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Platelet-Specific Deletion of Cyclooxygenase-1 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice.

Sacco A, Bruno A, Contursi A, Dovizio M, Tacconelli S, Ricciotti E, Guillem-Llobat P, Salvatore T, Di Francesco L, Fullone R, Ballerini P, Arena V, Alberti S, Liu G, Gong Y, Sgambato A, Patrono C, FitzGerald GA, Yu Y, Patrignani P.

J Pharmacol Exp Ther. 2019 Sep;370(3):416-426. doi: 10.1124/jpet.119.259382. Epub 2019 Jun 27.


miR-574-5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES-1 induction.

Saul MJ, Baumann I, Bruno A, Emmerich AC, Wellstein J, Ottinger SM, Contursi A, Dovizio M, Donnini S, Tacconelli S, Raouf J, Idborg H, Stein S, Korotkova M, Savai R, Terzuoli E, Sala G, Seeger W, Jakobsson PJ, Patrignani P, Suess B, Steinhilber D.

FASEB J. 2019 Jun;33(6):6933-6947. doi: 10.1096/fj.201802547R. Epub 2019 Mar 28.


Platelet-Derived Microparticles From Obese Individuals: Characterization of Number, Size, Proteomics, and Crosstalk With Cancer and Endothelial Cells.

Grande R, Dovizio M, Marcone S, Szklanna PB, Bruno A, Ebhardt HA, Cassidy H, Ní Áinle F, Caprodossi A, Lanuti P, Marchisio M, Mingrone G, Maguire PB, Patrignani P.

Front Pharmacol. 2019 Jan 22;10:7. doi: 10.3389/fphar.2019.00007. eCollection 2019.


Platelets in cancer development and diagnosis.

Contursi A, Grande R, Dovizio M, Bruno A, Fullone R, Patrignani P.

Biochem Soc Trans. 2018 Dec 17;46(6):1517-1527. doi: 10.1042/BST20180159. Epub 2018 Nov 12. Review.


Antithrombotic Agents and Cancer.

Bruno A, Dovizio M, Tacconelli S, Contursi A, Ballerini P, Patrignani P.

Cancers (Basel). 2018 Jul 31;10(8). pii: E253. doi: 10.3390/cancers10080253. Review.


Aspirin, platelet inhibition and cancer prevention.

Patrignani P, Patrono C.

Platelets. 2018 Dec;29(8):779-785. doi: 10.1080/09537104.2018.1492105. Epub 2018 Jul 9. Review.


Platelets and extracellular vesicles in cancer: diagnostic and therapeutic implications.

Dovizio M, Bruno A, Contursi A, Grande R, Patrignani P.

Cancer Metastasis Rev. 2018 Sep;37(2-3):455-467. doi: 10.1007/s10555-018-9730-4. Review.


Reduced Variability to Aspirin Antiplatelet Effect by the Coadministration of Statins in High-Risk Patients for Cardiovascular Disease.

Tacconelli S, Dovizio M, Di Francesco L, Meneguzzi A, D'Agostino I, Evangelista V, Manarini S, Capone ML, Grossi L, Porreca E, Di Febbo C, Bruno A, Ballerini P, Levantesi G, Fava C, Minuz P, Patrignani P.

Clin Pharmacol Ther. 2018 Jul;104(1):111-119. doi: 10.1002/cpt.1075. Epub 2018 Apr 19.


P2Y12 Receptors in Tumorigenesis and Metastasis.

Ballerini P, Dovizio M, Bruno A, Tacconelli S, Patrignani P.

Front Pharmacol. 2018 Feb 2;9:66. doi: 10.3389/fphar.2018.00066. eCollection 2018. Review.


Therapeutic targeting of dysregulated cellular communication.

Schiavone S, Contursi A, Grande R, Patrignani P.

Ann Transl Med. 2017 May;5(10):222. doi: 10.21037/atm.2017.03.62. No abstract available.


Nonsteroidal anti-inflammatory drugs and cardiovascular safety - translating pharmacological data into clinical readouts.

Tacconelli S, Bruno A, Grande R, Ballerini P, Patrignani P.

Expert Opin Drug Saf. 2017 Jul;16(7):791-807. doi: 10.1080/14740338.2017.1338272. Epub 2017 Jun 8. Review.


Platelets as crucial partners for tumor metastasis: from mechanistic aspects to pharmacological targeting.

Contursi A, Sacco A, Grande R, Dovizio M, Patrignani P.

Cell Mol Life Sci. 2017 Oct;74(19):3491-3507. doi: 10.1007/s00018-017-2536-7. Epub 2017 May 9. Review.


Low-Dose Aspirin Acetylates Cyclooxygenase-1 in Human Colorectal Mucosa: Implications for the Chemoprevention of Colorectal Cancer.

