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Items: 1 to 50 of 52

1.

Glycochenodeoxycholate Promotes Liver Fibrosis in Mice with Hepatocellular Cholestasis.

Hohenester S, Kanitz V, Kremer AE, Paulusma CC, Wimmer R, Kuehn H, Denk G, Horst D, Elferink RO, Beuers U.

Cells. 2020 Jan 23;9(2). pii: E281. doi: 10.3390/cells9020281.

2.

Farnesoid X receptor and bile acids regulate vitamin A storage.

Saeed A, Yang J, Heegsma J, Groen AK, van Mil SWC, Paulusma CC, Zhou L, Wang B, Faber KN.

Sci Rep. 2019 Dec 20;9(1):19493. doi: 10.1038/s41598-019-55988-w.

3.

Blocking Sodium-Taurocholate Cotransporting Polypeptide Stimulates Biliary Cholesterol and Phospholipid Secretion in Mice.

Roscam Abbing RLP, Slijepcevic D, Donkers JM, Havinga R, Duijst S, Paulusma CC, Kuiper J, Kuipers F, Groen AK, Oude Elferink RPJ, van de Graaf SFJ.

Hepatology. 2020 Jan;71(1):247-258. doi: 10.1002/hep.30792. Epub 2019 Aug 13.

4.

The P4-ATPase ATP9A is a novel determinant of exosome release.

Naik J, Hau CM, Ten Bloemendaal L, Mok KS, Hajji N, Wehman AM, Meisner S, Muncan V, Paauw NJ, de Vries HE, Nieuwland R, Paulusma CC, Bosma PJ.

PLoS One. 2019 Apr 4;14(4):e0213069. doi: 10.1371/journal.pone.0213069. eCollection 2019.

5.

Liver-directed gene therapy results in long-term correction of progressive familial intrahepatic cholestasis type 3 in mice.

Aronson SJ, Bakker RS, Shi X, Duijst S, Ten Bloemendaal L, de Waart DR, Verheij J, Ronzitti G, Oude Elferink RP, Beuers U, Paulusma CC, Bosma PJ.

J Hepatol. 2019 Jul;71(1):153-162. doi: 10.1016/j.jhep.2019.03.021. Epub 2019 Mar 29.

6.

Extended Abstract: Deficiency of Sodium Taurocholate Cotransporting Polypeptide (SLC10A1): A New Inborn Error of Metabolism with an Attenuated Phenotype.

Vaz FM, Huidekoper HH, Paulusma CC.

Dig Dis. 2017;35(3):259-260. doi: 10.1159/000450984. Epub 2017 Mar 1.

PMID:
28249272
7.

Erratum to: Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4.

van der Mark VA, Ghiboub M, Marsman C, Zhao J, van Dijk R, Hiralall JK, Ho-Mok KS, Castricum Z, de Jonge WJ, Elferink RP, Paulusma CC.

Cell Mol Life Sci. 2017 Apr;74(7):1365. doi: 10.1007/s00018-017-2475-3. No abstract available.

8.

Vps33b is crucial for structural and functional hepatocyte polarity.

Hanley J, Dhar DK, Mazzacuva F, Fiadeiro R, Burden JJ, Lyne AM, Smith H, Straatman-Iwanowska A, Banushi B, Virasami A, Mills K, Lemaigre FP, Knisely AS, Howe S, Sebire N, Waddington SN, Paulusma CC, Clayton P, Gissen P.

J Hepatol. 2017 May;66(5):1001-1011. doi: 10.1016/j.jhep.2017.01.001. Epub 2017 Jan 9.

9.

Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4.

van der Mark VA, Ghiboub M, Marsman C, Zhao J, van Dijk R, Hiralall JK, Ho-Mok KS, Castricum Z, de Jonge WJ, Oude Elferink RP, Paulusma CC.

Cell Mol Life Sci. 2017 Feb;74(4):715-730. doi: 10.1007/s00018-016-2360-5. Epub 2016 Sep 14. Erratum in: Cell Mol Life Sci. 2017 Apr;74(7):1365.

10.

Simple steatosis sensitizes cholestatic rats to liver injury and dysregulates bile salt synthesis and transport.

Lionarons DA, Heger M, van Golen RF, Alles LK, van der Mark VA, Kloek JJ, de Waart DR, Marsman HA, Rusch H, Verheij J, Beuers U, Paulusma CC, van Gulik TM.

