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Items: 14

1.

Gene-based FVIIa prophylaxis modulates the spontaneous bleeding phenotype of hemophilia A rats.

Zintner SM, Small JC, Pavani G, Dankner L, Marcos-Contreras OA, Gimotty PA, Kjelgaard-Hansen M, Wiinberg B, Margaritis P.

Blood Adv. 2019 Feb 12;3(3):301-311. doi: 10.1182/bloodadvances.2018027219.

2.

Optimization of CRISPR/Cas9 Delivery to Human Hematopoietic Stem and Progenitor Cells for Therapeutic Genomic Rearrangements.

Lattanzi A, Meneghini V, Pavani G, Amor F, Ramadier S, Felix T, Antoniani C, Masson C, Alibeu O, Lee C, Porteus MH, Bao G, Amendola M, Mavilio F, Miccio A.

Mol Ther. 2019 Jan 2;27(1):137-150. doi: 10.1016/j.ymthe.2018.10.008. Epub 2018 Oct 17.

PMID:
30424953
3.

Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of the human β-globin locus.

Antoniani C, Meneghini V, Lattanzi A, Felix T, Romano O, Magrin E, Weber L, Pavani G, El Hoss S, Kurita R, Nakamura Y, Cradick TJ, Lundberg AS, Porteus M, Amendola M, El Nemer W, Cavazzana M, Mavilio F, Miccio A.

Blood. 2018 Apr 26;131(17):1960-1973. doi: 10.1182/blood-2017-10-811505. Epub 2018 Mar 8.

4.

Research: Prevalence of Dense Bone Island.

Syed AZ, Yannam SD, Pavani G.

Compend Contin Educ Dent. 2017 Oct;38(9):e13-e16.

PMID:
28972383
5.

One amino acid in mouse activated factor VII defines its endothelial protein C receptor (EPCR) binding and modulates its EPCR-dependent hemostatic activity in vivo.

Pavani G, Zintner SM, Ivanciu L, Small JC, Stafford KA, Szeto JH, Margaritis P.

J Thromb Haemost. 2017 Mar;15(3):507-512. doi: 10.1111/jth.13607. Epub 2017 Feb 14.

6.

Sustained correction of FVII deficiency in dogs using AAV-mediated expression of zymogen FVII.

Marcos-Contreras OA, Smith SM, Bellinger DA, Raymer RA, Merricks E, Faella A, Pavani G, Zhou S, Nichols TC, High KA, Margaritis P.

Blood. 2016 Feb 4;127(5):565-71. doi: 10.1182/blood-2015-09-671420. Epub 2015 Dec 23.

7.

Asymmetric processing of mutant factor X Arg386Cys reveals differences between intrinsic and extrinsic pathway activation.

Baroni M, Pavani G, Pinotti M, Branchini A, Bernardi F, Camire RM.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt A):1351-6. doi: 10.1016/j.bbapap.2015.05.012. Epub 2015 May 23.

PMID:
26012870
8.

The endothelial protein C receptor enhances hemostasis of FVIIa administration in hemophilic mice in vivo.

Pavani G, Ivanciu L, Faella A, Marcos-Contreras OA, Margaritis P.

Blood. 2014 Aug 14;124(7):1157-65. doi: 10.1182/blood-2014-04-567297. Epub 2014 Jun 23.

9.

Overcoming preexisting humoral immunity to AAV using capsid decoys.

Mingozzi F, Anguela XM, Pavani G, Chen Y, Davidson RJ, Hui DJ, Yazicioglu M, Elkouby L, Hinderer CJ, Faella A, Howard C, Tai A, Podsakoff GM, Zhou S, Basner-Tschakarjan E, Wright JF, High KA.

Sci Transl Med. 2013 Jul 17;5(194):194ra92. doi: 10.1126/scitranslmed.3005795.

10.

Humoral immunity to AAV vectors in gene therapy: challenges and potential solutions.

Masat E, Pavani G, Mingozzi F.

Discov Med. 2013 Jun;15(85):379-89. Review.

11.

The protein C pathway and sepsis.

Della Valle P, Pavani G, D'Angelo A.

Thromb Res. 2012 Mar;129(3):296-300. doi: 10.1016/j.thromres.2011.11.013. Epub 2011 Dec 7. Review.

PMID:
22154246
12.

A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia.

Ivanciu L, Toso R, Margaritis P, Pavani G, Kim H, Schlachterman A, Liu JH, Clerin V, Pittman DD, Rose-Miranda R, Shields KM, Erbe DV, Tobin JF, Arruda VR, Camire RM.

Nat Biotechnol. 2011 Oct 23;29(11):1028-33. doi: 10.1038/nbt.1995.

13.

Catalytic domain modification and viral gene delivery of activated factor VII confers hemostasis at reduced expression levels and vector doses in vivo.

Margaritis P, Roy E, Faella A, Downey HD, Ivanciu L, Pavani G, Zhou S, Bunte RM, High KA.

Blood. 2011 Apr 14;117(15):3974-82. doi: 10.1182/blood-2010-09-309732. Epub 2011 Feb 16. Erratum in: Blood. 2012 May 10;119(19):4577.

14.

Membrane binding and anticoagulant properties of protein S natural variants.

Baroni M, Pavani G, Marescotti D, Kaabache T, Borgel D, Gandrille S, Marchetti G, Legnani C, D'Angelo A, Pinotti M, Bernardi F.

Thromb Res. 2010 Feb;125(2):e33-9. doi: 10.1016/j.thromres.2009.09.015. Epub 2009 Oct 29.

PMID:
19878975

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