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Items: 1 to 50 of 65

1.

Opioid receptor-mediated changes in the NMDA receptor in developing rat and chicken.

Fjelldal MF, Hadera MG, Kongstorp M, Austdal LPE, Šulović A, Andersen JM, Paulsen RE.

Int J Dev Neurosci. 2019 Nov;78:19-27. doi: 10.1016/j.ijdevneu.2019.07.009. Epub 2019 Jul 24.

PMID:
31351113
2.

Exploring the overlapping binding sites of ifenprodil and EVT-101 in GluN2B-containing NMDA receptors using novel chicken embryo forebrain cultures and molecular modeling.

Fjelldal MF, Freyd T, Evenseth LM, Sylte I, Ring A, Paulsen RE.

Pharmacol Res Perspect. 2019 May 30;7(3):e00480. doi: 10.1002/prp2.480. eCollection 2019 Jun.

3.

PFOS-induced excitotoxicity is dependent on Ca2+ influx via NMDA receptors in rat cerebellar granule neurons.

Berntsen HF, Bjørklund CG, Strandabø R, Haug TM, Moldes-Anaya A, Fuentes-Lazaro J, Verhaegen S, Paulsen RE, Tasker RA, Ropstad E.

Toxicol Appl Pharmacol. 2018 Oct 15;357:19-32. doi: 10.1016/j.taap.2018.08.015. Epub 2018 Aug 23.

PMID:
30144469
4.

Targeted deletion of the aquaglyceroporin AQP9 is protective in a mouse model of Parkinson's disease.

Stahl K, Rahmani S, Prydz A, Skauli N, MacAulay N, Mylonakou MN, Torp R, Skare Ø, Berg T, Leergaard TB, Paulsen RE, Ottersen OP, Amiry-Moghaddam M.

PLoS One. 2018 Mar 22;13(3):e0194896. doi: 10.1371/journal.pone.0194896. eCollection 2018.

5.

Early life exposure to air pollution particulate matter (PM) as risk factor for attention deficit/hyperactivity disorder (ADHD): Need for novel strategies for mechanisms and causalities.

Myhre O, Låg M, Villanger GD, Oftedal B, Øvrevik J, Holme JA, Aase H, Paulsen RE, Bal-Price A, Dirven H.

Toxicol Appl Pharmacol. 2018 Sep 1;354:196-214. doi: 10.1016/j.taap.2018.03.015. Epub 2018 Mar 14. Review.

PMID:
29550511
6.

Differential effects of some novel synthetic oestrogen analogs on oxidative PC12 cell death caused by serum deprivation.

Sørvik IB, Solum EJ, Labba NA, Hansen TV, Paulsen RE.

Free Radic Res. 2018 Feb;52(2):273-287. doi: 10.1080/10715762.2018.1430363. Epub 2018 Feb 6.

PMID:
29405079
7.

High and low concentration of 17α-estradiol protect cerebellar granule neurons in different time windows.

Sørvik IB, Paulsen RE.

Biochem Biophys Res Commun. 2017 Aug 26;490(3):676-681. doi: 10.1016/j.bbrc.2017.06.100. Epub 2017 Jun 17.

PMID:
28634070
8.

Glucocorticoid Effects on Cerebellar Development in a Chicken Embryo Model: Exploring Changes in PAX6 and Metalloproteinase-9 After Exposure to Dexamethasone.

Austdal LP, Bjørnstad S, Mathisen GH, Aden PK, Mikkola I, Paulsen RE, Rakkestad KE.

J Neuroendocrinol. 2016 Dec;28(12). doi: 10.1111/jne.12438.

PMID:
27791298
9.

Calcium-induced apoptosis of developing cerebellar granule neurons depends causally on NGFI-B.

Austdal LP, Mathisen GH, Løberg EM, Paulsen RE.

Int J Dev Neurosci. 2016 Dec;55:82-90. doi: 10.1016/j.ijdevneu.2016.10.003. Epub 2016 Oct 18.

PMID:
27769911
10.

Hampered Lung Maturation in Methimazole-Induced Hypothyroidism in Fetal Chicken: Morphological and Molecular Correlates to Human Fetal Development.

Bjørnstad S, Samara A, Erichsen A, Paulsen RE, Glover JC, Roald B.

Neonatology. 2016;110(2):83-92. doi: 10.1159/000444656. Epub 2016 Apr 13.

PMID:
27070722
11.

