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Items: 24

1.

Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies.

Brüll M, Spreng AS, Gutbier S, Loser D, Krebs A, Reich M, Kraushaar U, Britschgi M, Patsch C, Leist M.

ALTEX. 2020 Mar 7. doi: 10.14573/altex.1911111. [Epub ahead of print]

2.

Identification of a combination of transcription factors that synergistically increases endothelial cell barrier resistance.

Roudnicky F, Kim BK, Lan Y, Schmucki R, Küppers V, Christensen K, Graf M, Patsch C, Burcin M, Meyer CA, Westenskow PD, Cowan CA.

Sci Rep. 2020 Mar 3;10(1):3886. doi: 10.1038/s41598-020-60688-x.

3.

Modeling the Effects of Severe Metabolic Disease by Genome Editing of hPSC-Derived Endothelial Cells Reveals an Inflammatory Phenotype.

Roudnicky F, Lan Y, Friesen M, Dernick G, Zhang JD, Staempfli A, Bordag N, Wagner-Golbs A, Christensen K, Ebeling M, Graf M, Burcin M, Meyer CA, Cowan CA, Patsch C.

Int J Mol Sci. 2019 Dec 9;20(24). pii: E6201. doi: 10.3390/ijms20246201.

4.

Gamma secretase modulators and BACE inhibitors reduce Aβ production without altering gene expression in Alzheimer's disease iPSC-derived neurons and mice.

Cusulin C, Wells I, Badillo S, Duran-Pacheco GC, Baumann K, Patsch C.

Mol Cell Neurosci. 2019 Oct;100:103392. doi: 10.1016/j.mcn.2019.103392. Epub 2019 Aug 2.

PMID:
31381983
5.

Monolayer Generation of Vascular Endothelial Cells from Human Pluripotent Stem Cells.

Christensen K, Roudnicky F, Burcin M, Patsch C.

Methods Mol Biol. 2019;1994:17-29. doi: 10.1007/978-1-4939-9477-9_2.

PMID:
31124101
6.

Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study.

Volpato V, Smith J, Sandor C, Ried JS, Baud A, Handel A, Newey SE, Wessely F, Attar M, Whiteley E, Chintawar S, Verheyen A, Barta T, Lako M, Armstrong L, Muschet C, Artati A, Cusulin C, Christensen K, Patsch C, Sharma E, Nicod J, Brownjohn P, Stubbs V, Heywood WE, Gissen P, De Filippis R, Janssen K, Reinhardt P, Adamski J, Royaux I, Peeters PJ, Terstappen GC, Graf M, Livesey FJ, Akerman CJ, Mills K, Bowden R, Nicholson G, Webber C, Cader MZ, Lakics V.

Stem Cell Reports. 2018 Oct 9;11(4):897-911. doi: 10.1016/j.stemcr.2018.08.013. Epub 2018 Sep 20.

7.

Requirements for Using iPSC-Based Cell Models for Assay Development in Drug Discovery.

Christensen K, Roudnicky F, Patsch C, Burcin M.

Adv Biochem Eng Biotechnol. 2018;163:207-220. doi: 10.1007/10_2017_23. Review.

PMID:
29071405
8.

Generation of a homozygous GBA deletion human embryonic stem cell line.

Gündner AL, Meyer CA, Aigner S, Christensen K, Patsch C, Jagasia R, Baumann K, Burcin M.

Stem Cell Res. 2017 Aug;23:122-126. doi: 10.1016/j.scr.2017.07.009. Epub 2017 Jul 11.

9.

Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport.

Ruderisch N, Schlatter D, Kuglstatter A, Guba W, Huber S, Cusulin C, Benz J, Rufer AC, Hoernschemeyer J, Schweitzer C, Bülau T, Gärtner A, Hoffmann E, Niewoehner J, Patsch C, Baumann K, Loetscher H, Kitas E, Freskgård PO.

EBioMedicine. 2017 Oct;24:76-92. doi: 10.1016/j.ebiom.2017.09.004. Epub 2017 Sep 7.

10.

[The basics of knee osteotomy : Clinical examination, analysis of the deformity and correction planning].

Patsch C, Dirisamer F.

Orthopade. 2017 Jul;46(7):558-562. doi: 10.1007/s00132-017-3437-z. Review. German.

PMID:
28597242
11.

Establishment of a translational endothelial cell model using directed differentiation of induced pluripotent stem cells from Cynomolgus monkey.

Thoma EC, Heckel T, Keller D, Giroud N, Leonard B, Christensen K, Roth A, Bertinetti-Lapatki C, Graf M, Patsch C.

Sci Rep. 2016 Oct 25;6:35830. doi: 10.1038/srep35830.

12.

