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Items: 45

1.

Targeted deletion of PD-1 in myeloid cells induces antitumor immunity.

Strauss L, Mahmoud MAA, Weaver JD, Tijaro-Ovalle NM, Christofides A, Wang Q, Pal R, Yuan M, Asara J, Patsoukis N, Boussiotis VA.

Sci Immunol. 2020 Jan 3;5(43). pii: eaay1863. doi: 10.1126/sciimmunol.aay1863.

PMID:
31901074
2.

Phosphorylation of PD-1-Y248 is a marker of PD-1-mediated inhibitory function in human T cells.

Bardhan K, Aksoylar HI, Bourgeois TL, Strauss L, Weaver JD, Delcuze B, Charest A, Patsoukis N, Boussiotis VA.

Sci Rep. 2019 Nov 21;9(1):17252. doi: 10.1038/s41598-019-53463-0.

3.

A secreted PD-L1 splice variant that covalently dimerizes and mediates immunosuppression.

Mahoney KM, Shukla SA, Patsoukis N, Chaudhri A, Browne EP, Arazi A, Eisenhaure TM, Pendergraft WF 3rd, Hua P, Pham HC, Bu X, Zhu B, Hacohen N, Fritsch EF, Boussiotis VA, Wu CJ, Freeman GJ.

Cancer Immunol Immunother. 2019 Mar;68(3):421-432. doi: 10.1007/s00262-018-2282-1. Epub 2018 Dec 18.

4.

Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches.

Yazicioglu YF, Aksoylar HI, Pal R, Patsoukis N, Boussiotis VA.

J Vis Exp. 2018 Nov 21;(141). doi: 10.3791/58490.

PMID:
30531720
5.

Targeting T Cell Metabolism for Improvement of Cancer Immunotherapy.

Le Bourgeois T, Strauss L, Aksoylar HI, Daneshmandi S, Seth P, Patsoukis N, Boussiotis VA.

Front Oncol. 2018 Aug 3;8:237. doi: 10.3389/fonc.2018.00237. eCollection 2018. Review.

6.

Publisher Correction: Feeling stressed? It might be your T cells.

Strauss L, Patsoukis N, Boussiotis VA.

Nat Immunol. 2018 Sep;19(9):1037. doi: 10.1038/s41590-018-0140-0.

PMID:
29955108
7.

Feeling stressed? It might be your T cells.

Strauss L, Patsoukis N, Boussiotis VA.

Nat Immunol. 2017 Nov 16;18(12):1281-1283. doi: 10.1038/ni.3872. No abstract available. Erratum in: Nat Immunol. 2018 Sep;19(9):1037.

PMID:
29144505
8.

The adaptor molecule RIAM integrates signaling events critical for integrin-mediated control of immune function and cancer progression.

Patsoukis N, Bardhan K, Weaver JD, Sari D, Torres-Gomez A, Li L, Strauss L, Lafuente EM, Boussiotis VA.

Sci Signal. 2017 Aug 22;10(493). pii: eaam8298. doi: 10.1126/scisignal.aam8298. Review.

PMID:
28831022
9.

Immunometabolic Regulations Mediated by Coinhibitory Receptors and Their Impact on T Cell Immune Responses.

Patsoukis N, Weaver JD, Strauss L, Herbel C, Seth P, Boussiotis VA.

Front Immunol. 2017 Apr 11;8:330. doi: 10.3389/fimmu.2017.00330. eCollection 2017. Review.

10.

Clinical significance of T cell metabolic reprogramming in cancer.

Herbel C, Patsoukis N, Bardhan K, Seth P, Weaver JD, Boussiotis VA.

Clin Transl Med. 2016 Dec;5(1):29. doi: 10.1186/s40169-016-0110-9. Epub 2016 Aug 10. Review.

11.

The role of metabolic reprogramming in T cell fate and function.

Patsoukis N, Bardhan K, Weaver J, Herbel C, Seth P, Li L, Boussiotis VA.

Curr Trends Immunol. 2016;17:1-12.

12.

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation.

Patsoukis N, Bardhan K, Chatterjee P, Sari D, Liu B, Bell LN, Karoly ED, Freeman GJ, Petkova V, Seth P, Li L, Boussiotis VA.

Nat Commun. 2015 Mar 26;6:6692. doi: 10.1038/ncomms7692.

13.

The cyclin dependent kinase inhibitor (R)-roscovitine mediates selective suppression of alloreactive human T cells but preserves pathogen-specific and leukemia-specific effectors.

Nellore A, Liu B, Patsoukis N, Boussiotis VA, Li L.

