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Mitochondria at the crossroads of ATM-mediated stress signaling and regulation of reactive oxygen species.

Lee JH, Paull TT.

Redox Biol. 2020 Mar 21;32:101511. doi: 10.1016/j.redox.2020.101511. [Epub ahead of print]


Growth-regulated Hsp70 phosphorylation regulates stress responses and prion maintenance.

Kao CH, Ryu S, Kim MJ, Wen X, Wimalarathne O, Paull TT.

Mol Cell Biol. 2020 Mar 23. pii: MCB.00628-19. doi: 10.1128/MCB.00628-19. [Epub ahead of print]


ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis.

Paiano J, Wu W, Yamada S, Sciascia N, Callen E, Paola Cotrim A, Deshpande RA, Maman Y, Day A, Paull TT, Nussenzweig A.

Nat Commun. 2020 Feb 12;11(1):857. doi: 10.1038/s41467-020-14654-w.


DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP.

Deshpande RA, Myler LR, Soniat MM, Makharashvili N, Lee L, Lees-Miller SP, Finkelstein IJ, Paull TT.

Sci Adv. 2020 Jan 8;6(2):eaay0922. doi: 10.1126/sciadv.aay0922. eCollection 2020 Jan.


Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

Kim JJ, Lee SY, Gong F, Battenhouse AM, Boutz DR, Bashyal A, Refvik ST, Chiang CM, Xhemalce B, Paull TT, Brodbelt JS, Marcotte EM, Miller KM.

Genes Dev. 2019 Dec 1;33(23-24):1751-1774. doi: 10.1101/gad.331231.119. Epub 2019 Nov 21.


RNA-DNA hybrids and the convergence with DNA repair.

Paull TT.

Crit Rev Biochem Mol Biol. 2019 Aug;54(4):371-384. doi: 10.1080/10409238.2019.1670131. Epub 2019 Oct 2.


RPA Phosphorylation Inhibits DNA Resection.

Soniat MM, Myler LR, Kuo HC, Paull TT, Finkelstein IJ.

Mol Cell. 2019 Jul 11;75(1):145-153.e5. doi: 10.1016/j.molcel.2019.05.005. Epub 2019 May 29.


Purification and Biophysical Characterization of the Mre11-Rad50-Nbs1 Complex.

Myler LR, Soniat MM, Zhang X, Deshpande RA, Paull TT, Finkelstein IJ.

Methods Mol Biol. 2019;2004:269-287. doi: 10.1007/978-1-4939-9520-2_20.


Sae2/CtIP prevents R-loop accumulation in eukaryotic cells.

Makharashvili N, Arora S, Yin Y, Fu Q, Wen X, Lee JH, Kao CH, Leung JW, Miller KM, Paull TT.

Elife. 2018 Dec 7;7. pii: e42733. doi: 10.7554/eLife.42733.


Homeodomain Proteins Directly Regulate ATM Kinase Activity.

Johnson TE, Lee JH, Myler LR, Zhou Y, Mosley TJ, Yang SH; Bio-Bricks for Molecular Machines FRI Stream, Uprety N, Kim J, Paull TT.

Cell Rep. 2018 Aug 7;24(6):1471-1483. doi: 10.1016/j.celrep.2018.06.089.


20 Years of Mre11 Biology: No End in Sight.

Paull TT.

Mol Cell. 2018 Aug 2;71(3):419-427. doi: 10.1016/j.molcel.2018.06.033. Epub 2018 Jul 26. Review.


MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining.

Hung PJ, Johnson B, Chen BR, Byrum AK, Bredemeyer AL, Yewdell WT, Johnson TE, Lee BJ, Deivasigamani S, Hindi I, Amatya P, Gross ML, Paull TT, Pisapia DJ, Chaudhuri J, Petrini JJH, Mosammaparast N, Amarasinghe GK, Zha S, Tyler JK, Sleckman BP.

