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Structure, function and disease relevance of Wnt inhibitory factor 1, a secreted protein controlling the Wnt and hedgehog pathways.

Kerekes K, Bányai L, Trexler M, Patthy L.

Growth Factors. 2019 Apr;37(1-2):29-52. doi: 10.1080/08977194.2019.1626380. Epub 2019 Jun 18. Review.


Morphological Stasis and Proteome Innovation in Cephalochordates.

Bányai L, Kerekes K, Trexler M, Patthy L.

Genes (Basel). 2018 Jul 16;9(7). pii: E353. doi: 10.3390/genes9070353.


Influence of WFIKKN1 on BMP1-mediated activation of latent myostatin.

Szláma G, Vásárhelyi V, Trexler M, Patthy L.

FEBS J. 2016 Dec;283(24):4515-4527. doi: 10.1111/febs.13938. Epub 2016 Nov 16.


Identification and Correction of Erroneous Protein Sequences in Public Databases.

Patthy L.

Methods Mol Biol. 2016;1415:179-92. doi: 10.1007/978-1-4939-3572-7_9.


Wnts grasp the WIF domain of Wnt Inhibitory Factor 1 at two distinct binding sites.

Kerekes K, Bányai L, Patthy L.

FEBS Lett. 2015 Oct 7;589(20 Pt B):3044-51. doi: 10.1016/j.febslet.2015.08.031. Epub 2015 Sep 2.


K153R polymorphism in myostatin gene increases the rate of promyostatin activation by furin.

Szláma G, Trexler M, Buday L, Patthy L.

FEBS Lett. 2015 Jan 30;589(3):295-301. doi: 10.1016/j.febslet.2014.12.011. Epub 2014 Dec 25.


FixPred: a resource for correction of erroneous protein sequences.

Nagy A, Patthy L.

Database (Oxford). 2014 Apr 4;2014:bau032. doi: 10.1093/database/bau032. Print 2014.


Both LCCL-domains of human CRISPLD2 have high affinity for lipid A.

Vásárhelyi V, Trexler M, Patthy L.

Biochimie. 2014 Feb;97:66-71. doi: 10.1016/j.biochi.2013.09.021. Epub 2013 Oct 1.


MisPred: a resource for identification of erroneous protein sequences in public databases.

Nagy A, Patthy L.

Database (Oxford). 2013 Jul 17;2013:bat053. doi: 10.1093/database/bat053. Print 2013.


Latent myostatin has significant activity and this activity is controlled more efficiently by WFIKKN1 than by WFIKKN2.

Szláma G, Trexler M, Patthy L.

FEBS J. 2013 Aug;280(16):3822-39. doi: 10.1111/febs.12377. Epub 2013 Jul 5.


Characterization of a Wnt-binding site of the WIF-domain of Wnt inhibitory factor-1.

Bányai L, Kerekes K, Patthy L.

FEBS Lett. 2012 Sep 21;586(19):3122-6. doi: 10.1016/j.febslet.2012.07.072. Epub 2012 Aug 8.


A novel COCH mutation associated with autosomal dominant nonsyndromic hearing loss disrupts the structural stability of the vWFA2 domain.

Cho HJ, Park HJ, Trexler M, Venselaar H, Lee KY, Robertson NG, Baek JI, Kang BS, Morton CC, Vriend G, Patthy L, Kim UK.

J Mol Med (Berl). 2012 Nov;90(11):1321-1331. doi: 10.1007/s00109-012-0911-2. Epub 2012 May 19.


Biological functions of the WAP domain-containing multidomain proteins WFIKKN1 and WFIKKN2.

Kondás K, Szláma G, Nagy A, Trexler M, Patthy L.

Biochem Soc Trans. 2011 Oct;39(5):1416-20. doi: 10.1042/BST0391416. Review.


A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uparap/ENDO180.

Jürgensen HJ, Madsen DH, Ingvarsen S, Melander MC, Gårdsvoll H, Patthy L, Engelholm LH, Behrendt N.

J Biol Chem. 2011 Sep 16;286(37):32736-48. doi: 10.1074/jbc.M111.266692. Epub 2011 Jul 18.


Correction: Nagy, A., et al. Reassessing Domain Architecture Evolution of Metazoan Proteins: Major Impact of Gene Prediction Errors. Genes 2011, 2, 449-501.

