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SP94-Targeted Triblock Co-Polymer Nanoparticle Delivers Thymidine Kinase-p53-Nitroreductase Triple Therapeutic Gene and Restores Anticancer Function against Hepatocellular Carcinoma in vivo.

Sukumar UK, Rajendran JCB, Gambhir SS, Massoud TF, Paulmurugan R.

ACS Appl Mater Interfaces. 2020 Feb 12. doi: 10.1021/acsami.9b20071. [Epub ahead of print]


Assessment of Metastatic and Reactive Sentinel Lymph Nodes with B7-H3-Targeted Ultrasound Molecular Imaging: A Longitudinal Study in Mouse Models.

Zheng F, Li P, Bachawal SV, Wang H, Li C, Yuan W, Huang B, Paulmurugan R.

Mol Imaging Biol. 2020 Feb 7. doi: 10.1007/s11307-020-01478-9. [Epub ahead of print]


Ultrasound-mediated delivery of miRNA-122 and anti-miRNA-21 therapeutically immunomodulates murine hepatocellular carcinoma in vivo.

Wischhusen JC, Chowdhury SM, Lee T, Wang H, Bachawal S, Devulapally R, Afjei R, Sukumar UK, Paulmurugan R.

J Control Release. 2020 Jan 28. pii: S0168-3659(20)30070-5. doi: 10.1016/j.jconrel.2020.01.051. [Epub ahead of print]


Efficacy of affibody-based ultrasound molecular imaging of vascular B7-H3 for breast cancer detection.

Bam R, Lown PS, Stern LA, Sharma K, Wilson KE, Bean GR, Lutz AM, Paulmurugan R, Hackel BJ, Dahl J, Abou-Elkacem L.

Clin Cancer Res. 2020 Jan 10. pii: clincanres.1655.2019. doi: 10.1158/1078-0432.CCR-19-1655. [Epub ahead of print]


The Myocardial Microenvironment Modulates the Biology of Transplanted Mesenchymal Stem Cells.

Franchi F, Ramaswamy V, Olthoff M, Peterson KM, Paulmurugan R, Rodriguez-Porcel M.

Mol Imaging Biol. 2020 Jan 6. doi: 10.1007/s11307-019-01470-y. [Epub ahead of print]


Ligand-activated BRET9 imaging for measuring protein-protein interactions in living mice.

Bae Kim S, Fujii R, Natarajan A, Massoud TF, Paulmurugan R.

Chem Commun (Camb). 2019 Dec 19;56(2):281-284. doi: 10.1039/c9cc07634d.


Structural determination of Enzyme-Graphene Nanocomposite Sensor Material.

Rai DK, Gurusaran M, Urban V, Aran K, Ma L, Li P, Qian S, Narayanan TN, Ajayan PM, Liepmann D, Sekar K, Álvarez-Cao ME, Escuder-Rodríguez JJ, Cerdán ME, González-Siso MI, Viswanathan S, Paulmurugan R, Renugopalakrishnan V.

Sci Rep. 2019 Oct 29;9(1):15519. doi: 10.1038/s41598-019-51882-7.


Evaluation of integrin αvβ6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis.

Kimura RH, Wang L, Shen B, Huo L, Tummers W, Filipp FV, Guo HH, Haywood T, Abou-Elkacem L, Baratto L, Habte F, Devulapally R, Witney TH, Cheng Y, Tikole S, Chakraborti S, Nix J, Bonagura CA, Hatami N, Mooney JJ, Desai T, Turner S, Gaster RS, Otte A, Visser BC, Poultsides GA, Norton J, Park W, Stolowitz M, Lau K, Yang E, Natarajan A, Ilovich O, Srinivas S, Srinivasan A, Paulmurugan R, Willmann J, Chin FT, Cheng Z, Iagaru A, Li F, Gambhir SS.

Nat Commun. 2019 Oct 14;10(1):4673. doi: 10.1038/s41467-019-11863-w.


Chronic Model of Inflammatory Bowel Disease in IL-10-/- Transgenic Mice: Evaluation with Ultrasound Molecular Imaging.

Wang H, Vilches-Moure JG, Cherkaoui S, Tardy I, Alleaume C, Bettinger T, Lutz A, Paulmurugan R.

Theranostics. 2019 Aug 14;9(21):6031-6046. doi: 10.7150/thno.37397. eCollection 2019.


