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Stress Erythropoiesis is a Key Inflammatory Response.

Paulson RF, Ruan B, Hao S, Chen Y.

Cells. 2020 Mar 6;9(3). pii: E634. doi: 10.3390/cells9030634. Review.


Yap1 promotes proliferation of transiently amplifying stress erythroid progenitors during erythroid regeneration.

Hao S, Matsui Y, Lai ZC, Paulson RF.

Exp Hematol. 2019 Dec;80:42-54.e4. doi: 10.1016/j.exphem.2019.11.002. Epub 2019 Nov 19.


Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-κB activation in murine macrophages via changes in intracellular calcium.

Diwakar BT, Yoast R, Nettleford S, Qian F, Lee TJ, Berry S, Huffnagle I, Rossi RM, Trebak M, Paulson RF, Prabhu KS.

FASEB J. 2019 Nov;33(11):12838-12852. doi: 10.1096/fj.201802608R. Epub 2019 Sep 13.


Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C.

Bennett LF, Liao C, Quickel MD, Yeoh BS, Vijay-Kumar M, Hankey-Giblin P, Prabhu KS, Paulson RF.

Sci Signal. 2019 Sep 10;12(598). pii: eaap7336. doi: 10.1126/scisignal.aap7336.


Epo receptor marks the spot.

Paulson RF.

Blood. 2019 Aug 1;134(5):413-414. doi: 10.1182/blood.2019001581. No abstract available.


Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche.

Hao S, Xiang J, Wu DC, Fraser JW, Ruan B, Cai J, Patterson AD, Lai ZC, Paulson RF.

Blood Adv. 2019 Jul 23;3(14):2205-2217. doi: 10.1182/bloodadvances.2019000375.


Downregulation of CD73 associates with T cell exhaustion in AML patients.

Kong Y, Jia B, Zhao C, Claxton DF, Sharma A, Annageldiyev C, Fotos JS, Zeng H, Paulson RF, Prabhu KS, Zheng H.

J Hematol Oncol. 2019 Apr 24;12(1):40. doi: 10.1186/s13045-019-0728-3.


Dual Role of a C-Terminally Truncated Isoform of Large Tumor Suppressor Kinase 1 in the Regulation of Hippo Signaling and Tissue Growth.

Matsui Y, Zhang Y, Paulson RF, Lai ZC.

DNA Cell Biol. 2019 Jan;38(1):91-106. doi: 10.1089/dna.2018.4340. Epub 2018 Nov 21.


Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia.

Liao C, Prabhu KS, Paulson RF.

Blood. 2018 Dec 13;132(24):2580-2593. doi: 10.1182/blood-2018-06-856831. Epub 2018 Oct 15.


Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis.

Rothberg JLM, Maganti HB, Jrade H, Porter CJ, Palidwor GA, Cafariello C, Battaion HL, Khan ST, Perkins TJ, Paulson RF, Ito CY, Stanford WL.

Cell Discov. 2018 May 1;4:21. doi: 10.1038/s41421-018-0022-5. eCollection 2018.


The intricate role of selenium and selenoproteins in erythropoiesis.

Liao C, Carlson BA, Paulson RF, Prabhu KS.

Free Radic Biol Med. 2018 Nov 1;127:165-171. doi: 10.1016/j.freeradbiomed.2018.04.578. Epub 2018 Apr 30. Review.


Neuroprotective Role of the Ron Receptor Tyrosine Kinase Underlying Central Nervous System Inflammation in Health and Disease.

Dey A, Allen JN, Fraser JW, Snyder LM, Tian Y, Zhang L, Paulson RF, Patterson A, Cantorna MT, Hankey-Giblin PA.

Front Immunol. 2018 Mar 19;9:513. doi: 10.3389/fimmu.2018.00513. eCollection 2018.


Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis.

Liao C, Hardison RC, Kennett MJ, Carlson BA, Paulson RF, Prabhu KS.

