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Items: 48

1.

Association of crumbs homolog-2 with mTORC1 in developing podocyte.

Hamano S, Nishibori Y, Hada I, Mikami N, Ito-Nitta N, Fukuhara D, Kudo A, Xiao Z, Nukui M, Patrakka J, Tryggvason K, Yan K.

PLoS One. 2018 Aug 20;13(8):e0202400. doi: 10.1371/journal.pone.0202400. eCollection 2018.

2.

Understanding Podocyte Biology to Develop Novel Kidney Therapeutics.

Lal MA, Patrakka J.

Front Endocrinol (Lausanne). 2018 Jul 23;9:409. doi: 10.3389/fendo.2018.00409. eCollection 2018. Review.

3.

A CRISP(e)R view on kidney organoids allows generation of an induced pluripotent stem cell-derived kidney model for drug discovery.

Boreström C, Jonebring A, Guo J, Palmgren H, Cederblad L, Forslöw A, Svensson A, Söderberg M, Reznichenko A, Nyström J, Patrakka J, Hicks R, Maresca M, Valastro B, Collén A.

Kidney Int. 2018 Dec;94(6):1099-1110. doi: 10.1016/j.kint.2018.05.003. Epub 2018 Jul 31.

4.

Depletion of Gprc5a Promotes Development of Diabetic Nephropathy.

Ma X, Schwarz A, Sevilla SZ, Levin A, Hultenby K, Wernerson A, Lal M, Patrakka J.

J Am Soc Nephrol. 2018 Jun;29(6):1679-1689. doi: 10.1681/ASN.2017101135. Epub 2018 Apr 10.

PMID:
29636387
5.

FYVE domain-containing protein ZFYVE28 regulates EGFR-signaling in podocytes but is not critical for the function of filtration barrier in mice.

Zambrano S, Rodriguez PQ, Guo J, Möller-Hackbarth K, Schwarz A, Patrakka J.

Sci Rep. 2018 Mar 16;8(1):4712. doi: 10.1038/s41598-018-23104-z.

6.

Confocal super-resolution imaging of the glomerular filtration barrier enabled by tissue expansion.

Unnersjö-Jess D, Scott L, Sevilla SZ, Patrakka J, Blom H, Brismar H.

Kidney Int. 2018 Apr;93(4):1008-1013. doi: 10.1016/j.kint.2017.09.019. Epub 2017 Dec 11.

7.

Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease.

Falkevall A, Mehlem A, Palombo I, Heller Sahlgren B, Ebarasi L, He L, Ytterberg AJ, Olauson H, Axelsson J, Sundelin B, Patrakka J, Scotney P, Nash A, Eriksson U.

Cell Metab. 2017 Mar 7;25(3):713-726. doi: 10.1016/j.cmet.2017.01.004. Epub 2017 Feb 9.

8.

Novel NPHS2 variant in patients with familial steroid-resistant nephrotic syndrome with early onset, slow progression and dominant inheritance pattern.

Suvanto M, Patrakka J, Jahnukainen T, Sjöström PM, Nuutinen M, Arikoski P, Kataja J, Kestilä M, Jalanko H.

Clin Exp Nephrol. 2017 Aug;21(4):677-684. doi: 10.1007/s10157-016-1331-3. Epub 2016 Aug 29.

PMID:
27573339
9.

A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes.

Grahammer F, Wigge C, Schell C, Kretz O, Patrakka J, Schneider S, Klose M, Arnold SJ, Habermann A, Bräuniger R, Rinschen MM, Völker L, Bregenzer A, Rubbenstroth D, Boerries M, Kerjaschki D, Miner JH, Walz G, Benzing T, Fornoni A, Frangakis AS, Huber TB.

JCI Insight. 2016 Jun 16;1(9). pii: e86177.

10.

Knockdown of Tmem234 in zebrafish results in proteinuria.

Rodriguez PQ, Oddsson A, Ebarasi L, He B, Hultenby K, Wernerson A, Betsholtz C, Tryggvason K, Patrakka J.

Am J Physiol Renal Physiol. 2015 Dec 1;309(11):F955-66. doi: 10.1152/ajprenal.00525.2014. Epub 2015 Sep 16.

11.

Dendrin ablation prolongs life span by delaying kidney failure.

Weins A, Wong JS, Basgen JM, Gupta R, Daehn I, Casagrande L, Lessman D, Schwartzman M, Meliambro K, Patrakka J, Shaw A, Tryggvason K, He JC, Nicholas SB, Mundel P, Campbell KN.

Am J Pathol. 2015 Aug;185(8):2143-57. doi: 10.1016/j.ajpath.2015.04.011. Epub 2015 Jun 12.