Microvesicle-Mediated Delivery of Minicircle DNA Results in Effective Gene-Directed Enzyme Prodrug Cancer Therapy.

Kanada M, Kim BD, Hardy JW, Ronald JA, Bachmann MH, Bernard MP, Perez GI, Zarea AA, Ge TJ, Withrow A, Ibrahim SA, Toomajian V, Gambhir SS, Paulmurugan R, Contag CH.

Mol Cancer Ther. 2019 Dec;18(12):2331-2342. doi: 10.1158/1535-7163.MCT-19-0299. Epub 2019 Aug 26.


Intranasal delivery of targeted polyfunctional gold-iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to temozolomide.

Sukumar UK, Bose RJC, Malhotra M, Babikir HA, Afjei R, Robinson E, Zeng Y, Chang E, Habte F, Sinclair R, Gambhir SS, Massoud TF, Paulmurugan R.

Biomaterials. 2019 Oct;218:119342. doi: 10.1016/j.biomaterials.2019.119342. Epub 2019 Jul 12.


Ultrasound/microbubble-mediated targeted delivery of anticancer microRNA-loaded nanoparticles to deep tissues in pigs.

Di Ianni T, Bose RJC, Sukumar UK, Bachawal S, Wang H, Telichko A, Herickhoff C, Robinson E, Baker S, Vilches-Moure JG, Felt SA, Gambhir SS, Paulmurugan R, Dahl JD.

J Control Release. 2019 Sep 10;309:1-10. doi: 10.1016/j.jconrel.2019.07.024. Epub 2019 Jul 18.


Cell-based biosensors: Recent trends, challenges and future perspectives.

Gupta N, Renugopalakrishnan V, Liepmann D, Paulmurugan R, Malhotra BD.

Biosens Bioelectron. 2019 Sep 15;141:111435. doi: 10.1016/j.bios.2019.111435. Epub 2019 Jun 14. Review.


Highly bright and stable NIR-BRET with blue-shifted coelenterazine derivatives for deep-tissue imaging of molecular events in vivo.

Nishihara R, Paulmurugan R, Nakajima T, Yamamoto E, Natarajan A, Afjei R, Hiruta Y, Iwasawa N, Nishiyama S, Citterio D, Sato M, Kim SB, Suzuki K.

Theranostics. 2019 Apr 13;9(9):2646-2661. doi: 10.7150/thno.32219. eCollection 2019.


The protean world of non-coding RNAs in glioblastoma.

Paulmurugan R, Malhotra M, Massoud TF.

J Mol Med (Berl). 2019 Jul;97(7):909-925. doi: 10.1007/s00109-019-01798-6. Epub 2019 May 25. Review.


Molecular Imaging of Retinoic Acids in Live Cells Using Single-Chain Bioluminescence Probes.

Kim SB, Fujii R, Nishihara R, Bose RJ, Citterio D, Suzuki K, Massoud TF, Paulmurugan R.

ACS Comb Sci. 2019 Jun 10;21(6):473-481. doi: 10.1021/acscombsci.9b00035. Epub 2019 May 6.


Near-Infrared Bioluminescence Imaging with a through-Bond Energy Transfer Cassette.

Abe M, Nishihara R, Ikeda Y, Nakajima T, Sato M, Iwasawa N, Nishiyama S, Paulmurugan R, Citterio D, Kim SB, Suzuki K.

Chembiochem. 2019 Aug 1;20(15):1919-1923. doi: 10.1002/cbic.201900149. Epub 2019 Jul 2.


Intracellular MicroRNA Quantification in Intact Cells: A Novel Strategy based on Reduced Graphene Oxide Based Fluorescence Quenching.

Paulmurugan R, Ajayan PM, Liepmann D, Renugopalakrishnan V.

MRS Commun. 2018 Sep;8(3):642-651. doi: 10.1557/mrc.2018.120. Epub 2018 Jul 13.


In vitro Determination of Rapamycin-triggered FKBP-FRB Interactions Using a Molecular Tension Probe.

Kim SB, Nishihara R, Fujii R, Paulmurugan R, Citterio D, Suzuki K.

Anal Sci. 2019 Jan 10;35(1):71-78. doi: 10.2116/analsci.18SDP08. Epub 2018 Nov 30.


Comparison of cell-based assays to quantify treatment effects of anticancer drugs identifies a new application for Bodipy-L-cystine to measure apoptosis.

