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Items: 13


The repeat region of the circumsporozoite protein is critical for sporozoite formation and maturation in Plasmodium.

Ferguson DJ, Balaban AE, Patzewitz EM, Wall RJ, Hopp CS, Poulin B, Mohmmed A, Malhotra P, Coppi A, Sinnis P, Tewari R.

PLoS One. 2014 Dec 1;9(12):e113923. doi: 10.1371/journal.pone.0113923. eCollection 2014.


Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation.

Guttery DS, Poulin B, Ramaprasad A, Wall RJ, Ferguson DJ, Brady D, Patzewitz EM, Whipple S, Straschil U, Wright MH, Mohamed AM, Radhakrishnan A, Arold ST, Tate EW, Holder AA, Wickstead B, Pain A, Tewari R.

Cell Host Microbe. 2014 Jul 9;16(1):128-40. doi: 10.1016/j.chom.2014.05.020.


Development of a transgenic Plasmodium berghei line (Pb pfpkg) expressing the P. falciparum cGMP-dependent protein kinase, a novel antimalarial drug target.

Tewari R, Patzewitz EM, Poulin B, Stewart L, Baker DA.

PLoS One. 2014 May 7;9(5):e96923. doi: 10.1371/journal.pone.0096923. eCollection 2014.


Unique apicomplexan IMC sub-compartment proteins are early markers for apical polarity in the malaria parasite.

Poulin B, Patzewitz EM, Brady D, Silvie O, Wright MH, Ferguson DJ, Wall RJ, Whipple S, Guttery DS, Tate EW, Wickstead B, Holder AA, Tewari R.

Biol Open. 2013 Sep 16;2(11):1160-70. doi: 10.1242/bio.20136163. eCollection 2013.


An ancient protein phosphatase, SHLP1, is critical to microneme development in Plasmodium ookinetes and parasite transmission.

Patzewitz EM, Guttery DS, Poulin B, Ramakrishnan C, Ferguson DJ, Wall RJ, Brady D, Holder AA, Szöőr B, Tewari R.

Cell Rep. 2013 Mar 28;3(3):622-9. doi: 10.1016/j.celrep.2013.01.032. Epub 2013 Feb 21.


Glutathione transport: a new role for PfCRT in chloroquine resistance.

Patzewitz EM, Salcedo-Sora JE, Wong EH, Sethia S, Stocks PA, Maughan SC, Murray JA, Krishna S, Bray PG, Ward SA, Müller S.

Antioxid Redox Signal. 2013 Sep 1;19(7):683-95. doi: 10.1089/ars.2012.4625. Epub 2012 Dec 20.


A unique protein phosphatase with kelch-like domains (PPKL) in Plasmodium modulates ookinete differentiation, motility and invasion.

Guttery DS, Poulin B, Ferguson DJ, Szöőr B, Wickstead B, Carroll PL, Ramakrishnan C, Brady D, Patzewitz EM, Straschil U, Solyakov L, Green JL, Sinden RE, Tobin AB, Holder AA, Tewari R.

PLoS Pathog. 2012 Sep;8(9):e1002948. doi: 10.1371/journal.ppat.1002948. Epub 2012 Sep 20.


Dissecting the role of glutathione biosynthesis in Plasmodium falciparum.

Patzewitz EM, Wong EH, Müller S.

Mol Microbiol. 2012 Jan;83(2):304-18. doi: 10.1111/j.1365-2958.2011.07933.x. Epub 2011 Dec 11.


Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development.

Storm J, Perner J, Aparicio I, Patzewitz EM, Olszewski K, Llinas M, Engel PC, Müller S.

Malar J. 2011 Jul 14;10:193. doi: 10.1186/1475-2875-10-193.


Differential inhibition of high and low Mr thioredoxin reductases of parasites by organotelluriums supports the concept that low Mr thioredoxin reductases are good drug targets.

McMillan PJ, Patzewitz EM, Young SE, Westrop GD, Coombs GH, Engman L, Müller S.

Parasitology. 2009 Jan;136(1):27-33. doi: 10.1017/S0031182008005131. Epub 2008 Nov 4.


Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis.

Reid CM, Ebikeme C, Barrett MP, Patzewitz EM, Müller S, Robins DJ, Sutherland A.

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5399-401. doi: 10.1016/j.bmcl.2008.09.047. Epub 2008 Sep 14.


Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles.

Reid CM, Ebikeme C, Barrett MP, Patzewitz EM, Müller S, Robins DJ, Sutherland A.

Bioorg Med Chem Lett. 2008 Apr 1;18(7):2455-8. doi: 10.1016/j.bmcl.2008.02.037. Epub 2008 Feb 19.


Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum.

Günther S, Wallace L, Patzewitz EM, McMillan PJ, Storm J, Wrenger C, Bissett R, Smith TK, Müller S.

PLoS Pathog. 2007 Dec;3(12):e189.

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