12.

Correction: Schip1 Is a Novel Podocyte Foot Process Protein that Mediates Actin Cytoskeleton Rearrangements and Forms a Complex with Nherf2 and Ezrin.

Perisic L, Rodriguez PQ, Hultenby K, Sun Y, Lal M, Betsholtz C, Uhlén M, Wernerson A, Hedin U, Pikkarainen T, Tryggvason K, Patrakka J.

PLoS One. 2015 May 12;10(5):e0126079. doi: 10.1371/journal.pone.0126079. eCollection 2015. No abstract available.

13.

Schip1 is a novel podocyte foot process protein that mediates actin cytoskeleton rearrangements and forms a complex with Nherf2 and ezrin.

Perisic L, Rodriguez PQ, Hultenby K, Sun Y, Lal M, Betsholtz C, Uhlén M, Wernerson A, Hedin U, Pikkarainen T, Tryggvason K, Patrakka J.

PLoS One. 2015 Mar 25;10(3):e0122067. doi: 10.1371/journal.pone.0122067. eCollection 2015. Erratum in: PLoS One. 2015;10(5):e0126079.

14.

Neph1 is reduced in primary focal segmental glomerulosclerosis, minimal change nephrotic syndrome, and corresponding experimental animal models of adriamycin-induced nephropathy and puromycin aminonucleoside nephrosis.

Hulkko J, Patrakka J, Lal M, Tryggvason K, Hultenby K, Wernerson A.

Nephron Extra. 2014 Sep 19;4(3):146-54. doi: 10.1159/000365091. eCollection 2014 Sep.

15.

Wtip- and gadd45a-interacting protein dendrin is not crucial for the development or maintenance of the glomerular filtration barrier.

Xiao Z, Rodriguez PQ, He L, Betsholtz C, Tryggvason K, Patrakka J.

PLoS One. 2013 Dec 20;8(12):e83133. doi: 10.1371/journal.pone.0083133. eCollection 2013.

16.

Myo1e impairment results in actin reorganization, podocyte dysfunction, and proteinuria in zebrafish and cultured podocytes.

Mao J, Wang D, Mataleena P, He B, Niu D, Katayama K, Xu X, Ojala JR, Wang W, Shu Q, Du L, Liu A, Pikkarainen T, Patrakka J, Tryggvason K.

PLoS One. 2013 Aug 19;8(8):e72750. doi: 10.1371/journal.pone.0072750. eCollection 2013.

17.

Novel INF2 mutation p. L77P in a family with glomerulopathy and Charcot-Marie-Tooth neuropathy.

Rodriguez PQ, Lohkamp B, Celsi G, Mache CJ, Auer-Grumbach M, Wernerson A, Hamajima N, Tryggvason K, Patrakka J.

Pediatr Nephrol. 2013 Feb;28(2):339-43. doi: 10.1007/s00467-012-2299-1. Epub 2012 Sep 11.

PMID:
22961558
18.

Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation.

Sistani L, Rodriguez PQ, Hultenby K, Uhlen M, Betsholtz C, Jalanko H, Tryggvason K, Wernerson A, Patrakka J.

Kidney Int. 2013 Jan;83(1):63-71. doi: 10.1038/ki.2012.321. Epub 2012 Aug 22.

19.

Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics.

Perisic L, Lal M, Hulkko J, Hultenby K, Önfelt B, Sun Y, Dunér F, Patrakka J, Betsholtz C, Uhlen M, Brismar H, Tryggvason K, Wernerson A, Pikkarainen T.

Kidney Int. 2012 Nov;82(10):1071-83. doi: 10.1038/ki.2012.252. Epub 2012 Jul 25.

20.

Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice.

Xiao Z, Patrakka J, Nukui M, Chi L, Niu D, Betsholtz C, Pikkarainen T, Vainio S, Tryggvason K.

Dev Dyn. 2011 Dec;240(12):2646-56. doi: 10.1002/dvdy.22778. Erratum in: Dev Dyn. 2012 Feb;241(2):431. Pikkarainan, Timo [corrected to Pikkarainen, Timo].

21.

Glcci1 deficiency leads to proteinuria.

Nishibori Y, Katayama K, Parikka M, Oddsson A, Nukui M, Hultenby K, Wernerson A, He B, Ebarasi L, Raschperger E, Norlin J, Uhlén M, Patrakka J, Betsholtz C, Tryggvason K.

J Am Soc Nephrol. 2011 Nov;22(11):2037-46. doi: 10.1681/ASN.2010111147. Epub 2011 Sep 23.

22.

CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival.