Kumar N, Afjei R, Massoud TF, Paulmurugan R.

Sci Rep. 2018 Nov 5;8(1):16363. doi: 10.1038/s41598-018-34696-x.


Tumor Cell-Derived Extracellular Vesicle-Coated Nanocarriers: An Efficient Theranostic Platform for the Cancer-Specific Delivery of Anti-miR-21 and Imaging Agents.

Bose RJC, Uday Kumar S, Zeng Y, Afjei R, Robinson E, Lau K, Bermudez A, Habte F, Pitteri SJ, Sinclair R, Willmann JK, Massoud TF, Gambhir SS, Paulmurugan R.

ACS Nano. 2018 Nov 27;12(11):10817-10832. doi: 10.1021/acsnano.8b02587. Epub 2018 Oct 22.


Restoring guardianship of the genome: Anticancer drug strategies to reverse oncogenic mutant p53 misfolding.

Babikir HA, Afjei R, Paulmurugan R, Massoud TF.

Cancer Treat Rev. 2018 Dec;71:19-31. doi: 10.1016/j.ctrv.2018.09.004. Epub 2018 Sep 20. Review.


Bioengineered stem cell membrane functionalized nanocarriers for therapeutic targeting of severe hindlimb ischemia.

Bose RJ, Kim BJ, Arai Y, Han IB, Moon JJ, Paulmurugan R, Park H, Lee SH.

Biomaterials. 2018 Dec;185:360-370. doi: 10.1016/j.biomaterials.2018.08.018. Epub 2018 Aug 9.


Ferumoxytol-based Dual-modality Imaging Probe for Detection of Stem Cell Transplant Rejection.

Li K, Chan CT, Nejadnik H, Lenkov OD, Wolterman C, Paulmurugan R, Yang H, Gambhir SS, Daldrup-Link HE.

Nanotheranostics. 2018 Jun 23;2(4):306-319. doi: 10.7150/ntno.26389. eCollection 2018.


Ultrasound-guided delivery of thymidine kinase-nitroreductase dual therapeutic genes by PEGylated-PLGA/PIE nanoparticles for enhanced triple negative breast cancer therapy.

Devulapally R, Lee T, Barghava-Shah A, Sekar TV, Foygel K, Bachawal SV, Willmann JK, Paulmurugan R.

Nanomedicine (Lond). 2018 May;13(9):1051-1066. doi: 10.2217/nnm-2017-0328. Epub 2018 May 23.


A protein folding molecular imaging biosensor monitors the effects of drugs that restore mutant p53 structure and its downstream function in glioblastoma cells.

Paulmurugan R, Afjei R, Sekar TV, Babikir HA, Massoud TF.

Oncotarget. 2018 Apr 20;9(30):21495-21511. doi: 10.18632/oncotarget.25138. eCollection 2018 Apr 20.


Targeted nanoparticle delivery of therapeutic antisense microRNAs presensitizes glioblastoma cells to lower effective doses of temozolomide in vitro and in a mouse model.

Malhotra M, Sekar TV, Ananta JS, Devulapally R, Afjei R, Babikir HA, Paulmurugan R, Massoud TF.

Oncotarget. 2018 Apr 20;9(30):21478-21494. doi: 10.18632/oncotarget.25135. eCollection 2018 Apr 20.


Longitudinal assessment of ultrasound-guided complementary microRNA therapy of hepatocellular carcinoma.

Chowdhury SM, Lee T, Bachawal SV, Devulapally R, Abou-Elkacem L, Yeung TA, Wischhusen J, Tian L, Dahl J, Paulmurugan R, Willmann JK.

J Control Release. 2018 Jul 10;281:19-28. doi: 10.1016/j.jconrel.2018.05.009. Epub 2018 May 24.


Cell membrane-coated nanocarriers: the emerging targeted delivery system for cancer theranostics.

Bose RJ, Paulmurugan R, Moon J, Lee SH, Park H.

Drug Discov Today. 2018 Apr;23(4):891-899. doi: 10.1016/j.drudis.2018.02.001. Epub 2018 Feb 6. Review.


Engineering Intracellularly Retained Gaussia Luciferase Reporters for Improved Biosensing and Molecular Imaging Applications.

Gaur S, Bhargava-Shah A, Hori S, Afjei R, Sekar TV, Gambhir SS, Massoud TF, Paulmurugan R.

