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Items: 1 to 50 of 171

1.

Activity of aclidinium bromide, a new long-acting muscarinic antagonist: a phase I study.

Schelfhout VJ, Ferrer P, Jansat JM, Peris F, Gil EG, Pauwels RA, Joos GF.

Br J Clin Pharmacol. 2010 May;69(5):458-64. doi: 10.1111/j.1365-2125.2010.03622.x.

2.

Bronchodilatory effects of aclidinium bromide, a long-acting muscarinic antagonist, in COPD patients.

Joos GF, Schelfhout VJ, Pauwels RA, Kanniess F, Magnussen H, Lamarca R, Jansat JM, Garcia Gil E.

Respir Med. 2010 Jun;104(6):865-72. doi: 10.1016/j.rmed.2009.12.003. Epub 2009 Dec 30.

3.

The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma.

Busse WW, Pedersen S, Pauwels RA, Tan WC, Chen YZ, Lamm CJ, O'Byrne PM; START Investigators Group.

J Allergy Clin Immunol. 2008 May;121(5):1167-74. doi: 10.1016/j.jaci.2008.02.029. Epub 2008 Apr 11.

PMID:
18405951
4.

The severity of airways obstruction as a determinant of treatment response in COPD.

Calverley P, Pauwels RA, Jones PW, Anderson JA, Vestbos J.

Int J Chron Obstruct Pulmon Dis. 2006;1(3):209-18.

5.

Clinical trial design considerations in assessing long-term functional impacts of tiotropium in COPD: the UPLIFT trial.

Decramer M, Celli B, Tashkin DP, Pauwels RA, Burkhart D, Cassino C, Kesten S.

COPD. 2004;1(2):303-12.

PMID:
17136995
6.

Effectiveness of early budesonide intervention in Caucasian versus Asian patients with asthma: 3-year results of the START study.

Tan WC, Lamm CJ, Chen YZ, O'Byrne PM, Pedersen S, Busse WW, Ohlsson SV, Ullman A, Andersson B, Pauwels RA.

Respirology. 2006 Nov;11(6):767-75.

PMID:
17052306
7.

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease: GOLD Executive Summary updated 2003.

Fabbri L, Pauwels RA, Hurd SS; GOLD Scientific Committee.

COPD. 2004 Apr;1(1):105-41; discussion 103-4. No abstract available.

PMID:
16997745
8.

Murine TLR4 is implicated in cigarette smoke-induced pulmonary inflammation.

Maes T, Bracke KR, Vermaelen KY, Demedts IK, Joos GF, Pauwels RA, Brusselle GG.

Int Arch Allergy Immunol. 2006;141(4):354-68. Epub 2006 Aug 29.

PMID:
16940747
9.

Role of the tachykinin NK(1) receptor in mediating contraction to 5-hydroxytryptamine and antigen in the mouse trachea.

De Swert KO, Lefebvre RA, Pauwels RA, Joos GF.

Pulm Pharmacol Ther. 2007;20(5):588-95. Epub 2006 Jul 11.

PMID:
16919985
10.

Effects of early intervention with inhaled budesonide on lung function in newly diagnosed asthma.

O'Byrne PM, Pedersen S, Busse WW, Tan WC, Chen YZ, Ohlsson SV, Ullman A, Lamm CJ, Pauwels RA; START Investigators Group.

Chest. 2006 Jun;129(6):1478-85.

PMID:
16778264
11.

Role of tumour necrosis factor-alpha receptor p75 in cigarette smoke-induced pulmonary inflammation and emphysema.

D'hulst AI, Bracke KR, Maes T, De Bleecker JL, Pauwels RA, Joos GF, Brusselle GG.

Eur Respir J. 2006 Jul;28(1):102-12. Epub 2006 Mar 15.

12.

[Inhaled corticosteroids and mortality in chronic obstructive pulmonary disease].

Sin DD, Wu L, Anderson JA, Anthonisen NR, Buist A, Burge PS, Calverley PM, Connett JE, Lindmark B, Pauwels RA.

Rev Port Pneumol. 2005 Nov-Dec;11(6):603-7. Portuguese. No abstract available.

PMID:
16518885
13.

Outcome of pregnancy in a randomized controlled study of patients with asthma exposed to budesonide.

Silverman M, Sheffer A, Diaz PV, Lindmark B, Radner F, Broddene M, de Verdier MG, Pedersen S, Pauwels RA; START Investigators Group.

Ann Allergy Asthma Immunol. 2005 Dec;95(6):566-70.

PMID:
16400897
14.

Elevated MMP-12 protein levels in induced sputum from patients with COPD.

Demedts IK, Morel-Montero A, Lebecque S, Pacheco Y, Cataldo D, Joos GF, Pauwels RA, Brusselle GG.

Thorax. 2006 Mar;61(3):196-201. Epub 2005 Nov 24.

15.

Inhaled corticosteroids and mortality in chronic obstructive pulmonary disease.

