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Items: 1 to 50 of 69

1.

Novel potent capsid assembly modulators regulate multiple steps of the Hepatitis B virus life-cycle.

Lahlali T, Berke JM, Vergauwen K, Foca A, Vandyck K, Pauwels F, Zoulim F, Durantel D.

Antimicrob Agents Chemother. 2018 Jul 16. pii: AAC.00835-18. doi: 10.1128/AAC.00835-18. [Epub ahead of print]

PMID:
30012770
2.

2,4-Diaminoquinazolines as Dual Toll-like Receptor (TLR) 7/8 Modulators for the Treatment of Hepatitis B Virus.

Embrechts W, Herschke F, Pauwels F, Stoops B, Last S, Pieters S, Pande V, Pille G, Amssoms K, Smyej I, Dhuyvetter D, Scholliers A, Mostmans W, Van Dijck K, Van Schoubroeck B, Thone T, De Pooter D, Fanning G, Jonckers THM, Horton H, Raboisson P, McGowan D.

J Med Chem. 2018 Jul 26;61(14):6236-6246. doi: 10.1021/acs.jmedchem.8b00643. Epub 2018 Jul 17.

PMID:
29965759
3.

Discovery of selective 2,4-diaminoquinazoline toll-like receptor 7 (TLR 7) agonists.

Pieters S, McGowan D, Herschke F, Pauwels F, Stoops B, Last S, Embrechts W, Scholliers A, Mostmans W, Van Dijck K, Van Schoubroeck B, Thoné T, De Pooter D, Fanning G, Rosauro ML, Khamlichi MD, Houpis I, Arnoult E, Jonckers THM, Raboisson P.

Bioorg Med Chem Lett. 2018 Feb 15;28(4):711-719. doi: 10.1016/j.bmcl.2018.01.014. Epub 2018 Jan 16.

PMID:
29366653
4.

Characterization of a dengue NS4B inhibitor originating from an HCV small molecule library.

Hernandez-Morales I, Geluykens P, Clynhens M, Strijbos R, Goethals O, Megens S, Verheyen N, Last S, McGowan D, Coesemans E, De Boeck B, Stoops B, Devogelaere B, Pauwels F, Vandyck K, Berke JM, Raboisson P, Simmen K, Lory P, Van Loock M.

Antiviral Res. 2017 Nov;147:149-158. doi: 10.1016/j.antiviral.2017.10.011. Epub 2017 Oct 14.

PMID:
29037976
5.

Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B.

McGowan DC, Herschke F, Pauwels F, Stoops B, Smyej I, Last S, Pieters S, Embrechts W, Khamlichi MD, Thoné T, Van Schoubroeck B, Mostmans W, Wuyts D, Verstappen D, Scholliers A, De Pooter D, Dhuyvetter D, Borghys H, Tuefferd M, Arnoult E, Hong J, Fanning G, Bollekens J, Urmaliya V, Teisman A, Horton H, Jonckers THM, Raboisson P.

J Med Chem. 2017 Jul 27;60(14):6137-6151. doi: 10.1021/acs.jmedchem.7b00365. Epub 2017 Jul 14.

PMID:
28671847
6.

Antiviral profiling of the capsid assembly modulator BAY41-4109 on full-length HBV genotype A-H clinical isolates and core site-directed mutants in vitro.

Berke JM, Tan Y, Verbinnen T, Dehertogh P, Vergauwen K, Vos A, Lenz O, Pauwels F.

Antiviral Res. 2017 Aug;144:205-215. doi: 10.1016/j.antiviral.2017.06.016. Epub 2017 Jun 21.

PMID:
28647474
7.

Capsid Assembly Modulators Have a Dual Mechanism of Action in Primary Human Hepatocytes Infected with Hepatitis B Virus.

Berke JM, Dehertogh P, Vergauwen K, Van Damme E, Mostmans W, Vandyck K, Pauwels F.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00560-17. doi: 10.1128/AAC.00560-17. Print 2017 Aug.

8.

Synthesis and evaluation of novel HCV replication inhibitors.

McGowan DC, Khamlichi MD, De Groot A, Pauwels F, Delouvroy F, Van Emelen K, Simmen K, Raboisson P.

Mol Divers. 2017 May;21(2):475-481. doi: 10.1007/s11030-017-9733-z. Epub 2017 Mar 14.

PMID:
28293834
9.

