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Items: 1 to 50 of 121

1.

Stilbene compound trans-3,4,5,4´-tetramethoxystilbene, a potential anticancer drug, regulates constitutive androstane receptor (Car) target genes, but does not possess proliferative activity in mouse liver.

Dusek J, Skoda J, Holas O, Horvatova A, Smutny T, Linhartova L, Hirsova P, Kucera O, Micuda S, Braeuning A, Pavek P.

Toxicol Lett. 2019 Jun 3. pii: S0378-4274(19)30160-2. doi: 10.1016/j.toxlet.2019.05.024. [Epub ahead of print]

PMID:
31170421
2.

Genetic Predispositions of Glucocorticoid Resistance and Therapeutic Outcomes in Polymyalgia Rheumatica and Giant Cell Arteritis.

Smutny T, Barvik I, Veleta T, Pavek P, Soukup T.

J Clin Med. 2019 Apr 27;8(5). pii: E582. doi: 10.3390/jcm8050582. Review.

3.

The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group.

Koziolek M, Alcaro S, Augustijns P, Basit AW, Grimm M, Hens B, Hoad CL, Jedamzik P, Madla CM, Maliepaard M, Marciani L, Maruca A, Parrott N, Pávek P, Porter CJH, Reppas C, van Riet-Nales D, Rubbens J, Statelova M, Trevaskis NL, Valentová K, Vertzoni M, Čepo DV, Corsetti M.

Eur J Pharm Sci. 2019 Jun 15;134:31-59. doi: 10.1016/j.ejps.2019.04.003. Epub 2019 Apr 8.

4.

Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors.

Hyrsova L, Vanduchova A, Dusek J, Smutny T, Carazo A, Maresova V, Trejtnar F, Barta P, Anzenbacher P, Dvorak Z, Pavek P.

Toxicol Lett. 2019 Jan;300:81-91. doi: 10.1016/j.toxlet.2018.10.028. Epub 2018 Oct 27.

PMID:
30394306
5.

Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling.

Carazo A, Dusek J, Holas O, Skoda J, Hyrsova L, Smutny T, Soukup T, Dosedel M, Pávek P.

Front Pharmacol. 2018 Oct 11;9:993. doi: 10.3389/fphar.2018.00993. eCollection 2018.

6.

Correction to: Interaction of soy isoflavones and their main metabolites with hOATP2B1 transporter.

Navrátilová L, Applová L, Horký P, Mladěnka P, Pávek P, Trejtnar F.

Naunyn Schmiedebergs Arch Pharmacol. 2018 Oct;391(10):1073. doi: 10.1007/s00210-018-1541-1.

PMID:
30054682
7.

Interaction of soy isoflavones and their main metabolites with hOATP2B1 transporter.

Navrátilová L, Applová L, Horký P, Mladěnka P, Pávek P, Trejtnar F.

Naunyn Schmiedebergs Arch Pharmacol. 2018 Oct;391(10):1063-1071. doi: 10.1007/s00210-018-1528-y. Epub 2018 Jun 22. Erratum in: Naunyn Schmiedebergs Arch Pharmacol. 2018 Jul 28;:.

PMID:
29934673
8.

Mathematical Models in the Description of Pregnane X Receptor (PXR)-Regulated Cytochrome P450 Enzyme Induction.

Tebbens JD, Azar M, Friedmann E, Lanzendörfer M, Pávek P.

Int J Mol Sci. 2018 Jun 15;19(6). pii: E1785. doi: 10.3390/ijms19061785. Review.

9.

A feasibility study of the toxic responses of human induced pluripotent stem cell-derived hepatocytes to phytochemicals.

Smutný T, Harjumäki R, Kanninen L, Yliperttula M, Pávek P, Lou YR.

Toxicol In Vitro. 2018 Oct;52:94-105. doi: 10.1016/j.tiv.2018.06.012. Epub 2018 Jun 11.

PMID:
29902661
10.

Effect of Endocannabinoid Oleamide on Rat and Human Liver Cytochrome P450 Enzymes in In Vitro and In Vivo Models.

Dovrtelova G, Zendulka O, Noskova K, Jurica J, Pes O, Dusek J, Carazo A, Zapletalova I, Hlavacova N, Pavek P.

Drug Metab Dispos. 2018 Jun;46(6):913-923. doi: 10.1124/dmd.117.079582. Epub 2018 Apr 12.

PMID:
29650790
11.

Are haplotypes in a single methotrexate pathway more predictive for response in rheumatoid arthritis than in different pathways?

Soukup T, Barvik I, Nekvindova J, Veleta T, Kubena AA, Duintjer Tebbens J, Pavek P, Dosedel M.

