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Items: 1 to 50 of 62

1.

The structural basis of translational control by eIF2 phosphorylation.

Adomavicius T, Guaita M, Zhou Y, Jennings MD, Latif Z, Roseman AM, Pavitt GD.

Nat Commun. 2019 May 13;10(1):2136. doi: 10.1038/s41467-019-10167-3.

2.

Translational regulation in response to stress in Saccharomyces cerevisiae.

Crawford RA, Pavitt GD.

Yeast. 2019 Jan;36(1):5-21. doi: 10.1002/yea.3349. Epub 2018 Sep 3. Review.

3.

Regulation of translation initiation factor eIF2B at the hub of the integrated stress response.

Pavitt GD.

Wiley Interdiscip Rev RNA. 2018 Nov;9(6):e1491. doi: 10.1002/wrna.1491. Epub 2018 Jul 10. Review.

PMID:
29989343
4.

Archetypal transcriptional blocks underpin yeast gene regulation in response to changes in growth conditions.

Talavera D, Kershaw CJ, Costello JL, Castelli LM, Rowe W, Sims PFG, Ashe MP, Grant CM, Pavitt GD, Hubbard SJ.

Sci Rep. 2018 May 21;8(1):7949. doi: 10.1038/s41598-018-26170-5.

5.

Protein Synthesis Initiation in Eukaryotic Cells.

Merrick WC, Pavitt GD.

Cold Spring Harb Perspect Biol. 2018 Dec 3;10(12). pii: a033092. doi: 10.1101/cshperspect.a033092. Review.

PMID:
29735639
6.

Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses.

Costello JL, Kershaw CJ, Castelli LM, Talavera D, Rowe W, Sims PFG, Ashe MP, Grant CM, Hubbard SJ, Pavitt GD.

Genome Biol. 2017 Oct 27;18(1):201. doi: 10.1186/s13059-017-1338-4.

7.

Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes.

Jennings MD, Kershaw CJ, Adomavicius T, Pavitt GD.

Elife. 2017 Mar 18;6. pii: e24542. doi: 10.7554/eLife.24542.

8.

Corrigendum: Mutations in SNORD118 cause the cerebral microangiopathy leukoencephalopathy with calcifications and cysts.

Jenkinson EM, Rodero MP, Kasher PR, Uggenti C, Oojageer A, Goosey LC, Rose Y, Kershaw CJ, Urquhart JE, Williams SG, Bhaskar SS, O'Sullivan J, Baerlocher GM, Haubitz M, Aubert G, Barañano KW, Barnicoat AJ, Battini R, Berger A, Blair EM, Brunstrom-Hernandez JE, Buckard JA, Cassiman DM, Caumes R, Cordelli DM, De Waele LM, Fay AJ, Ferreira P, Fletcher NA, Fryer AE, Goel H, Hemingway CA, Henneke M, Hughes I, Jefferson RJ, Kumar R, Lagae L, Landrieu PG, Lourenço CM, Malpas TJ, Mehta SG, Metz I, Naidu S, Õunap K, Panzer A, Prabhakar P, Quaghebeur G, Schiffmann R, Sherr EH, Sinnathuray KR, Soh C, Stewart HS, Stone J, Van Esch H, Van Mol CE, Vanderver A, Wakeling EL, Whitney A, Pavitt GD, Griffiths-Jones S, Rice GI, Revy P, van der Knaap MS, Livingston JH, O'Keefe RT, Crow YJ.

Nat Genet. 2017 Jan 31;49(2):317. doi: 10.1038/ng0217-317b. No abstract available.

PMID:
28138155
9.

Mutations in SNORD118 cause the cerebral microangiopathy leukoencephalopathy with calcifications and cysts.

