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Items: 1 to 50 of 70

1.

Zebrafish MITF-low melanoma subtype models reveal transcriptional subclusters and MITF-independent residual disease.

Travnickova J, Wojciechowska S, Khamseh A, Gautier P, Brown DV, Lefevre T, Brombin A, Ewing A, Capper A, Spitzer M, Dilshat R, Semple CA, Mathers ME, Lister JA, Steingrímsson E, Voet T, Ponting CP, Patton EE.

Cancer Res. 2019 Oct 3. pii: canres.0037.2019. doi: 10.1158/0008-5472.CAN-19-0037. [Epub ahead of print]

PMID:
31582381
2.

Spotlight on zebrafish: the next wave of translational research.

Patton EE, Tobin DM.

Dis Model Mech. 2019 Mar 7;12(3). pii: dmm039370. doi: 10.1242/dmm.039370.

3.

Endothelin receptor Aa regulates proliferation and differentiation of Erb-dependent pigment progenitors in zebrafish.

Camargo-Sosa K, Colanesi S, Müller J, Schulte-Merker S, Stemple D, Patton EE, Kelsh RN.

PLoS Genet. 2019 Feb 27;15(2):e1007941. doi: 10.1371/journal.pgen.1007941. eCollection 2019 Feb.

4.

Notochord Injury Assays that Stimulate Transcriptional Responses in Zebrafish Larvae.

Zeng Z, Lopez-Baez JC, Lleras-Forero L, Brunsdon H, Wyatt C, Rybski W, Hastie ND, Schulte-Merker S, Patton EE.

Bio Protoc. 2018 Dec 5;8(23):e3100. doi: 10.21769/BioProtoc.3100.

5.

Bright insights into palladium-triggered local chemotherapy.

Bray TL, Salji M, Brombin A, Pérez-López AM, Rubio-Ruiz B, Galbraith LCA, Patton EE, Leung HY, Unciti-Broceta A.

Chem Sci. 2018 Jul 17;9(37):7354-7361. doi: 10.1039/c8sc02291g. eCollection 2018 Oct 7.

6.

Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy.

Al-Olabi L, Polubothu S, Dowsett K, Andrews KA, Stadnik P, Joseph AP, Knox R, Pittman A, Clark G, Baird W, Bulstrode N, Glover M, Gordon K, Hargrave D, Huson SM, Jacques TS, James G, Kondolf H, Kangesu L, Keppler-Noreuil KM, Khan A, Lindhurst MJ, Lipson M, Mansour S, O'Hara J, Mahon C, Mosica A, Moss C, Murthy A, Ong J, Parker VE, Rivière JB, Sapp JC, Sebire NJ, Shah R, Sivakumar B, Thomas A, Virasami A, Waelchli R, Zeng Z, Biesecker LG, Barnacle A, Topf M, Semple RK, Patton EE, Kinsler VA.

J Clin Invest. 2018 Nov 1;128(11):5185. doi: 10.1172/JCI124649. Epub 2018 Nov 1. No abstract available.

7.

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells.

Sarvi S, Crispin R, Lu Y, Zeng L, Hurley TD, Houston DR, von Kriegsheim A, Chen CH, Mochly-Rosen D, Ranzani M, Mathers ME, Xu X, Xu W, Adams DJ, Carragher NO, Fujita M, Schuchter L, Unciti-Broceta A, Brunton VG, Patton EE.

Cell Chem Biol. 2018 Dec 20;25(12):1456-1469.e6. doi: 10.1016/j.chembiol.2018.09.005. Epub 2018 Oct 4.

8.

BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export.

Ngeow KC, Friedrichsen HJ, Li L, Zeng Z, Andrews S, Volpon L, Brunsdon H, Berridge G, Picaud S, Fischer R, Lisle R, Knapp S, Filippakopoulos P, Knowles H, Steingrímsson E, Borden KLB, Patton EE, Goding CR.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8668-E8677. doi: 10.1073/pnas.1810498115. Epub 2018 Aug 27.

9.

Fishing for ancestry.

Brunsdon H, Patton EE.

Elife. 2018 Aug 2;7. pii: e39524. doi: 10.7554/eLife.39524.

10.

Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy.

Al-Olabi L, Polubothu S, Dowsett K, Andrews KA, Stadnik P, Joseph AP, Knox R, Pittman A, Clark G, Baird W, Bulstrode N, Glover M, Gordon K, Hargrave D, Huson SM, Jacques TS, James G, Kondolf H, Kangesu L, Keppler-Noreuil KM, Khan A, Lindhurst MJ, Lipson M, Mansour S, O'Hara J, Mahon C, Mosica A, Moss C, Murthy A, Ong J, Parker VE, Rivière JB, Sapp JC, Sebire NJ, Shah R, Sivakumar B, Thomas A, Virasami A, Waelchli R, Zeng Z, Biesecker LG, Barnacle A, Topf M, Semple RK, Patton EE, Kinsler VA.

