Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 81

1.

Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity.

Zhang Y, Lee JH, Paull TT, Gehrke S, D'Alessandro A, Dou Q, Gladyshev VN, Schroeder EA, Steyl SK, Christian BE, Shadel GS.

Sci Signal. 2018 Jul 10;11(538). pii: eaaq0702. doi: 10.1126/scisignal.aaq0702.

PMID:
29991649
2.

Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells.

Cánovas B, Igea A, Sartori AA, Gomis RR, Paull TT, Isoda M, Pérez-Montoyo H, Serra V, González-Suárez E, Stracker TH, Nebreda AR.

Cancer Cell. 2018 Jun 11;33(6):1094-1110.e8. doi: 10.1016/j.ccell.2018.04.010. Epub 2018 May 24.

PMID:
29805078
3.

ATM directs DNA damage responses and proteostasis via genetically separable pathways.

Lee JH, Mand MR, Kao CH, Zhou Y, Ryu SW, Richards AL, Coon JJ, Paull TT.

Sci Signal. 2018 Jan 9;11(512). pii: eaan5598. doi: 10.1126/scisignal.aan5598.

4.

The Conserved ATM Kinase RAG2-S365 Phosphorylation Site Limits Cleavage Events in Individual Cells Independent of Any Repair Defect.

Hewitt SL, Wong JB, Lee JH, Nishana M, Chen H, Coussens M, Arnal SM, Blumenberg LM, Roth DB, Paull TT, Skok JA.

Cell Rep. 2017 Oct 24;21(4):979-993. doi: 10.1016/j.celrep.2017.09.084.

5.

Genetic Separation of Sae2 Nuclease Activity from Mre11 Nuclease Functions in Budding Yeast.

Arora S, Deshpande RA, Budd M, Campbell J, Revere A, Zhang X, Schmidt KH, Paull TT.

Mol Cell Biol. 2017 Nov 28;37(24). pii: e00156-17. doi: 10.1128/MCB.00156-17. Print 2017 Dec 15.

6.

Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair.

Myler LR, Gallardo IF, Soniat MM, Deshpande RA, Gonzalez XB, Kim Y, Paull TT, Finkelstein IJ.

Mol Cell. 2017 Sep 7;67(5):891-898.e4. doi: 10.1016/j.molcel.2017.08.002. Epub 2017 Aug 31.

PMID:
28867292
7.

Rad50 ATPase activity is regulated by DNA ends and requires coordination of both active sites.

Deshpande RA, Lee JH, Paull TT.

Nucleic Acids Res. 2017 May 19;45(9):5255-5268. doi: 10.1093/nar/gkx173.

8.

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.

Leung JW, Makharashvili N, Agarwal P, Chiu LY, Pourpre R, Cammarata MB, Cannon JR, Sherker A, Durocher D, Brodbelt JS, Paull TT, Miller KM.

Genes Dev. 2017 Feb 1;31(3):260-274. doi: 10.1101/gad.292516.116. Epub 2017 Feb 27.

9.

Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM.

Zhou Y, Lee JH, Jiang W, Crowe JL, Zha S, Paull TT.

Mol Cell. 2017 Jan 5;65(1):91-104. doi: 10.1016/j.molcel.2016.11.004. Epub 2016 Dec 8.

10.

Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.

Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H.

Mol Cell. 2016 Dec 1;64(5):1010. doi: 10.1016/j.molcel.2016.11.028. No abstract available.

11.

Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts.

Deshpande RA, Lee JH, Arora S, Paull TT.

Mol Cell. 2016 Nov 3;64(3):593-606. doi: 10.1016/j.molcel.2016.10.010.

12.

Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.

Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H.

Mol Cell. 2016 Nov 3;64(3):580-592. doi: 10.1016/j.molcel.2016.10.011.

13.

ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.

Deshpande RA, Williams GJ, Limbo O, Williams RS, Kuhnlein J, Lee JH, Classen S, Guenther G, Russell P, Tainer JA, Paull TT.

