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Items: 26


Mevalonate 5-diphosphate mediates ATP binding to the mevalonate diphosphate decarboxylase from the bacterial pathogen Enterococcus faecalis.

Chen CL, Mermoud JC, Paul LN, Steussy CN, Stauffacher CV.

J Biol Chem. 2017 Dec 29;292(52):21340-21351. doi: 10.1074/jbc.M117.802223. Epub 2017 Oct 12.


Wolbachia Endosymbionts Modify Drosophila Ovary Protein Levels in a Context-Dependent Manner.

Christensen S, Pérez Dulzaides R, Hedrick VE, Momtaz AJ, Nakayasu ES, Paul LN, Serbus LR.

Appl Environ Microbiol. 2016 Aug 15;82(17):5354-63. doi: 10.1128/AEM.01255-16. Print 2016 Sep 1.


Antibacterial activity and mechanism of action of auranofin against multi-drug resistant bacterial pathogens.

Thangamani S, Mohammad H, Abushahba MF, Sobreira TJ, Hedrick VE, Paul LN, Seleem MN.

Sci Rep. 2016 Mar 3;6:22571. doi: 10.1038/srep22571.


Structural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitination.

Sheedlo MJ, Qiu J, Tan Y, Paul LN, Luo ZQ, Das C.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15090-5. doi: 10.1073/pnas.1514568112. Epub 2015 Nov 23.


Exploring simvastatin, an antihyperlipidemic drug, as a potential topical antibacterial agent.

Thangamani S, Mohammad H, Abushahba MF, Hamed MI, Sobreira TJ, Hedrick VE, Paul LN, Seleem MN.

Sci Rep. 2015 Nov 10;5:16407. doi: 10.1038/srep16407.


Dynamics of an Active-Site Flap Contributes to Catalysis in a JAMM Family Metallo Deubiquitinase.

Bueno AN, Shrestha RK, Ronau JA, Babar A, Sheedlo MJ, Fuchs JE, Paul LN, Das C.

Biochemistry. 2015 Oct 6;54(39):6038-51. doi: 10.1021/acs.biochem.5b00631.


Digestion, Purification, and Enrichment of Protein Samples for Mass Spectrometry.

Hedrick VE, LaLand MN, Nakayasu ES, Paul LN.

Curr Protoc Chem Biol. 2015 Sep 1;7(3):201-222. doi: 10.1002/9780470559277.ch140272.


Hsp31 Is a Stress Response Chaperone That Intervenes in the Protein Misfolding Process.

Tsai CJ, Aslam K, Drendel HM, Asiago JM, Goode KM, Paul LN, Rochet JC, Hazbun TR.

J Biol Chem. 2015 Oct 9;290(41):24816-34. doi: 10.1074/jbc.M115.678367. Epub 2015 Aug 25.


AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma.

Li YH, Luo J, Mosley YY, Hedrick VE, Paul LN, Chang J, Zhang G, Wang YK, Banko MR, Brunet A, Kuang S, Wu JL, Chang CJ, Scott MP, Yang JY.

Cell Rep. 2015 Jul 28;12(4):599-609. doi: 10.1016/j.celrep.2015.06.054. Epub 2015 Jul 16.


Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS.

Tomar S, Johnston ML, St John SE, Osswald HL, Nyalapatla PR, Paul LN, Ghosh AK, Denison MR, Mesecar AD.

J Biol Chem. 2015 Aug 7;290(32):19403-22. doi: 10.1074/jbc.M115.651463. Epub 2015 Jun 8.


Characterization of the proteome of cytoplasmic lipid droplets in mouse enterocytes after a dietary fat challenge.

D'Aquila T, Sirohi D, Grabowski JM, Hedrick VE, Paul LN, Greenberg AS, Kuhn RJ, Buhman KK.

PLoS One. 2015 May 18;10(5):e0126823. doi: 10.1371/journal.pone.0126823. eCollection 2015.


A conserved acidic residue in phenylalanine hydroxylase contributes to cofactor affinity and catalysis.

Ronau JA, Paul LN, Fuchs JE, Liedl KR, Abu-Omar MM, Das C.

Biochemistry. 2014 Nov 4;53(43):6834-48. doi: 10.1021/bi500734h. Epub 2014 Oct 23.


The structure of the catalytic domain of a plant cellulose synthase and its assembly into dimers.

Olek AT, Rayon C, Makowski L, Kim HR, Ciesielski P, Badger J, Paul LN, Ghosh S, Kihara D, Crowley M, Himmel ME, Bolin JT, Carpita NC.

Plant Cell. 2014 Jul;26(7):2996-3009. doi: 10.1105/tpc.114.126862. Epub 2014 Jul 10.