Clin Immunol. 2014 May-Jun;152(1-2):48-57. doi: 10.1016/j.clim.2014.02.015. Epub 2014 Mar 12.

14.

Prostaglandin E2 promotes survival of naive UCB T cells via the Wnt/β-catenin pathway and alters immune reconstitution after UCBT.

Li L, Kim HT, Nellore A, Patsoukis N, Petkova V, McDonough S, Politikos I, Nikiforow S, Soiffer R, Antin JH, Ballen K, Cutler C, Ritz J, Boussiotis VA.

Blood Cancer J. 2014 Jan 17;4:e178. doi: 10.1038/bcj.2013.75.

15.

PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2.

Patsoukis N, Li L, Sari D, Petkova V, Boussiotis VA.

Mol Cell Biol. 2013 Aug;33(16):3091-8. doi: 10.1128/MCB.00319-13. Epub 2013 Jun 3.

16.

Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector.

Wynne JP, Wu J, Su W, Mor A, Patsoukis N, Boussiotis VA, Hubbard SR, Philips MR.

J Cell Biol. 2012 Oct 15;199(2):317-30. doi: 10.1083/jcb.201201157. Epub 2012 Oct 8.

17.

PD-1 inhibits T cell proliferation by upregulating p27 and p15 and suppressing Cdc25A.

Patsoukis N, Sari D, Boussiotis VA.

Cell Cycle. 2012 Dec 1;11(23):4305-9. doi: 10.4161/cc.22135. Epub 2012 Oct 3.

18.

Runx1 and Runx3 are involved in the generation and function of highly suppressive IL-17-producing T regulatory cells.

Li L, Patsoukis N, Petkova V, Boussiotis VA.

PLoS One. 2012;7(9):e45115. doi: 10.1371/journal.pone.0045115. Epub 2012 Sep 12.

19.

Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation.

Patsoukis N, Brown J, Petkova V, Liu F, Li L, Boussiotis VA.

Sci Signal. 2012 Jun 26;5(230):ra46. doi: 10.1126/scisignal.2002796.

20.

RIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cells.

Patsoukis N, Lafuente EM, Meraner P, Kim Js, Dombkowski D, Li L, Boussiotis VA.

Sci Signal. 2009 Dec 1;2(99):ra79. doi: 10.1126/scisignal.2000409.

21.

Thiol redox state and related enzymes in sclerotium-forming filamentous phytopathogenic fungi.

Patsoukis N, Georgiou DC.

Mycol Res. 2008 May;112(Pt 5):602-10. doi: 10.1016/j.mycres.2007.10.006. Epub 2007 Nov 1.

PMID:
18400483
22.

Differentiation of Sclerotinia minor depends on thiol redox state and oxidative stress.

Patsoukis N, Georgiou CD.

Can J Microbiol. 2008 Jan;54(1):28-36. doi: 10.1139/w07-108.

PMID:
18388969
23.
24.

Effect of antioxidant treatments on the gut-liver axis oxidative status and function in bile duct-ligated rats.

Assimakopoulos SF, Maroulis I, Patsoukis N, Vagenas K, Scopa CD, Georgiou CD, Vagianos CE.

World J Surg. 2007 Oct;31(10):2023-32.

PMID:
17665241
25.
26.
27.

Sclerotial metamorphosis in filamentous fungi is induced by oxidative stress.

Georgiou CD, Patsoukis N, Papapostolou I, Zervoudakis G.

Integr Comp Biol. 2006 Dec;46(6):691-712. doi: 10.1093/icb/icj034. Epub 2006 Apr 26.

PMID:
21672779
28.

Evidence for oxidative stress in lens epithelial cells in pseudoexfoliation syndrome.

Gartaganis SP, Patsoukis NE, Nikolopoulos DK, Georgiou CD.

Eye (Lond). 2007 Nov;21(11):1406-11. Epub 2006 Sep 22.

PMID:
17001325
29.

Effect of N-acetylcysteine, allopurinol and vitamin E on jaundice-induced brain oxidative stress in rats.

Karageorgos N, Patsoukis N, Chroni E, Konstantinou D, Assimakopoulos SF, Georgiou C.

Brain Res. 2006 Sep 21;1111(1):203-12. Epub 2006 Aug 1.

PMID:
16884703
30.

Translational fidelity mutations in 18S rRNA affect the catalytic activity of ribosomes and the oxidative balance of yeast cells.

Konstantinidis TC, Patsoukis N, Georgiou CD, Synetos D.

Biochemistry. 2006 Mar 21;45(11):3525-33.

PMID:
16533033
31.

