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Items: 41


Integrin-Linked Kinase Deficiency in Collecting Duct Principal Cell Promotes Necroptosis of Principal Cell and Contributes to Kidney Inflammation and Fibrosis.

Huang M, Zhu S, Huang H, He J, Tsuji K, Jin WW, Xie D, Ham O, Capen DE, Lu W, Păunescu TG, Yang B, Lu HAJ.

J Am Soc Nephrol. 2019 Nov;30(11):2073-2090. doi: 10.1681/ASN.2018111162. Epub 2019 Oct 25.


Sex-dependent differences in water homeostasis in wild-type and V-ATPase B1-subunit deficient mice.

Nair AV, Yanhong W, Paunescu TG, Bouley R, Brown D.

PLoS One. 2019 Aug 6;14(8):e0219940. doi: 10.1371/journal.pone.0219940. eCollection 2019.


Targeted deletion of the Ncoa7 gene results in incomplete distal renal tubular acidosis in mice.

Merkulova M, Păunescu TG, Nair AV, Wang CY, Capen DE, Oliver PL, Breton S, Brown D.

Am J Physiol Renal Physiol. 2018 Jul 1;315(1):F173-F185. doi: 10.1152/ajprenal.00407.2017. Epub 2018 Jan 31.


Reply to Edemir: Physiological regulation and single-cell RNA sequencing.

Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, Păunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E351-E352. doi: 10.1073/pnas.1720333115. Epub 2018 Jan 8. No abstract available.


Identifying the localization and exploring a functional role for Gprc5c in the kidney.

Rajkumar P, Cha B, Yin J, Arend LJ, Păunescu TG, Hirabayashi Y, Donowitz M, Pluznick JL.

FASEB J. 2018 Apr;32(4):2046-2059. doi: 10.1096/fj.201700610RR. Epub 2018 Jan 5.


Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq.

Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, Păunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9989-E9998. doi: 10.1073/pnas.1710964114. Epub 2017 Oct 31.


Manganese promotes intracellular accumulation of AQP2 via modulating F-actin polymerization and reduces urinary concentration in mice.

Lei L, Huang M, Su L, Xie D, Mamuya FA, Ham O, Tsuji K, Păunescu TG, Yang B, Lu HAJ.

Am J Physiol Renal Physiol. 2018 Feb 1;314(2):F306-F316. doi: 10.1152/ajprenal.00391.2017. Epub 2017 Oct 18. Erratum in: Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1885.


Ultrastructural Characterization of the Glomerulopathy in Alport Mice by Helium Ion Scanning Microscopy (HIM).

Tsuji K, Suleiman H, Miner JH, Daley JM, Capen DE, Păunescu TG, Lu HAJ.

Sci Rep. 2017 Sep 15;7(1):11696. doi: 10.1038/s41598-017-12064-5.


Re-characterization of the Glomerulopathy in CD2AP Deficient Mice by High-Resolution Helium Ion Scanning Microscopy.

Tsuji K, Păunescu TG, Suleiman H, Xie D, Mamuya FA, Miner JH, Lu HAJ.

Sci Rep. 2017 Aug 16;7(1):8321. doi: 10.1038/s41598-017-08304-3.


Characterization and Correction of Olfactory Deficits in Kidney Disease.

Nigwekar SU, Weiser JM, Kalim S, Xu D, Wibecan JL, Dougherty SM, Mercier-Lafond L, Corapi KM, Eneanya ND, Holbrook EH, Brown D, Thadhani RI, Păunescu TG.

J Am Soc Nephrol. 2017 Nov;28(11):3395-3403. doi: 10.1681/ASN.2016121308. Epub 2017 Aug 3.


Ezrin directly interacts with AQP2 and promotes its endocytosis.

Li W, Jin WW, Tsuji K, Chen Y, Nomura N, Su L, Yui N, Arthur J, Cotecchia S, Paunescu TG, Brown D, Lu HAJ.

J Cell Sci. 2017 Sep 1;130(17):2914-2925. doi: 10.1242/jcs.204842. Epub 2017 Jul 28.


Deletion of β1-integrin in collecting duct principal cells leads to tubular injury and renal medullary fibrosis.

Mamuya FA, Xie D, Lei L, Huang M, Tsuji K, Capen DE, Yang B, Weissleder R, Păunescu TG, Lu HAJ.

Am J Physiol Renal Physiol. 2017 Oct 1;313(4):F1026-F1037. doi: 10.1152/ajprenal.00038.2017. Epub 2017 Jul 12.


The V-ATPase is expressed in the choroid plexus and mediates cAMP-induced intracellular pH alterations.

