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Patient-Reported Bowel Function in Patients with Rectal Cancer Managed by a Watch-and-Wait Strategy after Neoadjuvant Therapy: A Case-Control Study.

Quezada-Diaz FF, Smith JJ, Jimenez-Rodriguez RM, Wasserman I, Pappou EP, Patil S, Wei IH, Nash GM, Guillem JG, Weiser MR, Paty PB, Garcia-Aguilar J.

Dis Colon Rectum. 2020 Mar 23. doi: 10.1097/DCR.0000000000001646. [Epub ahead of print]


Sex Differences in Colon Cancer Metabolism Reveal A Novel Subphenotype.

Cai Y, Rattray NJW, Zhang Q, Mironova V, Santos-Neto A, Hsu KS, Rattray Z, Cross JR, Zhang Y, Paty PB, Khan SA, Johnson CH.

Sci Rep. 2020 Mar 17;10(1):4905. doi: 10.1038/s41598-020-61851-0.


Mismatch Repair Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy.

Cercek A, Dos Santos Fernandes G, Roxburgh CS, Ganesh K, Ng S, Sanchez-Vega F, Yaeger R, Segal NH, Reidy-Lagunes DL, Varghese AM, Markowitz A, Wu C, Szeglin B, Sauvé CG, Salo-Mullen E, Tran C, Patel Z, Krishnan A, Tkachuk K, Nash GM, Guillem J, Paty PB, Shia J, Schultz N, Garcia-Aguilar J, Diaz LA, Goodman K, Saltz LB, Weiser MR, Smith JJ, Stadler ZK.

Clin Cancer Res. 2020 Mar 6. pii: clincanres.3728.2019. doi: 10.1158/1078-0432.CCR-19-3728. [Epub ahead of print]


PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis.

Yamaguchi N, Weinberg EM, Nguyen A, Liberti MV, Goodarzi H, Janjigian YY, Paty PB, Saltz LB, Kingham TP, Loo JM, de Stanchina E, Tavazoie SF.

Elife. 2019 Dec 16;8. pii: e52135. doi: 10.7554/eLife.52135.


Coaltered Ras/B-raf and TP53 Is Associated with Extremes of Survivorship and Distinct Patterns of Metastasis in Patients with Metastatic Colorectal Cancer.

Datta J, Smith JJ, Chatila WK, McAuliffe JC, Kandoth C, Vakiani E, Frankel TL, Ganesh K, Wasserman I, Lipsyc-Sharf M, Guillem J, Nash GM, Paty PB, Weiser MR, Saltz LB, Berger MF, Jarnagin WR, Balachandran V, Kingham TP, Kemeny NE, Cercek A, Garcia-Aguilar J, Taylor BS, Viale A, Yaeger R, Solit DB, Schultz N, D'Angelica MI.

Clin Cancer Res. 2020 Mar 1;26(5):1077-1085. doi: 10.1158/1078-0432.CCR-19-2390. Epub 2019 Nov 12.


Organoids Reveal That Inherent Radiosensitivity of Small and Large Intestinal Stem Cells Determines Organ Sensitivity.

Martin ML, Adileh M, Hsu KS, Hua G, Lee SG, Li C, Fuller JD, Rotolo JA, Bodo S, Klingler S, Haimovitz-Friedman A, Deasy JO, Fuks Z, Paty PB, Kolesnick RN.

Cancer Res. 2020 Mar 1;80(5):1219-1227. doi: 10.1158/0008-5472.CAN-19-0312. Epub 2019 Nov 5.


A rectal cancer organoid platform to study individual responses to chemoradiation.

Ganesh K, Wu C, O'Rourke KP, Szeglin BC, Zheng Y, Sauvé CG, Adileh M, Wasserman I, Marco MR, Kim AS, Shady M, Sanchez-Vega F, Karthaus WR, Won HH, Choi SH, Pelossof R, Barlas A, Ntiamoah P, Pappou E, Elghouayel A, Strong JS, Chen CT, Harris JW, Weiser MR, Nash GM, Guillem JG, Wei IH, Kolesnick RN, Veeraraghavan H, Ortiz EJ, Petkovska I, Cercek A, Manova-Todorova KO, Saltz LB, Lavery JA, DeMatteo RP, Massagué J, Paty PB, Yaeger R, Chen X, Patil S, Clevers H, Berger MF, Lowe SW, Shia J, Romesser PB, Dow LE, Garcia-Aguilar J, Sawyers CL, Smith JJ.