Jenkinson EM, Rodero MP, Kasher PR, Uggenti C, Oojageer A, Goosey LC, Rose Y, Kershaw CJ, Urquhart JE, Williams SG, Bhaskar SS, O'Sullivan J, Baerlocher GM, Haubitz M, Aubert G, Barañano KW, Barnicoat AJ, Battini R, Berger A, Blair EM, Brunstrom-Hernandez JE, Buckard JA, Cassiman DM, Caumes R, Cordelli DM, De Waele LM, Fay AJ, Ferreira P, Fletcher NA, Fryer AE, Goel H, Hemingway CA, Henneke M, Hughes I, Jefferson RJ, Kumar R, Lagae L, Landrieu PG, Lourenço CM, Malpas TJ, Mehta SG, Metz I, Naidu S, Õunap K, Panzer A, Prabhakar P, Quaghebeur G, Schiffmann R, Sherr EH, Sinnathuray KR, Soh C, Stewart HS, Stone J, Van Esch H, Van Mol CE, Vanderver A, Wakeling EL, Whitney A, Pavitt GD, Griffiths-Jones S, Rice GI, Revy P, van der Knaap MS, Livingston JH, O'Keefe RT, Crow YJ.

Nat Genet. 2016 Oct;48(10):1185-92. doi: 10.1038/ng.3661. Epub 2016 Aug 29. Erratum in: Nat Genet. 2017 Jan 31;49(2):317.

10.

eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control.

Jennings MD, Kershaw CJ, White C, Hoyle D, Richardson JP, Costello JL, Donaldson IJ, Zhou Y, Pavitt GD.

Nucleic Acids Res. 2016 Nov 16;44(20):9698-9709. Epub 2016 Jul 25.

11.

Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae.

Dever TE, Kinzy TG, Pavitt GD.

Genetics. 2016 May;203(1):65-107. doi: 10.1534/genetics.115.186221. Review.

12.
13.

Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p.

Kershaw CJ, Costello JL, Talavera D, Rowe W, Castelli LM, Sims PF, Grant CM, Ashe MP, Hubbard SJ, Pavitt GD.

Sci Rep. 2015 Oct 23;5:15518. doi: 10.1038/srep15518.

14.

The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation.

Castelli LM, Talavera D, Kershaw CJ, Mohammad-Qureshi SS, Costello JL, Rowe W, Sims PF, Grant CM, Hubbard SJ, Ashe MP, Pavitt GD.

PLoS Genet. 2015 May 14;11(5):e1005233. doi: 10.1371/journal.pgen.1005233. eCollection 2015 May.

15.

Global mRNA selection mechanisms for translation initiation.

Costello J, Castelli LM, Rowe W, Kershaw CJ, Talavera D, Mohammad-Qureshi SS, Sims PF, Grant CM, Pavitt GD, Hubbard SJ, Ashe MP.

Genome Biol. 2015 Jan 5;16:10. doi: 10.1186/s13059-014-0559-z.

16.

The yeast La related protein Slf1p is a key activator of translation during the oxidative stress response.

Kershaw CJ, Costello JL, Castelli LM, Talavera D, Rowe W, Sims PF, Ashe MP, Hubbard SJ, Pavitt GD, Grant CM.

PLoS Genet. 2015 Jan 8;11(1):e1004903. doi: 10.1371/journal.pgen.1004903. eCollection 2015 Jan.

17.

A new function and complexity for protein translation initiation factor eIF2B.

Jennings MD, Pavitt GD.

Cell Cycle. 2014;13(17):2660-5. doi: 10.4161/15384101.2014.948797. Review.

18.

eIF2B is a decameric guanine nucleotide exchange factor with a γ2ε2 tetrameric core.

Gordiyenko Y, Schmidt C, Jennings MD, Matak-Vinkovic D, Pavitt GD, Robinson CV.

Nat Commun. 2014 May 23;5:3902. doi: 10.1038/ncomms4902.

19.

eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation.

Jennings MD, Zhou Y, Mohammad-Qureshi SS, Bennett D, Pavitt GD.

Genes Dev. 2013 Dec 15;27(24):2696-707. doi: 10.1101/gad.231514.113.

20.

Puf3p induces translational repression of genes linked to oxidative stress.

Rowe W, Kershaw CJ, Castelli LM, Costello JL, Ashe MP, Grant CM, Sims PF, Pavitt GD, Hubbard SJ.

Nucleic Acids Res. 2014 Jan;42(2):1026-41. doi: 10.1093/nar/gkt948. Epub 2013 Oct 25.

21.