Blood. 2018 Jun 7;131(23):2568-2580. doi: 10.1182/blood-2017-08-800607. Epub 2018 Apr 3.


Mechanisms of erythrocyte development and regeneration: implications for regenerative medicine and beyond.

Bresnick EH, Hewitt KJ, Mehta C, Keles S, Paulson RF, Johnson KD.

Development. 2018 Jan 10;145(1). pii: dev151423. doi: 10.1242/dev.151423. Review.


Stress Erythropoiesis Model Systems.

Bennett LF, Liao C, Paulson RF.

Methods Mol Biol. 2018;1698:91-102. doi: 10.1007/978-1-4939-7428-3_5.


The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium.

Diwakar BT, Korwar AM, Paulson RF, Prabhu KS.

Adv Cancer Res. 2017;136:153-172. doi: 10.1016/bs.acr.2017.07.003. Epub 2017 Aug 31. Review.


SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models.

Hengst JA, Dick TE, Sharma A, Doi K, Hegde S, Tan SF, Geffert LM, Fox TE, Sharma AK, Desai D, Amin S, Kester M, Loughran TP, Paulson RF, Claxton DF, Wang HG, Yun JK.

Cancer Transl Med. 2017 Jul-Aug;3(4):109-121. doi: 10.4103/ctm.ctm_7_17. Epub 2017 Aug 14.


GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia.

Hewitt KJ, Katsumura KR, Matson DR, Devadas P, Tanimura N, Hebert AS, Coon JJ, Kim JS, Dewey CN, Keles S, Hao S, Paulson RF, Bresnick EH.

Dev Cell. 2017 Aug 7;42(3):213-225.e4. doi: 10.1016/j.devcel.2017.07.009.


Activation of PPARγ by endogenous prostaglandin J2 mediates the antileukemic effect of selenium in murine leukemia.

Finch ER, Tukaramrao DB, Goodfield LL, Quickel MD, Paulson RF, Prabhu KS.

Blood. 2017 Mar 30;129(13):1802-1810. doi: 10.1182/blood-2016-08-736405. Epub 2017 Jan 23.


Chemopreventive Effects of Dietary Eicosapentaenoic Acid Supplementation in Experimental Myeloid Leukemia.

Finch ER, Kudva AK, Quickel MD, Goodfield LL, Kennett MJ, Whelan J, Paulson RF, Prabhu KS.

Cancer Prev Res (Phila). 2015 Oct;8(10):989-99. doi: 10.1158/1940-6207.CAPR-15-0050. Epub 2015 Aug 19.


In vitro culture of stress erythroid progenitors identifies distinct progenitor populations and analogous human progenitors.

Xiang J, Wu DC, Chen Y, Paulson RF.

Blood. 2015 Mar 12;125(11):1803-12. doi: 10.1182/blood-2014-07-591453. Epub 2015 Jan 21.


Selenium suppresses leukemia through the action of endogenous eicosanoids.

Gandhi UH, Kaushal N, Hegde S, Finch ER, Kudva AK, Kennett MJ, Jordan CT, Paulson RF, Prabhu KS.

Cancer Res. 2014 Jul 15;74(14):3890-901. doi: 10.1158/0008-5472.CAN-13-3694. Epub 2014 May 28.


Targeting a new regulator of erythropoiesis to alleviate anemia.

Paulson RF.

Nat Med. 2014 Apr;20(4):334-5. doi: 10.1038/nm.3524. No abstract available.


Evaluation of the stability, bioavailability, and hypersensitivity of the omega-3 derived anti-leukemic prostaglandin: Δ(12)-prostaglandin J3.

Kudva AK, Kaushal N, Mohinta S, Kennett MJ, August A, Paulson RF, Prabhu KS.

PLoS One. 2013 Dec 2;8(12):e80622. doi: 10.1371/journal.pone.0080622. eCollection 2013.


Enu mutagenesis identifies a novel platelet phenotype in a loss-of-function Jak2 allele.