Yaddanapudi S, Altintas MM, Kistler AD, Fernandez I, Möller CC, Wei C, Peev V, Flesche JB, Forst AL, Li J, Patrakka J, Xiao Z, Grahammer F, Schiffer M, Lohmüller T, Reinheckel T, Gu C, Huber TB, Ju W, Bitzer M, Rastaldi MP, Ruiz P, Tryggvason K, Shaw AS, Faul C, Sever S, Reiser J.

J Clin Invest. 2011 Oct;121(10):3965-80. doi: 10.1172/JCI58552. Epub 2011 Sep 12. Erratum in: J Clin Invest. 2012 Feb 1;122(2):780.

23.

Pdlim2 is a novel actin-regulating protein of podocyte foot processes.

Sistani L, Dunér F, Udumala S, Hultenby K, Uhlen M, Betsholtz C, Tryggvason K, Wernerson A, Patrakka J.

Kidney Int. 2011 Nov;80(10):1045-54. doi: 10.1038/ki.2011.231. Epub 2011 Aug 3.

24.

Glomerular podocytes express type 1 adenylate cyclase: inactivation results in susceptibility to proteinuria.

Xiao Z, He L, Takemoto M, Jalanko H, Chan GC, Storm DR, Betsholtz C, Tryggvason K, Patrakka J.

Nephron Exp Nephrol. 2011;118(3):e39-48. doi: 10.1159/000320382. Epub 2010 Dec 24.

25.

Expression of novel podocyte-associated proteins sult1b1 and ankrd25.

Xu X, Patrakka J, Sistani L, Uhlen M, Jalanko H, Betsholtz C, Tryggvason K.

Nephron Exp Nephrol. 2011;117(2):e39-46. doi: 10.1159/000320049. Epub 2010 Aug 18.

PMID:
20720434
26.

Permeability, ultrastructural changes, and distribution of novel proteins in the glomerular barrier in early puromycin aminonucleoside nephrosis.

Dunér F, Lindström K, Hultenby K, Hulkko J, Patrakka J, Tryggvason K, Haraldsson B, Wernerson A, Pettersson E.

Nephron Exp Nephrol. 2010;116(2):e42-52. doi: 10.1159/000317130. Epub 2010 Jun 29.

PMID:
20588063
27.

Molecular make-up of the glomerular filtration barrier.

Patrakka J, Tryggvason K.

Biochem Biophys Res Commun. 2010 May 21;396(1):164-9. doi: 10.1016/j.bbrc.2010.04.069. Review.

PMID:
20494132
28.

New insights into the role of podocytes in proteinuria.

Patrakka J, Tryggvason K.

Nat Rev Nephrol. 2009 Aug;5(8):463-8. doi: 10.1038/nrneph.2009.108. Epub 2009 Jul 7. Review.

PMID:
19581907
29.

Glomerular transcriptome changes associated with lipopolysaccharide-induced proteinuria.

Sun Y, He L, Takemoto M, Patrakka J, Pikkarainen T, Genové G, Norlin J, Truvé K, Tryggvason K, Betsholtz C.

Am J Nephrol. 2009;29(6):558-70. doi: 10.1159/000191469. Epub 2009 Jan 9.

PMID:
19136817
30.

Dendrin expression in glomerulogenesis and in human minimal change nephrotic syndrome.

Dunér F, Patrakka J, Xiao Z, Larsson J, Vlamis-Gardikas A, Pettersson E, Tryggvason K, Hultenby K, Wernerson A.

Nephrol Dial Transplant. 2008 Aug;23(8):2504-11. doi: 10.1093/ndt/gfn100. Epub 2008 Mar 20.

PMID:
18356187
31.

Nephrin--a unique structural and signaling protein of the kidney filter.

Patrakka J, Tryggvason K.

Trends Mol Med. 2007 Sep;13(9):396-403. Epub 2007 Sep 4. Review.

PMID:
17766183
32.

The glomerular transcriptome and proteome.

Betsholtz C, He L, Takemoto M, Norlin J, Sun Y, Patrakka J, Tryggvason K.

Nephron Exp Nephrol. 2007;106(2):e32-6. Epub 2007 Jun 6. Review.

PMID:
17570937
33.

Plasma exchange and retransplantation in recurrent nephrosis of patients with congenital nephrotic syndrome of the Finnish type (NPHS1).

Kuusniemi AM, Qvist E, Sun Y, Patrakka J, Rönnholm K, Karikoski R, Jalanko H.

Transplantation. 2007 May 27;83(10):1316-23.

PMID:
17519780
34.

Glomerulus-specific mRNA transcripts and proteins identified through kidney expressed sequence tag database analysis.

He L, Sun Y, Patrakka J, Mostad P, Norlin J, Xiao Z, Andrae J, Tryggvason K, Samuelsson T, Betsholtz C, Takemoto M.