RADIOGRAPHIC MEASUREMENTS OF HOOF BALANCE ARE SIGNIFICANTLY INFLUENCED BY A HORSE'S STANCE.

Pauwels FE, Rogers CW, Wharton H, Flemming H, Wightman PF, Green RW.

Vet Radiol Ultrasound. 2017 Jan;58(1):10-17. doi: 10.1111/vru.12443. Epub 2016 Nov 17.

PMID:
27859901
10.

Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus.

McGowan D, Herschke F, Pauwels F, Stoops B, Last S, Pieters S, Scholliers A, Thoné T, Van Schoubroeck B, De Pooter D, Mostmans W, Khamlichi MD, Embrechts W, Dhuyvetter D, Smyej I, Arnoult E, Demin S, Borghys H, Fanning G, Vlach J, Raboisson P.

J Med Chem. 2016 Sep 8;59(17):7936-49. doi: 10.1021/acs.jmedchem.6b00747. Epub 2016 Aug 23.

PMID:
27513093
11.

Necrotic hepatitis associated with Clostridium novyi infection (black disease) in a horse in New Zealand.

Whitfield LK, Cypher E, Gordon S, Pauwels F, Ling J, Collett MG, Uzal FA.

N Z Vet J. 2015 May;63(3):177-9. doi: 10.1080/00480169.2014.973461. Epub 2015 Mar 13. No abstract available.

PMID:
25324033
12.

What is your neurologic diagnosis? Vestibular disease.

Cypher EE, Kendall AT, Pauwels FE.

J Am Vet Med Assoc. 2014 Jun 15;244(12):1377-9. doi: 10.2460/javma.244.12.1377. No abstract available.

PMID:
24871057
13.

Development and validation of a fully GMP-compliant production process of autologous, tumor-lysate-pulsed dendritic cells.

Eyrich M, Schreiber SC, Rachor J, Krauss J, Pauwels F, Hain J, Wölfl M, Lutz MB, de Vleeschouwer S, Schlegel PG, Van Gool SW.

Cytotherapy. 2014 Jul;16(7):946-64. doi: 10.1016/j.jcyt.2014.02.017. Epub 2014 May 13.

PMID:
24831836
14.

1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice.

Ferreira GB, Gysemans CA, Demengeot J, da Cunha JP, Vanherwegen AS, Overbergh L, Van Belle TL, Pauwels F, Verstuyf A, Korf H, Mathieu C.

J Immunol. 2014 May 1;192(9):4210-20. doi: 10.4049/jimmunol.1302350. Epub 2014 Mar 24.

15.

Clinicopathologic observations on laryngoplasty failure in a horse.

Hardcastle MR, Pauwels FE, Collett MG.

Vet Surg. 2012 Jul;41(5):649-53. doi: 10.1111/j.1532-950X.2012.00975.x. Epub 2012 Apr 30.

PMID:
22548626
16.

Investigation into the morphology of the third metacarpal bone in the horse.

Dymock DC, Pauwels FE.

N Z Vet J. 2012 Jul;60(4):223-7. doi: 10.1080/00480169.2011.651056. Epub 2012 Apr 18.

PMID:
22512622
17.

Multi-drug-resistant Enterococcus spp. as a cause of non-responsive septic synovitis in three horses.

Herdan CL, Acke E, Dicken M, Archer RM, Forsyth SF, Gee EK, Pauwels FE.

N Z Vet J. 2012 Sep;60(5):297-304. doi: 10.1080/00480169.2011.651702. Epub 2012 Apr 16.

PMID:
22506887
18.

Bilateral ovarian adenocarcinoma in a mare causing haemoperitoneum and colic.

Pauwels FE, Wigley SJ, Munday JS, Roe WD.

N Z Vet J. 2012 May;60(3):198-202. doi: 10.1080/00480169.2011.647607.

PMID:
22480358
19.

Granulosa theca cell tumour in a pregnant mare: concentrations of inhibin and testosterone in serum before and after surgery.

Gee EK, Dicken M, Archer RM, Herdan CL, Pauwels FE, Drayton BM.

N Z Vet J. 2012 Mar;60(2):160-3. doi: 10.1080/00480169.2011.645776.

PMID:
22352936
20.

No effect of caffeine on exercise performance in high ambient temperature.

Roelands B, Buyse L, Pauwels F, Delbeke F, Deventer K, Meeusen R.