Patrignani P, Sacco A, Sostres C, Bruno A, Dovizio M, Piazuelo E, Di Francesco L, Contursi A, Zucchelli M, Schiavone S, Tacconelli S, Patrono C, Lanas A.

Clin Pharmacol Ther. 2017 Jul;102(1):52-61. doi: 10.1002/cpt.639. Epub 2017 Apr 4.


Curbing tumorigenesis and malignant progression through the pharmacological control of the wound healing process.

Dovizio M, Sacco A, Patrignani P.

Vascul Pharmacol. 2017 Feb;89:1-11. doi: 10.1016/j.vph.2017.01.003. Epub 2017 Jan 12. Review.


Aspirin and Cancer.

Patrignani P, Patrono C.

J Am Coll Cardiol. 2016 Aug 30;68(9):967-76. doi: 10.1016/j.jacc.2016.05.083. Review.


Time for Integrating Clinical, Lifestyle and Molecular Data to Predict Drug Responses.

Patrignani P, Dovizio M.

EBioMedicine. 2016 May;7:9-10. doi: 10.1016/j.ebiom.2016.03.031. Epub 2016 Mar 25. No abstract available.


Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells.

Guillem-Llobat P, Dovizio M, Bruno A, Ricciotti E, Cufino V, Sacco A, Grande R, Alberti S, Arena V, Cirillo M, Patrono C, FitzGerald GA, Steinhilber D, Sgambato A, Patrignani P.

Oncotarget. 2016 May 31;7(22):32462-77. doi: 10.18632/oncotarget.8655.


Aspirin in the 21st century-common mechanisms of disease and their modulation by aspirin: a report from the 2015 scientific conference of the international aspirin foundation, 28 August, London, UK.

Smith T, Hutchison P, Schrör K, Clària J, Lanas A, Patrignani P, Chan AT, Din F, Langley R, Elwood P, Freedman A, Eccles R.

Ecancermedicalscience. 2015 Oct 13;9:581. doi: 10.3332/ecancer.2015.581. eCollection 2015.


Novel insights into the regulation of cyclooxygenase-2 expression by platelet-cancer cell cross-talk.

Dovizio M, Alberti S, Sacco A, Guillem-Llobat P, Schiavone S, Maier TJ, Steinhilber D, Patrignani P.

Biochem Soc Trans. 2015 Aug;43(4):707-14. doi: 10.1042/BST20140322. Epub 2015 Aug 3. Review.


New Insights into the Mechanism of Action of Aspirin in the Prevention of Colorectal Neoplasia.

Di Francesco L, López Contreras LA, Sacco A, Patrignani P.

Curr Pharm Des. 2015;21(35):5116-26. Review.


Dysregulated post-transcriptional control of COX-2 gene expression in gestational diabetic endothelial cells.

Di Francesco L, Dovizio M, Trenti A, Marcantoni E, Moore A, O'Gaora P, McCarthy C, Tacconelli S, Bruno A, Alberti S, Gizzo S, Nardelli GB, Orso G, Belton O, Trevisi L, Dixon DA, Patrignani P.

Br J Pharmacol. 2015 Sep;172(18):4575-4587. doi: 10.1111/bph.13241. Epub 2015 Aug 3.


COX-2 and EGFR: Partners in Crime Split by Aspirin.

Patrignani P, Dovizio M.

EBioMedicine. 2015 Apr 21;2(5):372-3. doi: 10.1016/j.ebiom.2015.04.013. eCollection 2015 May. No abstract available.


Rare SNP rs12731181 in the miR-590-3p Target Site of the Prostaglandin F2α Receptor Gene Confers Risk for Essential Hypertension in the Han Chinese Population.

Xiao B, Gu SM, Li MJ, Li J, Tao B, Wang Y, Wang Y, Zuo S, Shen Y, Yu Y, Chen D, Chen G, Kong D, Tang J, Liu Q, Chen DR, Liu Y, Alberti S, Dovizio M, Landolfi R, Mucci L, Miao PZ, Gao P, Zhu DL, Wang J, Li B, Patrignani P, Yu Y.

Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1687-95. doi: 10.1161/ATVBAHA.115.305445. Epub 2015 May 14.


Advances in NSAID development: evolution of diclofenac products using pharmaceutical technology.

Altman R, Bosch B, Brune K, Patrignani P, Young C.

Drugs. 2015 May;75(8):859-77. doi: 10.1007/s40265-015-0392-z. Review.


MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer.

Olesch C, Sha W, Angioni C, Sha LK, Açaf E, Patrignani P, Jakobsson PJ, Radeke HH, Grösch S, Geisslinger G, von Knethen A, Weigert A, Brüne B.