Nat Med. 2019 Oct;25(10):1607-1614. doi: 10.1038/s41591-019-0584-2. Epub 2019 Oct 7.


Looking Forward, Not Backward, on Watch and Wait for Rectal Cancer-In Reply.

Smith JJ, Garcia-Aguilar J, Paty PB.

JAMA Oncol. 2019 Jun 27. doi: 10.1001/jamaoncol.2019.1887. [Epub ahead of print] No abstract available.


Assessment of the Value of Comorbidity Indices for Risk Adjustment in Colorectal Surgery Patients.

Strombom P, Widmar M, Keskin M, Gennarelli RL, Lynn P, Smith JJ, Guillem JG, Paty PB, Nash GM, Weiser MR, Garcia-Aguilar J.

Ann Surg Oncol. 2019 Sep;26(9):2797-2804. doi: 10.1245/s10434-019-07502-9. Epub 2019 Jun 17.


Contemporary Validation of a Nomogram Predicting Colon Cancer Recurrence, Revealing All-Stage Improved Outcomes.

Konishi T, Shimada Y, Hsu M, Wei IH, Pappou E, Smith JJ, Nash GM, Guillem JG, Paty PB, Garcia-Aguilar J, Cercek A, Yaeger R, Stadler ZK, Segal NH, Varghese A, Saltz LB, Shia J, Vakiani E, Gönen M, Weiser MR.

JNCI Cancer Spectr. 2019 Jun;3(2):pkz015. doi: 10.1093/jncics/pkz015. Epub 2019 Apr 25. Erratum in: JNCI Cancer Spectr. 2019 Nov 26;3(4):pkz089.


Changes in the multidisciplinary management of rectal cancer from 2009 to 2015 and associated improvements in short-term outcomes.

Roxburgh CSD, Strombom P, Lynn P, Cercek A, Gonen M, Smith JJ, Temple LKF, Nash GM, Guillem JG, Paty PB, Shia J, Vakiani E, Yaeger R, Stadler ZK, Segal NH, Reidy D, Varghese A, Wu AJ, Crane CH, Gollub MJ, Saltz LB, Garcia-Aguilar J, Weiser MR.

Colorectal Dis. 2019 Oct;21(10):1140-1150. doi: 10.1111/codi.14713. Epub 2019 Jul 1.


Induction Chemotherapy Reduces Patient-reported Toxicities During Neoadjuvant Chemoradiation with Intensity Modulated Radiotherapy for Rectal Cancer.

Ng SY, Colborn KL, Cambridge L, Cercek A, Reidy-Lagunes DL, Segal N, Stadler Z, Saltz LB, Paty PB, Guillem J, Weiser MR, Nash G, Garcia-Aguilar J, Goodman KA.

Clin Colorectal Cancer. 2019 Sep;18(3):167-174. doi: 10.1016/j.clcc.2019.04.001. Epub 2019 Apr 6.


Reducing the Morbidity of Rectal Cancer Treatment.

Paty PB, Cercek A, Crane CH.

JAMA Oncol. 2019 Jul 1;5(7):940-941. doi: 10.1001/jamaoncol.2019.0181. No abstract available.


Role of the Interval from Completion of Neoadjuvant Therapy to Surgery in Postoperative Morbidity in Patients with Locally Advanced Rectal Cancer.

Roxburgh CSD, Strombom P, Lynn P, Gonen M, Paty PB, Guillem JG, Nash GM, Smith JJ, Wei I, Pappou E, Garcia-Aguilar J, Weiser MR.

Ann Surg Oncol. 2019 Jul;26(7):2019-2027. doi: 10.1245/s10434-019-07340-9. Epub 2019 Apr 8.


Assessment of a Watch-and-Wait Strategy for Rectal Cancer in Patients With a Complete Response After Neoadjuvant Therapy.