Less translational control, more memory.

Pavitt GD.

Elife. 2013 May 28;2:e00895. doi: 10.7554/eLife.00895.

22.

A yeast purification system for human translation initiation factors eIF2 and eIF2Bε and their use in the diagnosis of CACH/VWM disease.

de Almeida RA, Fogli A, Gaillard M, Scheper GC, Boesflug-Tanguy O, Pavitt GD.

PLoS One. 2013;8(1):e53958. doi: 10.1371/journal.pone.0053958. Epub 2013 Jan 15.

23.

New insights into translational regulation in the endoplasmic reticulum unfolded protein response.

Pavitt GD, Ron D.

Cold Spring Harb Perspect Biol. 2012 Jun 1;4(6). pii: a012278. doi: 10.1101/cshperspect.a012278. Review.

24.

Identification of intersubunit domain interactions within eukaryotic initiation factor (eIF) 2B, the nucleotide exchange factor for translation initiation.

Reid PJ, Mohammad-Qureshi SS, Pavitt GD.

J Biol Chem. 2012 Mar 9;287(11):8275-85. doi: 10.1074/jbc.M111.331645. Epub 2012 Jan 11.

25.

The alpha subunit of eukaryotic initiation factor 2B (eIF2B) is required for eIF2-mediated translational suppression of vesicular stomatitis virus.

Elsby R, Heiber JF, Reid P, Kimball SR, Pavitt GD, Barber GN.

J Virol. 2011 Oct;85(19):9716-25. doi: 10.1128/JVI.05146-11. Epub 2011 Jul 27.

26.

Mechanisms of translational regulation by a human eIF5-mimic protein.

Singh CR, Watanabe R, Zhou D, Jennings MD, Fukao A, Lee B, Ikeda Y, Chiorini JA, Campbell SG, Ashe MP, Fujiwara T, Wek RC, Pavitt GD, Asano K.

Nucleic Acids Res. 2011 Oct;39(19):8314-28. doi: 10.1093/nar/gkr339. Epub 2011 Jul 10.

27.

eIF5 is a dual function GAP and GDI for eukaryotic translational control.

Jennings MD, Pavitt GD.

Small GTPases. 2010 Sep;1(2):118-123.

28.

Parallel High-Throughput Automated Assays to Measure Cell Growth and Beta-Galactosidase Reporter Gene Expression in the Yeast Saccharomyces cerevisiae.

Napper AD, Motlekar N, de Almeida RA, Pavitt GD.

Curr Protoc Chem Biol. 2011 Mar 1;3(1):1-14. doi: 10.1002/9780470559277.ch100119.

29.

Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins.

Cridge AG, Castelli LM, Smirnova JB, Selley JN, Rowe W, Hubbard SJ, McCarthy JE, Ashe MP, Grant CM, Pavitt GD.

Nucleic Acids Res. 2010 Dec;38(22):8039-50. doi: 10.1093/nar/gkq686. Epub 2010 Aug 12.

30.

eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation.

Jennings MD, Pavitt GD.

Nature. 2010 May 20;465(7296):378-81. doi: 10.1038/nature09003. Erratum in: Nature. 2010 Nov 4;468(7320):122.

31.

Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body.

Taylor EJ, Campbell SG, Griffiths CD, Reid PJ, Slaven JW, Harrison RJ, Sims PF, Pavitt GD, Delneri D, Ashe MP.

Mol Biol Cell. 2010 Jul 1;21(13):2202-16. doi: 10.1091/mbc.E09-11-0962. Epub 2010 May 5.

32.

Protein synthesis and its control in neuronal cells with a focus on vanishing white matter disease.

Pavitt GD, Proud CG.

Biochem Soc Trans. 2009 Dec;37(Pt 6):1298-310. doi: 10.1042/BST0371298. Review.

PMID:
19909266
33.

Discovery of chemical modulators of a conserved translational control pathway by parallel screening in yeast.

Motlekar N, de Almeida RA, Pavitt GD, Diamond SL, Napper AD.

Assay Drug Dev Technol. 2009 Oct;7(5):479-94. doi: 10.1089/adt.2009.0198.

34.

