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Items: 30

1.

Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase.

Adams ND, Adams JL, Burgess JL, Chaudhari AM, Copeland RA, Donatelli CA, Drewry DH, Fisher KE, Hamajima T, Hardwicke MA, Huffman WF, Koretke-Brown KK, Lai ZV, McDonald OB, Nakamura H, Newlander KA, Oleykowski CA, Parrish CA, Patrick DR, Plant R, Sarpong MA, Sasaki K, Schmidt SJ, Silva DJ, Sutton D, Tang J, Thompson CS, Tummino PJ, Wang JC, Xiang H, Yang J, Dhanak D.

J Med Chem. 2010 May 27;53(10):3973-4001. doi: 10.1021/jm901870q.

PMID:
20420387
2.

Genetic deficiency of Itgb2 or ItgaL prevents autoimmune diabetes through distinctly different mechanisms in NOD/LtJ mice.

Glawe JD, Patrick DR, Huang M, Sharp CD, Barlow SC, Kevil CG.

Diabetes. 2009 Jun;58(6):1292-301. doi: 10.2337/db08-0804. Epub 2009 Feb 17.

3.

Prognostic breast cancer signature identified from 3D culture model accurately predicts clinical outcome across independent datasets.

Martin KJ, Patrick DR, Bissell MJ, Fournier MV.

PLoS One. 2008 Aug 20;3(8):e2994. doi: 10.1371/journal.pone.0002994.

4.

Stromal cell-derived factor-1/CXCL12 stimulates chemorepulsion of NOD/LtJ T-cell adhesion to islet microvascular endothelium.

Sharp CD, Huang M, Glawe J, Patrick DR, Pardue S, Barlow SC, Kevil CG.

Diabetes. 2008 Jan;57(1):102-12. Epub 2007 Oct 1.

5.

Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2.

Miyazaki Y, Tang J, Maeda Y, Nakano M, Wang L, Nolte RT, Sato H, Sugai M, Okamoto Y, Truesdale AT, Hassler DF, Nartey EN, Patrick DR, Ho ML, Ozawa K.

Bioorg Med Chem Lett. 2007 Mar 15;17(6):1773-8. Epub 2006 Dec 24.

PMID:
17276055
6.

Targeted anti-mitotic therapies: can we improve on tubulin agents?

Jackson JR, Patrick DR, Dar MM, Huang PS.

Nat Rev Cancer. 2007 Feb;7(2):107-17. Review.

PMID:
17251917
7.

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.

King AJ, Patrick DR, Batorsky RS, Ho ML, Do HT, Zhang SY, Kumar R, Rusnak DW, Takle AK, Wilson DM, Hugger E, Wang L, Karreth F, Lougheed JC, Lee J, Chau D, Stout TJ, May EW, Rominger CM, Schaber MD, Luo L, Lakdawala AS, Adams JL, Contractor RG, Smalley KS, Herlyn M, Morrissey MM, Tuveson DA, Huang PS.

Cancer Res. 2006 Dec 1;66(23):11100-5.

8.

Evolutionary relationships of Aurora kinases: implications for model organism studies and the development of anti-cancer drugs.

Brown JR, Koretke KK, Birkeland ML, Sanseau P, Patrick DR.

BMC Evol Biol. 2004 Oct 12;4:39.

9.

Immobilized metal-ion affinity chromatography of recombinant Fab protein OPG C11 in the presence of EDTA-Mg(II).

Xiang H, Wynn R, Nguyen LH, Ross OH, Ahrens DP, O'Neil KT, Hollis GF, Patrick DR.

J Chromatogr A. 2002 Nov 29;978(1-2):153-64.

PMID:
12458952
10.

Large-scale purification of active platelet integrin glycoprotein IIb-IIIa.

Hillman MC, Zolotarjova NI, Patrick DR, McCabe DD, Shen K, Corman JI, Billheimer JT, Seiffert DA, Hollis GF, Wynn R.

Protein Expr Purif. 2002 Aug;25(3):494-502.

PMID:
12182831
11.

Resorcylic acid lactones: naturally occurring potent and selective inhibitors of MEK.

Zhao A, Lee SH, Mojena M, Jenkins RG, Patrick DR, Huber HE, Goetz MA, Hensens OD, Zink DL, Vilella D, Dombrowski AW, Lingham RB, Huang L.

J Antibiot (Tokyo). 1999 Dec;52(12):1086-94.

12.
13.
14.

Transcription factor E2F binds DNA as a heterodimer.

