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Items: 31


Human CD4+ T Cells Specific for Merkel Cell Polyomavirus Localize to Merkel Cell Carcinomas and Target a Required Oncogenic Domain.

Longino NV, Yang J, Iyer JG, Ibrani D, Chow IT, Laing KJ, Campbell VL, Paulson KG, Kulikauskas RM, Church CD, James EA, Nghiem P, Kwok WW, Koelle DM.

Cancer Immunol Res. 2019 Aug 12. doi: 10.1158/2326-6066.CIR-19-0103. [Epub ahead of print]


T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant.

Chapuis AG, Egan DN, Bar M, Schmitt TM, McAfee MS, Paulson KG, Voillet V, Gottardo R, Ragnarsson GB, Bleakley M, Yeung CC, Muhlhauser P, Nguyen HN, Kropp LA, Castelli L, Wagener F, Hunter D, Lindberg M, Cohen K, Seese A, McElrath MJ, Duerkopp N, Gooley TA, Greenberg PD.

Nat Med. 2019 Jul;25(7):1064-1072. doi: 10.1038/s41591-019-0472-9. Epub 2019 Jun 24.


Immunotherapy for skin cancer.

Paulson KG, Lahman MC, Chapuis AG, Brownell I.

Int Immunol. 2019 Jul 13;31(7):465-475. doi: 10.1093/intimm/dxz012.


Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA.

Paulson KG, Voillet V, McAfee MS, Hunter DS, Wagener FD, Perdicchio M, Valente WJ, Koelle SJ, Church CD, Vandeven N, Thomas H, Colunga AG, Iyer JG, Yee C, Kulikauskas R, Koelle DM, Pierce RH, Bielas JH, Greenberg PD, Bhatia S, Gottardo R, Nghiem P, Chapuis AG.

Nat Commun. 2018 Sep 24;9(1):3868. doi: 10.1038/s41467-018-06300-3.


Sarcoidosis Presenting as Isolated Anasarca and Hypercalcemia.

Romine PE, Eaton KD, Paulson KG, Hadi R, Paauw DS.

Am J Med. 2019 Jan;132(1):e13-e14. doi: 10.1016/j.amjmed.2018.09.009. Epub 2018 Sep 19. No abstract available.


One in a hundred million: Merkel cell carcinoma in pediatric and young adult patients is rare but more likely to present at advanced stages based on US registry data.

Paulson KG, Nghiem P.

J Am Acad Dermatol. 2019 Jun;80(6):1758-1760. doi: 10.1016/j.jaad.2018.08.021. Epub 2018 Aug 27. No abstract available.


Advances in Immunotherapy for Metastatic Merkel Cell Carcinoma: A Clinician's Guide.

Paulson KG, Bhatia S.

J Natl Compr Canc Netw. 2018 Jun;16(6):782-790. doi: 10.6004/jnccn.2018.7049. Review.


Merkel Cell Carcinoma Patients Presenting Without a Primary Lesion Have Elevated Markers of Immunity, Higher Tumor Mutation Burden, and Improved Survival.

Vandeven N, Lewis CW, Makarov V, Riaz N, Paulson KG, Hippe D, Bestick A, Doumani R, Marx T, Takagishi S, Chan TA, Choi J, Nghiem P.

Clin Cancer Res. 2018 Feb 15;24(4):963-971. doi: 10.1158/1078-0432.CCR-17-1678. Epub 2017 Dec 15.


Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics.

Paulson KG, Park SY, Vandeven NA, Lachance K, Thomas H, Chapuis AG, Harms KL, Thompson JA, Bhatia S, Stang A, Nghiem P.

J Am Acad Dermatol. 2018 Mar;78(3):457-463.e2. doi: 10.1016/j.jaad.2017.10.028. Epub 2017 Nov 2.


A second chance for success with BRAF and MEK inhibitors in melanoma.

Paulson KG, Thompson JA.

Lancet Oncol. 2017 Apr;18(4):418-419. doi: 10.1016/S1470-2045(17)30151-1. Epub 2017 Mar 4. No abstract available.


Viral oncoprotein antibodies as a marker for recurrence of Merkel cell carcinoma: A prospective validation study.