Pharmacogenomics. 2018 Apr;19(5):379-381. doi: 10.2217/pgs-2016-0182. Epub 2018 Mar 26.

PMID:
29577811
12.

Ursodeoxycholyl lysophosphatidylethanolamide negatively regulates TLR-mediated lipopolysaccharide response in human THP-1-derived macrophages.

Horvatova A, Utaipan T, Otto AC, Zhang Y, Gan-Schreier H, Pavek P, Pathil A, Stremmel W, Chamulitrat W.

Eur J Pharmacol. 2018 Apr 15;825:63-74. doi: 10.1016/j.ejphar.2018.02.030. Epub 2018 Feb 20.

PMID:
29475064
13.

Unexpected Effects of Propiconazole, Tebuconazole, and Their Mixture on the Receptors CAR and PXR in Human Liver Cells.

Knebel C, Neeb J, Zahn E, Schmidt F, Carazo A, Holas O, Pavek P, Püschel GP, Zanger UM, Süssmuth R, Lampen A, Marx-Stoelting P, Braeuning A.

Toxicol Sci. 2018 May 1;163(1):170-181. doi: 10.1093/toxsci/kfy026.

PMID:
29420809
14.

In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?

Soukup O, Korabecny J, Malinak D, Nepovimova E, Pham NL, Musilek K, Hrabinova M, Hepnarova V, Dolezal R, Pavek P, Jost P, Kobrlova T, Jankockova J, Gorecki L, Psotka M, Nguyen TD, Box K, Outhwaite B, Ceckova M, Sorf A, Jun D, Kuca K.

Med Chem. 2018;14(3):281-292. doi: 10.2174/1573406414666180112105657.

PMID:
29332594
15.

Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats.

Dolezelova E, Prasnicka A, Cermanova J, Carazo A, Hyrsova L, Hroch M, Mokry J, Adamcova M, Mrkvicova A, Pavek P, Micuda S.

World J Gastroenterol. 2017 Nov 21;23(43):7678-7692. doi: 10.3748/wjg.v23.i43.7678.

16.

Iron depletion induces hepatic secretion of biliary lipids and glutathione in rats.

Prasnicka A, Cermanova J, Hroch M, Dolezelova E, Rozkydalova L, Smutny T, Carazo A, Chladek J, Lenicek M, Nachtigal P, Vitek L, Pavek P, Micuda S.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Dec;1862(12):1469-1480. doi: 10.1016/j.bbalip.2017.09.003. Epub 2017 Sep 6.

PMID:
28888833
17.

Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation.

Dusek J, Carazo A, Trejtnar F, Hyrsova L, Holas O, Smutny T, Micuda S, Pavek P.

Food Chem Toxicol. 2017 Nov;109(Pt 1):130-142. doi: 10.1016/j.fct.2017.09.007. Epub 2017 Sep 5.

PMID:
28887089
18.

Development of water-soluble 3,5-dinitrophenyl tetrazole and oxadiazole antitubercular agents.

Roh J, Karabanovich G, Vlčková H, Carazo A, Němeček J, Sychra P, Valášková L, Pavliš O, Stolaříková J, Klimešová V, Vávrová K, Pávek P, Hrabálek A.

Bioorg Med Chem. 2017 Oct 15;25(20):5468-5476. doi: 10.1016/j.bmc.2017.08.010. Epub 2017 Aug 8.

PMID:
28835350
19.

Honey flavonoids inhibit hOATP2B1 and hOATP1A2 transporters and hOATP-mediated rosuvastatin cell uptake in vitro.

Navrátilová L, Ramos Mandíková J, Pávek P, Mladěnka P, Trejtnar F.

Xenobiotica. 2018 Jul;48(7):745-755. doi: 10.1080/00498254.2017.1358469. Epub 2017 Aug 18.

PMID:
28745105
20.

Correction to 2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists.

Smutny T, Nova A, Drechslerová M, Carazo A, Hyrsova L, Hrušková ZR, Kuneš J, Pour M, Špulák M, Pavek P.

J Med Chem. 2016 Dec 22;59(24):11195. doi: 10.1021/acs.jmedchem.6b01729. Epub 2016 Dec 8. No abstract available.

PMID:
28002962
22.

S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents.

Karabanovich G, Němeček J, Valášková L, Carazo A, Konečná K, Stolaříková J, Hrabálek A, Pavliš O, Pávek P, Vávrová K, Roh J, Klimešová V.

Eur J Med Chem. 2017 Jan 27;126:369-383. doi: 10.1016/j.ejmech.2016.11.041. Epub 2016 Nov 21.

PMID:
27907875
23.

Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor.