Eur J Appl Physiol. 2011 Dec;111(12):3089-95. doi: 10.1007/s00421-011-1945-9. Epub 2011 Apr 2.

PMID:
21461761
21.

Development of a high-content screening assay to identify compounds interfering with the formation of the hepatitis C virus replication complex.

Berke JM, Fenistein D, Pauwels F, Bobbaers R, Lenz O, Lin TI, Krausz E, Fanning G.

J Virol Methods. 2010 May;165(2):268-76. doi: 10.1016/j.jviromet.2010.02.007. Epub 2010 Feb 11.

PMID:
20153373
22.

Mechanism and specificity of a symmetrical benzimidazolephenylcarboxamide helicase inhibitor.

Belon CA, High YD, Lin TI, Pauwels F, Frick DN.

Biochemistry. 2010 Mar 9;49(9):1822-32. doi: 10.1021/bi901974a.

23.

1a/1b subtype profiling of nonnucleoside polymerase inhibitors of hepatitis C virus.

Nyanguile O, Devogelaere B, Vijgen L, Van den Broeck W, Pauwels F, Cummings MD, De Bondt HL, Vos AM, Berke JM, Lenz O, Vandercruyssen G, Vermeiren K, Mostmans W, Dehertogh P, Delouvroy F, Vendeville S, VanDyck K, Dockx K, Cleiren E, Raboisson P, Simmen KA, Fanning GC.

J Virol. 2010 Mar;84(6):2923-34. doi: 10.1128/JVI.01980-09. Epub 2010 Jan 13.

25.

Time trial performance in normal and high ambient temperature: is there a role for 5-HT?

Roelands B, Goekint M, Buyse L, Pauwels F, De Schutter G, Piacentini F, Hasegawa H, Watson P, Meeusen R.

Eur J Appl Physiol. 2009 Sep;107(1):119-26. doi: 10.1007/s00421-009-1109-3. Epub 2009 Jun 17.

PMID:
19533165
26.

1,5-Benzodiazepine inhibitors of HCV NS5B polymerase.

McGowan D, Nyanguile O, Cummings MD, Vendeville S, Vandyck K, Van den Broeck W, Boutton CW, De Bondt H, Quirynen L, Amssoms K, Bonfanti JF, Last S, Rombauts K, Tahri A, Hu L, Delouvroy F, Vermeiren K, Vandercruyssen G, Van der Helm L, Cleiren E, Mostmans W, Lory P, Pille G, Van Emelen K, Fanning G, Pauwels F, Lin TI, Simmen K, Raboisson P.

Bioorg Med Chem Lett. 2009 May 1;19(9):2492-6. doi: 10.1016/j.bmcl.2009.03.035. Epub 2009 Mar 14.

PMID:
19342234
27.

1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors.

Nyanguile O, Pauwels F, Van den Broeck W, Boutton CW, Quirynen L, Ivens T, van der Helm L, Vandercruyssen G, Mostmans W, Delouvroy F, Dehertogh P, Cummings MD, Bonfanti JF, Simmen KA, Raboisson P.

Antimicrob Agents Chemother. 2008 Dec;52(12):4420-31. doi: 10.1128/AAC.00669-08. Epub 2008 Oct 13.

28.

Acute norepinephrine reuptake inhibition decreases performance in normal and high ambient temperature.

Roelands B, Goekint M, Heyman E, Piacentini MF, Watson P, Hasegawa H, Buyse L, Pauwels F, De Schutter G, Meeusen R.

J Appl Physiol (1985). 2008 Jul;105(1):206-12. doi: 10.1152/japplphysiol.90509.2008. Epub 2008 May 22.

29.

Evaluation of the diffusion of corticosteroids between the distal interphalangeal joint and navicular bursa in horses.

Pauwels FE, Schumacher J, Castro FA, Holder TE, Carroll RC, Sega GA, Rogers CW.

Am J Vet Res. 2008 May;69(5):611-6. doi: 10.2460/ajvr.69.5.611.

PMID:
18447791
30.

Congenital retrosternal (Morgagni) diaphragmatic hernias in three horses.

Pauwels FF, Hawkins JF, MacHarg MA, Rothenbuhler RD, Baird DK, Moulton JS.

J Am Vet Med Assoc. 2007 Aug 1;231(3):427-32.

PMID:
17669046
31.

Binding-site identification and genotypic profiling of hepatitis C virus polymerase inhibitors.