EMBO J. 2016 Apr 1;35(7):791. doi: 10.15252/embj.201694047. No abstract available.

14.

Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins.

Myler LR, Gallardo IF, Zhou Y, Gong F, Yang SH, Wold MS, Miller KM, Paull TT, Finkelstein IJ.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1170-9. doi: 10.1073/pnas.1516674113. Epub 2016 Feb 16.

15.

EXD2 promotes homologous recombination by facilitating DNA end resection.

Broderick R, Nieminuszczy J, Baddock HT, Deshpande R, Gileadi O, Paull TT, McHugh PJ, Niedzwiedz W.

Nat Cell Biol. 2016 Mar;18(3):271-280. doi: 10.1038/ncb3303. Epub 2016 Jan 25.

16.

ATM functions at the peroxisome to induce pexophagy in response to ROS.

Zhang J, Tripathi DN, Jing J, Alexander A, Kim J, Powell RT, Dere R, Tait-Mulder J, Lee JH, Paull TT, Pandita RK, Charaka VK, Pandita TK, Kastan MB, Walker CL.

Nat Cell Biol. 2015 Oct;17(10):1259-1269. doi: 10.1038/ncb3230. Epub 2015 Sep 7.

17.

CtIP: A DNA damage response protein at the intersection of DNA metabolism.

Makharashvili N, Paull TT.

DNA Repair (Amst). 2015 Aug;32:75-81. doi: 10.1016/j.dnarep.2015.04.016. Epub 2015 May 2. Review.

PMID:
25957490
18.

BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination.

Hoa NN, Kobayashi J, Omura M, Hirakawa M, Yang SH, Komatsu K, Paull TT, Takeda S, Sasanuma H.

PLoS One. 2015 Apr 24;10(4):e0124495. doi: 10.1371/journal.pone.0124495. eCollection 2015.

19.

Direct measurement of single-stranded DNA intermediates in mammalian cells by quantitative polymerase chain reaction.

Zhou Y, Paull TT.

Anal Biochem. 2015 Jun 15;479:48-50. doi: 10.1016/j.ab.2015.03.025. Epub 2015 Apr 1.

PMID:
25841672
20.

Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection.

Parameswaran B, Chiang HC, Lu Y, Coates J, Deng CX, Baer R, Lin HK, Li R, Paull TT, Hu Y.

Cell Cycle. 2015;14(3):437-48. doi: 10.4161/15384101.2014.972901.

21.

Mechanisms of ATM Activation.

Paull TT.

Annu Rev Biochem. 2015;84:711-38. doi: 10.1146/annurev-biochem-060614-034335. Epub 2015 Jan 12. Review.

PMID:
25580527
22.

Sumoylation influences DNA break repair partly by increasing the solubility of a conserved end resection protein.

Sarangi P, Steinacher R, Altmannova V, Fu Q, Paull TT, Krejci L, Whitby MC, Zhao X.

PLoS Genet. 2015 Jan 8;11(1):e1004899. doi: 10.1371/journal.pgen.1004899. eCollection 2015 Jan.

23.

Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1.

Barton O, Naumann SC, Diemer-Biehs R, Künzel J, Steinlage M, Conrad S, Makharashvili N, Wang J, Feng L, Lopez BS, Paull TT, Chen J, Jeggo PA, Löbrich M.

J Cell Biol. 2014 Sep 29;206(7):877-94. doi: 10.1083/jcb.201401146.

24.

The Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changes.

Paull TT, Deshpande RA.

Exp Cell Res. 2014 Nov 15;329(1):139-47. doi: 10.1016/j.yexcr.2014.07.007. Epub 2014 Jul 9. Review. No abstract available.

25.

Direct activation of ATM by resveratrol under oxidizing conditions.

Lee JH, Guo Z, Myler LR, Zheng S, Paull TT.

PLoS One. 2014 Jun 16;9(6):e97969. doi: 10.1371/journal.pone.0097969. eCollection 2014.

26.

Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection.