Paulson KG, Lewis CW, Redman MW, Simonson WT, Lisberg A, Ritter D, Morishima C, Hutchinson K, Mudgistratova L, Blom A, Iyer J, Moshiri AS, Tarabadkar ES, Carter JJ, Bhatia S, Kawasumi M, Galloway DA, Wener MH, Nghiem P.

Cancer. 2017 Apr 15;123(8):1464-1474. doi: 10.1002/cncr.30475. Epub 2016 Dec 7.


Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma.

Ritter C, Fan K, Paulson KG, Nghiem P, Schrama D, Becker JC.

Sci Rep. 2016 Feb 23;6:21678. doi: 10.1038/srep21678.


CD8+ lymphocyte intratumoral infiltration as a stage-independent predictor of Merkel cell carcinoma survival: a population-based study.

Paulson KG, Iyer JG, Simonson WT, Blom A, Thibodeau RM, Schmidt M, Pietromonaco S, Sokil M, Warton EM, Asgari MM, Nghiem P.

Am J Clin Pathol. 2014 Oct;142(4):452-8. doi: 10.1309/AJCPIKDZM39CRPNC.


Downregulation of MHC-I expression is prevalent but reversible in Merkel cell carcinoma.

Paulson KG, Tegeder A, Willmes C, Iyer JG, Afanasiev OK, Schrama D, Koba S, Thibodeau R, Nagase K, Simonson WT, Seo A, Koelle DM, Madeleine M, Bhatia S, Nakajima H, Sano S, Hardwick JS, Disis ML, Cleary MA, Becker JC, Nghiem P.

Cancer Immunol Res. 2014 Nov;2(11):1071-9. doi: 10.1158/2326-6066.CIR-14-0005. Epub 2014 Aug 12.


Effect of host, tumor, diagnostic, and treatment variables on outcomes in a large cohort with Merkel cell carcinoma.

Asgari MM, Sokil MM, Warton EM, Iyer J, Paulson KG, Nghiem P.

JAMA Dermatol. 2014 Jul;150(7):716-23. doi: 10.1001/jamadermatol.2013.8116.


Relationships among primary tumor size, number of involved nodes, and survival for 8044 cases of Merkel cell carcinoma.

Iyer JG, Storer BE, Paulson KG, Lemos B, Phillips JL, Bichakjian CK, Zeitouni N, Gershenwald JE, Sondak V, Otley CC, Yu SS, Johnson TM, Liegeois NJ, Byrd D, Sober A, Nghiem P.

J Am Acad Dermatol. 2014 Apr;70(4):637-643. doi: 10.1016/j.jaad.2013.11.031. Epub 2014 Feb 9.


Regression of metastatic Merkel cell carcinoma following transfer of polyomavirus-specific T cells and therapies capable of re-inducing HLA class-I.

Chapuis AG, Afanasiev OK, Iyer JG, Paulson KG, Parvathaneni U, Hwang JH, Lai I, Roberts IM, Sloan HL, Bhatia S, Shibuya KC, Gooley T, Desmarais C, Koelle DM, Yee C, Nghiem P.

Cancer Immunol Res. 2014 Jan;2(1):27-36. doi: 10.1158/2326-6066.CIR-13-0087.


p63 expression in Merkel cell carcinoma predicts poorer survival yet may have limited clinical utility.

Stetsenko GY, Malekirad J, Paulson KG, Iyer JG, Thibodeau RM, Nagase K, Schmidt M, Storer BE, Argenyi ZB, Nghiem P.

Am J Clin Pathol. 2013 Dec;140(6):838-44. doi: 10.1309/AJCPE4PK6CTBNQJY.


Pathologic nodal evaluation is increasingly commonly performed for patients with Merkel cell carcinoma.

Paulson KG, Iyer JG, Byrd DR, Nghiem P.

J Am Acad Dermatol. 2013 Oct;69(4):653-4. doi: 10.1016/j.jaad.2013.06.002. No abstract available.


Merkel cell polyomavirus large T antigen has growth-promoting and inhibitory activities.

Cheng J, Rozenblatt-Rosen O, Paulson KG, Nghiem P, DeCaprio JA.

J Virol. 2013 Jun;87(11):6118-26. doi: 10.1128/JVI.00385-13. Epub 2013 Mar 20.


Systemic immune suppression predicts diminished Merkel cell carcinoma-specific survival independent of stage.