Sin DD, Wu L, Anderson JA, Anthonisen NR, Buist AS, Burge PS, Calverley PM, Connett JE, Lindmark B, Pauwels RA, Postma DS, Soriano JB, Szafranski W, Vestbo J.

Thorax. 2005 Dec;60(12):992-7. Epub 2005 Oct 14.

16.

Predictors of lung function and its decline in mild to moderate COPD in association with gender: results from the Euroscop study.

Watson L, Vonk JM, Löfdahl CG, Pride NB, Pauwels RA, Laitinen LA, Schouten JP, Postma DS; European Respiratory Society Study on Chronic Obstructive Pulmonary Disease.

Respir Med. 2006 Apr;100(4):746-53. Epub 2005 Sep 30.

17.

Matrix metalloproteinase-12 and cathepsin D expression in pulmonary macrophages and dendritic cells of cigarette smoke-exposed mice.

Bracke K, Cataldo D, Maes T, Gueders M, Noël A, Foidart JM, Brusselle G, Pauwels RA.

Int Arch Allergy Immunol. 2005 Oct;138(2):169-79. Epub 2005 Sep 23.

PMID:
16192742
18.
19.

Murine models of COPD.

Brusselle GG, Bracke KR, Maes T, D'hulst AI, Moerloose KB, Joos GF, Pauwels RA.

Pulm Pharmacol Ther. 2006;19(3):155-65. Epub 2005 Aug 3. Review.

PMID:
16084119
20.

Time course of cigarette smoke-induced pulmonary inflammation in mice.

D'hulst AI, Vermaelen KY, Brusselle GG, Joos GF, Pauwels RA.

Eur Respir J. 2005 Aug;26(2):204-13.

21.

Positioning of glucocorticosteroids in asthma and allergic rhinitis guidelines (versus other therapies).

Joos GF, Brusselle GG, Van Hoecke H, Van Cauwenberge P, Bousquet J, Pauwels RA.

Immunol Allergy Clin North Am. 2005 Aug;25(3):597-612, vii-viii. Review.

PMID:
16054545
22.
23.

Matrix metalloproteinases in asthma and COPD.

Demedts IK, Brusselle GG, Bracke KR, Vermaelen KY, Pauwels RA.

Curr Opin Pharmacol. 2005 Jun;5(3):257-63. Review.

PMID:
15907912
24.

Short-term cigarette smoke exposure enhances allergic airway inflammation in mice.

Moerloose KB, Pauwels RA, Joos GF.

Am J Respir Crit Care Med. 2005 Jul 15;172(2):168-72. Epub 2005 Apr 14.

PMID:
15831841
25.

Cost-effectiveness of formoterol and salbutamol as asthma reliever medication in Sweden and in Spain.

Lindgren B, Sears MR, Campbell M, Villasante C, Huang S, Lindh A, Petermann W, Svensson K, Berggren F, Pauwels RA; RELIEF study investigators.

Int J Clin Pract. 2005 Jan;59(1):62-8.

PMID:
15707467
26.

Identification and characterization of human pulmonary dendritic cells.

Demedts IK, Brusselle GG, Vermaelen KY, Pauwels RA.

Am J Respir Cell Mol Biol. 2005 Mar;32(3):177-84. Epub 2004 Dec 2.

PMID:
15576669
27.

Burden and clinical features of chronic obstructive pulmonary disease (COPD).

Pauwels RA, Rabe KF.

Lancet. 2004 Aug 14-20;364(9434):613-20. Review.

PMID:
15313363
28.

Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study.

Bateman ED, Boushey HA, Bousquet J, Busse WW, Clark TJ, Pauwels RA, Pedersen SE; GOAL Investigators Group.

Am J Respir Crit Care Med. 2004 Oct 15;170(8):836-44. Epub 2004 Jul 15.

PMID:
15256389
29.

Efficacy of flow- vs impedance-guided autoadjustable continuous positive airway pressure: a randomized cross-over trial.

Pevernagie DA, Proot PM, Hertegonne KB, Neyens MC, Hoornaert KP, Pauwels RA.

Chest. 2004 Jul;126(1):25-30.

PMID:
15249438
30.

The role of the tachykinin NK1 receptor in airway changes in a mouse model of allergic asthma.

De Swert KO, Tournoy KG, Joos GF, Pauwels RA.

J Allergy Clin Immunol. 2004 Jun;113(6):1093-9.

PMID:
15208590
31.

Dual tachykinin NK1/NK2 antagonist DNK333 inhibits neurokinin A-induced bronchoconstriction in asthma patients.

Joos GF, Vincken W, Louis R, Schelfhout VJ, Wang JH, Shaw MJ, Cioppa GD, Pauwels RA.

Eur Respir J. 2004 Jan;23(1):76-81.

32.

Cost-effectiveness analysis of early intervention with budesonide in mild persistent asthma.

Sullivan SD, Buxton M, Andersson LF, Lamm CJ, Liljas B, Chen YZ, Pauwels RA, Weiss KB.

J Allergy Clin Immunol. 2003 Dec;112(6):1229-36.

