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A Quantitative HILIC-MS/MS Assay of the Metabolic Response of Huh-7 Cells Exposed to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.

Liu Q, Cai J, Nichols RG, Tian Y, Zhang J, Smith PB, Wang Y, Yan C, Patterson AD.

Metabolites. 2019 Jun 20;9(6). pii: E118. doi: 10.3390/metabo9060118.


Interplay Between the Host, the Human Microbiome, and Drug Metabolism.

Nichols RG, Peters JM, Patterson AD.

Hum Genomics. 2019 Jun 11;13(1):27. doi: 10.1186/s40246-019-0211-9. Review.


Nutrient Sensing in CD11c Cells Alters the Gut Microbiota to Regulate Food Intake and Body Mass.

Chagwedera DN, Ang QY, Bisanz JE, Leong YA, Ganeshan K, Cai J, Patterson AD, Turnbaugh PJ, Chawla A.

Cell Metab. 2019 May 21. pii: S1550-4131(19)30242-6. doi: 10.1016/j.cmet.2019.05.002. [Epub ahead of print]


A review of analytical platforms for accurate bile acid measurement.

Dutta M, Cai J, Gui W, Patterson AD.

Anal Bioanal Chem. 2019 Jul;411(19):4541-4549. doi: 10.1007/s00216-019-01890-3. Epub 2019 May 24. Review.


Evaluating the structural complexity of isomeric bile acids with ion mobility spectrometry.

Zheng X, Smith FB, Aly NA, Cai J, Smith RD, Patterson AD, Baker ES.

Anal Bioanal Chem. 2019 Jul;411(19):4673-4682. doi: 10.1007/s00216-019-01869-0. Epub 2019 May 16.


Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline.

Hubbard TD, Liu Q, Murray IA, Dong F, Miller C 3rd, Smith PB, Gowda K, Lin JM, Amin S, Patterson AD, Perdew GH.

J Proteome Res. 2019 Apr 5;18(4):1715-1724. doi: 10.1021/acs.jproteome.8b00946. Epub 2019 Mar 4.


Retinoic Acid Mediated Clearance of Citrobacter rodentium in Vitamin A Deficient Mice Requires CD11b+ and T Cells.

Snyder LM, McDaniel KL, Tian Y, Wei CH, Kennett MJ, Patterson AD, Ross AC, Cantorna MT.

Front Immunol. 2019 Jan 8;9:3090. doi: 10.3389/fimmu.2018.03090. eCollection 2018.


Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation.

Singh V, Yeoh BS, Walker RE, Xiao X, Saha P, Golonka RM, Cai J, Bretin ACA, Cheng X, Liu Q, Flythe MD, Chassaing B, Shearer GC, Patterson AD, Gewirtz AT, Vijay-Kumar M.

Gut. 2019 Jan 22. pii: gutjnl-2018-316250. doi: 10.1136/gutjnl-2018-316250. [Epub ahead of print]


Multiplatform Physiologic and Metabolic Phenotyping Reveals Microbial Toxicity.

Cai J, Nichols RG, Koo I, Kalikow ZA, Zhang L, Tian Y, Zhang J, Smith PB, Patterson AD.

mSystems. 2018 Nov 6;3(6). pii: e00123-18. doi: 10.1128/mSystems.00123-18. eCollection 2018 Nov-Dec.


Berberine Directly Affects the Gut Microbiota to Promote Intestinal Farnesoid X Receptor Activation.

Tian Y, Cai J, Gui W, Nichols RG, Koo I, Zhang J, Anitha M, Patterson AD.

Drug Metab Dispos. 2019 Feb;47(2):86-93. doi: 10.1124/dmd.118.083691. Epub 2018 Nov 8.


Gut microbiota and intestinal FXR mediate the clinical benefits of metformin.

Sun L, Xie C, Wang G, Wu Y, Wu Q, Wang X, Liu J, Deng Y, Xia J, Chen B, Zhang S, Yun C, Lian G, Zhang X, Zhang H, Bisson WH, Shi J, Gao X, Ge P, Liu C, Krausz KW, Nichols RG, Cai J, Rimal B, Patterson AD, Wang X, Gonzalez FJ, Jiang C.

Nat Med. 2018 Dec;24(12):1919-1929. doi: 10.1038/s41591-018-0222-4. Epub 2018 Nov 5.


Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer.

Singh V, Yeoh BS, Chassaing B, Xiao X, Saha P, Aguilera Olvera R, Lapek JD Jr, Zhang L, Wang WB, Hao S, Flythe MD, Gonzalez DJ, Cani PD, Conejo-Garcia JR, Xiong N, Kennett MJ, Joe B, Patterson AD, Gewirtz AT, Vijay-Kumar M.