J Clin Invest. 2018 Apr 2;128(4):1496-1508. doi: 10.1172/JCI98589. Epub 2018 Mar 12. Erratum in: J Clin Invest. 2018 Nov 1;128(11):5185.

11.

Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair.

Lopez-Baez JC, Simpson DJ, LLeras Forero L, Zeng Z, Brunsdon H, Salzano A, Brombin A, Wyatt C, Rybski W, Huitema LFA, Dale RM, Kawakami K, Englert C, Chandra T, Schulte-Merker S, Hastie ND, Patton EE.

Elife. 2018 Feb 6;7. pii: e30657. doi: 10.7554/eLife.30657.

12.

Location, Location, Location: Spatio-Temporal Cues That Define the Cell of Origin in Melanoma.

Soengas MS, Patton EE.

Cell Stem Cell. 2017 Nov 2;21(5):559-561. doi: 10.1016/j.stem.2017.10.009.

13.

Cell signalling: Red alert about lipid's role in skin cancer.

Jackson IJ, Patton EE.

Nature. 2017 Sep 21;549(7672):337-339. doi: 10.1038/nature23550. Epub 2017 Sep 6. No abstract available.

14.

Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish.

Scahill CM, Digby Z, Sealy IM, Wojciechowska S, White RJ, Collins JE, Stemple DL, Bartke T, Mathers ME, Patton EE, Busch-Nentwich EM.

PLoS Genet. 2017 Aug 14;13(8):e1006959. doi: 10.1371/journal.pgen.1006959. eCollection 2017 Aug.

15.

Erratum.

Kawakami K, Patton EE, Orger M.

Methods Mol Biol. 2016;1451:E1. No abstract available.

PMID:
27714676
16.

Melanoma Regression and Recurrence in Zebrafish.

Wojciechowska S, Zeng Z, Lister JA, Ceol CJ, Patton EE.

Methods Mol Biol. 2016;1451:143-53. doi: 10.1007/978-1-4939-3771-4_10.

PMID:
27464806
17.

Generation and analysis of zebrafish melanoma models.

Wojciechowska S, van Rooijen E, Ceol C, Patton EE, White RM.

Methods Cell Biol. 2016;134:531-49. doi: 10.1016/bs.mcb.2016.03.008. Epub 2016 Apr 18.

PMID:
27312504
18.

Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.

Fraser C, Dawson JC, Dowling R, Houston DR, Weiss JT, Munro AF, Muir M, Harrington L, Webster SP, Frame MC, Brunton VG, Patton EE, Carragher NO, Unciti-Broceta A.

J Med Chem. 2016 May 26;59(10):4697-710. doi: 10.1021/acs.jmedchem.6b00065. Epub 2016 May 4.

19.

Fish from Head to Tail: The 9th European Zebrafish Meeting in Oslo.

Griffiths G, Müller F, Ledin J, Patton EE, Gjøen T, Lobert VH, Winther-Larsen HC, Mullins M, Joly JS, Weltzien FA, Press CM, Aleström P.

Zebrafish. 2016 Apr;13(2):132-7. doi: 10.1089/zeb.2015.1212. Epub 2016 Feb 9.

20.

Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis.

Thomas AC, Zeng Z, Rivière JB, O'Shaughnessy R, Al-Olabi L, St-Onge J, Atherton DJ, Aubert H, Bagazgoitia L, Barbarot S, Bourrat E, Chiaverini C, Chong WK, Duffourd Y, Glover M, Groesser L, Hadj-Rabia S, Hamm H, Happle R, Mushtaq I, Lacour JP, Waelchli R, Wobser M, Vabres P, Patton EE, Kinsler VA.

J Invest Dermatol. 2016 Apr;136(4):770-778. doi: 10.1016/j.jid.2015.11.027. Epub 2016 Jan 14.

21.

Assessment of biocompatibility of 3D printed photopolymers using zebrafish embryo toxicity assays.

Macdonald NP, Zhu F, Hall CJ, Reboud J, Crosier PS, Patton EE, Wlodkowic D, Cooper JM.

Lab Chip. 2016 Jan 21;16(2):291-7. doi: 10.1039/c5lc01374g.

22.

Let's make it happen: for gender equality in science!

Kos L, Patton EE, Soengas MS.

Pigment Cell Melanoma Res. 2015 Nov;28(6):641-2. doi: 10.1111/pcmr.12421. No abstract available.

PMID:
26475778
23.

MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish.

