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Items: 34


LMW-PTP targeting potentiates the effects of drugs used in chronic lymphocytic leukemia therapy.

Capitani N, Lori G, Paoli P, Patrussi L, Troilo A, Baldari CT, Raugei G, D'Elios MM.

Cancer Cell Int. 2019 Mar 21;19:67. doi: 10.1186/s12935-019-0786-1. eCollection 2019.


Abnormalities in chemokine receptor recycling in chronic lymphocytic leukemia.

Patrussi L, Capitani N, Baldari CT.

Cell Mol Life Sci. 2019 Aug;76(16):3249-3261. doi: 10.1007/s00018-019-03058-9. Epub 2019 Mar 4. Review.


p66Shc deficiency in the Eμ-TCL1 mouse model of chronic lymphocytic leukemia enhances leukemogenesis by altering the chemokine receptor landscape.

Patrussi L, Capitani N, Ulivieri C, Manganaro N, Granai M, Cattaneo F, Kabanova A, Mundo L, Gobessi S, Frezzato F, Visentin A, Finetti F, Pelicci PG, D'Elios MM, Trentin L, Semenzato G, Leoncini L, Efremov DG, Baldari CT.

Haematologica. 2019 Oct;104(10):2040-2052. doi: 10.3324/haematol.2018.209981. Epub 2019 Feb 28.


Boosting chemokine receptor recycling: an elixir of life for chronic lymphocytic leukemia.

Patrussi L, Baldari CT.

Oncotarget. 2018 Sep 11;9(71):33444-33445. doi: 10.18632/oncotarget.26099. eCollection 2018 Sep 11. No abstract available.


p66Shc deficiency enhances CXCR4 and CCR7 recycling in CLL B cells by facilitating their dephosphorylation-dependent release from β-arrestin at early endosomes.

Patrussi L, Capitani N, Cattaneo F, Manganaro N, Gamberucci A, Frezzato F, Martini V, Visentin A, Pelicci PG, D'Elios MM, Trentin L, Semenzato G, Baldari CT.

Oncogene. 2018 Mar;37(11):1534-1550. doi: 10.1038/s41388-017-0066-2. Epub 2018 Jan 12.


Themis releases the brakes on TCR signaling during thymocyte selection by disabling SHP-1.

Patrussi L, Baldari CT.

Cell Mol Immunol. 2017 Sep;14(9):724-726. doi: 10.1038/cmi.2017.41. Epub 2017 Jun 19. No abstract available.


Analysis of TCR/CD3 Recycling at the Immune Synapse.

Patrussi L, Baldari CT.

Methods Mol Biol. 2017;1584:143-155. doi: 10.1007/978-1-4939-6881-7_10.


Expression of the p66Shc protein adaptor is regulated by the activator of transcription STAT4 in normal and chronic lymphocytic leukemia B cells.

Cattaneo F, Patrussi L, Capitani N, Frezzato F, D'Elios MM, Trentin L, Semenzato G, Baldari CT.

Oncotarget. 2016 Aug 30;7(35):57086-57098. doi: 10.18632/oncotarget.10977.


Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1.

Ruffo E, Malacarne V, Larsen SE, Das R, Patrussi L, Wülfing C, Biskup C, Kapnick SM, Verbist K, Tedrick P, Schwartzberg PL, Baldari CT, Rubio I, Nichols KE, Snow AL, Baldanzi G, Graziani A.

Sci Transl Med. 2016 Jan 13;8(321):321ra7. doi: 10.1126/scitranslmed.aad1565.


The Rab GTPase Rab8 as a shared regulator of ciliogenesis and immune synapse assembly: From a conserved pathway to diverse cellular structures.

Patrussi L, Baldari CT.

Small GTPases. 2016;7(1):16-20. doi: 10.1080/21541248.2015.1111852. Epub 2015 Nov 20.