Kidney Int. 2007 May;71(9):889-900. Epub 2007 Feb 28.

35.

Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik.

Patrakka J, Xiao Z, Nukui M, Takemoto M, He L, Oddsson A, Perisic L, Kaukinen A, Szigyarto CA, Uhlén M, Jalanko H, Betsholtz C, Tryggvason K.

J Am Soc Nephrol. 2007 Mar;18(3):689-97. Epub 2007 Jan 24.

36.

Nck links nephrin to actin in kidney podocytes.

Tryggvason K, Pikkarainen T, Patrakka J.

Cell. 2006 Apr 21;125(2):221-4.

37.

Hereditary proteinuria syndromes and mechanisms of proteinuria.

Tryggvason K, Patrakka J, Wartiovaara J.

N Engl J Med. 2006 Mar 30;354(13):1387-401. Review. No abstract available.

PMID:
16571882
38.

Large-scale identification of genes implicated in kidney glomerulus development and function.

Takemoto M, He L, Norlin J, Patrakka J, Xiao Z, Petrova T, Bondjers C, Asp J, Wallgard E, Sun Y, Samuelsson T, Mostad P, Lundin S, Miura N, Sado Y, Alitalo K, Quaggin SE, Tryggvason K, Betsholtz C.

EMBO J. 2006 Mar 8;25(5):1160-74. Epub 2006 Feb 23.

39.

Thin basement membrane nephropathy.

Tryggvason K, Patrakka J.

J Am Soc Nephrol. 2006 Mar;17(3):813-22. Epub 2006 Feb 8. Review. No abstract available.

40.

Podocytes are firmly attached to glomerular basement membrane in kidneys with heavy proteinuria.

Lahdenkari AT, Lounatmaa K, Patrakka J, Holmberg C, Wartiovaara J, Kestilä M, Koskimies O, Jalanko H.

J Am Soc Nephrol. 2004 Oct;15(10):2611-8.

41.

Tissue expression of nephrin in human and pig.

Kuusniemi AM, Kestilä M, Patrakka J, Lahdenkari AT, Ruotsalainen V, Holmberg C, Karikoski R, Salonen R, Tryggvason K, Jalanko H.

Pediatr Res. 2004 May;55(5):774-81. Epub 2004 Feb 5.

PMID:
14764915
42.

The number of podocyte slit diaphragms is decreased in minimal change nephrotic syndrome.

Patrakka J, Lahdenkari AT, Koskimies O, Holmberg C, Wartiovaara J, Jalanko H.

Pediatr Res. 2002 Sep;52(3):349-55.

PMID:
12193666
43.

Proteinuria and prenatal diagnosis of congenital nephrosis in fetal carriers of nephrin gene mutations.

Patrakka J, Martin P, Salonen R, Kestilä M, Ruotsalainen V, Männikkö M, Ryynänen M, Rapola J, Holmberg C, Tryggvason K, Jalanko H.

Lancet. 2002 May 4;359(9317):1575-7.

PMID:
12047969
44.

Recurrence of nephrotic syndrome in kidney grafts of patients with congenital nephrotic syndrome of the Finnish type: role of nephrin.

Patrakka J, Ruotsalainen V, Reponen P, Qvist E, Laine J, Holmberg C, Tryggvason K, Jalanko H.

Transplantation. 2002 Feb 15;73(3):394-403.

PMID:
11884936
45.

Genetic kidney diseases disclose the pathogenesis of proteinuria.

Jalanko H, Patrakka J, Tryggvason K, Holmberg C.

Ann Med. 2001 Nov;33(8):526-33. Review.

PMID:
11730159
46.

Expression of nephrin in pediatric kidney diseases.

Patrakka J, Ruotsalainen V, Ketola I, Holmberg C, Heikinheimo M, Tryggvason K, Jalanko H.

J Am Soc Nephrol. 2001 Feb;12(2):289-96.

47.

Role of nephrin in cell junction formation in human nephrogenesis.

Ruotsalainen V, Patrakka J, Tissari P, Reponen P, Hess M, Kestilä M, Holmberg C, Salonen R, Heikinheimo M, Wartiovaara J, Tryggvason K, Jalanko H.

Am J Pathol. 2000 Dec;157(6):1905-16.

48.

Congenital nephrotic syndrome (NPHS1): features resulting from different mutations in Finnish patients.

Patrakka J, Kestilä M, Wartiovaara J, Ruotsalainen V, Tissari P, Lenkkeri U, Männikkö M, Visapää I, Holmberg C, Rapola J, Tryggvason K, Jalanko H.

Kidney Int. 2000 Sep;58(3):972-80.

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