Anderson NM, Javadi M, Berndl E, Berberovic Z, Bailey ML, Huang K, Flenniken AM, Osborne LR, Adamson SL, Rossant J, Carter-Su C, Wang C, McNagny KM, Paulson RF, Minden MD, Stanford WL, Barber DL.

PLoS One. 2013 Sep 25;8(9):e75472. doi: 10.1371/journal.pone.0075472. eCollection 2013.


Erythropoiesis lagging? pIgA1 steps in to assist Epo.

Paulson RF.

Nat Med. 2011 Nov 7;17(11):1346-8. doi: 10.1038/nm.2501. No abstract available.


Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration.

Trompouki E, Bowman TV, Lawton LN, Fan ZP, Wu DC, DiBiase A, Martin CS, Cech JN, Sessa AK, Leblanc JL, Li P, Durand EM, Mosimann C, Heffner GC, Daley GQ, Paulson RF, Young RA, Zon LI.

Cell. 2011 Oct 28;147(3):577-89. doi: 10.1016/j.cell.2011.09.044.


Δ12-prostaglandin J3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice.

Hegde S, Kaushal N, Ravindra KC, Chiaro C, Hafer KT, Gandhi UH, Thompson JT, van den Heuvel JP, Kennett MJ, Hankey P, Paulson RF, Prabhu KS.

Blood. 2011 Dec 22;118(26):6909-19. doi: 10.1182/blood-2010-11-317750. Epub 2011 Oct 3.


Cytopenia induction by 5-fluorouracil identifies thrombopoietic mutants in sensitized ENU mutagenesis screens.

Anderson NM, Berberovic Z, Berndl E, Bailey ML, Flenniken AM, Osborne LR, Adamson SL, Rossant J, Wang C, Minden MD, McNagny KM, Paulson RF, Barber DL, Stanford WL.

Exp Hematol. 2012 Jan;40(1):48-60. doi: 10.1016/j.exphem.2011.09.007. Epub 2011 Sep 14.


Selenoprotein-dependent up-regulation of hematopoietic prostaglandin D2 synthase in macrophages is mediated through the activation of peroxisome proliferator-activated receptor (PPAR) gamma.

Gandhi UH, Kaushal N, Ravindra KC, Hegde S, Nelson SM, Narayan V, Vunta H, Paulson RF, Prabhu KS.

J Biol Chem. 2011 Aug 5;286(31):27471-82. doi: 10.1074/jbc.M111.260547. Epub 2011 Jun 13.


Stress erythropoiesis: new signals and new stress progenitor cells.

Paulson RF, Shi L, Wu DC.

Curr Opin Hematol. 2011 May;18(3):139-45. doi: 10.1097/MOH.0b013e32834521c8. Review.


Interrelationships between tissue iron status and erythropoiesis during postweaning development following neonatal iron deficiency in rats.

Hegde NV, Unger EL, Jensen GL, Hankey PA, Paulson RF.

Am J Physiol Gastrointest Liver Physiol. 2011 Mar;300(3):G470-6. doi: 10.1152/ajpgi.00463.2010. Epub 2010 Dec 30.


A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis.

Hughes MR, Anderson N, Maltby S, Wong J, Berberovic Z, Birkenmeier CS, Haddon DJ, Garcha K, Flenniken A, Osborne LR, Adamson SL, Rossant J, Peters LL, Minden MD, Paulson RF, Wang C, Barber DL, McNagny KM, Stanford WL.

Exp Hematol. 2011 Mar;39(3):305-20, 320.e1-2. doi: 10.1016/j.exphem.2010.12.009. Epub 2010 Dec 28. Erratum in: Exp Hematol. 2011 May 39(5):601.


Murine erythroid short-term radioprotection requires a BMP4-dependent, self-renewing population of stress erythroid progenitors.

Harandi OF, Hedge S, Wu DC, McKeone D, Paulson RF.