Evidence for intestinal oxidative stress in patients with obstructive jaundice.

Assimakopoulos SF, Thomopoulos KC, Patsoukis N, Georgiou CD, Scopa CD, Nikolopoulou VN, Vagianos CE.

Eur J Clin Invest. 2006 Mar;36(3):181-7.

PMID:
16506963
32.

Brain oxidative stress induced by obstructive jaundice in rats.

Chroni E, Patsoukis N, Karageorgos N, Konstantinou D, Georgiou C.

J Neuropathol Exp Neurol. 2006 Feb;65(2):193-8.

PMID:
16462210
33.

Fluorometric determination of thiol redox state.

Patsoukis N, Georgiou CD.

Anal Bioanal Chem. 2005 Nov;383(6):923-9. Epub 2005 Nov 9.

PMID:
16261319
34.

An ultrasensitive fluorescent assay for the in vivo quantification of superoxide radical in organisms.

Georgiou CD, Papapostolou I, Patsoukis N, Tsegenidis T, Sideris T.

Anal Biochem. 2005 Dec 1;347(1):144-51. Epub 2005 Sep 30.

PMID:
16246291
35.

Glutathione and lipid peroxide changes in pseudoexfoliation syndrome.

Gartaganis SP, Georgakopoulos CD, Patsoukis NE, Gotsis SS, Gartaganis VS, Georgiou CD.

Curr Eye Res. 2005 Aug;30(8):647-51.

PMID:
16109644
36.

Thiol redox state and lipid and protein oxidation in the mouse striatum after pentylenetetrazol-induced epileptic seizure.

Patsoukis N, Zervoudakis G, Georgiou CD, Angelatou F, Matsokis NA, Panagopoulos NT.

Epilepsia. 2005 Aug;46(8):1205-11.

37.

Assay for the quantification of small-sized fragmented genomic DNA.

Georgiou CD, Patsoukis N, Papapostolou I.

Anal Biochem. 2005 Apr 15;339(2):223-30.

PMID:
15797562
38.

Thiol redox state and oxidative stress in midbrain and striatum of weaver mutant mice, a genetic model of nigrostriatal dopamine deficiency.

Patsoukis N, Papapostolou I, Zervoudakis G, Georgiou CD, Matsokis NA, Panagopoulos NT.

Neurosci Lett. 2005 Mar 7;376(1):24-8. Epub 2004 Dec 15.

PMID:
15694268
39.

Interference of non-specific peroxidases in the fluorescence detection of superoxide radical by hydroethidine oxidation: a new assay for H2O2.

Patsoukis N, Papapostolou I, Georgiou CD.

Anal Bioanal Chem. 2005 Mar;381(5):1065-72. Epub 2005 Feb 3.

PMID:
15690180
40.

Effect of pentylenetetrazol-induced epileptic seizure on thiol redox state in the mouse cerebral cortex.

Patsoukis N, Zervoudakis G, Georgiou CD, Angelatou F, Matsokis NA, Panagopoulos NT.

Epilepsy Res. 2004 Nov;62(1):65-74.

PMID:
15519133
41.

The fluorescence detection of superoxide radical using hydroethidine could be complicated by the presence of heme proteins.

Papapostolou I, Patsoukis N, Georgiou CD.

Anal Biochem. 2004 Sep 15;332(2):290-8.

PMID:
15325298
42.

Oxidative state in intestine and liver after partial hepatectomy in rats. Effect of bombesin and neurotensin.

Alexandris IH, Assimakopoulos SF, Vagianos CE, Patsoukis N, Georgiou C, Nikolopoulou V, Scopa CD.

Clin Biochem. 2004 May;37(5):350-6.

PMID:
15087249
43.

Thiol redox state (TRS) and oxidative stress in the mouse hippocampus after pentylenetetrazol-induced epileptic seizure.

Patsoukis N, Zervoudakis G, Panagopoulos NT, Georgiou CD, Angelatou F, Matsokis NA.

Neurosci Lett. 2004 Mar 4;357(2):83-6.

PMID:
15036580
44.

Determination of the thiol redox state of organisms: new oxidative stress indicators.

Patsoukis N, Georgiou CD.

Anal Bioanal Chem. 2004 Apr;378(7):1783-92. Epub 2004 Feb 25.

PMID:
14985909
45.

Evidence for intestinal oxidative stress in obstructive jaundice-induced gut barrier dysfunction in rats.

Assimakopoulos SF, Vagianos CE, Patsoukis N, Georgiou C, Nikolopoulou V, Scopa CD.

Acta Physiol Scand. 2004 Feb;180(2):177-85.

PMID:
14738476

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