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Items: 49

1.

The KRASG12C Inhibitor, MRTX849, Provides Insight Toward Therapeutic Susceptibility of KRAS Mutant Cancers in Mouse Models and Patients.

Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue JY, Gatto S, Fernandez-Banet J, Pavlicek A, Velastegui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Janne PA, Olson P, Christensen JG.

Cancer Discov. 2019 Oct 28. pii: CD-19-1167. doi: 10.1158/2159-8290.CD-19-1167. [Epub ahead of print]

PMID:
31658955
2.

Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease.

Lee EC, Valencia T, Allerson C, Schairer A, Flaten A, Yheskel M, Kersjes K, Li J, Gatto S, Takhar M, Lockton S, Pavlicek A, Kim M, Chu T, Soriano R, Davis S, Androsavich JR, Sarwary S, Owen T, Kaplan J, Liu K, Jang G, Neben S, Bentley P, Wright T, Patel V.

Nat Commun. 2019 Sep 12;10(1):4148. doi: 10.1038/s41467-019-11918-y.

3.

Towards a ground pattern reconstruction of bivalve nervous systems: neurogenesis in the zebra mussel Dreissena polymorpha.

Pavlicek A, Schwaha T, Wanninger A.

Org Divers Evol. 2018;18(1):101-114. doi: 10.1007/s13127-017-0356-0. Epub 2018 Jan 18.

4.

Lipid Nanoparticle-Mediated Delivery of Anti-miR-17 Family Oligonucleotide Suppresses Hepatocellular Carcinoma Growth.

Huang X, Magnus J, Kaimal V, Karmali P, Li J, Walls M, Prudente R, Sung E, Sorourian M, Lee R, Davis S, Yang X, Estrella H, Lee EC, Chau BN, Pavlicek A, Zabludoff S.

Mol Cancer Ther. 2017 May;16(5):905-913. doi: 10.1158/1535-7163.MCT-16-0613. Epub 2017 Feb 6.

5.

Safety, tolerability, and antiviral effect of RG-101 in patients with chronic hepatitis C: a phase 1B, double-blind, randomised controlled trial.

van der Ree MH, de Vree JM, Stelma F, Willemse S, van der Valk M, Rietdijk S, Molenkamp R, Schinkel J, van Nuenen AC, Beuers U, Hadi S, Harbers M, van der Veer E, Liu K, Grundy J, Patick AK, Pavlicek A, Blem J, Huang M, Grint P, Neben S, Gibson NW, Kootstra NA, Reesink HW.

Lancet. 2017 Feb 18;389(10070):709-717. doi: 10.1016/S0140-6736(16)31715-9. Epub 2017 Jan 11.

PMID:
28087069
6.

Anti-miR-21 Suppresses Hepatocellular Carcinoma Growth via Broad Transcriptional Network Deregulation.

Wagenaar TR, Zabludoff S, Ahn SM, Allerson C, Arlt H, Baffa R, Cao H, Davis S, Garcia-Echeverria C, Gaur R, Huang SM, Jiang L, Kim D, Metz-Weidmann C, Pavlicek A, Pollard J, Reeves J, Rocnik JL, Scheidler S, Shi C, Sun F, Tolstykh T, Weber W, Winter C, Yu E, Yu Q, Zheng G, Wiederschain D.

Mol Cancer Res. 2015 Jun;13(6):1009-21. doi: 10.1158/1541-7786.MCR-14-0703. Epub 2015 Mar 10.

7.

Test of four colon cancer risk-scores in formalin fixed paraffin embedded microarray gene expression data.

Di Narzo AF, Tejpar S, Rossi S, Yan P, Popovici V, Wirapati P, Budinska E, Xie T, Estrella H, Pavlicek A, Mao M, Martin E, Scott W, Bosman FT, Roth A, Delorenzi M.

J Natl Cancer Inst. 2014 Sep 22;106(10). pii: dju247. doi: 10.1093/jnci/dju247. Print 2014 Oct.