Mol Cell. 2018 Jul 19;71(2):332-342.e8. doi: 10.1016/j.molcel.2018.06.018. Epub 2018 Jul 12.


Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity.

Zhang Y, Lee JH, Paull TT, Gehrke S, D'Alessandro A, Dou Q, Gladyshev VN, Schroeder EA, Steyl SK, Christian BE, Shadel GS.

Sci Signal. 2018 Jul 10;11(538). pii: eaaq0702. doi: 10.1126/scisignal.aaq0702.


Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells.

Cánovas B, Igea A, Sartori AA, Gomis RR, Paull TT, Isoda M, Pérez-Montoyo H, Serra V, González-Suárez E, Stracker TH, Nebreda AR.

Cancer Cell. 2018 Jun 11;33(6):1094-1110.e8. doi: 10.1016/j.ccell.2018.04.010. Epub 2018 May 24.


ATM directs DNA damage responses and proteostasis via genetically separable pathways.

Lee JH, Mand MR, Kao CH, Zhou Y, Ryu SW, Richards AL, Coon JJ, Paull TT.

Sci Signal. 2018 Jan 9;11(512). pii: eaan5598. doi: 10.1126/scisignal.aan5598.


The Conserved ATM Kinase RAG2-S365 Phosphorylation Site Limits Cleavage Events in Individual Cells Independent of Any Repair Defect.

Hewitt SL, Wong JB, Lee JH, Nishana M, Chen H, Coussens M, Arnal SM, Blumenberg LM, Roth DB, Paull TT, Skok JA.

Cell Rep. 2017 Oct 24;21(4):979-993. doi: 10.1016/j.celrep.2017.09.084.


Genetic Separation of Sae2 Nuclease Activity from Mre11 Nuclease Functions in Budding Yeast.

Arora S, Deshpande RA, Budd M, Campbell J, Revere A, Zhang X, Schmidt KH, Paull TT.

Mol Cell Biol. 2017 Nov 28;37(24). pii: e00156-17. doi: 10.1128/MCB.00156-17. Print 2017 Dec 15.


Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair.

Myler LR, Gallardo IF, Soniat MM, Deshpande RA, Gonzalez XB, Kim Y, Paull TT, Finkelstein IJ.

Mol Cell. 2017 Sep 7;67(5):891-898.e4. doi: 10.1016/j.molcel.2017.08.002. Epub 2017 Aug 31.


Rad50 ATPase activity is regulated by DNA ends and requires coordination of both active sites.

Deshpande RA, Lee JH, Paull TT.

Nucleic Acids Res. 2017 May 19;45(9):5255-5268. doi: 10.1093/nar/gkx173.


ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.

Leung JW, Makharashvili N, Agarwal P, Chiu LY, Pourpre R, Cammarata MB, Cannon JR, Sherker A, Durocher D, Brodbelt JS, Paull TT, Miller KM.

Genes Dev. 2017 Feb 1;31(3):260-274. doi: 10.1101/gad.292516.116. Epub 2017 Feb 27.


Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM.

Zhou Y, Lee JH, Jiang W, Crowe JL, Zha S, Paull TT.

Mol Cell. 2017 Jan 5;65(1):91-104. doi: 10.1016/j.molcel.2016.11.004. Epub 2016 Dec 8.


Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.

Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H.

Mol Cell. 2016 Dec 1;64(5):1010. doi: 10.1016/j.molcel.2016.11.028. No abstract available.


Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts.

Deshpande RA, Lee JH, Arora S, Paull TT.

Mol Cell. 2016 Nov 3;64(3):593-606. doi: 10.1016/j.molcel.2016.10.010.


Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.

Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H.

Mol Cell. 2016 Nov 3;64(3):580-592. doi: 10.1016/j.molcel.2016.10.011. Erratum in: Mol Cell. 2016 Dec 1;64(5):1010.


ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.

Deshpande RA, Williams GJ, Limbo O, Williams RS, Kuhnlein J, Lee JH, Classen S, Guenther G, Russell P, Tainer JA, Paull TT.