Makharashvili N, Tubbs AT, Yang SH, Wang H, Barton O, Zhou Y, Deshpande RA, Lee JH, Lobrich M, Sleckman BP, Wu X, Paull TT.

Mol Cell. 2014 Jun 19;54(6):1022-33. doi: 10.1016/j.molcel.2014.04.011. Epub 2014 May 15.

27.

Rad17, the clamp loader that loads more than clamps.

Paull TT, Lee JH.

EMBO J. 2014 Apr 16;33(8):783-5. doi: 10.1002/embj.201488223. Epub 2014 Mar 11.

28.

ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.

Deshpande RA, Williams GJ, Limbo O, Williams RS, Kuhnlein J, Lee JH, Classen S, Guenther G, Russell P, Tainer JA, Paull TT.

EMBO J. 2014 Mar 3;33(5):482-500. doi: 10.1002/embj.201386100. Epub 2014 Feb 3. Erratum in: EMBO J. 2016 Apr 1;35(7):791.

29.

Quantitation of DNA double-strand break resection intermediates in human cells.

Zhou Y, Caron P, Legube G, Paull TT.

Nucleic Acids Res. 2014 Feb;42(3):e19. doi: 10.1093/nar/gkt1309. Epub 2013 Dec 19.

30.

Phosphorylation-regulated transitions in an oligomeric state control the activity of the Sae2 DNA repair enzyme.

Fu Q, Chow J, Bernstein KA, Makharashvili N, Arora S, Lee CF, Person MD, Rothstein R, Paull TT.

Mol Cell Biol. 2014 Mar;34(5):778-93. doi: 10.1128/MCB.00963-13. Epub 2013 Dec 16. Erratum in: Mol Cell Biol. 2014 Nov 15;34(22):4213.

31.

DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM).

Zhou Y, Paull TT.

J Biol Chem. 2013 Dec 27;288(52):37112-25. doi: 10.1074/jbc.M113.514398. Epub 2013 Nov 12.

32.

Visualization of local DNA unwinding by Mre11/Rad50/Nbs1 using single-molecule FRET.

Cannon B, Kuhnlein J, Yang SH, Cheng A, Schindler D, Stark JM, Russell R, Paull TT.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18868-73. doi: 10.1073/pnas.1309816110. Epub 2013 Nov 4.

33.

Proteome-wide detection and quantitative analysis of irreversible cysteine oxidation using long column UPLC-pSRM.

Lee CF, Paull TT, Person MD.

J Proteome Res. 2013 Oct 4;12(10):4302-15. doi: 10.1021/pr400201d. Epub 2013 Sep 6.

34.

Functional activation of ATM by the prostate cancer suppressor NKX3.1.

Bowen C, Ju JH, Lee JH, Paull TT, Gelmann EP.

Cell Rep. 2013 Aug 15;4(3):516-29. doi: 10.1016/j.celrep.2013.06.039. Epub 2013 Jul 25.

35.

Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.

Lee JH, Mand MR, Deshpande RA, Kinoshita E, Yang SH, Wyman C, Paull TT.

J Biol Chem. 2013 May 3;288(18):12840-51. doi: 10.1074/jbc.M113.460378. Epub 2013 Mar 22.

36.

The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1.

Yang SH, Zhou R, Campbell J, Chen J, Ha T, Paull TT.

EMBO J. 2013 Jan 9;32(1):126-39. doi: 10.1038/emboj.2012.314. Epub 2012 Nov 23.

37.

Loss of ATM kinase activity leads to embryonic lethality in mice.

Daniel JA, Pellegrini M, Lee BS, Guo Z, Filsuf D, Belkina NV, You Z, Paull TT, Sleckman BP, Feigenbaum L, Nussenzweig A.

J Cell Biol. 2012 Aug 6;198(3):295-304. doi: 10.1083/jcb.201204035.

38.

The ATM protein kinase and cellular redox signaling: beyond the DNA damage response.

Ditch S, Paull TT.