Sci Rep. 2016 Aug 18;6:31829. doi: 10.1038/srep31829.

11.

The phospholipid flippase ATP8B1 mediates apical localization of the cystic fibrosis transmembrane regulator.

van der Mark VA, de Jonge HR, Chang JC, Ho-Mok KS, Duijst S, Vidović D, Carlon MS, Oude Elferink RP, Paulusma CC.

Biochim Biophys Acta. 2016 Sep;1863(9):2280-8. doi: 10.1016/j.bbamcr.2016.06.005. Epub 2016 Jun 11.

12.

Soluble Adenylyl Cyclase Regulates Bile Salt-Induced Apoptosis in Human Cholangiocytes.

Chang JC, Go S, de Waart DR, Munoz-Garrido P, Beuers U, Paulusma CC, Oude Elferink R.

Hepatology. 2016 Aug;64(2):522-34. doi: 10.1002/hep.28550. Epub 2016 Apr 15.

13.

ATP11C targets basolateral bile salt transporter proteins in mouse central hepatocytes.

de Waart DR, Naik J, Utsunomiya KS, Duijst S, Ho-Mok K, Bolier AR, Hiralall J, Bull LN, Bosma PJ, Oude Elferink RP, Paulusma CC.

Hepatology. 2016 Jul;64(1):161-74. doi: 10.1002/hep.28522. Epub 2016 Apr 6.

14.

Rescue of defective ATP8B1 trafficking by CFTR correctors as a therapeutic strategy for familial intrahepatic cholestasis.

van der Woerd WL, Wichers CG, Vestergaard AL, Andersen JP, Paulusma CC, Houwen RH, van de Graaf SF.

J Hepatol. 2016 Jun;64(6):1339-47. doi: 10.1016/j.jhep.2016.02.001. Epub 2016 Feb 12.

PMID:
26879107
15.

MRP2 in cholestasis: Putting down the anchor.

Elferink RP, Paulusma CC.

J Hepatol. 2015 Dec;63(6):1309-10. doi: 10.1016/j.jhep.2015.09.020. Epub 2015 Oct 3. No abstract available.

PMID:
26434396
16.

ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization.

Bruurs LJ, Donker L, Zwakenberg S, Zwartkruis FJ, Begthel H, Knisely AS, Posthuma G, van de Graaf SF, Paulusma CC, Bos JL.

J Cell Biol. 2015 Sep 28;210(7):1055-63. doi: 10.1083/jcb.201505118.

17.

Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION.

Ansari IU, Longacre MJ, Paulusma CC, Stoker SW, Kendrick MA, MacDonald MJ.

J Biol Chem. 2015 Sep 18;290(38):23110-23. doi: 10.1074/jbc.M115.655027. Epub 2015 Aug 3.

18.

ATP8B1 and ATP11C: Two Lipid Flippases Important for Hepatocyte Function.

Naik J, de Waart DR, Utsunomiya K, Duijst S, Mok KH, Oude Elferink RP, Bosma PJ, Paulusma CC.

Dig Dis. 2015;33(3):314-8. doi: 10.1159/000371665. Epub 2015 May 27.

PMID:
26045263
19.

The lipid flippase heterodimer ATP8B1-CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells.

van der Mark VA, de Waart DR, Ho-Mok KS, Tabbers MM, Voogt HW, Oude Elferink RP, Knisely AS, Paulusma CC.

Biochim Biophys Acta. 2014 Dec;1842(12 Pt A):2378-86. doi: 10.1016/j.bbadis.2014.09.003. Epub 2014 Sep 16.

20.

Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis.

Kunne C, de Graaff M, Duijst S, de Waart DR, Oude Elferink RP, Paulusma CC.

Lab Invest. 2014 Oct;94(10):1103-13. doi: 10.1038/labinvest.2014.102. Epub 2014 Jul 28.

21.

Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype.

Vaz FM, Paulusma CC, Huidekoper H, de Ru M, Lim C, Koster J, Ho-Mok K, Bootsma AH, Groen AK, Schaap FG, Oude Elferink RP, Waterham HR, Wanders RJ.

Hepatology. 2015 Jan;61(1):260-7. doi: 10.1002/hep.27240. Epub 2014 Aug 25.

PMID:
24867799
22.

FXR-dependent reduction of hepatic steatosis in a bile salt deficient mouse model.