Smith JJ, Strombom P, Chow OS, Roxburgh CS, Lynn P, Eaton A, Widmar M, Ganesh K, Yaeger R, Cercek A, Weiser MR, Nash GM, Guillem JG, Temple LKF, Chalasani SB, Fuqua JL, Petkovska I, Wu AJ, Reyngold M, Vakiani E, Shia J, Segal NH, Smith JD, Crane C, Gollub MJ, Gonen M, Saltz LB, Garcia-Aguilar J, Paty PB.

JAMA Oncol. 2019 Apr 1;5(4):e185896. doi: 10.1001/jamaoncol.2018.5896. Epub 2019 Apr 11.


SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance.

Wasserman I, Lee LH, Ogino S, Marco MR, Wu C, Chen X, Datta J, Sadot E, Szeglin B, Guillem JG, Paty PB, Weiser MR, Nash GM, Saltz L, Barlas A, Manova-Todorova K, Uppada SPB, Elghouayel AE, Ntiamoah P, Glickman JN, Hamada T, Kosumi K, Inamura K, Chan AT, Nishihara R, Cercek A, Ganesh K, Kemeny NE, Dhawan P, Yaeger R, Sawyers CL, Garcia-Aguilar J, Giannakis M, Shia J, Smith JJ.

Clin Cancer Res. 2019 Mar 15;25(6):1948-1956. doi: 10.1158/1078-0432.CCR-18-1726. Epub 2018 Dec 26.


Outcomes of Low-Grade Appendiceal Mucinous Neoplasms with Remote Acellular Mucinous Peritoneal Deposits.

Roxburgh CS, Fenig YM, Cercek A, Shia J, Rassam RM, Paty PB, Nash GM.

Ann Surg Oncol. 2019 Jan;26(1):118-124. doi: 10.1245/s10434-018-7003-7. Epub 2018 Nov 12.


Effect of Neoadjuvant Systemic Chemotherapy With or Without Chemoradiation on Bowel Function in Rectal Cancer Patients Treated With Total Mesorectal Excision.

Quezada-Diaz F, Jimenez-Rodriguez RM, Pappou EP, Joshua Smith J, Patil S, Wei I, Guillem JG, Paty PB, Nash GM, Weiser MR, Garcia-Aguilar J.

J Gastrointest Surg. 2019 Apr;23(4):800-807. doi: 10.1007/s11605-018-4003-7. Epub 2018 Oct 22.


Use of the Xi robotic platform for total abdominal colectomy: a step forward in minimally invasive colorectal surgery.

Jimenez-Rodriguez RM, Quezada-Diaz F, Tchack M, Pappou E, Wei IH, Smith JJ, Nash GM, Guillem JG, Paty PB, Weiser MR, Garcia-Aguilar J.

Surg Endosc. 2019 Mar;33(3):966-971. doi: 10.1007/s00464-018-6529-x. Epub 2018 Oct 22.


A perioperative multidisciplinary care bundle reduces surgical site infections in patients undergoing synchronous colorectal and liver resection.

Tufts LS, Jarnagin ED, Flynn JR, Gonen M, Guillem JG, Paty PB, Nash GM, Smith JJ, Wei IH, Pappou E, D'Angelica MI, Allen PJ, Peter Kingham T, Balachandran VP, Drebin JA, Garcia-Aguilar J, Jarnagin WR, Weiser MR.

HPB (Oxford). 2019 Feb;21(2):181-186. doi: 10.1016/j.hpb.2018.07.001. Epub 2018 Aug 1.


Effectiveness of a multidisciplinary patient care bundle for reducing surgical-site infections.

Weiser MR, Gonen M, Usiak S, Pottinger T, Samedy P, Patel D, Seo S, Smith JJ, Guillem JG, Temple L, Nash GM, Paty PB, Baldwin-Medsker A, Cheavers CE, Eagan J, Garcia-Aguilar J; Memorial Sloan Kettering Multidisciplinary Surgical-Site Infection Reduction Team.

Br J Surg. 2018 Nov;105(12):1680-1687. doi: 10.1002/bjs.10896. Epub 2018 Jul 4.