Pauwels F, Mostmans W, Quirynen LM, van der Helm L, Boutton CW, Rueff AS, Cleiren E, Raboisson P, Surleraux D, Nyanguile O, Simmen KA.

J Virol. 2007 Jul;81(13):6909-19. Epub 2007 Apr 25.

32.

Arthrodesis of the talocalcaneal joint for the treatment of two horses with talocalcaneal osteoarthritis.

Pauwels FE, Adams SB, Blevins WB.

Vet Comp Orthop Traumatol. 2005;18(1):7-12.

PMID:
16594210
33.

A new approach for perineural injection of the lateral palmar nerve in the horse.

Castro FA, Schumacher JS, Pauwels F, Blackford JT.

Vet Surg. 2005 Nov-Dec;34(6):539-42.

PMID:
16343138
34.

Effects of extracorporeal shock wave therapy and radial pressure wave therapy on elasticity and microstructure of equine cortical bone.

Pauwels FE, McClure SR, Amin V, Van Sickle D, Evans RB.

Am J Vet Res. 2004 Feb;65(2):207-12.

PMID:
14974578
35.

Physiological characterization of Haemophilus influenzae Rd deficient in its glutathione-dependent peroxidase PGdx.

Pauwels F, Vergauwen B, Van Beeumen JJ.

J Biol Chem. 2004 Mar 26;279(13):12163-70. Epub 2003 Dec 29.

37.

Purification and characterization of a chimeric enzyme from Haemophilus influenzae Rd that exhibits glutathione-dependent peroxidase activity.

Pauwels F, Vergauwen B, Vanrobaeys F, Devreese B, Van Beeumen JJ.

J Biol Chem. 2003 May 9;278(19):16658-66. Epub 2003 Feb 26.

38.

Exogenous glutathione completes the defense against oxidative stress in Haemophilus influenzae.

Vergauwen B, Pauwels F, Vaneechoutte M, Van Beeumen JJ.

J Bacteriol. 2003 Mar;185(5):1572-81.

39.

Crystallization and preliminary X-ray crystallographic analysis of glutathione amide reductase from Chromatium gracile.

Vergauwen B, Van Petegem F, Remaut H, Pauwels F, Van Beeumen JJ.

Acta Crystallogr D Biol Crystallogr. 2002 Feb;58(Pt 2):339-40. Epub 2002 Jan 24.

PMID:
11807270
40.

Characterization of glutathione amide reductase from Chromatium gracile. Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide redox cycling.

Vergauwen B, Pauwels F, Jacquemotte F, Meyer TE, Cusanovich MA, Bartsch RG, Van Beeumen JJ.

J Biol Chem. 2001 Jun 15;276(24):20890-7. Epub 2001 Apr 3.

41.

[Developmental effects of the functional adaptation of bone].

Pauwels F.

Anat Anz. 1976;139(3):213-20. German. No abstract available.

PMID:
984424
42.
43.

[Importance of marrow-cavity with respect to the mechanical stress of tubular bones (author's transl)].

Pauwels F.

Z Anat Entwicklungsgesch. 1974;145(1):81-5. German. No abstract available.

PMID:
4450601
44.

[Short survey of mechanical stress of bone and its importance for the functional adaptation (author's transl)].

Pauwels F.

Z Orthop Ihre Grenzgeb. 1973 Oct;111(5):681-705. German. No abstract available.

PMID:
4273131
45.

[Biomechanics of bone grafts].

Pauwels F.

Acta Orthop Belg. 1971;37(6):701-25. French. No abstract available.

PMID:
4948622
46.

The place of osteotomy in the operative management of osteoarthritis of the hip.

Pauwels F.

Triangle. 1968;8(6):196-210. No abstract available.

PMID:
5723807
48.

[Surprising success with traction girding in fracture of the patella].

Pauwels FR.

Med Klin. 1966 Jun 3;61(22):888. German. No abstract available.

PMID:
5997030
49.

[Surprising success with the use of a traction binding in patellar fracture].

Pauwels F.

Langenbecks Arch Chir. 1966;316:221-4. German. No abstract available.

PMID:
5979685
50.

[NEW TRENDS IN THE SURGICAL TREATMENT OF COXARTHROSIS].

PAUWELS F.

Acta Chir Belg. 1964 Jan;63:37-76. French. No abstract available.

PMID:
14169760

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