Enhanced Chemokine Receptor Recycling and Impaired S1P1 Expression Promote Leukemic Cell Infiltration of Lymph Nodes in Chronic Lymphocytic Leukemia.

Patrussi L, Capitani N, Martini V, Pizzi M, Trimarco V, Frezzato F, Marino F, Semenzato G, Trentin L, Baldari CT.

Cancer Res. 2015 Oct 1;75(19):4153-63. doi: 10.1158/0008-5472.CAN-15-0986. Epub 2015 Aug 17.


The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling T-cell receptors to the immune synapse.

Finetti F, Patrussi L, Galgano D, Cassioli C, Perinetti G, Pazour GJ, Baldari CT.

J Cell Sci. 2015 Jul 15;128(14):2541-52. doi: 10.1242/jcs.171652. Epub 2015 Jun 1.


The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis.

Onnis A, Finetti F, Patrussi L, Gottardo M, Cassioli C, Spanò S, Baldari CT.

Cell Death Differ. 2015 Oct;22(10):1687-99. doi: 10.1038/cdd.2015.17. Epub 2015 Mar 13.


Negative regulation of chemokine receptor signaling and B-cell chemotaxis by p66Shc.

Patrussi L, Capitani N, Cannizzaro E, Finetti F, Lucherini OM, Pelicci PG, Baldari CT.

Cell Death Dis. 2014 Feb 20;5:e1068. doi: 10.1038/cddis.2014.44.


Specific recycling receptors are targeted to the immune synapse by the intraflagellar transport system.

Finetti F, Patrussi L, Masi G, Onnis A, Galgano D, Lucherini OM, Pazour GJ, Baldari CT.

J Cell Sci. 2014 May 1;127(Pt 9):1924-37. doi: 10.1242/jcs.139337. Epub 2014 Feb 19.


The glycerophosphoinositols: from lipid metabolites to modulators of T-cell signaling.

Patrussi L, Mariggiò S, Corda D, Baldari CT.

Front Immunol. 2013 Jul 29;4:213. doi: 10.3389/fimmu.2013.00213. eCollection 2013.


S1P1 expression is controlled by the pro-oxidant activity of p66Shc and is impaired in B-CLL patients with unfavorable prognosis.

Capitani N, Patrussi L, Trentin L, Lucherini OM, Cannizzaro E, Migliaccio E, Frezzato F, Gattazzo C, Forconi F, Pelicci P, Semenzato G, Baldari CT.

Blood. 2012 Nov 22;120(22):4391-9. doi: 10.1182/blood-2012-04-425959. Epub 2012 Oct 1.


SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling.

Baldanzi G, Pighini A, Bettio V, Rainero E, Traini S, Chianale F, Porporato PE, Filigheddu N, Mesturini R, Song S, Schweighoffer T, Patrussi L, Baldari CT, Zhong XP, van Blitterswijk WJ, Sinigaglia F, Nichols KE, Rubio I, Parolini O, Graziani A.

J Immunol. 2011 Dec 1;187(11):5941-51. doi: 10.4049/jimmunol.1002476. Epub 2011 Nov 2.


p66Shc-dependent apoptosis requires Lck and CamKII activity.

Patrussi L, Giommoni N, Pellegrini M, Gamberucci A, Baldari CT.

Apoptosis. 2012 Feb;17(2):174-86. doi: 10.1007/s10495-011-0663-4.


The Bordetella pertussis adenylate cyclase toxin binds to T cells via LFA-1 and induces its disengagement from the immune synapse.

Paccani SR, Finetti F, Davi M, Patrussi L, D'Elios MM, Ladant D, Baldari CT.

J Exp Med. 2011 Jun 6;208(6):1317-30. doi: 10.1084/jem.20101558. Epub 2011 May 16.


The CXCL12/CXCR4 axis as a therapeutic target in cancer and HIV-1 infection.

Patrussi L, Baldari CT.

Curr Med Chem. 2011;18(4):497-512. Review.


Intracellular mediators of CXCR4-dependent signaling in T cells.