Poorly Differentiated Clusters Predict Colon Cancer Recurrence: An In-Depth Comparative Analysis of Invasive-Front Prognostic Markers.

Konishi T, Shimada Y, Lee LH, Cavalcanti MS, Hsu M, Smith JJ, Nash GM, Temple LK, Guillem JG, Paty PB, Garcia-Aguilar J, Vakiani E, Gonen M, Shia J, Weiser MR.

Am J Surg Pathol. 2018 Jun;42(6):705-714. doi: 10.1097/PAS.0000000000001059.


Adoption of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer.

Cercek A, Roxburgh CSD, Strombom P, Smith JJ, Temple LKF, Nash GM, Guillem JG, Paty PB, Yaeger R, Stadler ZK, Seier K, Gonen M, Segal NH, Reidy DL, Varghese A, Shia J, Vakiani E, Wu AJ, Crane CH, Gollub MJ, Garcia-Aguilar J, Saltz LB, Weiser MR.

JAMA Oncol. 2018 Jun 14;4(6):e180071. doi: 10.1001/jamaoncol.2018.0071. Epub 2018 Jun 14.


Association of Preoperative and Postoperative Serum Carcinoembryonic Antigen and Colon Cancer Outcome.

Konishi T, Shimada Y, Hsu M, Tufts L, Jimenez-Rodriguez R, Cercek A, Yaeger R, Saltz L, Smith JJ, Nash GM, Guillem JG, Paty PB, Garcia-Aguilar J, Gonen M, Weiser MR.

JAMA Oncol. 2018 Mar 1;4(3):309-315. doi: 10.1001/jamaoncol.2017.4420.


Rectal Gastrointestinal Stromal Tumor (GIST) in the Era of Imatinib: Organ Preservation and Improved Oncologic Outcome.

Cavnar MJ, Wang L, Balachandran VP, Antonescu CR, Tap WD, Keohan M, Singer S, Temple L, Nash GM, Weiser MR, Guillem JG, Aguilar JG, DeMatteo RP, Paty PB.

Ann Surg Oncol. 2017 Dec;24(13):3972-3980. doi: 10.1245/s10434-017-6087-9. Epub 2017 Oct 20.


Logarithmic expansion of LGR5+ cells in human colorectal cancer.

Martin ML, Zeng Z, Adileh M, Jacobo A, Li C, Vakiani E, Hua G, Zhang L, Haimovitz-Friedman A, Fuks Z, Kolesnick R, Paty PB.

Cell Signal. 2018 Jan;42:97-105. doi: 10.1016/j.cellsig.2017.09.018. Epub 2017 Sep 25.


Distinct Levels of Radioresistance in Lgr5+ Colonic Epithelial Stem Cells versus Lgr5+ Small Intestinal Stem Cells.

Hua G, Wang C, Pan Y, Zeng Z, Lee SG, Martin ML, Haimovitz-Friedman A, Fuks Z, Paty PB, Kolesnick R.

Cancer Res. 2017 Apr 15;77(8):2124-2133. doi: 10.1158/0008-5472.CAN-15-2870. Epub 2017 Feb 15.


EGFR Gene Amplification and KRAS Mutation Predict Response to Combination Targeted Therapy in Metastatic Colorectal Cancer.

Khan SA, Zeng Z, Shia J, Paty PB.

Pathol Oncol Res. 2017 Jul;23(3):673-677. doi: 10.1007/s12253-016-0166-2. Epub 2016 Dec 26.


Developing a robotic colorectal cancer surgery program: understanding institutional and individual learning curves.

Guend H, Widmar M, Patel S, Nash GM, Paty PB, Guillem JG, Temple LK, Garcia-Aguilar J, Weiser MR.

Surg Endosc. 2017 Jul;31(7):2820-2828. doi: 10.1007/s00464-016-5292-0. Epub 2016 Nov 4.


Colorectal cancer in the very young: a comparative study of tumor markers, pathology and survival in early onset and adult onset patients.

Khan SA, Morris M, Idrees K, Gimbel MI, Rosenberg S, Zeng Z, Li F, Gan G, Shia J, LaQuaglia MP, Paty PB.

