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Items: 1 to 50 of 59

1.

Lrp4 Mediates Bone Homeostasis and Mechanotransduction through Interaction with Sclerostin In Vivo.

Bullock WA, Hoggatt AM, Horan DJ, Elmendorf AJ, Sato AY, Bellido T, Loots GG, Pavalko FM, Robling AG.

iScience. 2019 Oct 25;20:205-215. doi: 10.1016/j.isci.2019.09.023. Epub 2019 Sep 18.

2.

Expression of a Degradation-Resistant β-Catenin Mutant in Osteocytes Protects the Skeleton From Mechanodeprivation-Induced Bone Wasting.

Bullock WA, Hoggatt AM, Horan DJ, Lewis KJ, Yokota H, Hann S, Warman ML, Sebastian A, Loots GG, Pavalko FM, Robling AG.

J Bone Miner Res. 2019 Oct;34(10):1964-1975. doi: 10.1002/jbmr.3812. Epub 2019 Aug 5.

PMID:
31173667
3.

Osteocytes and mechanical loading: The Wnt connection.

Bullock WA, Pavalko FM, Robling AG.

Orthod Craniofac Res. 2019 May;22 Suppl 1:175-179. doi: 10.1111/ocr.12282.

PMID:
31074153
4.

Hydroxy-Safflower Yellow A inhibits the TNFR1-Mediated Classical NF-κB Pathway by Inducing Shedding of TNFR1.

Wang H, Liu J, Yang Y, Cao Q, Huo X, Ma S, Hu J, Pavalko FM, Liu Q.

Phytother Res. 2016 May;30(5):790-6. doi: 10.1002/ptr.5579. Epub 2016 Jan 25.

PMID:
26806653
5.

Genome-Wide Mapping and Interrogation of the Nmp4 Antianabolic Bone Axis.

Childress P, Stayrook KR, Alvarez MB, Wang Z, Shao Y, Hernandez-Buquer S, Mack JK, Grese ZR, He Y, Horan D, Pavalko FM, Warden SJ, Robling AG, Yang FC, Allen MR, Krishnan V, Liu Y, Bidwell JP.

Mol Endocrinol. 2015 Sep;29(9):1269-85. doi: 10.1210/me.2014-1406. Epub 2015 Aug 5.

6.

Signaling pathways involved in megakaryocyte-mediated proliferation of osteoblast lineage cells.

Cheng YH, Streicher DA, Waning DL, Chitteti BR, Gerard-O'Riley R, Horowitz MC, Bidwell JP, Pavalko FM, Srour EF, Mayo LD, Kacena MA.

J Cell Physiol. 2015 Mar;230(3):578-86. doi: 10.1002/jcp.24774.

7.

Mechanical loading in osteocytes induces formation of a Src/Pyk2/MBD2 complex that suppresses anabolic gene expression.

Hum JM, Day RN, Bidwell JP, Wang Y, Pavalko FM.

PLoS One. 2014 May 19;9(5):e97942. doi: 10.1371/journal.pone.0097942. eCollection 2014.

8.

Estrogen receptor-β regulates mechanical signaling in primary osteoblasts.

Castillo AB, Triplett JW, Pavalko FM, Turner CH.

Am J Physiol Endocrinol Metab. 2014 Apr 15;306(8):E937-44. doi: 10.1152/ajpendo.00458.2013. Epub 2014 Mar 11.

9.

Pyk2 regulates megakaryocyte-induced increases in osteoblast number and bone formation.

Cheng YH, Hooker RA, Nguyen K, Gerard-O'Riley R, Waning DL, Chitteti BR, Meijome TE, Chua HL, Plett AP, Orschell CM, Srour EF, Mayo LD, Pavalko FM, Bruzzaniti A, Kacena MA.

J Bone Miner Res. 2013 Jun;28(6):1434-45. doi: 10.1002/jbmr.1876.

10.

Monitoring biosensor activity in living cells with fluorescence lifetime imaging microscopy.

Hum JM, Siegel AP, Pavalko FM, Day RN.

Int J Mol Sci. 2012 Nov 7;13(11):14385-400. doi: 10.3390/ijms131114385. Review.

11.

Nmp4/CIZ closes the parathyroid hormone anabolic window.

Bidwell JP, Childress P, Alvarez MB, Hood M Jr, He Y, Pavalko FM, Kacena MA, Yang FC.

Crit Rev Eukaryot Gene Expr. 2012;22(3):205-18. Review.

12.

Immortalization and characterization of osteoblast cell lines generated from wild-type and Nmp4-null mouse bone marrow stromal cells using murine telomerase reverse transcriptase (mTERT).

Alvarez MB, Childress P, Philip BK, Gerard-O'Riley R, Hanlon M, Herbert BS, Robling AG, Pavalko FM, Bidwell JP.

