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Items: 1 to 50 of 500

1.

To help aging populations, classify organismal senescence.

Calimport SRG, Bentley BL, Stewart CE, Pawelec G, Scuteri A, Vinciguerra M, Slack C, Chen D, Harries LW, Marchant G, Fleming GA, Conboy M, Antebi A, Small GW, Gil J, Lakatta EG, Richardson A, Rosen C, Nikolich K, Wyss-Coray T, Steinman L, Montine T, de Magalhães JP, Campisi J, Church G.

Science. 2019 Nov 1;366(6465):576-578. doi: 10.1126/science.aay7319. No abstract available.

PMID:
31672885
2.

Peripheral PD-1+CD56+ T-cell frequencies correlate with outcome in stage IV melanoma under PD-1 blockade.

Bochem J, Zelba H, Amaral T, Spreuer J, Soffel D, Eigentler T, Wagner NB, Uslu U, Terheyden P, Meier F, Garbe C, Pawelec G, Weide B, Wistuba-Hamprecht K.

PLoS One. 2019 Aug 16;14(8):e0221301. doi: 10.1371/journal.pone.0221301. eCollection 2019.

3.

Frequency of Immune Cell Subtypes in Peripheral Blood Correlates With Outcome for Patients With Metastatic Breast Cancer Treated With High-Dose Chemotherapy.

Lafrenie RM, Speigl L, Buckner CA, Pawelec G, Conlon MS, Shipp C.

Clin Breast Cancer. 2019 May 27. pii: S1526-8209(19)30015-1. doi: 10.1016/j.clbc.2019.05.002. [Epub ahead of print]

PMID:
31383605
4.

Editorial: Immunology of Aging.

Pawelec G, Gupta S.

Front Immunol. 2019 Jul 10;10:1614. doi: 10.3389/fimmu.2019.01614. eCollection 2019. No abstract available.

5.

Research on immunity and ageing comes of age.

Weng NP, Pawelec G.

Immun Ageing. 2019 Apr 29;16:8. doi: 10.1186/s12979-019-0148-9. eCollection 2019.

6.

Myeloid-Derived Suppressor Cells: Not Only in Tumor Immunity.

Pawelec G, Verschoor CP, Ostrand-Rosenberg S.

Front Immunol. 2019 May 15;10:1099. doi: 10.3389/fimmu.2019.01099. eCollection 2019. Review.

7.

Are skin senescence and immunosenescence linked within individuals?

Waaijer MEC, Goldeck D, Gunn DA, van Heemst D, Westendorp RGJ, Pawelec G, Maier AB.

Aging Cell. 2019 Aug;18(4):e12956. doi: 10.1111/acel.12956. Epub 2019 May 6.

8.

Zoster vaccination in older adults: efficacy and public health implications.

McElhaney JE, Verschoor C, Pawelec G.

J Gerontol A Biol Sci Med Sci. 2019 Apr 4. pii: glz085. doi: 10.1093/gerona/glz085. [Epub ahead of print]

PMID:
30945744
9.

The Immune System and Its Dysregulation with Aging.

Müller L, Di Benedetto S, Pawelec G.

Subcell Biochem. 2019;91:21-43. doi: 10.1007/978-981-13-3681-2_2. Review.

PMID:
30888648
10.

Is There a Positive Side to T Cell Exhaustion?

Pawelec G.

Front Immunol. 2019 Jan 29;10:111. doi: 10.3389/fimmu.2019.00111. eCollection 2019. Review.

11.

Expansion and Determination of Antigen-Reactive T Cells by Flow Cytometry.

Martens A, Pawelec G, Shipp C.

Methods Mol Biol. 2019;1913:141-151. doi: 10.1007/978-1-4939-8979-9_10.

PMID:
30666604
12.

Influenza Vaccination in Older Adults: Recent Innovations and Practical Applications.

Andrew MK, Bowles SK, Pawelec G, Haynes L, Kuchel GA, McNeil SA, McElhaney JE.

Drugs Aging. 2019 Jan;36(1):29-37. doi: 10.1007/s40266-018-0597-4. Review.

PMID:
30411283
13.

Accurate quantification of T-cells expressing PD-1 in patients on anti-PD-1 immunotherapy.

Zelba H, Bochem J, Pawelec G, Garbe C, Wistuba-Hamprecht K, Weide B.

Cancer Immunol Immunother. 2018 Dec;67(12):1845-1851. doi: 10.1007/s00262-018-2244-7. Epub 2018 Sep 14.

PMID:
30218171
14.

CASIN the joint: immune aging at the stem cell level.

Pawelec GP.