J Pediatr Surg. 2016 Nov;51(11):1812-1817. doi: 10.1016/j.jpedsurg.2016.07.015. Epub 2016 Aug 5.


Incisional hernias after laparoscopic and robotic right colectomy.

Widmar M, Keskin M, Beltran P, Nash GM, Guillem JG, Temple LK, Paty PB, Weiser MR, Garcia-Aguilar J.

Hernia. 2016 Oct;20(5):723-8. doi: 10.1007/s10029-016-1518-2. Epub 2016 Jul 28.


Long-term oncologic outcomes for simultaneous resection of synchronous metastatic liver and primary colorectal cancer.

Silberhumer GR, Paty PB, Denton B, Guillem J, Gonen M, Araujo RLC, Nash GM, Temple LK, Allen PJ, DeMatteo RP, Weiser MR, Wong WD, Jarnagin WR, D'Angelica MI, Fong Y.

Surgery. 2016 Jul;160(1):67-73. doi: 10.1016/j.surg.2016.02.029. Epub 2016 Apr 11.


PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis.

Nguyen A, Loo JM, Mital R, Weinberg EM, Man FY, Zeng Z, Paty PB, Saltz L, Janjigian YY, de Stanchina E, Tavazoie SF.

J Clin Invest. 2016 Feb;126(2):681-94. doi: 10.1172/JCI83587. Epub 2016 Jan 19.


Oncogenic KRAS activates an embryonic stem cell-like program in human colon cancer initiation.

Le Rolle AF, Chiu TK, Zeng Z, Shia J, Weiser MR, Paty PB, Chiu VK.

Oncotarget. 2016 Jan 19;7(3):2159-74. doi: 10.18632/oncotarget.6818.


Free Jejunal Flap for Pharyngoesophageal Reconstruction in Head and Neck Cancer Patients: An Evaluation of Donor-Site Complications.

Razdan SN, Albornoz CR, Matros E, Paty PB, Cordeiro PG.

J Reconstr Microsurg. 2015 Nov;31(9):643-6. doi: 10.1055/s-0035-1556872. Epub 2015 Jul 28.


The prognostic significance of CXCL1 hypersecretion by human colorectal cancer epithelia and myofibroblasts.

le Rolle AF, Chiu TK, Fara M, Shia J, Zeng Z, Weiser MR, Paty PB, Chiu VK.

J Transl Med. 2015 Jun 24;13:199. doi: 10.1186/s12967-015-0555-4.


Erratum to: Lymph Node Metastasis Predicts Disease Recurrence in a Single-Center Experience of 70 Stages 1-3 Appendix Cancers: A Retrospective Review.

Nash GM, Smith JD, Cercek A, Tang L, Weiser MR, Temple LK, O'Reilly E, Saltz LB, Guillem JG, Paty PB.

Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1613. doi: 10.1245/s10434-015-4568-2. No abstract available.


Lymph Node Metastasis Predicts Disease Recurrence in a Single-Center Experience of 70 Stages 1-3 Appendix Cancers: A Retrospective Review.

Nash GM, Smith JD, Tang L, Weiser MR, Temple LK, O'Reilly E, Saltz LB, Guillem JG, Paty PB.

Ann Surg Oncol. 2015 Oct;22(11):3613-7. doi: 10.1245/s10434-015-4415-5. Epub 2015 Feb 7. Erratum in: Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1613.


Long-Term Survival After High-Dose-Rate Brachytherapy for Locally Advanced or Recurrent Colorectal Adenocarcinoma.

Terezakis S, Morikawa L, Wu A, Zhang Z, Shi W, Weiser MR, Paty PB, Guillem J, Temple L, Nash GM, Zelefsky MJ, Goodman KA.

Ann Surg Oncol. 2015 Jul;22(7):2168-78. doi: 10.1245/s10434-014-4271-8. Epub 2015 Jan 29.


Simultaneous resection for rectal cancer with synchronous liver metastasis is a safe procedure.

Silberhumer GR, Paty PB, Temple LK, Araujo RL, Denton B, Gonen M, Nash GM, Allen PJ, DeMatteo RP, Guillem J, Weiser MR, D'Angelica MI, Jarnagin WR, Wong DW, Fong Y.