ACS Chem Biol. 2017 Sep 15;12(9):2345-2353. doi: 10.1021/acschembio.7b00454. Epub 2017 Aug 10.


A Model-Based Personalized Cancer Screening Strategy for Detecting Early-Stage Tumors Using Blood-Borne Biomarkers.

Hori SS, Lutz AM, Paulmurugan R, Gambhir SS.

Cancer Res. 2017 May 15;77(10):2570-2584. doi: 10.1158/0008-5472.CAN-16-2904. Epub 2017 Mar 10.


Gemcitabine and Antisense-microRNA Co-encapsulated PLGA-PEG Polymer Nanoparticles for Hepatocellular Carcinoma Therapy.

Devulapally R, Foygel K, Sekar TV, Willmann JK, Paulmurugan R.

ACS Appl Mater Interfaces. 2016 Dec 14;8(49):33412-33422. Epub 2016 Dec 2.


RRx-001: a systemically non-toxic M2-to-M1 macrophage stimulating and prosensitizing agent in Phase II clinical trials.

Oronsky B, Paulmurugan R, Foygel K, Scicinski J, Knox SJ, Peehl D, Zhao H, Ning S, Cabrales P, Summers TA Jr, Reid TR, Fitch WL, Kim MM, Trepel JB, Lee MJ, Kesari S, Abrouk ND, Day RM, Oronsky A, Ray CM, Carter CA.

Expert Opin Investig Drugs. 2017 Jan;26(1):109-119. doi: 10.1080/13543784.2017.1268600. Review. Erratum in: Expert Opin Investig Drugs. 2017 Feb;26(2):261. Carterg, Corey A [corrected to Carter, Corey A].


Molecular Imaging Biosensor Monitors p53 Sumoylation in Cells and Living Mice.

Sekar TV, Foygel K, Devulapally R, Kumar V, Malhotra S, Massoud TF, Paulmurugan R.

Anal Chem. 2016 Dec 6;88(23):11420-11428. Epub 2016 Nov 22.


Dynamic Microenvironment Induces Phenotypic Plasticity of Esophageal Cancer Cells Under Flow.

Calibasi Kocal G, Güven S, Foygel K, Goldman A, Chen P, Sengupta S, Paulmurugan R, Baskin Y, Demirci U.

Sci Rep. 2016 Dec 2;6:38221. doi: 10.1038/srep38221.


A transgenic mouse model expressing an ERα folding biosensor reveals the effects of Bisphenol A on estrogen receptor signaling.

Sekar TV, Foygel K, Massoud TF, Gambhir SS, Paulmurugan R.

Sci Rep. 2016 Oct 10;6:34788. doi: 10.1038/srep34788.


Tailored Nanoparticle Codelivery of antimiR-21 and antimiR-10b Augments Glioblastoma Cell Kill by Temozolomide: Toward a "Personalized" Anti-microRNA Therapy.

Ananta JS, Paulmurugan R, Massoud TF.

Mol Pharm. 2016 Sep 6;13(9):3164-75. doi: 10.1021/acs.molpharmaceut.6b00388. Epub 2016 Aug 19.


Ultrasound-guided therapeutic modulation of hepatocellular carcinoma using complementary microRNAs.

Mullick Chowdhury S, Wang TY, Bachawal S, Devulapally R, Choe JW, Abou Elkacem L, Yakub BK, Wang DS, Tian L, Paulmurugan R, Willmann JK.

J Control Release. 2016 Sep 28;238:272-280. doi: 10.1016/j.jconrel.2016.08.005. Epub 2016 Aug 5.


Theranostic Imaging of Cancer Gene Therapy.

Sekar TV, Paulmurugan R.

Methods Mol Biol. 2016;1461:241-54. doi: 10.1007/978-1-4939-3813-1_20.


Imaging Histone Methylations in Living Animals.

Sekar TV, Paulmurugan R.

Methods Mol Biol. 2016;1461:203-15. doi: 10.1007/978-1-4939-3813-1_17.


Multimodality Molecular Imaging of Cardiac Cell Transplantation: Part II. In Vivo Imaging of Bone Marrow Stromal Cells in Swine with PET/CT and MR Imaging.