Cell. 2018 Oct 18;175(3):679-694.e22. doi: 10.1016/j.cell.2018.09.004.


Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism.

Chen F, Coslo DM, Chen T, Zhang L, Tian Y, Smith PB, Patterson AD, Omiecinski CJ.

J Proteome Res. 2019 Jan 4;18(1):239-251. doi: 10.1021/acs.jproteome.8b00566. Epub 2018 Oct 30.


Structural and Functional Analysis of the Gut Microbiome for Toxicologists.

Nichols RG, Cai J, Murray IA, Koo I, Smith PB, Perdew GH, Patterson AD.

Curr Protoc Toxicol. 2018 Nov;78(1):e54. doi: 10.1002/cptx.54. Epub 2018 Sep 19.


Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model.

Allen J, Zhang J, Quickel MD, Kennett M, Patterson AD, Hankey-Giblin PA.

J Proteome Res. 2018 Sep 7;17(9):3268-3280. doi: 10.1021/acs.jproteome.8b00379. Epub 2018 Aug 23.


Molecular Regulation of Carcinogenesis: Friend and Foe.

Patterson AD, Gonzalez FJ, Perdew GH, Peters JM.

Toxicol Sci. 2018 Oct 1;165(2):277-283. doi: 10.1093/toxsci/kfy185.


The association of lipophilic phospholipids with native bovine casein micelles in skim milk: Effect of lactation stage and casein micelle size.

Cheema M, Smith PB, Patterson AD, Hristov A, Harte FM.

J Dairy Sci. 2018 Oct;101(10):8672-8687. doi: 10.3168/jds.2017-14137. Epub 2018 Jul 19.


The Gut Microbiota Regulates Endocrine Vitamin D Metabolism through Fibroblast Growth Factor 23.

Bora SA, Kennett MJ, Smith PB, Patterson AD, Cantorna MT.

Front Immunol. 2018 Mar 2;9:408. doi: 10.3389/fimmu.2018.00408. eCollection 2018.


The aryl hydrocarbon receptor as a moderator of host-microbiota communication.

Zhang L, Nichols RG, Patterson AD.

Curr Opin Toxicol. 2017 Feb;2:30-35. doi: 10.1016/j.cotox.2017.02.001. Epub 2017 Feb 12.


Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice.

Belton KR, Tian Y, Zhang L, Anitha M, Smith PB, Perdew GH, Patterson AD.

J Proteome Res. 2018 Apr 6;17(4):1375-1382. doi: 10.1021/acs.jproteome.7b00709. Epub 2018 Mar 21.


Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism.

Pathak P, Xie C, Nichols RG, Ferrell JM, Boehme S, Krausz KW, Patterson AD, Gonzalez FJ, Chiang JYL.

Hepatology. 2018 Oct;68(4):1574-1588. doi: 10.1002/hep.29857. Epub 2018 May 21.


Regulation of vitamin D metabolism following disruption of the microbiota using broad spectrum antibiotics.

Bora SA, Kennett MJ, Smith PB, Patterson AD, Cantorna MT.

J Nutr Biochem. 2018 Jun;56:65-73. doi: 10.1016/j.jnutbio.2018.01.011. Epub 2018 Feb 2.


Lipid metabolism and lipophagy in cancer.

Maan M, Peters JM, Dutta M, Patterson AD.

Biochem Biophys Res Commun. 2018 Oct 7;504(3):582-589. doi: 10.1016/j.bbrc.2018.02.097. Epub 2018 Feb 10. Review.


Dietary Broccoli Impacts Microbial Community Structure and Attenuates Chemically Induced Colitis in Mice in an Ah receptor dependent manner.

Hubbard TD, Murray IA, Nichols RG, Cassel K, Podolsky M, Kuzu G, Tian Y, Smith P, Kennett MJ, Patterson AD, Perdew GH.

J Funct Foods. 2017 Oct;37:685-698. doi: 10.1016/j.jff.2017.08.038. Epub 2017 Sep 1.


Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis.

Tian Y, Nichols RG, Cai J, Patterson AD, Cantorna MT.

J Nutr Biochem. 2018 Apr;54:28-34. doi: 10.1016/j.jnutbio.2017.10.011. Epub 2017 Nov 5.


Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota.

Li G, Xie C, Lu S, Nichols RG, Tian Y, Li L, Patel D, Ma Y, Brocker CN, Yan T, Krausz KW, Xiang R, Gavrilova O, Patterson AD, Gonzalez FJ.

