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Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.

Yang H, Jiang X, Li B, Yang HJ, Miller M, Yang A, Dhar A, Pavletich NP.

Nature. 2017 Dec 21;552(7685):368-373. doi: 10.1038/nature25023. Epub 2017 Dec 13.


N-Terminal Amino Acid Sequence Determination of Proteins by N-Terminal Dimethyl Labeling: Pitfalls and Advantages When Compared with Edman Degradation Sequence Analysis.

Chang E, Pourmal S, Zhou C, Kumar R, Teplova M, Pavletich NP, Marians KJ, Erdjument-Bromage H.

J Biomol Tech. 2016 Jul;27(2):61-74. doi: 10.7171/jbt.16-2702-002. Epub 2016 Mar 7.


Dna2 nuclease-helicase structure, mechanism and regulation by Rpa.

Zhou C, Pourmal S, Pavletich NP.

Elife. 2015 Nov 2;4. pii: e09832. doi: 10.7554/eLife.09832.


Correction to N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent.

Misra RN, Xiao HY, Kim KS, Lu S, Han WC, Barbosa SA, Hunt JT, Rawlins DB, Shan W, Ahmed SZ, Qian L, Chen BC, Zhao R, Bednarz MS, Kellar KA, Mulheron JG, Batorsky R, Roongta U, Kamath A, Marathe P, Ranadive SA, Sack JS, Tokarski JS, Pavletich NP, Lee FY, Webster KR, Kimball SD.

J Med Chem. 2015 Sep 24;58(18):7609. doi: 10.1021/acs.jmedchem.5b01294. Epub 2015 Sep 2. No abstract available.


DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1.

Wang R, Persky NS, Yoo B, Ouerfelli O, Smogorzewska A, Elledge SJ, Pavletich NP.

Science. 2014 Nov 28;346(6213):1127-30. doi: 10.1126/science.1258973.


mTOR kinase structure, mechanism and regulation.

Yang H, Rudge DG, Koos JD, Vaidialingam B, Yang HJ, Pavletich NP.

Nature. 2013 May 9;497(7448):217-23. doi: 10.1038/nature12122. Epub 2013 May 1.


Structure and conformational change of a replication protein A heterotrimer bound to ssDNA.

Fan J, Pavletich NP.

Genes Dev. 2012 Oct 15;26(20):2337-47. doi: 10.1101/gad.194787.112.


Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway.

Joo W, Xu G, Persky NS, Smogorzewska A, Rudge DG, Buzovetsky O, Elledge SJ, Pavletich NP.

Science. 2011 Jul 15;333(6040):312-6. doi: 10.1126/science.1205805.


Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.

Takai H, Xie Y, de Lange T, Pavletich NP.

Genes Dev. 2010 Sep 15;24(18):2019-30. doi: 10.1101/gad.1956410. Epub 2010 Aug 27.


Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase.

Cai Z, Chehab NH, Pavletich NP.

Mol Cell. 2009 Sep 24;35(6):818-29. doi: 10.1016/j.molcel.2009.09.007.


Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex.

Scrima A, Konícková R, Czyzewski BK, Kawasaki Y, Jeffrey PD, Groisman R, Nakatani Y, Iwai S, Pavletich NP, Thomä NH.

Cell. 2008 Dec 26;135(7):1213-23. doi: 10.1016/j.cell.2008.10.045.


Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures.

Chen Z, Yang H, Pavletich NP.

Nature. 2008 May 22;453(7194):489-4. doi: 10.1038/nature06971.


Recognition of DNA damage by the Rad4 nucleotide excision repair protein.

Min JH, Pavletich NP.

Nature. 2007 Oct 4;449(7162):570-5. Epub 2007 Sep 19.


Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.

Hao B, Oehlmann S, Sowa ME, Harper JW, Pavletich NP.

Mol Cell. 2007 Apr 13;26(1):131-43.


Ubiquitination regulates PTEN nuclear import and tumor suppression.

Trotman LC, Wang X, Alimonti A, Chen Z, Teruya-Feldstein J, Yang H, Pavletich NP, Carver BS, Cordon-Cardo C, Erdjument-Bromage H, Tempst P, Chi SG, Kim HJ, Misteli T, Jiang X, Pandolfi PP.

Cell. 2007 Jan 12;128(1):141-56.


High-level expression and purification of recombinant SCF ubiquitin ligases.

Li T, Pavletich NP, Schulman BA, Zheng N.

Methods Enzymol. 2005;398:125-42.


Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.

Hao B, Zheng N, Schulman BA, Wu G, Miller JJ, Pagano M, Pavletich NP.

Mol Cell. 2005 Oct 7;20(1):9-19.


Structural biology of ubiquitin-protein ligases.

Pavletich NP.

Harvey Lect. 2002-2003;98:65-102. Review. No abstract available.


Structure of the SWI2/SNF2 chromatin-remodeling domain of eukaryotic Rad54.

Thomä NH, Czyzewski BK, Alexeev AA, Mazin AV, Kowalczykowski SC, Pavletich NP.

Nat Struct Mol Biol. 2005 Apr;12(4):350-6. Epub 2005 Apr 3.


The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction.

Yang H, Li Q, Fan J, Holloman WK, Pavletich NP.

Nature. 2005 Feb 10;433(7026):653-7.


Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1.

Huyen Y, Jeffrey PD, Derry WB, Rothman JH, Pavletich NP, Stavridi ES, Halazonetis TD.

Structure. 2004 Jul;12(7):1237-43.


N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent.