PMID:
14657888
33.

Formoterol as relief medication in asthma: a worldwide safety and effectiveness trial.

Pauwels RA, Sears MR, Campbell M, Villasante C, Huang S, Lindh A, Petermann W, Aubier M, Schwabe G, Bengtsson T; RELIEF Study investigators.

Eur Respir J. 2003 Nov;22(5):787-94.

34.

Chronic obstructive pulmonary disease: molecular and cellular mechanisms.

Barnes PJ, Shapiro SD, Pauwels RA.

Eur Respir J. 2003 Oct;22(4):672-88. Review.

35.

Murine models of asthma.

Kips JC, Anderson GP, Fredberg JJ, Herz U, Inman MD, Jordana M, Kemeny DM, Lötvall J, Pauwels RA, Plopper CG, Schmidt D, Sterk PJ, Van Oosterhout AJ, Vargaftig BB, Chung KF.

Eur Respir J. 2003 Aug;22(2):374-82. Review.

36.

Comfort and pressure profiles of two auto-adjustable positive airway pressure devices: a technical report.

Hertegonne KB, Proot PM, Pauwels RA, Pevernagie DA.

Respir Med. 2003 Aug;97(8):903-8.

37.

The role of neural inflammation in asthma and chronic obstructive pulmonary disease.

Joos GF, De Swert KO, Schelfhout V, Pauwels RA.

Ann N Y Acad Sci. 2003 May;992:218-30. Review.

PMID:
12794061
38.

Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial.

Pauwels RA, Pedersen S, Busse WW, Tan WC, Chen YZ, Ohlsson SV, Ullman A, Lamm CJ, O'Byrne PM; START Investigators Group.

Lancet. 2003 Mar 29;361(9363):1071-6.

PMID:
12672309
39.

Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study.

Kips JC, O'Connor BJ, Langley SJ, Woodcock A, Kerstjens HA, Postma DS, Danzig M, Cuss F, Pauwels RA.

Am J Respir Crit Care Med. 2003 Jun 15;167(12):1655-9. Epub 2003 Mar 20.

PMID:
12649124
40.

Modulatory role of tachykinin NK1 receptor in cholinergic contraction of mouse trachea.

Tournoy KG, De Swert KO, Leclere PG, Lefebvre RA, Pauwels RA, Joos GF.

Eur Respir J. 2003 Jan;21(1):3-10.

41.

Gene expression and immunolocalization of 15-lipoxygenase isozymes in the airway mucosa of smokers with chronic bronchitis.

Zhu J, Kilty I, Granger H, Gamble E, Qiu YS, Hattotuwa K, Elston W, Liu WL, Oliva A, Pauwels RA, Kips JC, De Rose V, Barnes N, Yeadon M, Jenkinson S, Jeffery PK.

Am J Respir Cell Mol Biol. 2002 Dec;27(6):666-77.

PMID:
12444026
42.

Dose-related effect of inhaled fluticasone on allergen-induced airway changes in rats.

Vanacker NJ, Palmans E, Pauwels RA, Kips JC.

Eur Respir J. 2002 Oct;20(4):873-9.

43.

Effect of combining salmeterol and fluticasone on the progression of airway remodeling.

Vanacker NJ, Palmans E, Pauwels RA, Kips JC.

Am J Respir Crit Care Med. 2002 Oct 15;166(8):1128-34.

PMID:
12379559
44.
45.

Effects of formoterol (Oxis Turbuhaler) and ipratropium on exercise capacity in patients with COPD.

Liesker JJ, Van De Velde V, Meysman M, Vincken W, Wollmer P, Hansson L, Kerstjens HA, Qvint U, Pauwels RA.

Respir Med. 2002 Aug;96(8):559-66.

46.

Matrix metalloproteinase-9 deficiency impairs cellular infiltration and bronchial hyperresponsiveness during allergen-induced airway inflammation.

Cataldo DD, Tournoy KG, Vermaelen K, Munaut C, Foidart JM, Louis R, Noël A, Pauwels RA.

Am J Pathol. 2002 Aug;161(2):491-8.

47.

Effect of inhaled fluticasone on bronchial responsiveness to neurokinin A in asthma.

Van Schoor J, Joos GF, Pauwels RA.

Eur Respir J. 2002 Jun;19(6):997-1002.

48.

Fluticasone inhibits the progression of allergen-induced structural airway changes.

Vanacker NJ, Palmans E, Pauwels RA, Kips JC.

Clin Exp Allergy. 2002 Jun;32(6):914-20.

PMID:
12047439
49.

Is Th1 the solution for Th2 in asthma?

Tournoy KG, Kips JC, Pauwels RA.

Clin Exp Allergy. 2002 Jan;32(1):17-29. Review. No abstract available.

PMID:
12002732
50.

Effect of age on allergen-induced structural airway changes in brown Norway rats.

Palmans E, Vanacker NJ, Pauwels RA, Kips JC.

Am J Respir Crit Care Med. 2002 May 1;165(9):1280-4.

PMID:
11991879

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