PMID:
25246611
8.

Predictive markers of efficacy for an angiopoietin-2 targeting therapeutic in xenograft models.

Triana-Baltzer G, Pavlicek A, Goulart A, Huang H, Pirie-Shepherd S, Levin N.

PLoS One. 2013 Nov 14;8(11):e80132. doi: 10.1371/journal.pone.0080132. eCollection 2013.

9.

Molecular predictors of sensitivity to the insulin-like growth factor 1 receptor inhibitor Figitumumab (CP-751,871).

Pavlicek A, Lira ME, Lee NV, Ching KA, Ye J, Cao J, Garza SJ, Hook KE, Ozeck M, Shi ST, Yuan J, Zheng X, Rejto PA, Kan JL, Christensen JG.

Mol Cancer Ther. 2013 Dec;12(12):2929-39. doi: 10.1158/1535-7163.MCT-13-0442-T. Epub 2013 Oct 9.

10.

Biomarker and pharmacologic evaluation of the γ-secretase inhibitor PF-03084014 in breast cancer models.

Zhang CC, Pavlicek A, Zhang Q, Lira ME, Painter CL, Yan Z, Zheng X, Lee NV, Ozeck M, Qiu M, Zong Q, Lappin PB, Wong A, Rejto PA, Smeal T, Christensen JG.

Clin Cancer Res. 2012 Sep 15;18(18):5008-19. doi: 10.1158/1078-0432.CCR-12-1379. Epub 2012 Jul 17.

11.

A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through [corrected] MAPK activation.

Lee NV, Lira ME, Pavlicek A, Ye J, Buckman D, Bagrodia S, Srinivasa SP, Zhao Y, Aparicio S, Rejto PA, Christensen JG, Ching KA.

PLoS One. 2012;7(6):e39653. doi: 10.1371/journal.pone.0039653. Epub 2012 Jun 22. Erratum in: PLoS One. 2012;7(8). doi: 10.1371/annotation/d988dd75-bcd2-4859-b20b-487e1bf2513b.

12.

Exclusion of the 750-kb genetically unstable region at Xq27 as a candidate locus for prostate malignancy in HPCX1-linked families.

Kouprina N, Lee NC, Pavlicek A, Samoshkin A, Kim JH, Lee HS, Varma S, Reinhold WC, Otstot J, Solomon G, Davis S, Meltzer PS, Schleutker J, Larionov V.

Genes Chromosomes Cancer. 2012 Oct;51(10):933-48. doi: 10.1002/gcc.21977. Epub 2012 Jun 26.

13.

An integrated genomic approach to identify predictive biomarkers of response to the aurora kinase inhibitor PF-03814735.

Hook KE, Garza SJ, Lira ME, Ching KA, Lee NV, Cao J, Yuan J, Ye J, Ozeck M, Shi ST, Zheng X, Rejto PA, Kan JL, Christensen JG, Pavlicek A.

Mol Cancer Ther. 2012 Mar;11(3):710-9. doi: 10.1158/1535-7163.MCT-11-0184. Epub 2012 Jan 5.

14.

tRNA genes protect a reporter gene from epigenetic silencing in mouse cells.

Ebersole T, Kim JH, Samoshkin A, Kouprina N, Pavlicek A, White RJ, Larionov V.

Cell Cycle. 2011 Aug 15;10(16):2779-91. Epub 2011 Aug 15.

15.

No alignment of cattle along geomagnetic field lines found.

Hert J, Jelinek L, Pekarek L, Pavlicek A.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2011 Jun;197(6):677-82. doi: 10.1007/s00359-011-0628-7. Epub 2011 Feb 12.

PMID:
21318402
16.

Statistical method on nonrandom clustering with application to somatic mutations in cancer.

Ye J, Pavlicek A, Lunney EA, Rejto PA, Teng CH.