Huber HE, Edwards G, Goodhart PJ, Patrick DR, Huang PS, Ivey-Hoyle M, Barnett SF, Oliff A, Heimbrook DC.

Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3525-9.

15.

Protein domains governing interactions between E2F, the retinoblastoma gene product, and human papillomavirus type 16 E7 protein.

Huang PS, Patrick DR, Edwards G, Goodhart PJ, Huber HE, Miles L, Garsky VM, Oliff A, Heimbrook DC.

Mol Cell Biol. 1993 Feb;13(2):953-60.

16.

Achieving anterior aesthetics with an anti-rotational abutment.

Patrick DR, Dorfman WM.

Pract Periodontics Aesthet Dent. 1992 Aug;4(6):13-6.

PMID:
1391929
17.

Human papillomavirus type 16 E7 protein inhibits DNA binding by the retinoblastoma gene product.

Stirdivant SM, Huber HE, Patrick DR, Defeo-Jones D, McAvoy EM, Garsky VM, Oliff A, Heimbrook DC.

Mol Cell Biol. 1992 May;12(5):1905-14.

18.

Characterization of functional HPV-16 E7 protein produced in Escherichia coli.

Patrick DR, Zhang K, Defeo-Jones D, Vuocolo GR, Maigetter RZ, Sardana MK, Oliff A, Heimbrook DC.

J Biol Chem. 1992 Apr 5;267(10):6910-5.

19.

Biological activity of a transforming growth factor-alpha--Pseudomonas exotoxin fusion protein in vitro and in vivo.

Heimbrook DC, Stirdivant SM, Ahern JD, Balishin NL, Patrick DR, Edwards GM, Defeo-Jones D, FitzGerald DJ, Pastan I, Oliff A.

J Ind Microbiol. 1991 Apr;7(3):203-7.

PMID:
1367127
20.

Identification of HPV-16 E7 peptides that are potent antagonists of E7 binding to the retinoblastoma suppressor protein.

Jones RE, Wegrzyn RJ, Patrick DR, Balishin NL, Vuocolo GA, Riemen MW, Defeo-Jones D, Garsky VM, Heimbrook DC, Oliff A.

J Biol Chem. 1990 Aug 5;265(22):12782-5.

21.

Transforming growth factor alpha-Pseudomonas exotoxin fusion protein prolongs survival of nude mice bearing tumor xenografts.

Heimbrook DC, Stirdivant SM, Ahern JD, Balishin NL, Patrick DR, Edwards GM, Defeo-Jones D, FitzGerald DJ, Pastan I, Oliff A.

Proc Natl Acad Sci U S A. 1990 Jun;87(12):4697-701.

22.

Management of microsystems at Forbes Health System.

Patrick DR, Odell MG.

J Soc Health Syst. 1989 Nov;1(2):65-76.

PMID:
2519108
23.
24.

Long-term captopril therapy: evolving hemodynamic effects.

Sullivan JM, Taylor JC, Patrick DR, Johnson JG, Ratts TE, Muirhead EE.

J Clin Pharmacol. 1982 Oct;22(10):450-8.

PMID:
6757280
25.
26.

Hemodynamic effects of dietary sodium in man: a preliminary report.

Sullivan JM, Ratts TE, Taylor JC, Kraus DH, Barton BR, Patrick DR, Reed SW.

Hypertension. 1980 Jul-Aug;2(4):506-14. No abstract available.

PMID:
6995291
27.

Incorporation of P in the muscle by normal and thyrotoxic resting rats.

JOHNSON PC, POSEY AF, PATRICK DR, CAPUTTO R.

Am J Physiol. 1958 Feb;192(2):279-82. No abstract available.

PMID:
13508869
28.

The diagnosis of hemolysis by a simplified Cr51 determination.

JOHNSON PC, HUGHES WL, BIRD RM, PATRICK DR.

AMA Arch Intern Med. 1957 Sep;100(3):415-8. No abstract available.

PMID:
13457461
29.

The serum polysaccharide-protein ratio (PR) as a measure of rheumatoid arthritis activity.

PAYNE RW, SHETLAR MR, BULLOCK JA, PATRICK DR, HELLBAUM AA, ISHMAEL WK.

Ann Intern Med. 1954 Oct;41(4):775-9. No abstract available.

PMID:
13198023
30.

Comparative studies of serum polysaccharides in rheumatoid arthritis and degenerative joint disease.

SHETLAR MR, PAYNE RW, BULLOCK JA, PATRICK DR, HELLBAUM AA, ISHMAEL WK.

J Clin Invest. 1953 Dec;32(12):1208-13. No abstract available.

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