J Cell Physiol. 2012 May;227(5):1873-82. doi: 10.1002/jcp.22915.

13.

The Load-Bearing Mechanosome Revisited.

Bidwell JP, Pavalko FM.

Clin Rev Bone Miner Metab. 2010 Nov 11;8(4):213-223.

14.

Non-overlapping functions for Pyk2 and FAK in osteoblasts during fluid shear stress-induced mechanotransduction.

Young SR, Hum JM, Rodenberg E, Turner CH, Pavalko FM.

PLoS One. 2011 Jan 25;6(1):e16026. doi: 10.1371/journal.pone.0016026.

15.

Mechanosomes carry a loaded message.

Bidwell JP, Pavalko FM.

Sci Signal. 2010 Dec 21;3(153):pe51. doi: 10.1126/scisignal.3153pe51.

PMID:
21177492
16.

Blockade of TNFR1 signaling: A role of oscillatory fluid shear stress in osteoblasts.

Wang H, Young SR, Gerard-O'Riley R, Hum JM, Yang Z, Bidwell JP, Pavalko FM.

J Cell Physiol. 2011 Apr;226(4):1044-51. doi: 10.1002/jcp.22427.

PMID:
20857415
17.

Activation of NF-kappaB by fluid shear stress, but not TNF-alpha, requires focal adhesion kinase in osteoblasts.

Young SR, Gerard-O'Riley R, Harrington M, Pavalko FM.

Bone. 2010 Jul;47(1):74-82. doi: 10.1016/j.bone.2010.03.014. Epub 2010 Mar 27.

18.

Nmp4/CIZ inhibits mechanically induced beta-catenin signaling activity in osteoblasts.

Yang Z, Bidwell JP, Young SR, Gerard-O'Riley R, Wang H, Pavalko FM.

J Cell Physiol. 2010 May;223(2):435-41. doi: 10.1002/jcp.22057.

19.

Focal adhesion kinase is important for fluid shear stress-induced mechanotransduction in osteoblasts.

Young SR, Gerard-O'Riley R, Kim JB, Pavalko FM.

J Bone Miner Res. 2009 Mar;24(3):411-24. doi: 10.1359/jbmr.081102. Erratum in: J Bone Miner Res. 2013 Nov;28(11):2431.

21.

Mechanical loading by fluid shear stress enhances IGF-1 receptor signaling in osteoblasts in a PKCzeta-dependent manner.

Triplett JW, O'Riley R, Tekulve K, Norvell SM, Pavalko FM.

Mol Cell Biomech. 2007 Mar;4(1):13-25.

PMID:
17879768
22.

Nmp4/CIZ contributes to fluid shear stress induced MMP-13 gene induction in osteoblasts.

Charoonpatrapong-Panyayong K, Shah R, Yang J, Alvarez M, Pavalko FM, Gerard-O'Riley R, Robling AG, Templeton E, Bidwell JP.

J Cell Biochem. 2007 Dec 1;102(5):1202-13.

PMID:
17455210
23.

Osteoblasts and osteocytes respond differently to oscillatory and unidirectional fluid flow profiles.

Ponik SM, Triplett JW, Pavalko FM.

J Cell Biochem. 2007 Feb 15;100(3):794-807.

PMID:
17031855
24.

Disruption of alpha-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis.

Triplett JW, Pavalko FM.

Am J Physiol Cell Physiol. 2006 Nov;291(5):C909-21. Epub 2006 Jun 28.

25.

HMGB1 expression and release by bone cells.

Charoonpatrapong K, Shah R, Robling AG, Alvarez M, Clapp DW, Chen S, Kopp RP, Pavalko FM, Yu J, Bidwell JP.

J Cell Physiol. 2006 May;207(2):480-90.

PMID:
16419037
26.

Adenoviral transgene expression enhanced by cotreatment with etoposide in cultured cells.

Triplett JW, Herring BP, Pavalko FM.

Biotechniques. 2005 Dec;39(6):826, 828, 830, passim. No abstract available.

27.

Fluid shear stress induces beta-catenin signaling in osteoblasts.

Norvell SM, Alvarez M, Bidwell JP, Pavalko FM.

Calcif Tissue Int. 2004 Nov;75(5):396-404. Epub 2004 Aug 12.

PMID:
15592796
28.

Nmp4/CIZ regulation of matrix metalloproteinase 13 (MMP-13) response to parathyroid hormone in osteoblasts.

Shah R, Alvarez M, Jones DR, Torrungruang K, Watt AJ, Selvamurugan N, Partridge NC, Quinn CO, Pavalko FM, Rhodes SJ, Bidwell JP.

Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E289-96. Epub 2004 Mar 16.

29.
30.