Christensen HL, Păunescu TG, Matchkov V, Barbuskaite D, Brown D, Damkier HH, Praetorius J.

Physiol Rep. 2017 Jan;5(1). pii: e13072. doi: 10.14814/phy2.13072.


Intercalated Cell Depletion and Vacuolar H+-ATPase Mistargeting in an Ae1 R607H Knockin Model.

Mumtaz R, Trepiccione F, Hennings JC, Huebner AK, Serbin B, Picard N, Ullah AKMS, Păunescu TG, Capen DE, Lashhab RM, Mouro-Chanteloup I, Alper SL, Wagner CA, Cordat E, Brown D, Eladari D, Hübner CA.

J Am Soc Nephrol. 2017 May;28(5):1507-1520. doi: 10.1681/ASN.2016020169. Epub 2016 Dec 8.


Renal Atp6ap2/(Pro)renin Receptor Is Required for Normal Vacuolar H+-ATPase Function but Not for the Renin-Angiotensin System.

Trepiccione F, Gerber SD, Grahammer F, López-Cayuqueo KI, Baudrie V, Păunescu TG, Capen DE, Picard N, Alexander RT, Huber TB, Chambrey R, Brown D, Houillier P, Eladari D, Simons M.

J Am Soc Nephrol. 2016 Nov;27(11):3320-3330. Epub 2016 Apr 4.


Mapping the H(+) (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation.

Merkulova M, Păunescu TG, Azroyan A, Marshansky V, Breton S, Brown D.

Sci Rep. 2015 Oct 7;5:14827. doi: 10.1038/srep14827.


Polarized Trafficking of AQP2 Revealed in Three Dimensional Epithelial Culture.

Rice WL, Li W, Mamuya F, McKee M, Păunescu TG, Lu HA.

PLoS One. 2015 Jul 6;10(7):e0131719. doi: 10.1371/journal.pone.0131719. eCollection 2015.


High-resolution helium ion microscopy of epididymal epithelial cells and their interaction with spermatozoa.

Păunescu TG, Shum WW, Huynh C, Lechner L, Goetze B, Brown D, Breton S.

Mol Hum Reprod. 2014 Oct;20(10):929-37. doi: 10.1093/molehr/gau052. Epub 2014 Jul 11.


Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells.

Păunescu TG, Lu HA, Russo LM, Pastor-Soler NM, McKee M, McLaughlin MM, Bartlett BE, Breton S, Brown D.

Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1783-95. doi: 10.1152/ajprenal.00622.2012. Epub 2013 Oct 16.


Circulating aldosterone induces the apical accumulation of the proton pumping V-ATPase and increases proton secretion in clear cells in the caput epididymis.

Roy JW, Hill E, Ruan YC, Vedovelli L, Păunescu TG, Brown D, Breton S.

Am J Physiol Cell Physiol. 2013 Aug 15;305(4):C436-46. doi: 10.1152/ajpcell.00410.2012. Epub 2013 Jun 12.


High resolution helium ion scanning microscopy of the rat kidney.

Rice WL, Van Hoek AN, Păunescu TG, Huynh C, Goetze B, Singh B, Scipioni L, Stern LA, Brown D.

PLoS One. 2013;8(3):e57051. doi: 10.1371/journal.pone.0057051. Epub 2013 Mar 7.


Altered V-ATPase expression in renal intercalated cells isolated from B1 subunit-deficient mice by fluorescence-activated cell sorting.

Vedovelli L, Rothermel JT, Finberg KE, Wagner CA, Azroyan A, Hill E, Breton S, Brown D, Paunescu TG.

Am J Physiol Renal Physiol. 2013 Mar 1;304(5):F522-32. doi: 10.1152/ajprenal.00394.2012. Epub 2012 Dec 26.


Loss of the V-ATPase B1 subunit isoform expressed in non-neuronal cells of the mouse olfactory epithelium impairs olfactory function.

Păunescu TG, Rodriguez S, Benz E, McKee M, Tyszkowski R, Albers MW, Brown D.

PLoS One. 2012;7(9):e45395. doi: 10.1371/journal.pone.0045395. Epub 2012 Sep 20.


New insights into the dynamic regulation of water and acid-base balance by renal epithelial cells.

Brown D, Bouley R, Păunescu TG, Breton S, Lu HA.

Am J Physiol Cell Physiol. 2012 May 15;302(10):C1421-33. doi: 10.1152/ajpcell.00085.2012. Epub 2012 Mar 28. Review.


Aldosterone stimulates vacuolar H(+)-ATPase activity in renal acid-secretory intercalated cells mainly via a protein kinase C-dependent pathway.