Carazo A, Hyrsova L, Dusek J, Chodounska H, Horvatova A, Berka K, Bazgier V, Gan-Schreier H, Chamulitrat W, Kudova E, Pavek P.

Toxicol Lett. 2017 Jan 4;265:86-96. doi: 10.1016/j.toxlet.2016.11.013. Epub 2016 Nov 18.

PMID:
27871908
24.

The plausible association of MTHFR and ADORA2A polymorphisms with nodules in rheumatoid arthritis patients treated with methotrexate.

Soukup T, Dosedel M, Nekvindova J, Antonin Kubena A, Tacheci I, Duintjer Tebbens J, Vlcek J, Bradna P, Barvik I, Pavek P.

Pharmacogenet Genomics. 2017 Feb;27(2):43-50. doi: 10.1097/FPC.0000000000000256.

PMID:
27846189
25.

Methotrexate impact on radiographic progression in biologic-treated rheumatoid arthritis under clinical remission: A case report on monozygotic Caucasian twins.

Soukup T, Nekvindova J, Dosedel M, Brtkova J, Toms J, Bastecka D, Bradna P, Vlcek J, Pavek P.

Int J Immunopathol Pharmacol. 2016 Dec;29(4):790-795. Epub 2016 Oct 21.

26.

Pregnane X Receptor and Cancer: Context-Specificity is Key.

Pondugula SR, Pavek P, Mani S.

Nucl Receptor Res. 2016 Jun 12;3. pii: 101198.

27.

Expression of organic cation transporter 1 (OCT1): unique patterns of indirect regulation by nuclear receptors and hepatospecific gene regulation.

Hyrsova L, Smutny T, Trejtnar F, Pavek P.

Drug Metab Rev. 2016 May;48(2):139-58. doi: 10.1080/03602532.2016.1188936. Epub 2016 Jun 9. Review.

PMID:
27278216
28.

2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists.

Smutny T, Nova A, Drechslerová M, Carazo A, Hyrsova L, Hrušková ZR, Kuneš J, Pour M, Špulák M, Pavek P.

J Med Chem. 2016 May 26;59(10):4601-10. doi: 10.1021/acs.jmedchem.5b01891. Epub 2016 May 12. Erratum in: J Med Chem. 2016 Dec 22;59(24):11195.

PMID:
27145071
29.

Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis.

Karabanovich G, Zemanová J, Smutný T, Székely R, Šarkan M, Centárová I, Vocat A, Pávková I, Čonka P, Němeček J, Stolaříková J, Vejsová M, Vávrová K, Klimešová V, Hrabálek A, Pávek P, Cole ST, Mikušová K, Roh J.

J Med Chem. 2016 Mar 24;59(6):2362-80. doi: 10.1021/acs.jmedchem.5b00608. Epub 2016 Mar 15.

PMID:
26948407
30.

The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator.

Hyrsova L, Smutny T, Carazo A, Moravcik S, Mandikova J, Trejtnar F, Gerbal-Chaloin S, Pavek P.

Br J Pharmacol. 2016 May;173(10):1703-15. doi: 10.1111/bph.13472. Epub 2016 Apr 8.

31.

Entecavir Interacts with Influx Transporters hOAT1, hCNT2, hCNT3, but Not with hOCT2: The Potential for Renal Transporter-Mediated Cytotoxicity and Drug-Drug Interactions.

Mandíková J, Volková M, Pávek P, Navrátilová L, Hyršová L, Janeba Z, Pavlík J, Bárta P, Trejtnar F.

Front Pharmacol. 2016 Jan 5;6:304. doi: 10.3389/fphar.2015.00304. eCollection 2015.

32.

Role of dihydromyricetin in cytochrome P450-mediated metabolism and carcinogen activation.

Bostikova Z, Moserova M, Pavek P, Stiborova M, Hodek P.

Neuro Endocrinol Lett. 2015;36 Suppl 1:46-52.

PMID:
26757127
33.

Fully automatic flow-based device for monitoring of drug permeation across a cell monolayer.

Zelená L, Marques SS, Segundo MA, Miró M, Pávek P, Sklenářová H, Solich P.

Anal Bioanal Chem. 2016 Jan;408(3):971-81. doi: 10.1007/s00216-015-9194-0. Epub 2015 Nov 28.

PMID:
26615589
34.

Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity.

Paraskevopoulos G, Krátký M, Mandíková J, Trejtnar F, Stolaříková J, Pávek P, Besra G, Vinšová J.

Bioorg Med Chem. 2015 Nov 15;23(22):7292-301. doi: 10.1016/j.bmc.2015.10.029. Epub 2015 Oct 24.