Blood. 2018 Aug 9;132(6):553-554. doi: 10.1182/blood-2018-06-858696. No abstract available.

PMID:
30093381
15.

Can an Infection Hypothesis Explain the Beta Amyloid Hypothesis of Alzheimer's Disease?

Fulop T, Witkowski JM, Bourgade K, Khalil A, Zerif E, Larbi A, Hirokawa K, Pawelec G, Bocti C, Lacombe G, Dupuis G, Frost EH.

Front Aging Neurosci. 2018 Jul 24;10:224. doi: 10.3389/fnagi.2018.00224. eCollection 2018. Review.

16.

Does patient age influence anti-cancer immunity?

Pawelec G.

Semin Immunopathol. 2019 Jan;41(1):125-131. doi: 10.1007/s00281-018-0697-6. Epub 2018 Jul 13. Review.

PMID:
30006738
17.

Involvement of MicroRNAs in the Aging-Related Decline of CD28 Expression by Human T Cells.

Teteloshvili N, Dekkema G, Boots AM, Heeringa P, Jellema P, de Jong D, Terpstra M, Brouwer E, Pawelec G, Kok K, van den Berg A, Kluiver J, Kroesen BJ.

Front Immunol. 2018 Jun 18;9:1400. doi: 10.3389/fimmu.2018.01400. eCollection 2018.

18.

Relationships between the inflammatory potential of the diet, aging and anthropometric measurements in a cross-sectional study in Pakistan.

Alam I, Shivappa N, Hebert JR, Pawelec G, Larbi A.

Nutr Healthy Aging. 2018 Jun 15;4(4):335-343. doi: 10.3233/NHA-180042.

19.

Unexpected Benefits of Aging for Favorable Responses to PD-1 Blockade in Melanoma?

Pawelec G.

Clin Cancer Res. 2018 Nov 1;24(21):5193-5194. doi: 10.1158/1078-0432.CCR-18-1475. Epub 2018 Jun 15.

20.

Low levels of intra-tumoural T cells in breast cancer identify clinically frail patients with shorter disease-specific survival.

Speigl L, Grieb A, Janssen N, Hatse S, Brouwers B, Smeets A, Floris G, Bailur JK, Kenis C, Neven P, Wildiers H, Pawelec G, Shipp C.

J Geriatr Oncol. 2018 Nov;9(6):606-612. doi: 10.1016/j.jgo.2018.03.021. Epub 2018 Apr 21.

PMID:
29685380
21.

Immune signatures associated with mortality differ in elderly populations from different birth cohorts and countries even within northern Europe.

Pawelec G.

Mech Ageing Dev. 2019 Jan;177:182-185. doi: 10.1016/j.mad.2018.04.005. Epub 2018 Apr 11. Review.

PMID:
29654793
22.

Immune signatures predicting responses to immunomodulatory antibody therapy.

Pawelec G.

Curr Opin Immunol. 2018 Apr;51:91-96. doi: 10.1016/j.coi.2018.03.003. Epub 2018 Mar 15. Review.

PMID:
29550661
23.

Vaccines for Improved Cellular Immunity to Influenza.

Pawelec G, McElhaney J.

EBioMedicine. 2018 Apr;30:12-13. doi: 10.1016/j.ebiom.2018.03.001. Epub 2018 Mar 5. No abstract available.

24.

Inhibiting HSP90 prevents the induction of myeloid-derived suppressor cells by melanoma cells.

Janssen N, Speigl L, Pawelec G, Niessner H, Shipp C.

Cell Immunol. 2018 May;327:68-76. doi: 10.1016/j.cellimm.2018.02.012. Epub 2018 Feb 21.

PMID:
29478948
25.

Role of the peripheral innate immune system in the development of Alzheimer's disease.

Le Page A, Dupuis G, Frost EH, Larbi A, Pawelec G, Witkowski JM, Fulop T.

Exp Gerontol. 2018 Jul 1;107:59-66. doi: 10.1016/j.exger.2017.12.019. Epub 2017 Dec 21. Review.

PMID:
29275160
26.

CD14+ HLA-DR-/low MDSCs are elevated in the periphery of early-stage breast cancer patients and suppress autologous T cell proliferation.

Speigl L, Burow H, Bailur JK, Janssen N, Walter CB, Pawelec G, Shipp C.

Breast Cancer Res Treat. 2018 Apr;168(2):401-411. doi: 10.1007/s10549-017-4594-9. Epub 2017 Dec 11.

PMID:
29230664
27.

2nd Symposium on Advances in Cancer Immunology and Immunotherapy, December 15-17, 2016, Athens, Greece.