Cracking the Egg: Potential of the Developing Chicken as a Model System for Nonclinical Safety Studies of Pharmaceuticals.

Bjørnstad S, Austdal LP, Roald B, Glover JC, Paulsen RE.

J Pharmacol Exp Ther. 2015 Dec;355(3):386-96. doi: 10.1124/jpet.115.227025. Epub 2015 Oct 2. Review.

PMID:
26432906
12.

Reactive oxygen species and cytotoxicity in rainbow trout hepatocytes: effects of medium and incubation time.

Yazdani M, Paulsen RE, Gjøen T, Hylland K.

Bull Environ Contam Toxicol. 2015 Feb;94(2):193-8. doi: 10.1007/s00128-014-1433-0. Epub 2014 Nov 29.

PMID:
25432295
13.

Synthesis and biological evaluations of new analogs of 2-methoxyestradiol: inhibitors of tubulin and angiogenesis.

Solum EJ, Cheng JJ, Sørvik IB, Paulsen RE, Vik A, Hansen TV.

Eur J Med Chem. 2014 Oct 6;85:391-8. doi: 10.1016/j.ejmech.2014.08.002. Epub 2014 Aug 2.

PMID:
25108078
14.

17α-Estradiol down-regulates glutathione synthesis in serum deprived PC-12 cells.

Rakkestad KE, Sørvik IB, Øverby GR, Debernard KA, Mathisen GH, Paulsen RE.

Free Radic Res. 2014 Oct;48(10):1170-8. doi: 10.3109/10715762.2014.930455. Epub 2014 Jul 1.

PMID:
24896367
15.

Type I and II pneumocyte differentiation in the developing fetal chicken lung: conservation of pivotal proteins from birds to human in the struggle for life at birth.

Bjørnstad S, Paulsen RE, Erichsen A, Glover JC, Roald B.

Neonatology. 2014;105(2):112-20. doi: 10.1159/000355346. Epub 2013 Dec 6.

PMID:
24335141
16.

Prenatal exposure to bisphenol A interferes with the development of cerebellar granule neurons in mice and chicken.

Mathisen GH, Yazdani M, Rakkestad KE, Aden PK, Bodin J, Samuelsen M, Nygaard UC, Goverud IL, Gaarder M, Løberg EM, Bølling AK, Becher R, Paulsen RE.

Int J Dev Neurosci. 2013 Dec;31(8):762-9. doi: 10.1016/j.ijdevneu.2013.09.009. Epub 2013 Sep 30.

PMID:
24091367
17.

Synthesis and initial in vitro biological evaluation of two new zinc-chelating compounds: comparison with TPEN and PAC-1.

Strand OA, Aziz G, Ali SF, Paulsen RE, Hansen TV, Rongved P.

Bioorg Med Chem. 2013 Sep 1;21(17):5175-81. doi: 10.1016/j.bmc.2013.06.037. Epub 2013 Jun 26.

PMID:
23859779
18.

Combretastatin A-4 and structurally related triazole analogues induce caspase-3 and reactive oxygen species-dependent cell death in PC12 cells.

Aziz G, Odlo K, Hansen TV, Paulsen RE, Mathisen GH.

Eur J Pharmacol. 2013 Mar 5;703(1-3):25-32. doi: 10.1016/j.ejphar.2013.01.043. Epub 2013 Feb 14.

PMID:
23416212
19.

Differences in NGFI-B, Nurr1, and NOR-1 expression and nucleocytoplasmic translocation in glutamate-treated neurons.

Boldingh Debernard KA, Mathisen GH, Paulsen RE.

Neurochem Int. 2012 Jul;61(1):79-88. doi: 10.1016/j.neuint.2012.04.002. Epub 2012 Apr 16.

PMID:
22525717
20.

Apoptosis inducer NGFI-B is degraded by the proteasome and stabilized by treatment with EGF.

Strøm BO, Paulsen RE.

Biochem Biophys Res Commun. 2012 Jan 27;417(4):1292-7. doi: 10.1016/j.bbrc.2011.12.132. Epub 2012 Jan 3.

PMID:
22234305
21.

Mono-2-ethylhexylphthalate (MEHP) induces TNF-α release and macrophage differentiation through different signalling pathways in RAW264.7 cells.

Bølling AK, Ovrevik J, Samuelsen JT, Holme JA, Rakkestad KE, Mathisen GH, Paulsen RE, Korsnes MS, Becher R.

