth factor-beta in the oral cavity and esophagus of mice and its expression by mast cells in these tissues.

Vitsky A, Waire J, Pawliuk R, Bond A, Matthews D, Lacasse E, Hawes ML, Nelson C, Richards S, Piepenhagen PA, Garman RD, Andrews L, Thurberg BL, Lonning S, Ledbetter S, Ruzek MC.

Am J Pathol. 2009 Jun;174(6):2137-49. doi: 10.2353/ajpath.2009.080723. Epub 2009 Apr 30.


Tolerance by selective in vivo expansion of foreign major histocompatibility complex-transduced autologous bone marrow.

Zhang JL, Cai J, Walls S, Jackson JD, Kuszynski CA, Zhao Y, Pawliuk R, Leboulch P, Fox IJ.

Transplantation. 2005 Aug 15;80(3):362-9.


eGFP reporter genes silence LCRbeta-globin transgene expression via CpG dinucleotides.

Dalle B, Rubin JE, Alkan O, Sukonnik T, Pasceri P, Yao S, Pawliuk R, Leboulch P, Ellis J.

Mol Ther. 2005 Apr;11(4):591-9.


Prevention of murine erythropoietic protoporphyria-associated skin photosensitivity and liver disease by dermal and hepatic ferrochelatase.

Pawliuk R, Tighe R, Wise RJ, Mathews-Roth MM, Leboulch P.

J Invest Dermatol. 2005 Jan;124(1):256-62.


High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells.

Imren S, Fabry ME, Westerman KA, Pawliuk R, Tang P, Rosten PM, Nagel RL, Leboulch P, Eaves CJ, Humphries RK.

J Clin Invest. 2004 Oct;114(7):953-62.


Expression of an anti-sickling beta-globin in human erythroblasts derived from retrovirally transduced primitive normal and sickle cell disease hematopoietic cells.

Oh IH, Fabry ME, Humphries RK, Pawliuk R, Leboulch P, Hoffman R, Nagel RL, Eaves C.

Exp Hematol. 2004 May;32(5):461-9.


Glycoprotein 170 induces platelet-activating factor receptor membrane expression and confers tumor cell hypersensitivity to NK-dependent cell lysis.

Geromin D, Bourge JF, Soulié A, Pawliuk R, Fleet C, Michel E, Denizot Y, Berthou C, Leboulch P, Sigaux F, Sasportes M.

J Immunol. 2004 Mar 15;172(6):3604-11.


LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.

Hacein-Bey-Abina S, Von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P, Lim A, Osborne CS, Pawliuk R, Morillon E, Sorensen R, Forster A, Fraser P, Cohen JI, de Saint Basile G, Alexander I, Wintergerst U, Frebourg T, Aurias A, Stoppa-Lyonnet D, Romana S, Radford-Weiss I, Gross F, Valensi F, Delabesse E, Macintyre E, Sigaux F, Soulier J, Leiva LE, Wissler M, Prinz C, Rabbitts TH, Le Deist F, Fischer A, Cavazzana-Calvo M.

Science. 2003 Oct 17;302(5644):415-9. Erratum in: Science. 2003 Oct 24;302(5645):568.


Lentiviral-mediated gene delivery to synovium: potent intra-articular expression with amplification by inflammation.

Gouze E, Pawliuk R, Gouze JN, Pilapil C, Fleet C, Palmer GD, Evans CH, Leboulch P, Ghivizzani SC.

Mol Ther. 2003 Apr;7(4):460-6.


Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2.

Cao R, Bråkenhielm E, Pawliuk R, Wariaro D, Post MJ, Wahlberg E, Leboulch P, Cao Y.

Nat Med. 2003 May;9(5):604-13. Epub 2003 Mar 31.


Permanent and panerythroid correction of murine beta thalassemia by multiple lentiviral integration in hematopoietic stem cells.

Imren S, Payen E, Westerman KA, Pawliuk R, Fabry ME, Eaves CJ, Cavilla B, Wadsworth LD, Beuzard Y, Bouhassira EE, Russell R, London IM, Nagel RL, Leboulch P, Humphries RK.

Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14380-5. Epub 2002 Oct 21.


Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers.

Eriksson A, Cao R, Pawliuk R, Berg SM, Tsang M, Zhou D, Fleet C, Tritsaris K, Dissing S, Leboulch P, Cao Y.

Cancer Cell. 2002 Feb;1(1):99-108.


In vivo gene delivery to synovium by lentiviral vectors.

Gouze E, Pawliuk R, Pilapil C, Gouze JN, Fleet C, Palmer GD, Evans CH, Leboulch P, Ghivizzani SC.

Mol Ther. 2002 Apr;5(4):397-404.


Unfulfilled promise of endostatin in a gene therapy-xenotransplant model of human acute lymphocytic leukemia.

Eisterer W, Jiang X, Bachelot T, Pawliuk R, Abramovich C, Leboulch P, Hogge D, Eaves C.

Mol Ther. 2002 Apr;5(4):352-9.


Continuous intravascular secretion of endostatin in mice from transduced hematopoietic stem cells.

Pawliuk R, Bachelot T, Zurkiya O, Eriksson A, Cao Y, Leboulch P.

Mol Ther. 2002 Apr;5(4):345-51.


Correction of sickle cell disease in transgenic mouse models by gene therapy.

Pawliuk R, Westerman KA, Fabry ME, Payen E, Tighe R, Bouhassira EE, Acharya SA, Ellis J, London IM, Eaves CJ, Humphries RK, Beuzard Y, Nagel RL, Leboulch P.

Science. 2001 Dec 14;294(5550):2368-71.


Preselection of retrovirally transduced bone marrow avoids subsequent stem cell gene silencing and age-dependent extinction of expression of human beta-globin in engrafted mice.

Kalberer CP, Pawliuk R, Imren S, Bachelot T, Takekoshi KJ, Fabry M, Eaves CJ, London IM, Humphries RK, Leboulch P.

Proc Natl Acad Sci U S A. 2000 May 9;97(10):5411-5.


Tracking RPE transplants labeled by retroviral gene transfer with green fluorescent protein.

Lai CC, Gouras P, Doi K, Lu F, Kjeldbye H, Goff SP, Pawliuk R, Leboulch P, Tsang SH.

Invest Ophthalmol Vis Sci. 1999 Aug;40(9):2141-6.


Long-term cure of the photosensitivity of murine erythropoietic protoporphyria by preselective gene therapy.

Pawliuk R, Bachelot T, Wise RJ, Mathews-Roth MM, Leboulch P.

Nat Med. 1999 Jul;5(7):768-73.


Optimization of retroviral-mediated gene transfer to human NOD/SCID mouse repopulating cord blood cells through a systematic analysis of protocol variables.

Hennemann B, Conneally E, Pawliuk R, Leboulch P, Rose-John S, Reid D, Chuo JY, Humphries RK, Eaves CJ.

Exp Hematol. 1999 May;27(5):817-25.


Retroviral vectors aimed at the gene therapy of human beta-globin gene disorders.

Pawliuk R, Bachelot T, Raftopoulos H, Kalberer C, Humphries RK, Bank A, Leboulch P.

Ann N Y Acad Sci. 1998 Jun 30;850:151-62. Review.


A bicistronic therapeutic retroviral vector enables sorting of transduced CD34+ cells and corrects the enzyme deficiency in cells from Gaucher patients.

Medin JA, Migita M, Pawliuk R, Jacobson S, Amiri M, Kluepfel-Stahl S, Brady RO, Humphries RK, Karlsson S.

Blood. 1996 Mar 1;87(5):1754-62.


Selection of transduced CD34+ progenitors and enzymatic correction of cells from Gaucher patients, with bicistronic vectors.

Migita M, Medin JA, Pawliuk R, Jacobson S, Nagle JW, Anderson S, Amiri M, Humphries RK, Karlsson S.

Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12075-9.


Selection of retrovirally transduced hematopoietic cells using CD24 as a marker of gene transfer.

Pawliuk R, Kay R, Lansdorp P, Humphries RK.

Blood. 1994 Nov 1;84(9):2868-77.

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