Lundegaard PR, Anastasaki C, Grant NJ, Sillito RR, Zich J, Zeng Z, Paranthaman K, Larsen AP, Armstrong JD, Porteous DJ, Patton EE.

Chem Biol. 2015 Oct 22;22(10):1335-46. doi: 10.1016/j.chembiol.2015.08.010. Epub 2015 Sep 17.

24.

Cross-species models of human melanoma.

van der Weyden L, Patton EE, Wood GA, Foote AK, Brenn T, Arends MJ, Adams DJ.

J Pathol. 2016 Jan;238(2):152-65. doi: 10.1002/path.4632. Epub 2015 Oct 9. Review.

25.

The melanocyte lineage in development and disease.

Mort RL, Jackson IJ, Patton EE.

Development. 2015 Apr 1;142(7):1387. doi: 10.1242/dev.123729. No abstract available.

26.

The melanocyte lineage in development and disease.

Mort RL, Jackson IJ, Patton EE.

Development. 2015 Feb 15;142(4):620-32. doi: 10.1242/dev.106567. Review. Erratum in: Development. 2015 Apr 1;142(7):1387.

27.

Temperature-sensitive splicing of mitfa by an intron mutation in zebrafish.

Zeng Z, Johnson SL, Lister JA, Patton EE.

Pigment Cell Melanoma Res. 2015 Mar;28(2):229-32. doi: 10.1111/pcmr.12336. Epub 2014 Dec 29. No abstract available.

28.

Going forward together: cooperative invasion in melanoma.

Wojciechowska S, Patton EE.

Pigment Cell Melanoma Res. 2015 Jan;28(1):6-7. doi: 10.1111/pcmr.12323. Epub 2014 Nov 10. No abstract available.

PMID:
25308321
29.

N-alkynyl derivatives of 5-fluorouracil: susceptibility to palladium-mediated dealkylation and toxigenicity in cancer cell culture.

Weiss JT, Fraser C, Rubio-Ruiz B, Myers SH, Crispin R, Dawson JC, Brunton VG, Patton EE, Carragher NO, Unciti-Broceta A.

Front Chem. 2014 Jul 29;2:56. doi: 10.3389/fchem.2014.00056. eCollection 2014.

30.

Spotlight on zebrafish: translational impact.

Patton EE, Dhillon P, Amatruda JF, Ramakrishnan L.

Dis Model Mech. 2014 Jul;7(7):731-3. doi: 10.1242/dmm.017004.

31.

Development and bioorthogonal activation of palladium-labile prodrugs of gemcitabine.

Weiss JT, Dawson JC, Fraser C, Rybski W, Torres-Sánchez C, Bradley M, Patton EE, Carragher NO, Unciti-Broceta A.

J Med Chem. 2014 Jun 26;57(12):5395-404. doi: 10.1021/jm500531z. Epub 2014 Jun 12.

32.

Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach.

Weiss JT, Dawson JC, Macleod KG, Rybski W, Fraser C, Torres-Sánchez C, Patton EE, Bradley M, Carragher NO, Unciti-Broceta A.

Nat Commun. 2014;5:3277. doi: 10.1038/ncomms4277.

33.

The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models.

Yen J, White RM, Wedge DC, Van Loo P, de Ridder J, Capper A, Richardson J, Jones D, Raine K, Watson IR, Wu CJ, Cheng J, Martincorena I, Nik-Zainal S, Mudie L, Moreau Y, Marshall J, Ramakrishna M, Tarpey P, Shlien A, Whitmore I, Gamble S, Latimer C, Langdon E, Kaufman C, Dovey M, Taylor A, Menzies A, McLaren S, O'Meara S, Butler A, Teague J, Lister J, Chin L, Campbell P, Adams DJ, Zon LI, Patton EE, Stemple DL, Futreal PA.

Genome Biol. 2013;14(10):R113.

34.

DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans.

Longman D, Hug N, Keith M, Anastasaki C, Patton EE, Grimes G, Cáceres JF.

Nucleic Acids Res. 2013 Sep;41(17):8319-31. doi: 10.1093/nar/gkt585. Epub 2013 Jul 4.

35.

Dopamine from the brain promotes spinal motor neuron generation during development and adult regeneration.

Reimer MM, Norris A, Ohnmacht J, Patani R, Zhong Z, Dias TB, Kuscha V, Scott AL, Chen YC, Rozov S, Frazer SL, Wyatt C, Higashijima S, Patton EE, Panula P, Chandran S, Becker T, Becker CG.

Dev Cell. 2013 Jun 10;25(5):478-91. doi: 10.1016/j.devcel.2013.04.012. Epub 2013 May 23.

36.

Cancer: Trouble upstream.

Patton EE, Harrington L.

Nature. 2013 Mar 21;495(7441):320-1. doi: 10.1038/495320a. No abstract available.