Generation of functional podocytes from human induced pluripotent stem cells.

Ciampi O, Iacone R, Longaretti L, Benedetti V, Graf M, Magnone MC, Patsch C, Xinaris C, Remuzzi G, Benigni A, Tomasoni S.

Stem Cell Res. 2016 Jul;17(1):130-9. doi: 10.1016/j.scr.2016.06.001. Epub 2016 Jun 3.

13.

mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis.

Costa V, Aigner S, Vukcevic M, Sauter E, Behr K, Ebeling M, Dunkley T, Friedlein A, Zoffmann S, Meyer CA, Knoflach F, Lugert S, Patsch C, Fjeldskaar F, Chicha-Gaudimier L, Kiialainen A, Piraino P, Bedoucha M, Graf M, Jessberger S, Ghosh A, Bischofberger J, Jagasia R.

Cell Rep. 2016 Apr 5;15(1):86-95. doi: 10.1016/j.celrep.2016.02.090. Epub 2016 Mar 24.

14.

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells.

Patsch C, Challet-Meylan L, Thoma EC, Urich E, Heckel T, O'Sullivan JF, Grainger SJ, Kapp FG, Sun L, Christensen K, Xia Y, Florido MH, He W, Pan W, Prummer M, Warren CR, Jakob-Roetne R, Certa U, Jagasia R, Freskgård PO, Adatto I, Kling D, Huang P, Zon LI, Chaikof EL, Gerszten RE, Graf M, Iacone R, Cowan CA.

Nat Cell Biol. 2015 Aug;17(8):994-1003. doi: 10.1038/ncb3205. Epub 2015 Jul 27.

15.

Characterization of a human pluripotent stem cell-derived model of neuronal development using multiplexed targeted proteomics.

Dunkley T, Costa V, Friedlein A, Lugert S, Aigner S, Ebeling M, Miller MT, Patsch C, Piraino P, Cutler P, Jagasia R.

Proteomics Clin Appl. 2015 Aug;9(7-8):684-94. doi: 10.1002/prca.201400150. Epub 2015 May 26.

PMID:
25684324
16.

Multicellular self-assembled spheroidal model of the blood brain barrier.

Urich E, Patsch C, Aigner S, Graf M, Iacone R, Freskgård PO.

Sci Rep. 2013;3:1500. doi: 10.1038/srep01500.

17.

Genetic engineering of mammalian cells by direct delivery of FLP recombinase protein.

Patsch C, Kesseler D, Edenhofer F.

Methods. 2011 Apr;53(4):386-93. doi: 10.1016/j.ymeth.2010.12.018. Epub 2010 Dec 23.

PMID:
21185381
18.

Sox2 is essential for formation of trophectoderm in the preimplantation embryo.

Keramari M, Razavi J, Ingman KA, Patsch C, Edenhofer F, Ward CM, Kimber SJ.

PLoS One. 2010 Nov 12;5(11):e13952. doi: 10.1371/journal.pone.0013952.

19.

Engineering cell-permeant FLP recombinase for tightly controlled inducible and reversible overexpression in embryonic stem cells.

Patsch C, Peitz M, Otte DM, Kesseler D, Jungverdorben J, Wunderlich FT, Brüstle O, Zimmer A, Edenhofer F.

Stem Cells. 2010 May;28(5):894-902. doi: 10.1002/stem.417.

20.

Engineering cell-permeable protein.

Münst B, Patsch C, Edenhofer F.

J Vis Exp. 2009 Dec 28;(34). pii: 1627. doi: 10.3791/1627.

21.

Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice.

Anastassiadis K, Fu J, Patsch C, Hu S, Weidlich S, Duerschke K, Buchholz F, Edenhofer F, Stewart AF.

Dis Model Mech. 2009 Sep-Oct;2(9-10):508-15. doi: 10.1242/dmm.003087. Epub 2009 Aug 19.

22.

Enhanced purification of cell-permeant Cre and germline transmission after transduction into mouse embryonic stem cells.

Peitz M, Jäger R, Patsch C, Jäger A, Egert A, Schorle H, Edenhofer F.

Genesis. 2007 Aug;45(8):508-17.

PMID:
17661398
23.

Conditional mutagenesis by cell-permeable proteins: potential, limitations and prospects.

Patsch C, Edenhofer F.

Handb Exp Pharmacol. 2007;(178):203-32. Review.

PMID:
17203657
24.

Cargo-dependent mode of uptake and bioavailability of TAT-containing proteins and peptides in living cells.

Tünnemann G, Martin RM, Haupt S, Patsch C, Edenhofer F, Cardoso MC.

FASEB J. 2006 Sep;20(11):1775-84.

PMID:
16940149

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