Toxicol Lett. 2012 Feb 25;209(1):43-50. doi: 10.1016/j.toxlet.2011.11.016. Epub 2011 Nov 26.

PMID:
22143055
22.

Delayed translocation of NGFI-B/RXR in glutamate stimulated neurons allows late protection by 9-cis retinoic acid.

Mathisen GH, Fallgren ÅB, Strøm BO, Boldingh Debernard KA, Mohebi BU, Paulsen RE.

Biochem Biophys Res Commun. 2011 Oct 14;414(1):90-5. doi: 10.1016/j.bbrc.2011.09.028. Epub 2011 Sep 14.

PMID:
21945431
23.

Glucocorticoids dexamethasone and hydrocortisone inhibit proliferation and accelerate maturation of chicken cerebellar granule neurons.

Aden P, Paulsen RE, Mæhlen J, Løberg EM, Goverud IL, Liestøl K, Lømo J.

Brain Res. 2011 Oct 18;1418:32-41. doi: 10.1016/j.brainres.2011.08.053. Epub 2011 Aug 27.

PMID:
21925649
24.

Cell death induced by novel procaspase-3 activators can be reduced by growth factors.

Boldingh Debernard KA, Aziz G, Gjesvik AT, Paulsen RE.

Biochem Biophys Res Commun. 2011 Sep 23;413(2):364-9. doi: 10.1016/j.bbrc.2011.08.107. Epub 2011 Aug 27.

PMID:
21893038
25.

Transfection of chicken cerebellar granule neurons used to study glucocorticoid receptor regulation by nuclear receptor 4A (NR4A).

Strøm BO, Aden P, Mathisen GH, Lømo J, Davanger S, Paulsen RE.

J Neurosci Methods. 2010 Oct 30;193(1):39-46. doi: 10.1016/j.jneumeth.2010.08.012. Epub 2010 Aug 19.

PMID:
20727911
26.

Procaspase-activating compound 1 induces a caspase-3-dependent cell death in cerebellar granule neurons.

Aziz G, Akselsen ØW, Hansen TV, Paulsen RE.

Toxicol Appl Pharmacol. 2010 Sep 15;247(3):238-42. doi: 10.1016/j.taap.2010.07.002. Epub 2010 Jul 16.

PMID:
20638399
27.

Mono(2-ethylhexyl) phthalate induces both pro- and anti-inflammatory responses in rat alveolar macrophages through crosstalk between p38, the lipoxygenase pathway and PPARalpha.

Rakkestad KE, Holme JA, Paulsen RE, Schwarze PE, Becher R.

Inhal Toxicol. 2010 Feb;22(2):140-50. doi: 10.3109/08958370903019885.

PMID:
19938896
28.

Low-potency glucocorticoid hydrocortisone has similar neurotoxic effects as high-potency glucocorticoid dexamethasone on neurons in the immature chicken cerebellum.

Aden P, Goverud I, Liestøl K, Løberg EM, Paulsen RE, Maehlen J, Lømo J.

Brain Res. 2008 Oct 21;1236:39-48. doi: 10.1016/j.brainres.2008.07.095. Epub 2008 Aug 3.

PMID:
18706896
29.

Secretory PLA2-IIA and ROS generation in peripheral mitochondria are critical for neuronal death.

Mathisen GH, Thorkildsen IH, Paulsen RE.

Brain Res. 2007 Jun 11;1153:43-51. Epub 2007 Mar 28.

PMID:
17462609
30.

Preconditioning with estradiol abolishes its neuroprotection in cerebellar neurons.

Fallgren AB, Mathisen GH, Maehlen J, Blomhoff R, Paulsen RE.

Biochem Biophys Res Commun. 2007 Jan 26;352(4):966-72. Epub 2006 Dec 6.

PMID:
17157803
31.

Chicken cerebellar granule neurons rapidly develop excitotoxicity in culture.

Jacobs CM, Aden P, Mathisen GH, Khuong E, Gaarder M, Løberg EM, Lømo J, Maehlen J, Paulsen RE.

J Neurosci Methods. 2006 Sep 30;156(1-2):129-35. Epub 2006 Mar 27.

PMID:
16564575
32.

Dexamethasone induces cell death which may be blocked by NMDA receptor antagonists but is insensitive to Mg2+ in cerebellar granule neurons.