Am J Surg. 2015 Jun;209(6):935-42. doi: 10.1016/j.amjsurg.2014.09.024. Epub 2014 Dec 13.


Extracellular metabolic energetics can promote cancer progression.

Loo JM, Scherl A, Nguyen A, Man FY, Weinberg E, Zeng Z, Saltz L, Paty PB, Tavazoie SF.

Cell. 2015 Jan 29;160(3):393-406. doi: 10.1016/j.cell.2014.12.018. Epub 2015 Jan 15.


Does endoscopic ultrasound improve detection of locally recurrent anal squamous-cell cancer?

Peterson CY, Weiser MR, Paty PB, Guillem JG, Nash GM, Garcia-Aguilar J, Patil S, Temple LK.

Dis Colon Rectum. 2015 Feb;58(2):193-8. doi: 10.1097/DCR.0000000000000291.


Comparison of tumor regression grade systems for locally advanced rectal cancer after multimodality treatment.

Trakarnsanga A, Gönen M, Shia J, Nash GM, Temple LK, Guillem JG, Paty PB, Goodman KA, Wu A, Gollub M, Segal N, Saltz L, Garcia-Aguilar J, Weiser MR.

J Natl Cancer Inst. 2014 Sep 22;106(10). pii: dju248. doi: 10.1093/jnci/dju248. Print 2014 Oct.


Percutaneous Cryoablation for Local Control of Metachronous Inguinal Lymph Node Metastases.

Cornelis F, Paty PB, Sofocleous CT, Solomon SB, Durack JC.

Cardiovasc Intervent Radiol. 2015 Oct;38(5):1369-72. doi: 10.1007/s00270-014-0946-6. Epub 2014 Jul 1. No abstract available.


Management and outcome of perianal Paget's disease: a 6-decade institutional experience.

Perez DR, Trakarnsanga A, Shia J, Nash GM, Temple LK, Paty PB, Guillem JG, Garcia-Aguilar J, Weiser MR.

Dis Colon Rectum. 2014 Jun;57(6):747-751. doi: 10.1097/DCR.0000000000000100.


Neoadjuvant chemotherapy first, followed by chemoradiation and then surgery, in the management of locally advanced rectal cancer.

Cercek A, Goodman KA, Hajj C, Weisberger E, Segal NH, Reidy-Lagunes DL, Stadler ZK, Wu AJ, Weiser MR, Paty PB, Guillem JG, Nash GM, Temple LK, Garcia-Aguilar J, Saltz LB.

J Natl Compr Canc Netw. 2014 Apr;12(4):513-9.


Phase II trial of hepatic artery infusional and systemic chemotherapy for patients with unresectable hepatic metastases from colorectal cancer: conversion to resection and long-term outcomes.

DʼAngelica MI, Correa-Gallego C, Paty PB, Cercek A, Gewirtz AN, Chou JF, Capanu M, Kingham TP, Fong Y, DeMatteo RP, Allen PJ, Jarnagin WR, Kemeny N.

Ann Surg. 2015 Feb;261(2):353-60. doi: 10.1097/SLA.0000000000000614.


Neoadjuvant radiation therapy prior to total mesorectal excision for rectal cancer is not associated with postoperative complications using current techniques.

Milgrom SA, Goodman KA, Nash GM, Paty PB, Guillem JG, Temple LK, Weiser MR, Garcia-Aguilar J.

Ann Surg Oncol. 2014 Jul;21(7):2295-302. doi: 10.1245/s10434-014-3624-7. Epub 2014 Mar 7.


Neoadjuvant chemotherapy without routine use of radiation therapy for patients with locally advanced rectal cancer: a pilot trial.

Schrag D, Weiser MR, Goodman KA, Gonen M, Hollywood E, Cercek A, Reidy-Lagunes DL, Gollub MJ, Shia J, Guillem JG, Temple LK, Paty PB, Saltz LB.

J Clin Oncol. 2014 Feb 20;32(6):513-8. doi: 10.1200/JCO.2013.51.7904. Epub 2014 Jan 13.

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