Kunne C, Acco A, Duijst S, de Waart DR, Paulusma CC, Gaemers I, Oude Elferink RP.

Biochim Biophys Acta. 2014 May;1842(5):739-46. doi: 10.1016/j.bbadis.2014.02.004. Epub 2014 Feb 15.

23.

P4 ATPases: flippases in health and disease.

van der Mark VA, Elferink RP, Paulusma CC.

Int J Mol Sci. 2013 Apr 11;14(4):7897-922. doi: 10.3390/ijms14047897. Review.

24.

Cellular localization and biochemical analysis of mammalian CDC50A, a glycosylated β-subunit for P4 ATPases.

Folmer DE, Mok KS, de Wee SW, Duijst S, Hiralall JK, Seppen J, Oude Elferink RP, Paulusma CC.

J Histochem Cytochem. 2012 Mar;60(3):205-18. doi: 10.1369/0022155411435705. Epub 2012 Jan 17.

25.

Oral availability of cefadroxil depends on ABCC3 and ABCC4.

de Waart DR, van de Wetering K, Kunne C, Duijst S, Paulusma CC, Oude Elferink RP.

Drug Metab Dispos. 2012 Mar;40(3):515-21. doi: 10.1124/dmd.111.041731. Epub 2011 Dec 13.

PMID:
22166395
26.

A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes.

Hohenester S, Wenniger LM, Paulusma CC, van Vliet SJ, Jefferson DM, Elferink RP, Beuers U.

Hepatology. 2012 Jan;55(1):173-83. doi: 10.1002/hep.24691.

PMID:
21932391
27.

Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity.

Groen A, Romero MR, Kunne C, Hoosdally SJ, Dixon PH, Wooding C, Williamson C, Seppen J, Van den Oever K, Mok KS, Paulusma CC, Linton KJ, Oude Elferink RP.

Gastroenterology. 2011 Nov;141(5):1927-37.e1-4. doi: 10.1053/j.gastro.2011.07.042. Epub 2011 Aug 4.

PMID:
21820390
28.

The flip side of cardiolipin import.

Paulusma CC, Houwen RH, Williamson PL.

Nat Med. 2011 Apr;17(4):413; author reply 413-4. doi: 10.1038/nm0411-413a. No abstract available.

PMID:
21475228
29.

P4 ATPases--the physiological relevance of lipid flipping transporters.

Paulusma CC, Elferink RP.

FEBS Lett. 2010 Jul 2;584(13):2708-16. doi: 10.1016/j.febslet.2010.04.071. Epub 2010 May 7. Review.

30.

Progressive familial intrahepatic cholestasis type 1.

Paulusma CC, Elferink RP, Jansen PL.

Semin Liver Dis. 2010 May;30(2):117-24. doi: 10.1055/s-0030-1253221. Epub 2010 Apr 26. Review.

PMID:
20422494
31.

Strain background modifies phenotypes in the ATP8B1-deficient mouse.

Shah S, Sanford UR, Vargas JC, Xu H, Groen A, Paulusma CC, Grenert JP, Pawlikowska L, Sen S, Elferink RP, Bull LN.

PLoS One. 2010 Feb 1;5(2):e8984. doi: 10.1371/journal.pone.0008984.

32.

Differential effects of progressive familial intrahepatic cholestasis type 1 and benign recurrent intrahepatic cholestasis type 1 mutations on canalicular localization of ATP8B1.

Folmer DE, van der Mark VA, Ho-Mok KS, Oude Elferink RP, Paulusma CC.

Hepatology. 2009 Nov;50(5):1597-605. doi: 10.1002/hep.23158.

PMID:
19731236
33.

P4 ATPases - lipid flippases and their role in disease.

Folmer DE, Elferink RP, Paulusma CC.

Biochim Biophys Acta. 2009 Jul;1791(7):628-35. doi: 10.1016/j.bbalip.2009.02.008. Epub 2009 Feb 27. Review.

PMID:
19254779
34.

Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content.

Paulusma CC, de Waart DR, Kunne C, Mok KS, Elferink RP.

J Biol Chem. 2009 Apr 10;284(15):9947-54. doi: 10.1074/jbc.M808667200. Epub 2009 Feb 19.

35.

Abcg5/8 independent biliary cholesterol excretion in Atp8b1-deficient mice.

Groen A, Kunne C, Jongsma G, van den Oever K, Mok KS, Petruzzelli M, Vrins CL, Bull L, Paulusma CC, Oude Elferink RP.