Trends Biochem Sci. 2012 Jan;37(1):15-22. doi: 10.1016/j.tibs.2011.10.002. Epub 2011 Nov 11. Review.

39.

Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway.

Della-Maria J, Zhou Y, Tsai MS, Kuhnlein J, Carney JP, Paull TT, Tomkinson AE.

J Biol Chem. 2011 Sep 30;286(39):33845-53. doi: 10.1074/jbc.M111.274159. Epub 2011 Aug 3.

40.

ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.

Gatei M, Jakob B, Chen P, Kijas AW, Becherel OJ, Gueven N, Birrell G, Lee JH, Paull TT, Lerenthal Y, Fazry S, Taucher-Scholz G, Kalb R, Schindler D, Waltes R, Dörk T, Lavin MF.

J Biol Chem. 2011 Sep 9;286(36):31542-56. doi: 10.1074/jbc.M111.258152. Epub 2011 Jul 14.

41.

ATM activation in the presence of oxidative stress.

Guo Z, Deshpande R, Paull TT.

Cell Cycle. 2010 Dec 15;9(24):4805-11. Epub 2010 Dec 15.

42.

Mre11-Rad50-Xrs2 and Sae2 promote 5' strand resection of DNA double-strand breaks.

Nicolette ML, Lee K, Guo Z, Rani M, Chow JM, Lee SE, Paull TT.

Nat Struct Mol Biol. 2010 Dec;17(12):1478-85. doi: 10.1038/nsmb.1957. Epub 2010 Nov 21.

43.

Making the best of the loose ends: Mre11/Rad50 complexes and Sae2 promote DNA double-strand break resection.

Paull TT.

DNA Repair (Amst). 2010 Dec 10;9(12):1283-91. doi: 10.1016/j.dnarep.2010.09.015. Epub 2010 Nov 2. Review.

44.

Ancient and recent adaptive evolution of primate non-homologous end joining genes.

Demogines A, East AM, Lee JH, Grossman SR, Sabeti PC, Paull TT, Sawyer SL.

PLoS Genet. 2010 Oct 21;6(10):e1001169. doi: 10.1371/journal.pgen.1001169.

45.

ATM activation by oxidative stress.

Guo Z, Kozlov S, Lavin MF, Person MD, Paull TT.

Science. 2010 Oct 22;330(6003):517-21. doi: 10.1126/science.1192912.

46.

Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks.

Shim EY, Chung WH, Nicolette ML, Zhang Y, Davis M, Zhu Z, Paull TT, Ira G, Lee SE.

EMBO J. 2010 Oct 6;29(19):3370-80. doi: 10.1038/emboj.2010.219. Epub 2010 Sep 10.

47.

53BP1 promotes ATM activity through direct interactions with the MRN complex.

Lee JH, Goodarzi AA, Jeggo PA, Paull TT.

EMBO J. 2010 Feb 3;29(3):574-85. doi: 10.1038/emboj.2009.372. Epub 2009 Dec 10.

48.

Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo.

Daniel JA, Pellegrini M, Lee JH, Paull TT, Feigenbaum L, Nussenzweig A.

J Cell Biol. 2008 Dec 1;183(5):777-83. doi: 10.1083/jcb.200805154.

49.

The P. furiosus mre11/rad50 complex promotes 5' strand resection at a DNA double-strand break.

Hopkins BB, Paull TT.

Cell. 2008 Oct 17;135(2):250-60. doi: 10.1016/j.cell.2008.09.054.

50.

Single-stranded DNA-binding protein hSSB1 is critical for genomic stability.

Richard DJ, Bolderson E, Cubeddu L, Wadsworth RI, Savage K, Sharma GG, Nicolette ML, Tsvetanov S, McIlwraith MJ, Pandita RK, Takeda S, Hay RT, Gautier J, West SC, Paull TT, Pandita TK, White MF, Khanna KK.

Nature. 2008 May 29;453(7195):677-81. doi: 10.1038/nature06883. Epub 2008 Apr 30.

PMID:
18449195

Supplemental Content

Loading ...
Support Center