PMID:
26526729
35.

Bisamidate Prodrugs of 2-Substituted 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA, adefovir) as Selective Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis.

Česnek M, Jansa P, Šmídková M, Mertlíková-Kaiserová H, Dračínský M, Brust TF, Pávek P, Trejtnar F, Watts VJ, Janeba Z.

ChemMedChem. 2015 Aug;10(8):1351-64. doi: 10.1002/cmdc.201500183. Epub 2015 Jul 1.

PMID:
26136378
36.
37.

Boldine enhances bile production in rats via osmotic and farnesoid X receptor dependent mechanisms.

Cermanova J, Kadova Z, Zagorova M, Hroch M, Tomsik P, Nachtigal P, Kudlackova Z, Pavek P, Dubecka M, Ceckova M, Staud F, Laho T, Micuda S.

Toxicol Appl Pharmacol. 2015 May 15;285(1):12-22. doi: 10.1016/j.taap.2015.03.004. Epub 2015 Mar 12.

PMID:
25771127
38.

Genetic polymorphisms in metabolic pathways of leflunomide in the treatment of rheumatoid arthritis.

Soukup T, Dosedel M, Nekvindova J, Toms J, Vlcek J, Pavek P.

Clin Exp Rheumatol. 2015 May-Jun;33(3):426-32. Epub 2015 Jan 29. Review.

PMID:
25664505
39.

Effect of dihydromyricetin on benzo[a]pyrene activation in rats.

Hodek P, Fousova P, Brabencova E, Moserova M, Pavek P, Anzenbacherova E, Brotanek J, Hudecek J, Frei E, Stiborova M.

Neuro Endocrinol Lett. 2014;35 Suppl 2:158-68.

PMID:
25638381
40.

Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR).

Carazo Fernández A, Smutny T, Hyrsová L, Berka K, Pavek P.

Toxicol Lett. 2015 Mar 4;233(2):68-77. doi: 10.1016/j.toxlet.2015.01.013. Epub 2015 Jan 24.

PMID:
25625231
41.

The impact of C677T and A1298C MTHFR polymorphisms on methotrexate therapeutic response in East Bohemian region rheumatoid arthritis patients.

Soukup T, Dosedel M, Pavek P, Nekvindova J, Barvik I, Bubancova I, Bradna P, Kubena AA, Carazo AF, Veleta T, Vlcek J.

Rheumatol Int. 2015 Jul;35(7):1149-61. doi: 10.1007/s00296-015-3219-z. Epub 2015 Jan 25.

PMID:
25618758
42.
43.

1-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant mycobacteria.

Karabanovich G, Roh J, Smutný T, Němeček J, Vicherek P, Stolaříková J, Vejsová M, Dufková I, Vávrová K, Pávek P, Klimešová V, Hrabálek A.

Eur J Med Chem. 2014 Jul 23;82:324-40. doi: 10.1016/j.ejmech.2014.05.069. Epub 2014 Jun 2.

PMID:
24927053
44.

U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.

Smutny T, Bitman M, Urban M, Dubecka M, Vrzal R, Dvorak Z, Pavek P.

Arch Toxicol. 2014 Dec;88(12):2243-59. doi: 10.1007/s00204-014-1254-2. Epub 2014 May 14.

PMID:
24819614
45.

Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction.

Matoulková P, Pávek P, Malý J, Vlček J.

Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):425-35. doi: 10.1517/17425255.2014.878703. Epub 2014 Jan 23. Review.

PMID:
24451000
46.

Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions.

Aatsinki SM, Buler M, Salomäki H, Koulu M, Pavek P, Hakkola J.

Br J Pharmacol. 2014 May;171(9):2351-63. doi: 10.1111/bph.12585.

47.

Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes.

Rulcova A, Krausova L, Smutny T, Vrzal R, Dvorak Z, Jover R, Pavek P.

Pharmacol Rep. 2013;65(5):1322-35.

48.
49.

Dexamethasone accelerates degradation of aryl hydrocarbon receptor (AHR) and suppresses CYP1A1 induction in placental JEG-3 cell line.

Stejskalova L, Rulcova A, Vrzal R, Dvorak Z, Pavek P.

Toxicol Lett. 2013 Nov 25;223(2):183-91. doi: 10.1016/j.toxlet.2013.09.014. Epub 2013 Sep 30.

PMID:
24091107
50.

Nuclear receptors in regulation of biotransformation enzymes and drug transporters in the placental barrier.

Pavek P, Smutny T.

Drug Metab Rev. 2014 Feb;46(1):19-32. doi: 10.3109/03602532.2013.835819. Epub 2013 Sep 10. Review.

PMID:
24020384

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