EMBO J. 2016 Apr 1;35(7):791. doi: 10.15252/embj.201694047. No abstract available.


Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins.

Myler LR, Gallardo IF, Zhou Y, Gong F, Yang SH, Wold MS, Miller KM, Paull TT, Finkelstein IJ.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1170-9. doi: 10.1073/pnas.1516674113. Epub 2016 Feb 16.


EXD2 promotes homologous recombination by facilitating DNA end resection.

Broderick R, Nieminuszczy J, Baddock HT, Deshpande R, Gileadi O, Paull TT, McHugh PJ, Niedzwiedz W.

Nat Cell Biol. 2016 Mar;18(3):271-280. doi: 10.1038/ncb3303. Epub 2016 Jan 25.


ATM functions at the peroxisome to induce pexophagy in response to ROS.

Zhang J, Tripathi DN, Jing J, Alexander A, Kim J, Powell RT, Dere R, Tait-Mulder J, Lee JH, Paull TT, Pandita RK, Charaka VK, Pandita TK, Kastan MB, Walker CL.

Nat Cell Biol. 2015 Oct;17(10):1259-1269. doi: 10.1038/ncb3230. Epub 2015 Sep 7.


CtIP: A DNA damage response protein at the intersection of DNA metabolism.

Makharashvili N, Paull TT.

DNA Repair (Amst). 2015 Aug;32:75-81. doi: 10.1016/j.dnarep.2015.04.016. Epub 2015 May 2. Review.


BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination.

Hoa NN, Kobayashi J, Omura M, Hirakawa M, Yang SH, Komatsu K, Paull TT, Takeda S, Sasanuma H.

PLoS One. 2015 Apr 24;10(4):e0124495. doi: 10.1371/journal.pone.0124495. eCollection 2015.


Direct measurement of single-stranded DNA intermediates in mammalian cells by quantitative polymerase chain reaction.

Zhou Y, Paull TT.

Anal Biochem. 2015 Jun 15;479:48-50. doi: 10.1016/j.ab.2015.03.025. Epub 2015 Apr 1.


Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection.

Parameswaran B, Chiang HC, Lu Y, Coates J, Deng CX, Baer R, Lin HK, Li R, Paull TT, Hu Y.

Cell Cycle. 2015;14(3):437-48. doi: 10.4161/15384101.2014.972901.


Mechanisms of ATM Activation.

Paull TT.

Annu Rev Biochem. 2015;84:711-38. doi: 10.1146/annurev-biochem-060614-034335. Epub 2015 Jan 12. Review.


Sumoylation influences DNA break repair partly by increasing the solubility of a conserved end resection protein.

Sarangi P, Steinacher R, Altmannova V, Fu Q, Paull TT, Krejci L, Whitby MC, Zhao X.

PLoS Genet. 2015 Jan 8;11(1):e1004899. doi: 10.1371/journal.pgen.1004899. eCollection 2015 Jan.


Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1.

Barton O, Naumann SC, Diemer-Biehs R, Künzel J, Steinlage M, Conrad S, Makharashvili N, Wang J, Feng L, Lopez BS, Paull TT, Chen J, Jeggo PA, Löbrich M.

J Cell Biol. 2014 Sep 29;206(7):877-94. doi: 10.1083/jcb.201401146.


The Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changes.

Paull TT, Deshpande RA.

Exp Cell Res. 2014 Nov 15;329(1):139-47. doi: 10.1016/j.yexcr.2014.07.007. Epub 2014 Jul 9. Review. No abstract available.


Direct activation of ATM by resveratrol under oxidizing conditions.

Lee JH, Guo Z, Myler LR, Zheng S, Paull TT.

PLoS One. 2014 Jun 16;9(6):e97969. doi: 10.1371/journal.pone.0097969. eCollection 2014.


Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection.