Jacobs CM, Trinh MD, Rootwelt T, Lømo J, Paulsen RE.

Brain Res. 2006 Jan 27;1070(1):116-23. Epub 2006 Jan 3.

PMID:
16403471
33.

Crosstalk between ERK2 and RXR regulates nuclear import of transcription factor NGFI-B.

Jacobs CM, Paulsen RE.

Biochem Biophys Res Commun. 2005 Oct 21;336(2):646-52.

PMID:
16140267
34.

Cytoplasmic retention of peroxide-activated ERK provides survival in primary cultures of rat hepatocytes.

Rosseland CM, Wierød L, Oksvold MP, Werner H, Ostvold AC, Thoresen GH, Paulsen RE, Huitfeldt HS, Skarpen E.

Hepatology. 2005 Jul;42(1):200-7.

PMID:
15962331
35.

ERK2 prohibits apoptosis-induced subcellular translocation of orphan nuclear receptor NGFI-B/TR3.

Jacobs CM, Boldingh KA, Slagsvold HH, Thoresen GH, Paulsen RE.

J Biol Chem. 2004 Nov 26;279(48):50097-101. Epub 2004 Sep 23.

36.

High molecular weight DNA fragments are processed by caspase sensitive or caspase independent pathways in cultures of cerebellar granule neurons.

Slagsvold HH, Rosseland CM, Jacobs C, Khuong E, Kristoffersen N, Gaarder M, Fallgren AB, Huitfeldt HS, Paulsen RE.

Brain Res. 2003 Sep 12;984(1-2):111-21.

PMID:
12932845
37.

Nuclear receptor and apoptosis initiator NGFI-B is a substrate for kinase ERK2.

Slagsvold HH, Østvold AC, Fallgren AB, Paulsen RE.

Biochem Biophys Res Commun. 2002 Mar 15;291(5):1146-50.

PMID:
11883936
38.

Re-localization of activated EGF receptor and its signal transducers to multivesicular compartments downstream of early endosomes in response to EGF.

Oksvold MP, Skarpen E, Wierød L, Paulsen RE, Huitfeldt HS.

Eur J Cell Biol. 2001 Apr;80(4):285-94.

PMID:
11370743
39.

Detection of high molecular weight DNA fragments characteristic of early stage apoptosis in cerebellar granule cells exposed to glutamate.

Slagsvold HH, Marvik OJ, Eidem G, Kristoffersen N, Paulsen RE.

Exp Brain Res. 2000 Nov;135(2):173-8.

PMID:
11131501
40.

[Glutamate, apoptosis and necrosis of the nervous system].

Paulsen RE, Ottersen OP.

Tidsskr Nor Laegeforen. 2000 Jan 10;120(1):63-4. Norwegian. No abstract available.

41.

3-Nitropropionic acid: an astrocyte-sparing neurotoxin in vitro.

Olsen C, Rustad A, Fonnum F, Paulsen RE, Hassel B.

Brain Res. 1999 Dec 11;850(1-2):144-9.

PMID:
10629758
43.

Chronic pre-explant blockade of the NMDA receptor affects survival of cerebellar granule cells explanted in vitro.

Ciani E, Rizzi S, Paulsen RE, Contestabile A.

Brain Res Dev Brain Res. 1997 Mar 17;99(1):112-7.

PMID:
9088572
44.
45.

Contributing mechanisms for cysteine excitotoxicity in cultured cerebellar granule cells.

Mathisen GA, Fonnum F, Paulsen RE.

Neurochem Res. 1996 Mar;21(3):293-8.

PMID:
9139233
46.

A microdialysis study in rat brain of dihydrokainate, a glutamate uptake inhibitor.

Fallgren AB, Paulsen RE.

Neurochem Res. 1996 Jan;21(1):19-25.

PMID:
8833219
47.
48.

Role of glutamate and glutamate receptors in memory function and Alzheimer's disease.

Fonnum F, Myhrer T, Paulsen RE, Wangen K, Oksengård AR.

Ann N Y Acad Sci. 1995 May 10;757:475-86. No abstract available.

PMID:
7611704
49.
50.

Acute and long-term inhibition of agonist-stimulated phosphoinositide hydrolysis by pulse treatment of cerebellar granule cells with TPA.

Paulsen RE, Raulli R, Grayson DR, Wroblewski JT.

Mol Chem Neuropathol. 1994 May;22(1):67-79.

PMID:
7916769

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