Fluid shear stress induction of COX-2 protein and prostaglandin release in cultured MC3T3-E1 osteoblasts does not require intact microfilaments or microtubules.

Norvell SM, Ponik SM, Bowen DK, Gerard R, Pavalko FM.

J Appl Physiol (1985). 2004 Mar;96(3):957-66. Epub 2003 Nov 14.

31.

Improved biocompatibility of small intestinal submucosa (SIS) following conditioning by human endothelial cells.

Woods AM, Rodenberg EJ, Hiles MC, Pavalko FM.

Biomaterials. 2004 Feb;25(3):515-25.

PMID:
14585701
32.

Fluid shear-induced NFkappaB translocation in osteoblasts is mediated by intracellular calcium release.

Chen NX, Geist DJ, Genetos DC, Pavalko FM, Duncan RL.

Bone. 2003 Sep;33(3):399-410.

PMID:
13678782
33.

Fluid shear stress inhibits TNF-alpha-induced apoptosis in osteoblasts: a role for fluid shear stress-induced activation of PI3-kinase and inhibition of caspase-3.

Pavalko FM, Gerard RL, Ponik SM, Gallagher PJ, Jin Y, Norvell SM.

J Cell Physiol. 2003 Feb;194(2):194-205.

PMID:
12494458
34.

A model for mechanotransduction in bone cells: the load-bearing mechanosomes.

Pavalko FM, Norvell SM, Burr DB, Turner CH, Duncan RL, Bidwell JP.

J Cell Biochem. 2003 Jan 1;88(1):104-12. Review.

PMID:
12461779
35.

Osteoblast intracellular localization of Nmp4 proteins.

Torrungruang K, Shah R, Alvarez M, Bowen DK, Gerard R, Pavalko FM, Elmendorf JS, Charoonpatrapong K, Hock J, Rhodes SJ, Bidwell JP.

Bone. 2002 Jun;30(6):931-6.

PMID:
12052465
36.

Regulation of PGE(2) and PGI(2) release from human umbilical vein endothelial cells by actin cytoskeleton.

Sawyer SJ, Norvell SM, Ponik SM, Pavalko FM.

Am J Physiol Cell Physiol. 2001 Sep;281(3):C1038-45.

37.

Ca(2+) regulates fluid shear-induced cytoskeletal reorganization and gene expression in osteoblasts.

Chen NX, Ryder KD, Pavalko FM, Turner CH, Burr DB, Qiu J, Duncan RL.

Am J Physiol Cell Physiol. 2000 May;278(5):C989-97.

38.

Fluid shear-induced mechanical signaling in MC3T3-E1 osteoblasts requires cytoskeleton-integrin interactions.

Pavalko FM, Chen NX, Turner CH, Burr DB, Atkinson S, Hsieh YF, Qiu J, Duncan RL.

Am J Physiol. 1998 Dec;275(6 Pt 1):C1591-601.

PMID:
9843721
40.
41.

Thrombin-mediated focal adhesion plaque reorganization in endothelium: role of protein phosphorylation.

Schaphorst KL, Pavalko FM, Patterson CE, Garcia JG.

Am J Respir Cell Mol Biol. 1997 Oct;17(4):443-55.

PMID:
9376119
42.

Tyrosine phosphorylation of the dense plaque protein paxillin is regulated during smooth muscle contraction.

Wang Z, Pavalko FM, Gunst SJ.

Am J Physiol. 1996 Nov;271(5 Pt 1):C1594-602.

PMID:
8944643
44.

Vascular endothelial cell activation and permeability responses to thrombin.

Garcia JG, Pavalko FM, Patterson CE.

Blood Coagul Fibrinolysis. 1995 Oct;6(7):609-26. Review.

PMID:
8562832
45.
46.

Immunodetection of alpha-actinin in focal adhesions is limited by antibody inaccessibility.

Pavalko FM, Schneider G, Burridge K, Lim SS.

Exp Cell Res. 1995 Apr;217(2):534-40.

PMID:
7698254
47.

Phosphorylation of dense-plaque proteins talin and paxillin during tracheal smooth muscle contraction.

Pavalko FM, Adam LP, Wu MF, Walker TL, Gunst SJ.

Am J Physiol. 1995 Mar;268(3 Pt 1):C563-71.

PMID:
7534979
48.

Role of adhesion molecule cytoplasmic domains in mediating interactions with the cytoskeleton.

Pavalko FM, Otey CA.

Proc Soc Exp Biol Med. 1994 Apr;205(4):282-93. Review.

PMID:
8171051
50.

Alpha-actinin: a direct link between actin and integrins.

Pavalko FM, Otey CA, Simon KO, Burridge K.

Biochem Soc Trans. 1991 Nov;19(4):1065-9. Review. No abstract available.

PMID:
1794463

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