Paulson KG, Iyer JG, Blom A, Warton EM, Sokil M, Yelistratova L, Schuman L, Nagase K, Bhatia S, Asgari MM, Nghiem P.

J Invest Dermatol. 2013 Mar;133(3):642-646. doi: 10.1038/jid.2012.388. Epub 2012 Nov 29.


Diagnostic biopsy does not commonly induce intratumoral CD8 T cell infiltration in Merkel cell carcinoma.

Koba S, Paulson KG, Nagase K, Tegeder A, Thibodeau R, Iyer JG, Narisawa Y, Nghiem P.

PLoS One. 2012;7(7):e41465. doi: 10.1371/journal.pone.0041465. Epub 2012 Jul 31. Erratum in: PLoS One. 2012;7(10). doi: 10.1371/annotation/c4df91b0-618f-464d-a613-d99758de3f3d.


Identification and validation of a novel mature microRNA encoded by the Merkel cell polyomavirus in human Merkel cell carcinomas.

Lee S, Paulson KG, Murchison EP, Afanasiev OK, Alkan C, Leonard JH, Byrd DR, Hannon GJ, Nghiem P.

J Clin Virol. 2011 Nov;52(3):272-5. doi: 10.1016/j.jcv.2011.08.012. Epub 2011 Sep 9.


Asymmetric lateral distribution of melanoma and Merkel cell carcinoma in the United States.

Paulson KG, Iyer JG, Nghiem P.

J Am Acad Dermatol. 2011 Jul;65(1):35-9. doi: 10.1016/j.jaad.2010.05.026. Epub 2011 Apr 21.


Transcriptome-wide studies of merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival.

Paulson KG, Iyer JG, Tegeder AR, Thibodeau R, Schelter J, Koba S, Schrama D, Simonson WT, Lemos BD, Byrd DR, Koelle DM, Galloway DA, Leonard JH, Madeleine MM, Argenyi ZB, Disis ML, Becker JC, Cleary MA, Nghiem P.

J Clin Oncol. 2011 Apr 20;29(12):1539-46. doi: 10.1200/JCO.2010.30.6308. Epub 2011 Mar 21.


Antibodies to merkel cell polyomavirus T antigen oncoproteins reflect tumor burden in merkel cell carcinoma patients.

Paulson KG, Carter JJ, Johnson LG, Cahill KW, Iyer JG, Schrama D, Becker JC, Madeleine MM, Nghiem P, Galloway DA.

Cancer Res. 2010 Nov 1;70(21):8388-97. doi: 10.1158/0008-5472.CAN-10-2128. Epub 2010 Oct 19.


Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system.

Lemos BD, Storer BE, Iyer JG, Phillips JL, Bichakjian CK, Fang LC, Johnson TM, Liegeois-Kwon NJ, Otley CC, Paulson KG, Ross MI, Yu SS, Zeitouni NC, Byrd DR, Sondak VK, Gershenwald JE, Sober AJ, Nghiem P.

J Am Acad Dermatol. 2010 Nov;63(5):751-61. doi: 10.1016/j.jaad.2010.02.056. Epub 2010 Jun 19.


Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinoma.

Carter JJ, Paulson KG, Wipf GC, Miranda D, Madeleine MM, Johnson LG, Lemos BD, Lee S, Warcola AH, Iyer JG, Nghiem P, Galloway DA.

J Natl Cancer Inst. 2009 Nov 4;101(21):1510-22. doi: 10.1093/jnci/djp332. Epub 2009 Sep 23.


Merkel cell polyomavirus is not detected in prostate cancers, surrounding stroma, or benign prostate controls.

Bluemn EG, Paulson KG, Higgins EE, Sun Y, Nghiem P, Nelson PS.

J Clin Virol. 2009 Feb;44(2):164-6. doi: 10.1016/j.jcv.2008.11.008. Epub 2009 Jan 6.


Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-Myc.

Paulson KG, Lemos BD, Feng B, Jaimes N, Peñas PF, Bi X, Maher E, Cohen L, Leonard JH, Granter SR, Chin L, Nghiem P.

J Invest Dermatol. 2009 Jun;129(6):1547-55. doi: 10.1038/jid.2008.365. Epub 2008 Nov 20.


Effects of medial preoptic area and septal lesions on puberty in female guinea pigs.

Olster DH, Paulson KG.

Biol Reprod. 1997 Mar;56(3):731-8.


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