Misra RN, Xiao HY, Kim KS, Lu S, Han WC, Barbosa SA, Hunt JT, Rawlins DB, Shan W, Ahmed SZ, Qian L, Chen BC, Zhao R, Bednarz MS, Kellar KA, Mulheron JG, Batorsky R, Roongta U, Kamath A, Marathe P, Ranadive SA, Sack JS, Tokarski JS, Pavletich NP, Lee FY, Webster KR, Kimball SD.

J Med Chem. 2004 Mar 25;47(7):1719-28. Erratum in: J Med Chem. 2015 Sep 24;58(18):7609.


The BRCA2-interacting protein DSS1 is vital for DNA repair, recombination, and genome stability in Ustilago maydis.

Kojic M, Yang H, Kostrub CF, Pavletich NP, Holloman WK.

Mol Cell. 2003 Oct;12(4):1043-9.


Werner syndrome protein contains three structure-specific DNA binding domains.

von Kobbe C, Thomä NH, Czyzewski BK, Pavletich NP, Bohr VA.

J Biol Chem. 2003 Dec 26;278(52):52997-3006. Epub 2003 Oct 8.


Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways.

Stavridi ES, Harris KG, Huyen Y, Bothos J, Verwoerd PM, Stayrook SE, Pavletich NP, Jeffrey PD, Luca FC.

Structure. 2003 Sep;11(9):1163-70.


Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding.

Chai J, Wu JW, Yan N, Massagué J, Pavletich NP, Shi Y.

J Biol Chem. 2003 May 30;278(22):20327-31. Epub 2003 Apr 9.


Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography.

Nowakowski J, Cronin CN, McRee DE, Knuth MW, Nelson CG, Pavletich NP, Rogers J, Sang BC, Scheibe DN, Swanson RV, Thompson DA.

Structure. 2002 Dec;10(12):1659-67.


BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.

Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thoma NH, Zheng N, Chen PL, Lee WH, Pavletich NP.

Science. 2002 Sep 13;297(5588):1837-48.


Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate.

Stavridi ES, Huyen Y, Loreto IR, Scolnick DM, Halazonetis TD, Pavletich NP, Jeffrey PD.

Structure. 2002 Jul;10(7):891-9.


Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.

Min JH, Yang H, Ivan M, Gertler F, Kaelin WG Jr, Pavletich NP.

Science. 2002 Jun 7;296(5574):1886-9. Epub 2002 May 9.


Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.

Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, Conaway RC, Conaway JW, Harper JW, Pavletich NP.

Nature. 2002 Apr 18;416(6882):703-9.


Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.

Joo WS, Jeffrey PD, Cantor SB, Finnin MS, Livingston DM, Pavletich NP.

Genes Dev. 2002 Mar 1;16(5):583-93.


Structure of the histone deacetylase SIRT2.

Finnin MS, Donigian JR, Pavletich NP.

Nat Struct Biol. 2001 Jul;8(7):621-5.


Role of the F-box protein Skp2 in lymphomagenesis.

Latres E, Chiarle R, Schulman BA, Pavletich NP, Pellicer A, Inghirami G, Pagano M.

Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2515-20. Epub 2001 Feb 20.


Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor.

Georgescu MM, Kirsch KH, Kaloudis P, Yang H, Pavletich NP, Hanafusa H.

Cancer Res. 2000 Dec 15;60(24):7033-8.


Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors.

Jeffrey PD, Tong L, Pavletich NP.

Genes Dev. 2000 Dec 15;14(24):3115-25.


Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.

Schulman BA, Carrano AC, Jeffrey PD, Bowen Z, Kinnucan ER, Finnin MS, Elledge SJ, Harper JW, Pagano M, Pavletich NP.

Nature. 2000 Nov 16;408(6810):381-6.


Kinetic basis for activation of CDK2/cyclin A by phosphorylation.

Hagopian JC, Kirtley MP, Stevenson LM, Gergis RM, Russo AA, Pavletich NP, Parsons SM, Lew J.

J Biol Chem. 2001 Jan 5;276(1):275-80.


Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.

Zheng N, Wang P, Jeffrey PD, Pavletich NP.

Cell. 2000 Aug 18;102(4):533-9.


Identification and characterization of a p53 homologue in Drosophila melanogaster.

Jin S, Martinek S, Joo WS, Wortman JR, Mirkovic N, Sali A, Yandell MD, Pavletich NP, Young MW, Levine AJ.

Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7301-6.


Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein.

Ohh M, Takagi Y, Aso T, Stebbins CE, Pavletich NP, Zbar B, Conaway RC, Conaway JW, Kaelin WG Jr.

J Clin Invest. 1999 Dec;104(11):1583-91.


Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.

Huang L, Kinnucan E, Wang G, Beaudenon S, Howley PM, Huibregtse JM, Pavletich NP.

Science. 1999 Nov 12;286(5443):1321-6.


Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association.

Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P, Pavletich NP.

Cell. 1999 Oct 29;99(3):323-34.


Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.

Finnin MS, Donigian JR, Cohen A, Richon VM, Rifkind RA, Marks PA, Breslow R, Pavletich NP.

Nature. 1999 Sep 9;401(6749):188-93.


Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.

Stebbins CE, Kaelin WG Jr, Pavletich NP.

Science. 1999 Apr 16;284(5413):455-61.


Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP.

Zheng N, Fraenkel E, Pabo CO, Pavletich NP.

Genes Dev. 1999 Mar 15;13(6):666-74.


In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis.

Obermann WM, Sondermann H, Russo AA, Pavletich NP, Hartl FU.

J Cell Biol. 1998 Nov 16;143(4):901-10.

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