Gastroenterology. 2008 Jun;134(7):2091-100. doi: 10.1053/j.gastro.2008.02.097. Epub 2008 Mar 8.

PMID:
18466903
36.

Alteration of viral lipid composition by expression of the phospholipid floppase ABCB4 reduces HIV vector infectivity.

van Til NP, Heutinck KM, van der Rijt R, Paulusma CC, van Wijland M, Markusic DM, Elferink RP, Seppen J.

Retrovirology. 2008 Feb 1;5:14. doi: 10.1186/1742-4690-5-14.

37.

ATP8B1 requires an accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity.

Paulusma CC, Folmer DE, Ho-Mok KS, de Waart DR, Hilarius PM, Verhoeven AJ, Oude Elferink RP.

Hepatology. 2008 Jan;47(1):268-78.

PMID:
17948906
38.

Intestinal bile salt absorption in Atp8b1 deficient mice.

Groen A, Kunne C, Paulusma CC, Kramer W, Agellon LB, Bull LN, Oude Elferink RP.

J Hepatol. 2007 Jul;47(1):114-22. Epub 2007 Mar 7.

PMID:
17448567
39.

Diseases of intramembranous lipid transport.

Paulusma CC, Oude Elferink RP.

FEBS Lett. 2006 Oct 9;580(23):5500-9. Epub 2006 Jun 30. Review.

40.

Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport.

Paulusma CC, Groen A, Kunne C, Ho-Mok KS, Spijkerboer AL, Rudi de Waart D, Hoek FJ, Vreeling H, Hoeben KA, van Marle J, Pawlikowska L, Bull LN, Hofmann AF, Knisely AS, Oude Elferink RP.

Hepatology. 2006 Jul;44(1):195-204.

PMID:
16799980
41.

Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein).

Oude Elferink RP, Paulusma CC.

Pflugers Arch. 2007 Feb;453(5):601-10. Epub 2006 Apr 19. Review.

PMID:
16622704
42.

Multidrug resistance associated protein 2 mediates transport of prostaglandin E2.

de Waart DR, Paulusma CC, Kunne C, Oude Elferink RP.

Liver Int. 2006 Apr;26(3):362-8.

PMID:
16584400
43.

Hepatocanalicular transport defects: pathophysiologic mechanisms of rare diseases.

Oude Elferink RP, Paulusma CC, Groen AK.

Gastroenterology. 2006 Mar;130(3):908-25. Review.

PMID:
16530529
44.

The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease.

Paulusma CC, Oude Elferink RP.

Biochim Biophys Acta. 2005 Jun 30;1741(1-2):11-24. Review.

45.

Ionizing radiation-induced foci formation of mammalian Rad51 and Rad54 depends on the Rad51 paralogs, but not on Rad52.

van Veelen LR, Essers J, van de Rakt MW, Odijk H, Pastink A, Zdzienicka MZ, Paulusma CC, Kanaar R.

Mutat Res. 2005 Jul 1;574(1-2):34-49. Epub 2005 Apr 9.

PMID:
15914205
46.

Zonal down-regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver.

Paulusma CC, Kothe MJ, Bakker CT, Bosma PJ, van Bokhoven I, van Marle J, Bolder U, Tytgat GN, Oude Elferink RP.

Hepatology. 2000 Mar;31(3):684-93.

PMID:
10706559
47.

Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione.

Paulusma CC, van Geer MA, Evers R, Heijn M, Ottenhoff R, Borst P, Oude Elferink RP.

Biochem J. 1999 Mar 1;338 ( Pt 2):393-401.

48.

Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.

Evers R, Kool M, van Deemter L, Janssen H, Calafat J, Oomen LC, Paulusma CC, Oude Elferink RP, Baas F, Schinkel AH, Borst P.

J Clin Invest. 1998 Apr 1;101(7):1310-9.

49.

The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man.

Paulusma CC, Oude Elferink RP.

J Mol Med (Berl). 1997 Jun;75(6):420-8. Review.

PMID:
9231882
50.

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome.

Paulusma CC, Kool M, Bosma PJ, Scheffer GL, ter Borg F, Scheper RJ, Tytgat GN, Borst P, Baas F, Oude Elferink RP.

Hepatology. 1997 Jun;25(6):1539-42.

PMID:
9185779

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