Upstream sequence elements direct post-transcriptional regulation of gene expression under stress conditions in yeast.

Lawless C, Pearson RD, Selley JN, Smirnova JB, Grant CM, Ashe MP, Pavitt GD, Hubbard SJ.

BMC Genomics. 2009 Jan 7;10:7. doi: 10.1186/1471-2164-10-7.

35.

Translation controlled.

Pavitt GD, Ashe MP.

Genome Biol. 2008 Oct 21;9(10):323. doi: 10.1186/gb-2008-9-10-323.

36.

Clues to the mechanism of action of eIF2B, the guanine-nucleotide-exchange factor for translation initiation.

Mohammad-Qureshi SS, Jennings MD, Pavitt GD.

Biochem Soc Trans. 2008 Aug;36(Pt 4):658-64. doi: 10.1042/BST0360658. Review.

PMID:
18631136
37.

A Saccharomyces cerevisiae cell-based quantitative beta-galactosidase assay compatible with robotic handling and high-throughput screening.

de Almeida RA, Burgess D, Shema R, Motlekar N, Napper AD, Diamond SL, Pavitt GD.

Yeast. 2008 Jan;25(1):71-6.

38.

Purification of FLAG-tagged eukaryotic initiation factor 2B complexes, subcomplexes, and fragments from Saccharomyces cerevisiae.

Mohammad-Qureshi SS, Haddad R, Palmer KS, Richardson JP, Gomez E, Pavitt GD.

Methods Enzymol. 2007;431:1-13. Review.

PMID:
17923227
39.

Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange.

Mohammad-Qureshi SS, Haddad R, Hemingway EJ, Richardson JP, Pavitt GD.

Mol Cell Biol. 2007 Jul;27(14):5225-34. Epub 2007 May 25.

40.

Change in nutritional status modulates the abundance of critical pre-initiation intermediate complexes during translation initiation in vivo.

Singh CR, Udagawa T, Lee B, Wassink S, He H, Yamamoto Y, Anderson JT, Pavitt GD, Asano K.

J Mol Biol. 2007 Jul 6;370(2):315-30. Epub 2007 Apr 19.

41.

An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiation.

Singh CR, Lee B, Udagawa T, Mohammad-Qureshi SS, Yamamoto Y, Pavitt GD, Asano K.

EMBO J. 2006 Oct 4;25(19):4537-46. Epub 2006 Sep 21.

42.

Global translational responses to oxidative stress impact upon multiple levels of protein synthesis.

Shenton D, Smirnova JB, Selley JN, Carroll K, Hubbard SJ, Pavitt GD, Ashe MP, Grant CM.

J Biol Chem. 2006 Sep 29;281(39):29011-21. Epub 2006 Jul 18.

43.

eIF2B, a mediator of general and gene-specific translational control.

Pavitt GD.

Biochem Soc Trans. 2005 Dec;33(Pt 6):1487-92. Review.

PMID:
16246152
44.

Global gene expression profiling reveals widespread yet distinctive translational responses to different eukaryotic translation initiation factor 2B-targeting stress pathways.

Smirnova JB, Selley JN, Sanchez-Cabo F, Carroll K, Eddy AA, McCarthy JE, Hubbard SJ, Pavitt GD, Grant CM, Ashe MP.

Mol Cell Biol. 2005 Nov;25(21):9340-9.

46.

Structure of the catalytic fragment of translation initiation factor 2B and identification of a critically important catalytic residue.

Boesen T, Mohammad SS, Pavitt GD, Andersen GR.

J Biol Chem. 2004 Mar 12;279(11):10584-92. Epub 2003 Dec 17.

48.

Analysis and reconstitution of translation initiation in vitro.

Asano K, Phan L, Krishnamoorthy T, Pavitt GD, Gomez E, Hannig EM, Nika J, Donahue TF, Huang HK, Hinnebusch AG.

Methods Enzymol. 2002;351:221-47. Review. No abstract available.

PMID:
12073347
50.

Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster.

Williams DD, Pavitt GD, Proud CG.

J Biol Chem. 2001 Feb 9;276(6):3733-42. Epub 2000 Nov 1.

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