Oncotarget. 2015 Apr 30;6(12):10284-96.


Dysregulation of gene expression in human fetal endothelial cells from gestational diabetes in response to TGF-β1.

Marcantoni E, Dovizio M, O'Gaora P, Di Francesco L, Bendaya I, Schiavone S, Trenti A, Guillem-Llobat P, Zambon A, Nardelli GB, Trevisi L, Patrignani P, Belton O.

Prostaglandins Other Lipid Mediat. 2015 Jul;120:103-14. doi: 10.1016/j.prostaglandins.2015.03.004. Epub 2015 Mar 26.


New insights into the use of currently available non-steroidal anti-inflammatory drugs.

Brune K, Patrignani P.

J Pain Res. 2015 Feb 20;8:105-18. doi: 10.2147/JPR.S75160. eCollection 2015. Review.


Inside epoxyeicosatrienoic acids and cardiovascular disease.

Tacconelli S, Patrignani P.

Front Pharmacol. 2014 Nov 10;5:239. doi: 10.3389/fphar.2014.00239. eCollection 2014. Review.


Gut microbiota, host gene expression, and aging.

Patrignani P, Tacconelli S, Bruno A.

J Clin Gastroenterol. 2014 Nov-Dec;48 Suppl 1:S28-31. doi: 10.1097/MCG.0000000000000229. Review.


Cyclooxygenase inhibitors: From pharmacology to clinical read-outs.

Patrignani P, Patrono C.

Biochim Biophys Acta. 2015 Apr;1851(4):422-32. doi: 10.1016/j.bbalip.2014.09.016. Epub 2014 Sep 28. Review.


Platelets, cyclooxygenases, and colon cancer.

Guillem-Llobat P, Dovizio M, Alberti S, Bruno A, Patrignani P.

Semin Oncol. 2014 Jun;41(3):385-96. doi: 10.1053/j.seminoncol.2014.04.008. Epub 2014 Apr 24. Review.


Reappraisal of the clinical pharmacology of low-dose aspirin by comparing novel direct and traditional indirect biomarkers of drug action.

Patrignani P, Tacconelli S, Piazuelo E, Di Francesco L, Dovizio M, Sostres C, Marcantoni E, Guillem-Llobat P, Del Boccio P, Zucchelli M, Patrono C, Lanas A.

J Thromb Haemost. 2014 Aug;12(8):1320-30. doi: 10.1111/jth.12637. Epub 2014 Jul 18.


Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors.

Biava M, Battilocchio C, Poce G, Alfonso S, Consalvi S, Di Capua A, Calderone V, Martelli A, Testai L, Sautebin L, Rossi A, Ghelardini C, Di Cesare Mannelli L, Giordani A, Persiani S, Colovic M, Dovizio M, Patrignani P, Anzini M.

Bioorg Med Chem. 2014 Jan 15;22(2):772-86. doi: 10.1016/j.bmc.2013.12.008. Epub 2013 Dec 18.


Role of platelets in inflammation and cancer: novel therapeutic strategies.

Dovizio M, Alberti S, Guillem-Llobat P, Patrignani P.

Basic Clin Pharmacol Toxicol. 2014 Jan;114(1):118-27. doi: 10.1111/bcpt.12156. Epub 2013 Nov 8. Review.


The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and endothelial dysfunction.

Martelli A, Testai L, Anzini M, Cappelli A, Di Capua A, Biava M, Poce G, Consalvi S, Giordani A, Caselli G, Rovati L, Ghelardini C, Patrignani P, Sautebin L, Breschi MC, Calderone V.

Pharmacol Res. 2013 Dec;78:1-9. doi: 10.1016/j.phrs.2013.09.008. Epub 2013 Sep 29.


In vitro morphine metabolism by rat microglia.

Togna AR, Antonilli L, Dovizio M, Salemme A, De Carolis L, Togna GI, Patrignani P, Nencini P.

Neuropharmacology. 2013 Dec;75:391-8. doi: 10.1016/j.neuropharm.2013.08.019. Epub 2013 Aug 27.


Variability in the response to non-steroidal anti-inflammatory drugs: mechanisms and perspectives.

Bruno A, Tacconelli S, Patrignani P.

Basic Clin Pharmacol Toxicol. 2014 Jan;114(1):56-63. doi: 10.1111/bcpt.12117. Epub 2013 Sep 3. Review.


Lipid peroxidation and depressed mood in community-dwelling older men and women.

Milaneschi Y, Cesari M, Simonsick EM, Vogelzangs N, Kanaya AM, Yaffe K, Patrignani P, Metti A, Kritchevsky SB, Pahor M, Ferrucci L, Penninx BW; Health ABC study.