Winter C, Kampik NB, Vedovelli L, Rothenberger F, Paunescu TG, Stehberger PA, Brown D, John H, Wagner CA.

Am J Physiol Cell Physiol. 2011 Nov;301(5):C1251-61. doi: 10.1152/ajpcell.00076.2011. Epub 2011 Aug 10.


Deletion of hensin/DMBT1 blocks conversion of beta- to alpha-intercalated cells and induces distal renal tubular acidosis.

Gao X, Eladari D, Leviel F, Tew BY, Miró-Julià C, Cheema FH, Miller L, Nelson R, Paunescu TG, McKee M, Brown D, Al-Awqati Q.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21872-7. doi: 10.1073/pnas.1010364107. Epub 2010 Nov 22. Erratum in: Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18625. Cheema, Faisal [corrected to Cheema, Faisal H].


Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease.

Miranda KC, Bond DT, McKee M, Skog J, Păunescu TG, Da Silva N, Brown D, Russo LM.

Kidney Int. 2010 Jul;78(2):191-9. doi: 10.1038/ki.2010.106. Epub 2010 Apr 28.


cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells.

Păunescu TG, Ljubojevic M, Russo LM, Winter C, McLaughlin MM, Wagner CA, Breton S, Brown D.

Am J Physiol Renal Physiol. 2010 Mar;298(3):F643-54. doi: 10.1152/ajprenal.00584.2009. Epub 2010 Jan 6.


Regulation of the V-ATPase in kidney epithelial cells: dual role in acid-base homeostasis and vesicle trafficking.

Brown D, Paunescu TG, Breton S, Marshansky V.

J Exp Biol. 2009 Jun;212(Pt 11):1762-72. doi: 10.1242/jeb.028803. Review.


V-ATPase expression in the mouse olfactory epithelium.

Paunescu TG, Jones AC, Tyszkowski R, Brown D.

Am J Physiol Cell Physiol. 2008 Oct;295(4):C923-30. doi: 10.1152/ajpcell.00237.2008. Epub 2008 Jul 30.


Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells.

Paunescu TG, Da Silva N, Russo LM, McKee M, Lu HA, Breton S, Brown D.

Am J Physiol Renal Physiol. 2008 Jan;294(1):F130-8. Epub 2007 Oct 24.


Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice.

Paunescu TG, Russo LM, Da Silva N, Kovacikova J, Mohebbi N, Van Hoek AN, McKee M, Wagner CA, Breton S, Brown D.

Am J Physiol Renal Physiol. 2007 Dec;293(6):F1915-26. Epub 2007 Sep 26.


Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit.

Da Silva N, Shum WW, El-Annan J, Păunescu TG, McKee M, Smith PJ, Brown D, Breton S.

Am J Physiol Cell Physiol. 2007 Jul;293(1):C199-210. Epub 2007 Mar 28.


The B1-subunit of the H(+) ATPase is required for maximal urinary acidification.

Finberg KE, Wagner CA, Bailey MA, Paunescu TG, Breton S, Brown D, Giebisch G, Geibel JP, Lifton RP.

Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13616-21. Epub 2005 Sep 8.


V-ATPase B1-subunit promoter drives expression of EGFP in intercalated cells of kidney, clear cells of epididymis and airway cells of lung in transgenic mice.

Miller RL, Zhang P, Smith M, Beaulieu V, Paunescu TG, Brown D, Breton S, Nelson RD.

Am J Physiol Cell Physiol. 2005 May;288(5):C1134-44. Epub 2005 Jan 5.


Mechanisms of regulation of epithelial sodium channel by SGK1 in A6 cells.

Alvarez de la Rosa D, Paunescu TG, Els WJ, Helman SI, Canessa CM.

J Gen Physiol. 2004 Oct;124(4):395-407.


Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis.

Paunescu TG, Da Silva N, Marshansky V, McKee M, Breton S, Brown D.

Am J Physiol Cell Physiol. 2004 Jul;287(1):C149-62. Epub 2004 Mar 10.


LY-294002-inhibitable PI 3-kinase and regulation of baseline rates of Na(+) transport in A6 epithelia.

Păunescu TG, Blazer-Yost BL, Vlahos CJ, Helman SI.

Am J Physiol Cell Physiol. 2000 Jul;279(1):C236-47.


Phosphoinositide 3-kinase is required for aldosterone-regulated sodium reabsorption.

Blazer-Yost BL, Păunescu TG, Helman SI, Lee KD, Vlahos CJ.

Am J Physiol. 1999 Sep;277(3):C531-6. doi: 10.1152/ajpcell.1999.277.3.C531.


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