PMID:
23518559
37.

ALDH2 mediates 5-nitrofuran activity in multiple species.

Zhou L, Ishizaki H, Spitzer M, Taylor KL, Temperley ND, Johnson SL, Brear P, Gautier P, Zeng Z, Mitchell A, Narayan V, McNeil EM, Melton DW, Smith TK, Tyers M, Westwood NJ, Patton EE.

Chem Biol. 2012 Jul 27;19(7):883-92. doi: 10.1016/j.chembiol.2012.05.017.

38.

Live imaging in zebrafish reveals neu(trophil) insight into the metastatic niche.

Patton EE.

J Pathol. 2012 Aug;227(4):381-4. doi: 10.1002/path.4051. Epub 2012 Jul 2.

PMID:
22611003
39.

Continual low-level MEK inhibition ameliorates cardio-facio-cutaneous phenotypes in zebrafish.

Anastasaki C, Rauen KA, Patton EE.

Dis Model Mech. 2012 Jul;5(4):546-52. doi: 10.1242/dmm.008672. Epub 2012 Feb 2.

40.

Small molecule screening identifies targetable zebrafish pigmentation pathways.

Colanesi S, Taylor KL, Temperley ND, Lundegaard PR, Liu D, North TE, Ishizaki H, Kelsh RN, Patton EE.

Pigment Cell Melanoma Res. 2012 Mar;25(2):131-43. doi: 10.1111/j.1755-148X.2012.00977.x.

PMID:
22252091
41.

Generating and analyzing fish models of melanoma.

Patton EE, Mathers ME, Schartl M.

Methods Cell Biol. 2011;105:339-66. doi: 10.1016/B978-0-12-381320-6.00014-X.

PMID:
21951537
42.

Differentiated melanocyte cell division occurs in vivo and is promoted by mutations in Mitf.

Taylor KL, Lister JA, Zeng Z, Ishizaki H, Anderson C, Kelsh RN, Jackson IJ, Patton EE.

Development. 2011 Aug;138(16):3579-89. doi: 10.1242/dev.064014. Epub 2011 Jul 19.

43.

A zebrafish model for nevus regeneration.

Richardson J, Zeng Z, Ceol C, Mione M, Jackson IJ, Patton EE.

Pigment Cell Melanoma Res. 2011 Apr;24(2):378-81. doi: 10.1111/j.1755-148X.2011.00839.x. No abstract available.

44.

Rapid synthesis and zebrafish evaluation of a phenanthridine-based small molecule library.

Donaldson LR, Wallace S, Haigh D, Patton EE, Hulme AN.

Org Biomol Chem. 2011 Apr 7;9(7):2233-9. doi: 10.1039/c0ob00449a. Epub 2011 Feb 7.

PMID:
21298172
45.

Knockdown of the zebrafish ortholog of the retinitis pigmentosa 2 (RP2) gene results in retinal degeneration.

Shu X, Zeng Z, Gautier P, Lennon A, Gakovic M, Cheetham ME, Patton EE, Wright AF.

Invest Ophthalmol Vis Sci. 2011 May 5;52(6):2960-6. doi: 10.1167/iovs.10-6800.

PMID:
21282572
46.

Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish.

Anastasaki C, Longman D, Capper A, Patton EE, Cáceres JF.

Nucleic Acids Res. 2011 May;39(9):3686-94. doi: 10.1093/nar/gkq1319. Epub 2011 Jan 11.

47.

Combined zebrafish-yeast chemical-genetic screens reveal gene-copper-nutrition interactions that modulate melanocyte pigmentation.

Ishizaki H, Spitzer M, Wildenhain J, Anastasaki C, Zeng Z, Dolma S, Shaw M, Madsen E, Gitlin J, Marais R, Tyers M, Patton EE.

Dis Model Mech. 2010 Sep-Oct;3(9-10):639-51. doi: 10.1242/dmm.005769. Epub 2010 Aug 16.

48.

Small molecule screening in zebrafish: an in vivo approach to identifying new chemical tools and drug leads.

Taylor KL, Grant NJ, Temperley ND, Patton EE.

Cell Commun Signal. 2010 Jun 12;8:11. doi: 10.1186/1478-811X-8-11.

49.

Sharing chemical libraries within the European zebrafish community.

Grabher C, Patton EE, Strähle U.

Zebrafish. 2010 Mar;7(1):83. doi: 10.1089/zeb.2010.0651. No abstract available.

PMID:
20384485
50.

Genetic and environmental melanoma models in fish.

Patton EE, Mitchell DL, Nairn RS.

Pigment Cell Melanoma Res. 2010 Jun;23(3):314-37. doi: 10.1111/j.1755-148X.2010.00693.x. Epub 2010 Mar 8. Review.

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