PLoS One. 2013 Jun 11;8(6):e65406. doi: 10.1371/journal.pone.0065406. Print 2013.


Clinical pharmacology of cyclooxygenase inhibition and pharmacodynamic interaction with aspirin by floctafenine in Thai healthy subjects.

Maenthaisong R, Tacconelli S, Sritara P, Del Boccio P, Di Francesco L, Sacchetta P, Archararit N, Aryurachai K, Patrignani P, Suthisisang C.

Int J Immunopathol Pharmacol. 2013 Apr-Jun;26(2):403-17.


A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity.

Battilocchio C, Poce G, Alfonso S, Porretta GC, Consalvi S, Sautebin L, Pace S, Rossi A, Ghelardini C, Di Cesare Mannelli L, Schenone S, Giordani A, Di Francesco L, Patrignani P, Biava M.

Bioorg Med Chem. 2013 Jul 1;21(13):3695-701. doi: 10.1016/j.bmc.2013.04.031. Epub 2013 Apr 26.


Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors.

Vitale P, Tacconelli S, Perrone MG, Malerba P, Simone L, Scilimati A, Lavecchia A, Dovizio M, Marcantoni E, Bruno A, Patrignani P.

J Med Chem. 2013 Jun 13;56(11):4277-99. doi: 10.1021/jm301905a. Epub 2013 May 16.


Pharmacological inhibition of platelet-tumor cell cross-talk prevents platelet-induced overexpression of cyclooxygenase-2 in HT29 human colon carcinoma cells.

Dovizio M, Maier TJ, Alberti S, Di Francesco L, Marcantoni E, Münch G, John CM, Suess B, Sgambato A, Steinhilber D, Patrignani P.

Mol Pharmacol. 2013 Jul;84(1):25-40. doi: 10.1124/mol.113.084988. Epub 2013 Apr 11.


Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors.

Anzini M, Di Capua A, Valenti S, Brogi S, Rovini M, Giuliani G, Cappelli A, Vomero S, Chiasserini L, Sega A, Poce G, Giorgi G, Calderone V, Martelli A, Testai L, Sautebin L, Rossi A, Pace S, Ghelardini C, Di Cesare Mannelli L, Benetti V, Giordani A, Anzellotti P, Dovizio M, Patrignani P, Biava M.

J Med Chem. 2013 Apr 25;56(8):3191-206. doi: 10.1021/jm301370e. Epub 2013 Apr 11. Erratum in: J Med Chem. 2013 Jun 13;56(11):4821.


Mechanisms of the antitumoural effects of aspirin in the gastrointestinal tract.

Bruno A, Dovizio M, Tacconelli S, Patrignani P.

Best Pract Res Clin Gastroenterol. 2012 Aug;26(4):e1-e13. doi: 10.1016/j.bpg.2012.10.001. Review.


Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme.

Biava M, Battilocchio C, Poce G, Alfonso S, Consalvi S, Porretta GC, Schenone S, Calderone V, Martelli A, Testai L, Ghelardini C, Di Cesare Mannelli L, Sautebin L, Rossi A, Giordani A, Patrignani P, Anzini M.

Eur J Med Chem. 2012 Dec;58:287-98. doi: 10.1016/j.ejmech.2012.10.014. Epub 2012 Oct 18.


Repeated exposure to codeine alters morphine glucuronidation by affecting UGT gene expression in the rat.

Antonilli L, De Carolis L, Brusadin V, Togna AR, Dovizio M, Togna GI, Patrignani P, Nencini P.

Eur J Pharmacol. 2012 Oct 15;693(1-3):7-14. doi: 10.1016/j.ejphar.2012.07.045. Epub 2012 Aug 21.


Coxibs: pharmacology, toxicity and efficacy in cancer clinical trials.

Garcia Rodriguez LA, Cea-Soriano L, Tacconelli S, Patrignani P.

Recent Results Cancer Res. 2013;191:67-93. doi: 10.1007/978-3-642-30331-9_4. Review.


Mode of action of aspirin as a chemopreventive agent.

Dovizio M, Bruno A, Tacconelli S, Patrignani P.

Recent Results Cancer Res. 2013;191:39-65. doi: 10.1007/978-3-642-30331-9_3. Review.


Mechanistic aspects of COX-2 expression in colorectal neoplasia.

Dixon DA, Blanco FF, Bruno A, Patrignani P.

Recent Results Cancer Res. 2013;191:7-37. doi: 10.1007/978-3-642-30331-9_2. Review.


Novel insights into the vasoprotective role of heme oxygenase-1.

Marcantoni E, Di Francesco L, Dovizio M, Bruno A, Patrignani P.

Int J Hypertens. 2012;2012:127910. doi: 10.1155/2012/127910. Epub 2012 Feb 22.

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