J Clin Invest. 2010 Dec;120(12):4507-19. doi: 10.1172/JCI41291. Epub 2010 Nov 8.


The regulation of erythropoiesis by selenium in mice.

Kaushal N, Hegde S, Lumadue J, Paulson RF, Prabhu KS.

Antioxid Redox Signal. 2011 Apr 15;14(8):1403-12. doi: 10.1089/ars.2010.3323. Epub 2011 Feb 25.


Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia.

Wu DC, Paulson RF.

PLoS One. 2010 Jun 24;5(6):e11303. doi: 10.1371/journal.pone.0011303.


Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation.

Hegde S, Ni S, He S, Yoon D, Feng GS, Watowich SS, Paulson RF, Hankey PA.

Oncogene. 2009 Sep 24;28(38):3349-59. doi: 10.1038/onc.2009.202. Epub 2009 Jul 6.


Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells.

Tanno T, Porayette P, Sripichai O, Noh SJ, Byrnes C, Bhupatiraju A, Lee YT, Goodnough JB, Harandi O, Ganz T, Paulson RF, Miller JL.

Blood. 2009 Jul 2;114(1):181-6. doi: 10.1182/blood-2008-12-195503. Epub 2009 May 4.


Extramedullary erythropoiesis in the adult liver requires BMP-4/Smad5-dependent signaling.

Lenox LE, Shi L, Hegde S, Paulson RF.

Exp Hematol. 2009 May;37(5):549-58. doi: 10.1016/j.exphem.2009.01.004.


Podocalyxin selectively marks erythroid-committed progenitors during anemic stress but is dispensable for efficient recovery.

Maltby S, Hughes MR, Zbytnuik L, Paulson RF, McNagny KM.

Exp Hematol. 2009 Jan;37(1):10-8. doi: 10.1016/j.exphem.2008.09.006. Epub 2008 Nov 11.


Maintenance of the BMP4-dependent stress erythropoiesis pathway in the murine spleen requires hedgehog signaling.

Perry JM, Harandi OF, Porayette P, Hegde S, Kannan AK, Paulson RF.

Blood. 2009 Jan 22;113(4):911-8. doi: 10.1182/blood-2008-03-147892. Epub 2008 Oct 16.


BMP4/Smad5 dependent stress erythropoiesis is required for the expansion of erythroid progenitors during fetal development.

Porayette P, Paulson RF.

Dev Biol. 2008 May 1;317(1):24-35. doi: 10.1016/j.ydbio.2008.01.047. Epub 2008 Feb 15.


An intronic sequence mutated in flexed-tail mice regulates splicing of Smad5.

Hegde S, Lenox LE, Lariviere A, Porayette P, Perry JM, Yon M, Paulson RF.

Mamm Genome. 2007 Dec;18(12):852-60. Epub 2007 Nov 30.


Friend virus utilizes the BMP4-dependent stress erythropoiesis pathway to induce erythroleukemia.

Subramanian A, Hegde S, Porayette P, Yon M, Hankey P, Paulson RF.

J Virol. 2008 Jan;82(1):382-93. Epub 2007 Oct 17.


BMP4, SCF, and hypoxia cooperatively regulate the expansion of murine stress erythroid progenitors.

Perry JM, Harandi OF, Paulson RF.

Blood. 2007 May 15;109(10):4494-502. Epub 2007 Feb 6.


Vitamin D receptor expression by the lung micro-environment is required for maximal induction of lung inflammation.

Wittke A, Chang A, Froicu M, Harandi OF, Weaver V, August A, Paulson RF, Cantorna MT.

Arch Biochem Biophys. 2007 Apr 15;460(2):306-13. Epub 2007 Jan 2.


Mutation of the Lyn tyrosine kinase delays the progression of Friend virus induced erythroleukemia without affecting susceptibility.

Subramanian A, Hegde S, Correll PH, Paulson RF.

Leuk Res. 2006 Sep;30(9):1141-9. Epub 2006 Mar 9.


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