BMC Bioinformatics. 2010 Jan 7;11:11. doi: 10.1186/1471-2105-11-11.

17.

Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing.

Kim JH, Ebersole T, Kouprina N, Noskov VN, Ohzeki J, Masumoto H, Mravinac B, Sullivan BA, Pavlicek A, Dovat S, Pack SD, Kwon YW, Flanagan PT, Loukinov D, Lobanenkov V, Larionov V.

Genome Res. 2009 Apr;19(4):533-44. doi: 10.1101/gr.086496.108. Epub 2009 Jan 13.

18.

Rapid identification of somatic mutations in colorectal and breast cancer tissues using mismatch repair detection (MRD).

Bentivegna S, Zheng J, Namsaraev E, Carlton VE, Pavlicek A, Moorhead M, Siddiqui F, Wang Z, Lee L, Ireland JS, Suyenaga K, Willis TD, Faham M, Seymour AB.

Hum Mutat. 2008 Mar;29(3):441-50. doi: 10.1002/humu.20672.

PMID:
18186519
19.

Production, purification and oxidative folding of the mouse recombinant prion protein.

Pavlícek A, Bednárová L, Holada K.

Folia Microbiol (Praha). 2007;52(4):391-7.

PMID:
18062188
20.

Evolutionary diversification of SPANX-N sperm protein gene structure and expression.

Kouprina N, Noskov VN, Pavlicek A, Collins NK, Schoppee Bortz PD, Ottolenghi C, Loukinov D, Goldsmith P, Risinger JI, Kim JH, Westbrook VA, Solomon G, Sounders H, Herr JC, Jurka J, Lobanenkov V, Schlessinger D, Larionov V.

PLoS One. 2007 Apr 4;2(4):e359.

21.

Identification of sequence motifs at the breakpoint junctions in three t(1;9)(p36.3;q34) and delineation of mechanisms involved in generating balanced translocations.

Gajecka M, Pavlicek A, Glotzbach CD, Ballif BC, Jarmuz M, Jurka J, Shaffer LG.

Hum Genet. 2006 Nov;120(4):519-26. Epub 2006 Jul 18.

PMID:
16847692
22.
23.

CpG methylation suppresses transcriptional activity of human syncytin-1 in non-placental tissues.

Matousková M, Blazková J, Pajer P, Pavlícek A, Hejnar J.

Exp Cell Res. 2006 Apr 15;312(7):1011-20. Epub 2006 Jan 20.

PMID:
16427621
24.

Retroposition of processed pseudogenes: the impact of RNA stability and translational control.

Pavlicek A, Gentles AJ, Paces J, Paces V, Jurka J.

Trends Genet. 2006 Feb;22(2):69-73. Epub 2005 Dec 13. Review.

25.
26.

Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27.

Kouprina N, Pavlicek A, Noskov VN, Solomon G, Otstot J, Isaacs W, Carpten JD, Trent JM, Schleutker J, Barrett JC, Jurka J, Larionov V.

Genome Res. 2005 Nov;15(11):1477-86.

27.

Repbase Update, a database of eukaryotic repetitive elements.

Jurka J, Kapitonov VV, Pavlicek A, Klonowski P, Kohany O, Walichiewicz J.

Cytogenet Genome Res. 2005;110(1-4):462-7. Review.

PMID:
16093699
28.

Clustering, duplication and chromosomal distribution of mouse SINE retrotransposons.

Jurka J, Kohany O, Pavlicek A, Kapitonov VV, Jurka MV.

Cytogenet Genome Res. 2005;110(1-4):117-23.

PMID:
16093663
29.

The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein.

Kouprina N, Pavlicek A, Collins NK, Nakano M, Noskov VN, Ohzeki J, Mochida GH, Risinger JI, Goldsmith P, Gunsior M, Solomon G, Gersch W, Kim JH, Barrett JC, Walsh CA, Jurka J, Masumoto H, Larionov V.