Cell Metab. 2017 Nov 7;26(5):801. doi: 10.1016/j.cmet.2017.10.007. No abstract available.


Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis.

Xie C, Yagai T, Luo Y, Liang X, Chen T, Wang Q, Sun D, Zhao J, Ramakrishnan SK, Sun L, Jiang C, Xue X, Tian Y, Krausz KW, Patterson AD, Shah YM, Wu Y, Jiang C, Gonzalez FJ.

Nat Med. 2017 Nov;23(11):1298-1308. doi: 10.1038/nm.4412. Epub 2017 Oct 9.


Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota.

Li G, Xie C, Lu S, Nichols RG, Tian Y, Li L, Patel D, Ma Y, Brocker CN, Yan T, Krausz KW, Xiang R, Gavrilova O, Patterson AD, Gonzalez FJ.

Cell Metab. 2017 Oct 3;26(4):672-685.e4. doi: 10.1016/j.cmet.2017.08.019. Epub 2017 Sep 14. Erratum in: Cell Metab. 2017 Nov 7;26(5):801.


Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA.

DiMarzio M, Rusconi B, Yennawar NH, Eppinger M, Patterson AD, Dudley EG.

PLoS One. 2017 Sep 14;12(9):e0183564. doi: 10.1371/journal.pone.0183564. eCollection 2017.


Orthogonal Comparison of GC-MS and 1H NMR Spectroscopy for Short Chain Fatty Acid Quantitation.

Cai J, Zhang J, Tian Y, Zhang L, Hatzakis E, Krausz KW, Smith PB, Gonzalez FJ, Patterson AD.

Anal Chem. 2017 Aug 1;89(15):7900-7906. doi: 10.1021/acs.analchem.7b00848. Epub 2017 Jul 12.


Lipid Emulsion Added to a Liquid High-Carbohydrate Diet and Voluntary Running Exercise Reduce Lipogenesis and Ameliorate Early-Stage Hepatic Steatosis in Mice.

Huang KH, Hao L, Smith PB, Rogers CJ, Patterson AD, Ross AC.

J Nutr. 2017 May;147(5):746-753. doi: 10.3945/jn.116.245951. Epub 2017 Mar 15.


Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease.

Gonzalez FJ, Jiang C, Xie C, Patterson AD.

Dig Dis. 2017;35(3):178-184. doi: 10.1159/000450908. Epub 2017 Mar 1. Review.


An Intestinal Farnesoid X Receptor-Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice.

Xie C, Jiang C, Shi J, Gao X, Sun D, Sun L, Wang T, Takahashi S, Anitha M, Krausz KW, Patterson AD, Gonzalez FJ.

Diabetes. 2017 Mar;66(3):613-626. doi: 10.2337/db16-0663. Epub 2016 Nov 8.


Modulation of urinary siderophores by the diet, gut microbiota and inflammation in mice.

Xiao X, Yeoh BS, Saha P, Tian Y, Singh V, Patterson AD, Vijay-Kumar M.

J Nutr Biochem. 2017 Mar;41:25-33. doi: 10.1016/j.jnutbio.2016.11.014. Epub 2016 Dec 2.


Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism.

Zhang L, Xie C, Nichols RG, Chan SH, Jiang C, Hao R, Smith PB, Cai J, Simons MN, Hatzakis E, Maranas CD, Gonzalez FJ, Patterson AD.

mSystems. 2016 Oct 11;1(5). pii: e00070-16. eCollection 2016 Sep-Oct.


Omics Approaches To Probe Microbiota and Drug Metabolism Interactions.

Nichols RG, Hume NE, Smith PB, Peters JM, Patterson AD.

Chem Res Toxicol. 2016 Dec 19;29(12):1987-1997. Epub 2016 Oct 26. Review.


Expression of the aryl hydrocarbon receptor contributes to the establishment of intestinal microbial community structure in mice.

Murray IA, Nichols RG, Zhang L, Patterson AD, Perdew GH.

Sci Rep. 2016 Sep 23;6:33969. doi: 10.1038/srep33969.


An Intestinal Microbiota-Farnesoid X Receptor Axis Modulates Metabolic Disease.

Gonzalez FJ, Jiang C, Patterson AD.

Gastroenterology. 2016 Nov;151(5):845-859. doi: 10.1053/j.gastro.2016.08.057. Epub 2016 Sep 14. Review.


Editor's Highlight: Perfluorooctane Sulfonate-Choline Ion Pair Formation: A Potential Mechanism Modulating Hepatic Steatosis and Oxidative Stress in Mice.