Samara P, Kotsakis A, Tsitsilonis O, Georgoulias V, Pawelec G, Baxevanis CN.

Cancer Immunol Immunother. 2018 Jan;67(1):153-159. doi: 10.1007/s00262-017-2096-6. Epub 2017 Dec 1.

PMID:
29196790
28.

Immune parameters associated with mortality in the elderly are context-dependent: lessons from Sweden, Holland and Belgium.

Pawelec G.

Biogerontology. 2018 Dec;19(6):537-545. doi: 10.1007/s10522-017-9739-z. Epub 2017 Nov 28.

PMID:
29185165
29.

Immune correlates of clinical outcome in melanoma.

Pawelec G.

Immunology. 2018 Apr;153(4):415-422. doi: 10.1111/imm.12870. Epub 2017 Dec 20. Review.

30.

Age and immunity: What is "immunosenescence"?

Pawelec G.

Exp Gerontol. 2018 May;105:4-9. doi: 10.1016/j.exger.2017.10.024. Epub 2017 Oct 27. Review.

PMID:
29111233
31.

Does the human immune system ever really become "senescent"?

Pawelec G.

F1000Res. 2017 Aug 4;6. pii: F1000 Faculty Rev-1323. doi: 10.12688/f1000research.11297.1. eCollection 2017. Review.

32.

KEYNOTE-006: a success in melanoma, but a long way to go.

Wistuba-Hamprecht K, Pawelec G.

Lancet. 2017 Oct 21;390(10105):1816-1817. doi: 10.1016/S0140-6736(17)31816-0. Epub 2017 Aug 16. No abstract available.

PMID:
28822577
33.

Polymorphonuclear Neutrophil Functions are Differentially Altered in Amnestic Mild Cognitive Impairment and Mild Alzheimer's Disease Patients.

Le Page A, Lamoureux J, Bourgade K, Frost EH, Pawelec G, Witkowski JM, Larbi A, Dupuis G, Fülöp T.

J Alzheimers Dis. 2017;60(1):23-42. doi: 10.3233/JAD-170124.

PMID:
28777750
34.

Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection.

Merani S, Pawelec G, Kuchel GA, McElhaney JE.

Front Immunol. 2017 Jul 17;8:784. doi: 10.3389/fimmu.2017.00784. eCollection 2017. Review.

35.

Differential Phenotypes of Myeloid-Derived Suppressor and T Regulatory Cells and Cytokine Levels in Amnestic Mild Cognitive Impairment Subjects Compared to Mild Alzheimer Diseased Patients.

Le Page A, Garneau H, Dupuis G, Frost EH, Larbi A, Witkowski JM, Pawelec G, Fülöp T.

Front Immunol. 2017 Jul 7;8:783. doi: 10.3389/fimmu.2017.00783. eCollection 2017.

36.

Frequencies of peripheral immune cells in older adults following seasonal influenza vaccination with an adjuvanted vaccine.

Goldeck D, Theeten H, Hassouneh F, Oettinger L, Wistuba-Hamprecht K, Cools N, Tsitsilonis OE, Pawelec G.

Vaccine. 2017 Aug 3;35(34):4330-4338. doi: 10.1016/j.vaccine.2017.06.082. Epub 2017 Jul 6.

PMID:
28689651
37.

Erratum to: Differential intratumoral distributions of CD8 and CD163 immune cells as prognostic biomarkers in breast cancer.

Fortis SP, Sofopoulos M, Sotiriadou NN, Haritos C, Vaxevanis CK, Anastasopoulou EA, Janssen N, Arnogiannaki N, Ardavanis A, Pawelec G, Perez SA, Baxevanis CN.

J Immunother Cancer. 2017 May 30;5:48. doi: 10.1186/s40425-017-0248-z. eCollection 2017.

38.

Professor Enrico Mihich, 1928-2016.

Pawelec G, Ostrand-Rosenberg S.

Cancer Immunol Immunother. 2017 Jul;66(7):955-957. doi: 10.1007/s00262-017-2024-9. Epub 2017 May 29. No abstract available.

PMID:
28555257
39.

Differential intratumoral distributions of CD8 and CD163 immune cells as prognostic biomarkers in breast cancer.

Fortis SP, Sofopoulos M, Sotiriadou NN, Haritos C, Vaxevanis CK, Anastasopoulou EA, Janssen N, Arnogiannaki N, Ardavanis A, Pawelec G, Perez SA, Baxevanis CN.

J Immunother Cancer. 2017 Apr 18;5:39. doi: 10.1186/s40425-017-0240-7. eCollection 2017. Erratum in: J Immunother Cancer. 2017 May 30;5:48.