Nagy A, Szláma G, Szarka E, Trexler M, Bányai L, Patthy L.

Genes (Basel). 2011 Aug 16;2(3):599-607. doi: 10.3390/genes2030599.


Reassessing domain architecture evolution of metazoan proteins: major impact of errors caused by confusing paralogs and epaktologs.

Nagy A, Bányai L, Patthy L.

Genes (Basel). 2011 Aug 2;2(3):516-61. doi: 10.3390/genes2030516.


Reassessing domain architecture evolution of metazoan proteins: major impact of gene prediction errors.

Nagy A, Szláma G, Szarka E, Trexler M, Bányai L, Patthy L.

Genes (Basel). 2011 Jul 13;2(3):449-501. doi: 10.3390/genes2030449. Erratum in: Genes (Basel). 2011;2(3):599-607.


WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity.

Szláma G, Kondás K, Trexler M, Patthy L.

FEBS J. 2010 Dec;277(24):5040-50. doi: 10.1111/j.1742-4658.2010.07909.x. Epub 2010 Nov 5.


Agrin binds BMP2, BMP4 and TGFbeta1.

Bányai L, Sonderegger P, Patthy L.

PLoS One. 2010 May 21;5(5):e10758. doi: 10.1371/journal.pone.0010758.


[Developments in cancer care with innovative genomics. 2008 report of the National Cancer Consortium].

Tímár J, Kásler M, Heringh A, Soós M, Mathiász D, Romány A, Józsa A, Szilák L, Forrai T, Patthy L, Kovács G.

Magy Onkol. 2009 Dec;53(4):321-34. doi: 10.1556/MOnkol.53.2009.4.1. Hungarian.


Identifying protein-coding genes in genomic sequences.

Harrow J, Nagy A, Reymond A, Alioto T, Patthy L, Antonarakis SE, Guigó R.

Genome Biol. 2009;10(1):201. doi: 10.1186/gb-2009-10-1-201. Epub 2009 Jan 30. Review.


The second von Willebrand type A domain of cochlin has high affinity for type I, type II and type IV collagens.

Nagy I, Trexler M, Patthy L.

FEBS Lett. 2008 Dec 10;582(29):4003-7. doi: 10.1016/j.febslet.2008.10.050. Epub 2008 Nov 12.


NMR solution structure of the neurotrypsin Kringle domain.

Ozhogina OA, Grishaev A, Bominaar EL, Patthy L, Trexler M, Llinás M.

Biochemistry. 2008 Nov 25;47(47):12290-8. doi: 10.1021/bi800555z.


Identification and correction of abnormal, incomplete and mispredicted proteins in public databases.

Nagy A, Hegyi H, Farkas K, Tordai H, Kozma E, Bányai L, Patthy L.

BMC Bioinformatics. 2008 Aug 27;9:353. doi: 10.1186/1471-2105-9-353.


Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11.

Kondás K, Szláma G, Trexler M, Patthy L.

J Biol Chem. 2008 Aug 29;283(35):23677-84. doi: 10.1074/jbc.M803025200. Epub 2008 Jul 1.


Collagen-binding domains of gelatinase A and thrombospondin-derived peptides impede endocytic clearance of active gelatinase A and promote HT1080 fibrosarcoma cell invasion.

Robinet A, Emonard H, Banyai L, Laronze JY, Patthy L, Hornebeck W, Bellon G.

Life Sci. 2008 Feb 13;82(7-8):376-82. doi: 10.1016/j.lfs.2007.11.018. Epub 2007 Dec 5.


Comment on "Tequila, a neurotrypsin ortholog, regulates long-term memory formation in Drosophila".

Sonderegger P, Patthy L.

Science. 2007 Jun 22;316(5832):1698; author reply 1698.


The implications of alternative splicing in the ENCODE protein complement.

Tress ML, Martelli PL, Frankish A, Reeves GA, Wesselink JJ, Yeats C, Olason PI, Albrecht M, Hegyi H, Giorgetti A, Raimondo D, Lagarde J, Laskowski RA, López G, Sadowski MI, Watson JD, Fariselli P, Rossi I, Nagy A, Kai W, Størling Z, Orsini M, Assenov Y, Blankenburg H, Huthmacher C, Ramírez F, Schlicker A, Denoeud F, Jones P, Kerrien S, Orchard S, Antonarakis SE, Reymond A, Birney E, Brunak S, Casadio R, Guigo R, Harrow J, Hermjakob H, Jones DT, Lengauer T, Orengo CA, Patthy L, Thornton JM, Tramontano A, Valencia A.

Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5495-500. Epub 2007 Mar 19.


[Developments in cancer management by innovative genomics. 2006 report of the National Cancer Consortium].

Tímár J, Kásler M, Kátai J, Soós M, Mathiasz D, Romány A, Patthy L, Kovács G, Józsa A, Szilák L, Forrai T.

Magy Onkol. 2006;50(4):349-59. Epub 2007 Jan 10. Review. Hungarian.


Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein.

Liepinsh E, Nagy A, Trexler M, Patthy L, Otting G.

J Biomol NMR. 2006 May;35(1):73-8. Epub 2006 Jun 1. No abstract available.


NMR structure of the WIF domain of the human Wnt-inhibitory factor-1.

Liepinsh E, Bányai L, Patthy L, Otting G.

J Mol Biol. 2006 Mar 31;357(3):942-50. Epub 2006 Jan 31.


Modules, multidomain proteins and organismic complexity.

Tordai H, Nagy A, Farkas K, Bányai L, Patthy L.

FEBS J. 2005 Oct;272(19):5064-78.


Hydroxamate-based peptide inhibitors of matrix metalloprotease 2.

Jani M, Tordai H, Trexler M, Bányai L, Patthy L.

Biochimie. 2005 Mar-Apr;87(3-4):385-92.


DoOP: Databases of Orthologous Promoters, collections of clusters of orthologous upstream sequences from chordates and plants.

Barta E, Sebestyén E, Pálfy TB, Tóth G, Ortutay CP, Patthy L.

Nucleic Acids Res. 2005 Jan 1;33(Database issue):D86-90.


Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2.TIMP-2 complex through a thrombospondin-independent mechanism.

Emonard H, Bellon G, Troeberg L, Berton A, Robinet A, Henriet P, Marbaix E, Kirkegaard K, Patthy L, Eeckhout Y, Nagase H, Hornebeck W, Courtoy PJ.

J Biol Chem. 2004 Dec 24;279(52):54944-51. Epub 2004 Oct 15.


Modular autonomy, ligand specificity, and functional cooperativity of the three in-tandem fibronectin type II repeats from human matrix metalloproteinase 2.

Gehrmann ML, Douglas JT, Bányai L, Tordai H, Patthy L, Llinás M.

J Biol Chem. 2004 Nov 5;279(45):46921-9. Epub 2004 Aug 17.


Gene Symbol: COCH. Disease: DFNA9.

Patthy L, Nagy I, Horváth M, Trexler M, Répássy G.

Hum Genet. 2004 May;114(6):607. No abstract available.


A novel COCH mutation, V104del, impairs folding of the LCCL domain of cochlin and causes progressive hearing loss.

Nagy I, Horváth M, Trexler M, Répássy G, Patthy L.

J Med Genet. 2004 Jan;41(1):e9. No abstract available.


Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach.

Gan L, Ye S, Chu A, Anton K, Yi S, Vincent VA, von Schack D, Chin D, Murray J, Lohr S, Patthy L, Gonzalez-Zulueta M, Nikolich K, Urfer R.

J Biol Chem. 2004 Feb 13;279(7):5565-72. Epub 2003 Nov 10. Erratum in: J Biol Chem. 2004 May 28;279(22):23845.


Mutations in the COCH gene are a frequent cause of autosomal dominant progressive cochleo-vestibular dysfunction, but not of Meniere's disease.

Usami S, Takahashi K, Yuge I, Ohtsuka A, Namba A, Abe S, Fransen E, Patthy L, Otting G, Van Camp G.

Eur J Hum Genet. 2003 Oct;11(10):744-8.


Mapping modifiers affecting muscularity of the myostatin mutant (Mstn(Cmpt-dl1Abc)) compact mouse.

Varga L, Müller G, Szabó G, Pinke O, Korom E, Kovács B, Patthy L, Soller M.

Genetics. 2003 Sep;165(1):257-67.


Modular assembly of genes and the evolution of new functions.

Patthy L.

Genetica. 2003 Jul;118(2-3):217-31. Review.


Expression and characterization of the olfactomedin domain of human myocilin.

Nagy I, Trexler M, Patthy L.

Biochem Biophys Res Commun. 2003 Mar 14;302(3):554-61.


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