Zhang L, Krishnan P, Ehresman DJ, Smith PB, Dutta M, Bagley BD, Chang SC, Butenhoff JL, Patterson AD, Peters JM.

Toxicol Sci. 2016 Sep;153(1):186-97. doi: 10.1093/toxsci/kfw120. Epub 2016 Jul 13.


Factual accuracy and the cultural context of science in popular media: Perspectives of media makers, middle school students, and university students on an entertainment television program.

Szu E, Osborne J, Patterson AD.

Public Underst Sci. 2017 Jul;26(5):596-611. doi: 10.1177/0963662516655685. Epub 2016 Jun 23.


Metabolomics Reveals Altered Lipid Metabolism in a Mouse Model of Endometriosis.

Dutta M, Anitha M, Smith PB, Chiaro CR, Maan M, Chaudhury K, Patterson AD.

J Proteome Res. 2016 Aug 5;15(8):2626-33. doi: 10.1021/acs.jproteome.6b00197. Epub 2016 Jul 5.


Mass Spectrometry-Based Metabolomics Identifies Longitudinal Urinary Metabolite Profiles Predictive of Radiation-Induced Cancer.

Cook JA, Chandramouli GV, Anver MR, Sowers AL, Thetford A, Krausz KW, Gonzalez FJ, Mitchell JB, Patterson AD.

Cancer Res. 2016 Mar 15;76(6):1569-77. doi: 10.1158/0008-5472.CAN-15-2416. Epub 2016 Feb 15.


Reversing methanogenesis to capture methane for liquid biofuel precursors.

Soo VW, McAnulty MJ, Tripathi A, Zhu F, Zhang L, Hatzakis E, Smith PB, Agrawal S, Nazem-Bokaee H, Gopalakrishnan S, Salis HM, Ferry JG, Maranas CD, Patterson AD, Wood TK.

Microb Cell Fact. 2016 Jan 14;15:11. doi: 10.1186/s12934-015-0397-z.


Antioxidant Drug Tempol Promotes Functional Metabolic Changes in the Gut Microbiota.

Cai J, Zhang L, Jones RA, Correll JB, Hatzakis E, Smith PB, Gonzalez FJ, Patterson AD.

J Proteome Res. 2016 Feb 5;15(2):563-71. doi: 10.1021/acs.jproteome.5b00957. Epub 2016 Jan 12.


Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction.

Jiang C, Xie C, Lv Y, Li J, Krausz KW, Shi J, Brocker CN, Desai D, Amin SG, Bisson WH, Liu Y, Gavrilova O, Patterson AD, Gonzalez FJ.

Nat Commun. 2015 Dec 15;6:10166. doi: 10.1038/ncomms10166.


Impaired recovery from peritoneal inflammation in a mouse model of mild dietary zinc restriction.

Phillips BE, Geletzke AK, Smith PB, Podany AB, Chacon A, Kelleher SL, Patterson AD, Soybel DI.

Mol Nutr Food Res. 2016 Mar;60(3):672-81. doi: 10.1002/mnfr.201500688. Epub 2016 Feb 2.


Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice.

Singh V, Chassaing B, Zhang L, San Yeoh B, Xiao X, Kumar M, Baker MT, Cai J, Walker R, Borkowski K, Harvatine KJ, Singh N, Shearer GC, Ntambi JM, Joe B, Patterson AD, Gewirtz AT, Vijay-Kumar M.

Cell Metab. 2015 Dec 1;22(6):983-96. doi: 10.1016/j.cmet.2015.09.028. Epub 2015 Oct 29.


Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles.

Hubbard TD, Murray IA, Bisson WH, Lahoti TS, Gowda K, Amin SG, Patterson AD, Perdew GH.

Sci Rep. 2015 Aug 3;5:12689. doi: 10.1038/srep12689.


Lack of soluble fiber drives diet-induced adiposity in mice.

Chassaing B, Miles-Brown J, Pellizzon M, Ulman E, Ricci M, Zhang L, Patterson AD, Vijay-Kumar M, Gewirtz AT.

Am J Physiol Gastrointest Liver Physiol. 2015 Oct 1;309(7):G528-41. doi: 10.1152/ajpgi.00172.2015. Epub 2015 Jul 16.


Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice.

Zhang L, Hatzakis E, Nichols RG, Hao R, Correll J, Smith PB, Chiaro CR, Perdew GH, Patterson AD.

Environ Sci Technol. 2015 Jul 7;49(13):8067-77. doi: 10.1021/acs.est.5b01389. Epub 2015 Jun 12.

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