Perturbation of the monomer-monomer interfaces of the benzoylformate decarboxylase tetramer.

Andrews FH, Rogers MP, Paul LN, McLeish MJ.

Biochemistry. 2014 Jul 15;53(27):4358-67. doi: 10.1021/bi500081r. Epub 2014 Jul 3.


Insights into the mechanism of deubiquitination by JAMM deubiquitinases from cocrystal structures of the enzyme with the substrate and product.

Shrestha RK, Ronau JA, Davies CW, Guenette RG, Strieter ER, Paul LN, Das C.

Biochemistry. 2014 May 20;53(19):3199-217. doi: 10.1021/bi5003162. Epub 2014 May 9.


Effect of cross-linking of interfacial sodium caseinate by natural processing on the oxidative stability of oil-in-water (o/w) emulsions.

Phoon PY, Paul LN, Burgner JW 2nd, San Martin-Gonzalez MF, Narsimhan G.

J Agric Food Chem. 2014 Apr 2;62(13):2822-9. doi: 10.1021/jf403285z. Epub 2014 Mar 18.


An asymmetric heterodomain interface stabilizes a response regulator-DNA complex.

Narayanan A, Kumar S, Evrard AN, Paul LN, Yernool DA.

Nat Commun. 2014;5:3282. doi: 10.1038/ncomms4282.


Mechanism of recruitment and activation of the endosome-associated deubiquitinase AMSH.

Davies CW, Paul LN, Das C.

Biochemistry. 2013 Nov 5;52(44):7818-29. doi: 10.1021/bi401106b. Epub 2013 Oct 23.


An additional substrate binding site in a bacterial phenylalanine hydroxylase.

Ronau JA, Paul LN, Fuchs JE, Corn IR, Wagner KT, Liedl KR, Abu-Omar MM, Das C.

Eur Biophys J. 2013 Sep;42(9):691-708. doi: 10.1007/s00249-013-0919-8. Epub 2013 Jul 17.


Stabilization of an unusual salt bridge in ubiquitin by the extra C-terminal domain of the proteasome-associated deubiquitinase UCH37 as a mechanism of its exo specificity.

Morrow ME, Kim MI, Ronau JA, Sheedlo MJ, White RR, Chaney J, Paul LN, Lill MA, Artavanis-Tsakonas K, Das C.

Biochemistry. 2013 May 21;52(20):3564-78. doi: 10.1021/bi4003106. Epub 2013 May 9.


Synthesis, characterization, and evaluation of pluronic-based β-cyclodextrin polyrotaxanes for mobilization of accumulated cholesterol from Niemann-Pick type C fibroblasts.

Collins CJ, McCauliff LA, Hyun SH, Zhang Z, Paul LN, Kulkarni A, Zick K, Wirth M, Storch J, Thompson DH.

Biochemistry. 2013 May 14;52(19):3242-53. doi: 10.1021/bi3010889. Epub 2013 Apr 30.


Structure-function studies of DNA binding domain of response regulator KdpE reveals equal affinity interactions at DNA half-sites.

Narayanan A, Paul LN, Tomar S, Patil DN, Kumar P, Yernool DA.

PLoS One. 2012;7(1):e30102. doi: 10.1371/journal.pone.0030102. Epub 2012 Jan 23.


Crystal structure and characterization of coiled-coil domain of the transient receptor potential channel PKD2L1.

Molland KL, Paul LN, Yernool DA.

Biochim Biophys Acta. 2012 Mar;1824(3):413-21. doi: 10.1016/j.bbapap.2011.12.002. Epub 2011 Dec 13.


Structural and thermodynamic comparison of the catalytic domain of AMSH and AMSH-LP: nearly identical fold but different stability.

Davies CW, Paul LN, Kim MI, Das C.

J Mol Biol. 2011 Oct 21;413(2):416-29. doi: 10.1016/j.jmb.2011.08.029. Epub 2011 Aug 24.


Folding dynamics of phenylalanine hydroxylase depends on the enzyme's metallation state: the native metal, iron, protects against aggregate intermediates.

Loaiza A, Ronau JA, Ribbe A, Stanciu L, Burgner JW 2nd, Paul LN, Abu-Omar MM.

Eur Biophys J. 2011 Aug;40(8):959-68. doi: 10.1007/s00249-011-0711-6. Epub 2011 Jun 7.


Specificity of HCPTP variants toward EphA2 tyrosines by quantitative selected reaction monitoring.

Balasubramaniam D, Paul LN, Homan KT, Hall MC, Stauffacher CV.

Protein Sci. 2011 Jul;20(7):1172-81. doi: 10.1002/pro.646. Epub 2011 May 23.

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