Parashurama N, Ahn BC, Ziv K, Ito K, Paulmurugan R, Willmann JK, Chung J, Ikeno F, Swanson JC, Merk DR, Lyons JK, Yerushalmi D, Teramoto T, Kosuge H, Dao CN, Ray P, Patel M, Chang YF, Mahmoudi M, Cohen JE, Goldstone AB, Habte F, Bhaumik S, Yaghoubi S, Robbins RC, Dash R, Yang PC, Brinton TJ, Yock PG, McConnell MV, Gambhir SS.

Radiology. 2016 Sep;280(3):826-36. doi: 10.1148/radiol.2016151150. Epub 2016 Jun 22.


Pterostilbene-mediated Nrf2 activation: Mechanistic insights on Keap1:Nrf2 interface.

Bhakkiyalakshmi E, Dineshkumar K, Karthik S, Sireesh D, Hopper W, Paulmurugan R, Ramkumar KM.

Bioorg Med Chem. 2016 Aug 15;24(16):3378-86. doi: 10.1016/j.bmc.2016.05.011. Epub 2016 May 11.


Multimodality Molecular Imaging of Cardiac Cell Transplantation: Part I. Reporter Gene Design, Characterization, and Optical in Vivo Imaging of Bone Marrow Stromal Cells after Myocardial Infarction.

Parashurama N, Ahn BC, Ziv K, Ito K, Paulmurugan R, Willmann JK, Chung J, Ikeno F, Swanson JC, Merk DR, Lyons JK, Yerushalmi D, Teramoto T, Kosuge H, Dao CN, Ray P, Patel M, Chang YF, Mahmoudi M, Cohen JE, Goldstone AB, Habte F, Bhaumik S, Yaghoubi S, Robbins RC, Dash R, Yang PC, Brinton TJ, Yock PG, McConnell MV, Gambhir SS.

Radiology. 2016 Sep;280(3):815-25. doi: 10.1148/radiol.2016140049. Epub 2016 Jun 16.


A molecular imaging biosensor detects in vivo protein folding and misfolding.

Sheahan AV, Sekar TV, Chen K, Paulmurugan R, Massoud TF.

J Mol Med (Berl). 2016 Jul;94(7):799-808. doi: 10.1007/s00109-016-1437-9. Epub 2016 Jun 8.


GHR/PRLR Heteromultimer Is Composed of GHR Homodimers and PRLR Homodimers.

Liu Y, Zhang Y, Jiang J, Lobie PE, Paulmurugan R, Langenheim JF, Chen WY, Zinn KR, Frank SJ.

Mol Endocrinol. 2016 May;30(5):504-17. doi: 10.1210/me.2015-1319. Epub 2016 Mar 22.


Temozolomide-loaded PLGA nanoparticles to treat glioblastoma cells: a biophysical and cell culture evaluation.

Ananta JS, Paulmurugan R, Massoud TF.

Neurol Res. 2016 Jan;38(1):51-9. doi: 10.1080/01616412.2015.1133025. Epub 2016 Feb 22.


Noninvasive Monitoring of the Mitochondrial Function in Mesenchymal Stromal Cells.

Franchi F, Peterson KM, Paulmurugan R, Folmes C, Lanza IR, Lerman A, Rodriguez-Porcel M.

Mol Imaging Biol. 2016 Aug;18(4):510-8. doi: 10.1007/s11307-016-0929-x.


Orlistat and antisense-miRNA-loaded PLGA-PEG nanoparticles for enhanced triple negative breast cancer therapy.

Bhargava-Shah A, Foygel K, Devulapally R, Paulmurugan R.

Nanomedicine (Lond). 2016 Feb;11(3):235-47. doi: 10.2217/nnm.15.193. Epub 2016 Jan 20.


Pterostilbene Ameliorates Streptozotocin-Induced Diabetes through Enhancing Antioxidant Signaling Pathways Mediated by Nrf2.

Elango B, Dornadula S, Paulmurugan R, Ramkumar KM.

Chem Res Toxicol. 2016 Jan 19;29(1):47-57. doi: 10.1021/acs.chemrestox.5b00378. Epub 2016 Jan 7.


Engineering cancer microenvironments for in vitro 3-D tumor models.

Asghar W, El Assal R, Shafiee H, Pitteri S, Paulmurugan R, Demirci U.

Mater Today (Kidlington). 2015 Dec;18(10):539-553. doi: 10.1016/j.mattod.2015.05.002.

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