40.

Alteration of high-density lipoprotein functionality in Alzheimer's disease patients.

Camponova P, Le Page A, Berrougui H, Lamoureux J, Pawelec G, Witkowski MJ, Fulop T, Khalil A.

Can J Physiol Pharmacol. 2017 Aug;95(8):894-903. doi: 10.1139/cjpp-2016-0710. Epub 2017 Apr 6.

PMID:
28384414
41.

Immune profiles of elderly breast cancer patients are altered by chemotherapy and relate to clinical frailty.

Bailur JK, Pawelec G, Hatse S, Brouwers B, Smeets A, Neven P, Laenen A, Wildiers H, Shipp C.

Breast Cancer Res. 2017 Feb 28;19(1):20. doi: 10.1186/s13058-017-0813-x.

42.

Immunosenescence and cancer.

Pawelec G.

Biogerontology. 2017 Aug;18(4):717-721. doi: 10.1007/s10522-017-9682-z. Epub 2017 Feb 20. Review.

PMID:
28220304
43.

Peripheral CD8 effector-memory type 1 T-cells correlate with outcome in ipilimumab-treated stage IV melanoma patients.

Wistuba-Hamprecht K, Martens A, Heubach F, Romano E, Geukes Foppen M, Yuan J, Postow M, Wong P, Mallardo D, Schilling B, Di Giacomo AM, Khammari A, Dreno B, Maio M, Schadendorf D, Ascierto PA, Wolchok JD, Blank CU, Garbe C, Pawelec G, Weide B.

Eur J Cancer. 2017 Mar;73:61-70. doi: 10.1016/j.ejca.2016.12.011. Epub 2017 Feb 4.

44.

Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions.

Di Benedetto S, Müller L, Wenger E, Düzel S, Pawelec G.

Neurosci Biobehav Rev. 2017 Apr;75:114-128. doi: 10.1016/j.neubiorev.2017.01.044. Epub 2017 Feb 1. Review.

PMID:
28161508
45.

Establishing High Dimensional Immune Signatures from Peripheral Blood via Mass Cytometry in a Discovery Cohort of Stage IV Melanoma Patients.

Wistuba-Hamprecht K, Martens A, Weide B, Teng KW, Zelba H, Guffart E, Chen J, Garbe C, Newell EW, Larbi A, Pawelec G.

J Immunol. 2017 Jan 15;198(2):927-936. doi: 10.4049/jimmunol.1600875. Epub 2016 Dec 16.

46.

CD4:8 Ratio Above 5 Is Associated With All-Cause Mortality in CMV-Seronegative Very Old Women: Results From the BELFRAIL Study.

Adriaensen W, Pawelec G, Vaes B, Hamprecht K, Derhovanessian E, van Pottelbergh G, Degryse JM, Matheï C.

J Gerontol A Biol Sci Med Sci. 2017 Sep 1;72(9):1155-1162. doi: 10.1093/gerona/glw215.

PMID:
27927759
47.

Cellular Senescence, Immunosenescence and HIV.

Fülöp T, Herbein G, Cossarizza A, Witkowski JM, Frost E, Dupuis G, Pawelec G, Larbi A.

Interdiscip Top Gerontol Geriatr. 2017;42:28-46. Epub 2016 Nov 22. Review.

PMID:
27875822
48.

Prognostic impact of the putative cancer stem cell markers ABCG2, CD133, ALDH1A1 and CD44V7/8 in metastatic melanoma.

Speigl L, Janssen N, Weide B, Pawelec G, Shipp C.

Br J Dermatol. 2017 Nov;177(5):1447-1449. doi: 10.1111/bjd.15194. Epub 2017 Jul 9. No abstract available.

PMID:
27870003
49.

Are lower antibody responses to influenza vaccination in cytomegalovirus-seropositive older adults the result of beta adrenergic blockade?

Pawelec G.

Brain Behav Immun. 2017 Mar;61:12-13. doi: 10.1016/j.bbi.2016.11.016. Epub 2016 Nov 16. No abstract available.

PMID:
27865946
50.

Cytomegalovirus Seropositivity Predicts a Decline in the T Cell But Not the Antibody Response to Influenza in Vaccinated Older Adults Independent of Type 2 Diabetes Status.

Haq K, Fulop T, Tedder G, Gentleman B, Garneau H, Meneilly GS, Kleppinger A, Pawelec G, McElhaney JE.

J Gerontol A Biol Sci Med Sci. 2017 Sep 1;72(9):1163-1170. doi: 10.1093/gerona/glw216.

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