Makharashvili N, Tubbs AT, Yang SH, Wang H, Barton O, Zhou Y, Deshpande RA, Lee JH, Lobrich M, Sleckman BP, Wu X, Paull TT.

Mol Cell. 2014 Jun 19;54(6):1022-33. doi: 10.1016/j.molcel.2014.04.011. Epub 2014 May 15.


Rad17, the clamp loader that loads more than clamps.

Paull TT, Lee JH.

EMBO J. 2014 Apr 16;33(8):783-5. doi: 10.1002/embj.201488223. Epub 2014 Mar 11.


ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.

Deshpande RA, Williams GJ, Limbo O, Williams RS, Kuhnlein J, Lee JH, Classen S, Guenther G, Russell P, Tainer JA, Paull TT.

EMBO J. 2014 Mar 3;33(5):482-500. doi: 10.1002/embj.201386100. Epub 2014 Feb 3. Erratum in: EMBO J. 2016 Apr 1;35(7):791.


Quantitation of DNA double-strand break resection intermediates in human cells.

Zhou Y, Caron P, Legube G, Paull TT.

Nucleic Acids Res. 2014 Feb;42(3):e19. doi: 10.1093/nar/gkt1309. Epub 2013 Dec 19.


Phosphorylation-regulated transitions in an oligomeric state control the activity of the Sae2 DNA repair enzyme.

Fu Q, Chow J, Bernstein KA, Makharashvili N, Arora S, Lee CF, Person MD, Rothstein R, Paull TT.

Mol Cell Biol. 2014 Mar;34(5):778-93. doi: 10.1128/MCB.00963-13. Epub 2013 Dec 16. Erratum in: Mol Cell Biol. 2014 Nov 15;34(22):4213.


DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM).

Zhou Y, Paull TT.

J Biol Chem. 2013 Dec 27;288(52):37112-25. doi: 10.1074/jbc.M113.514398. Epub 2013 Nov 12.


Visualization of local DNA unwinding by Mre11/Rad50/Nbs1 using single-molecule FRET.

Cannon B, Kuhnlein J, Yang SH, Cheng A, Schindler D, Stark JM, Russell R, Paull TT.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18868-73. doi: 10.1073/pnas.1309816110. Epub 2013 Nov 4.


Proteome-wide detection and quantitative analysis of irreversible cysteine oxidation using long column UPLC-pSRM.

Lee CF, Paull TT, Person MD.

J Proteome Res. 2013 Oct 4;12(10):4302-15. doi: 10.1021/pr400201d. Epub 2013 Sep 6.


Functional activation of ATM by the prostate cancer suppressor NKX3.1.

Bowen C, Ju JH, Lee JH, Paull TT, Gelmann EP.

Cell Rep. 2013 Aug 15;4(3):516-29. doi: 10.1016/j.celrep.2013.06.039. Epub 2013 Jul 25.


Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.

Lee JH, Mand MR, Deshpande RA, Kinoshita E, Yang SH, Wyman C, Paull TT.

J Biol Chem. 2013 May 3;288(18):12840-51. doi: 10.1074/jbc.M113.460378. Epub 2013 Mar 22.


The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1.

Yang SH, Zhou R, Campbell J, Chen J, Ha T, Paull TT.

EMBO J. 2013 Jan 9;32(1):126-39. doi: 10.1038/emboj.2012.314. Epub 2012 Nov 23.


Loss of ATM kinase activity leads to embryonic lethality in mice.

Daniel JA, Pellegrini M, Lee BS, Guo Z, Filsuf D, Belkina NV, You Z, Paull TT, Sleckman BP, Feigenbaum L, Nussenzweig A.

J Cell Biol. 2012 Aug 6;198(3):295-304. doi: 10.1083/jcb.201204035.


The ATM protein kinase and cellular redox signaling: beyond the DNA damage response.

Ditch S, Paull TT.

Trends Biochem Sci. 2012 Jan;37(1):15-22. doi: 10.1016/j.tibs.2011.10.002. Epub 2011 Nov 11. Review.

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