Patrussi L, Baldari CT.

Immunol Lett. 2008 Jan 29;115(2):75-82. Epub 2007 Nov 20. Review.


Glycerophosphoinositol-4-phosphate enhances SDF-1alpha-stimulated T-cell chemotaxis through PTK-dependent activation of Vav.

Patrussi L, Mariggio' S, Paccani SR, Capitani N, Zizza P, Corda D, Baldari CT.

Cell Signal. 2007 Nov;19(11):2351-60. Epub 2007 Jul 28.


p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.

Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT.

Blood. 2007 Sep 15;110(6):1730-8. Epub 2007 May 30.


Anthrax toxins inhibit immune cell chemotaxis by perturbing chemokine receptor signalling.

Rossi Paccani S, Tonello F, Patrussi L, Capitani N, Simonato M, Montecucco C, Baldari CT.

Cell Microbiol. 2007 Apr;9(4):924-9. Epub 2006 Nov 3.


Simvastatin inhibits the MHC class II pathway of antigen presentation by impairing Ras superfamily GTPases.

Ghittoni R, Napolitani G, Benati D, Ulivieri C, Patrussi L, Laghi Pasini F, Lanzavecchia A, Baldari CT.

Eur J Immunol. 2006 Nov;36(11):2885-93. Erratum in: Eur J Immunol. 2006 Dec;36(12):3381. Uliveri, Cristina [corrected to Ulivieri, Cristina].


Defective Vav expression and impaired F-actin reorganization in a subset of patients with common variable immunodeficiency characterized by T-cell defects.

Paccani SR, Boncristiano M, Patrussi L, Ulivieri C, Wack A, Valensin S, Hirst TR, Amedei A, Del Prete G, Telford JL, D'Elios MM, Baldari CT.

Blood. 2005 Jul 15;106(2):626-34. Epub 2005 Apr 7.


Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival.

Patrussi L, Savino MT, Pellegrini M, Paccani SR, Migliaccio E, Plyte S, Lanfrancone L, Pelicci PG, Baldari CT.

Oncogene. 2005 Mar 24;24(13):2218-28.


Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases.

Ghittoni R, Patrussi L, Pirozzi K, Pellegrini M, Lazzerini PE, Capecchi PL, Pasini FL, Baldari CT.

FASEB J. 2005 Apr;19(6):605-7. Epub 2005 Jan 27.


Nonsteroidal anti-inflammatory drugs inhibit a Fyn-dependent pathway coupled to Rac and stress kinase activation in TCR signaling.

Paccani SR, Patrussi L, Ulivieri C, Masferrer JL, D'Elios MM, Baldari CT.

Blood. 2005 Mar 1;105(5):2042-8. Epub 2004 Oct 28.


p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.

Pacini S, Pellegrini M, Migliaccio E, Patrussi L, Ulivieri C, Ventura A, Carraro F, Naldini A, Lanfrancone L, Pelicci P, Baldari CT.

Mol Cell Biol. 2004 Feb;24(4):1747-57.


The Helicobacter pylori vacuolating toxin inhibits T cell activation by two independent mechanisms.

Boncristiano M, Paccani SR, Barone S, Ulivieri C, Patrussi L, Ilver D, Amedei A, D'Elios MM, Telford JL, Baldari CT.

J Exp Med. 2003 Dec 15;198(12):1887-97.


F-actin dynamics control segregation of the TCR signaling cascade to clustered lipid rafts.

Valensin S, Paccani SR, Ulivieri C, Mercati D, Pacini S, Patrussi L, Hirst T, Lupetti P, Baldari CT.

Eur J Immunol. 2002 Feb;32(2):435-46.


[Prognosis of stroke patients undergoing intubation and mechanical ventilation].

Magi E, Recine C, Patrussi L, Becattini G, Nannoni S, Gabini R.

Minerva Med. 2000 May-Jun;91(5-6):99-104. Italian.


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