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Items: 13


Dephosphorylation of the adaptor LAT and phospholipase C-γ by SHP-1 inhibits natural killer cell cytotoxicity.

Matalon O, Fried S, Ben-Shmuel A, Pauker MH, Joseph N, Keizer D, Piterburg M, Barda-Saad M.

Sci Signal. 2016 May 24;9(429):ra54. doi: 10.1126/scisignal.aad6182.


RTVP-1 regulates glioma cell migration and invasion via interaction with N-WASP and hnRNPK.

Ziv-Av A, Giladi ND, Lee HK, Cazacu S, Finniss S, Xiang C, Pauker MH, Barda-Saad M, Poisson L, Brodie C.

Oncotarget. 2015 Aug 14;6(23):19826-40.


WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor site.

Pauker MH, Reicher B, Joseph N, Wortzel I, Jakubowicz S, Noy E, Perl O, Barda-Saad M.

J Biol Chem. 2014 Dec 12;289(50):34503-19. doi: 10.1074/jbc.M114.591685. Epub 2014 Oct 23.


Triple-color FRET analysis reveals conformational changes in the WIP-WASp actin-regulating complex.

Fried S, Reicher B, Pauker MH, Eliyahu S, Matalon O, Noy E, Chill J, Barda-Saad M.

Sci Signal. 2014 Jun 24;7(331):ra60. doi: 10.1126/scisignal.2005198.


The nucleolar PICT-1/GLTSCR2 protein forms homo-oligomers.

Borodianskiy-Shteinberg T, Kalt I, Kipper S, Nachum N, Katz S, Pauker MH, Barda-Saad M, Gerber D, Sarid R.

J Mol Biol. 2014 Jun 12;426(12):2363-78. doi: 10.1016/j.jmb.2014.04.006. Epub 2014 Apr 13.


Redox modulation of adjacent thiols in VLA-4 by AS101 converts myeloid leukemia cells from a drug-resistant to drug-sensitive state.

Layani-Bazar A, Skornick I, Berrebi A, Pauker MH, Noy E, Silberman A, Albeck M, Longo DL, Kalechman Y, Sredni B.

Cancer Res. 2014 Jun 1;74(11):3092-103. doi: 10.1158/0008-5472.CAN-13-2159. Epub 2014 Apr 3.


Unique ζ-chain motifs mediate a direct TCR-actin linkage critical for immunological synapse formation and T-cell activation.

Klieger Y, Almogi-Hazan O, Ish-Shalom E, Pato A, Pauker MH, Barda-Saad M, Wang L, Baniyash M.

Eur J Immunol. 2014 Jan;44(1):58-68. doi: 10.1002/eji.201243099. Epub 2013 Nov 4.


Real-time live imaging of T-cell signaling complex formation.

Noy E, Pauker MH, Barda-Saad M.

J Vis Exp. 2013 Jun 23;(76). doi: 10.3791/50076.


Ubiquitylation-dependent negative regulation of WASp is essential for actin cytoskeleton dynamics.

Reicher B, Joseph N, David A, Pauker MH, Perl O, Barda-Saad M.

Mol Cell Biol. 2012 Aug;32(15):3153-63. doi: 10.1128/MCB.00161-12. Epub 2012 Jun 4.


Studying the dynamics of SLP-76, Nck, and Vav1 multimolecular complex formation in live human cells with triple-color FRET.

Pauker MH, Hassan N, Noy E, Reicher B, Barda-Saad M.

Sci Signal. 2012 Apr 24;5(221):rs3. doi: 10.1126/scisignal.2002423.


Studies of novel interactions between Nck and VAV SH3 domains.

Pauker MH, Barda-Saad M.

Commun Integr Biol. 2011 Mar;4(2):175-7. doi: 10.4161/cib.4.2.14235.


Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization.

Pauker MH, Reicher B, Fried S, Perl O, Barda-Saad M.

Mol Cell Biol. 2011 Jul;31(13):2653-66. doi: 10.1128/MCB.01358-10. Epub 2011 May 2.


Cooperative interactions at the SLP-76 complex are critical for actin polymerization.

Barda-Saad M, Shirasu N, Pauker MH, Hassan N, Perl O, Balbo A, Yamaguchi H, Houtman JC, Appella E, Schuck P, Samelson LE.

EMBO J. 2010 Jul 21;29(14):2315-28. doi: 10.1038/emboj.2010.133. Epub 2010 Jun 18.

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