Hum Mol Genet. 2005 Aug 1;14(15):2155-65. Epub 2005 Jun 22.

PMID:
15972725
30.

Evolution of the tumor suppressor BRCA1 locus in primates: implications for cancer predisposition.

Pavlicek A, Noskov VN, Kouprina N, Barrett JC, Jurka J, Larionov V.

Hum Mol Genet. 2004 Nov 15;13(22):2737-51. Epub 2004 Sep 22.

PMID:
15385441
31.

WAViS server for handling, visualization and presentation of multiple alignments of nucleotide or amino acids sequences.

Zika R, Paces J, Pavlícek A, Paces V.

Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W48-9.

32.

Representing GC variation along eukaryotic chromosomes.

Paces J, Zíka R, Paces V, Pavlícek A, Clay O, Bernardi G.

Gene. 2004 May 26;333:135-41.

PMID:
15177688
33.

Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion.

Kouprina N, Pavlicek A, Mochida GH, Solomon G, Gersch W, Yoon YH, Collura R, Ruvolo M, Barrett JC, Woods CG, Walsh CA, Jurka J, Larionov V.

PLoS Biol. 2004 May;2(5):E126. Epub 2004 Mar 23.

34.

Duplication, coclustering, and selection of human Alu retrotransposons.

Jurka J, Kohany O, Pavlicek A, Kapitonov VV, Jurka MV.

Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1268-72. Epub 2004 Jan 21.

35.

HERVd: the Human Endogenous RetroViruses Database: update.

Paces J, Pavlícek A, Zika R, Kapitonov VV, Jurka J, Paces V.

Nucleic Acids Res. 2004 Jan 1;32(Database issue):D50.

36.

Shuffling of genes within low-copy repeats on 22q11 (LCR22) by Alu-mediated recombination events during evolution.

Babcock M, Pavlicek A, Spiteri E, Kashork CD, Ioshikhes I, Shaffer LG, Jurka J, Morrow BE.

Genome Res. 2003 Dec;13(12):2519-32.

37.

A unification of mosaic structures in the human genome.

Lercher MJ, Urrutia AO, Pavlícek A, Hurst LD.

Hum Mol Genet. 2003 Oct 1;12(19):2411-5. Epub 2003 Jul 29.

PMID:
12915446
39.

Transposable elements encoding functional proteins: pitfalls in unprocessed genomic data?

Pavlícek A, Clay O, Bernardi G.

FEBS Lett. 2002 Jul 17;523(1-3):252-3. No abstract available.

40.
41.
42.

Isochore conservation between MHC regions on human chromosome 6 and mouse chromosome 17.

Pavlícek A, Clay O, Jabbari K, Paces J, Bernardi G.

FEBS Lett. 2002 Jan 30;511(1-3):175-7. No abstract available.

43.

A compact view of isochores in the draft human genome sequence.

Pavlícek A, Paces J, Clay O, Bernardi G.

FEBS Lett. 2002 Jan 30;511(1-3):165-9.

44.

HERVd: database of human endogenous retroviruses.

Paces J, Pavlícek A, Paces V.

Nucleic Acids Res. 2002 Jan 1;30(1):205-6.

45.

Genes, isochores and bands in human chromosomes 21 and 22.

Saccone S, Pavlicek A, Federico C, Paces J, Bernard G.

Chromosome Res. 2001;9(7):533-9.

PMID:
11721952
46.

Similar integration but different stability of Alus and LINEs in the human genome.

Pavlícek A, Jabbari K, Paces J, Paces V, Hejnar JV, Bernardi G.

Gene. 2001 Oct 3;276(1-2):39-45.

PMID:
11591470
47.
49.

Electron microscopic observation of potato virus A using murine monoclonal antibodies.

Moravec T, Cerovská N, Pavlícek A.

Acta Virol. 1998 Nov;42(5):341-5.

PMID:
10358736

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