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Identification of signal peptide features for substrate specificity in human Sec62/Sec63-dependent ER protein import.

Schorr S, Nguyen D, Haßdenteufel S, Nagaraj N, Cavalié A, Greiner M, Weissgerber P, Loi M, Paton AW, Paton JC, Molinari M, Förster F, Dudek J, Lang S, Helms V, Zimmermann R.

FEBS J. 2020 Mar 4. doi: 10.1111/febs.15274. [Epub ahead of print]


Host-glycan metabolism is regulated by a species-conserved two-component system in Streptococcus pneumoniae.

Andreassen PR, Trappetti C, Minhas V, Nielsen FD, Pakula K, Paton JC, Jørgensen MG.

PLoS Pathog. 2020 Mar 4;16(3):e1008332. doi: 10.1371/journal.ppat.1008332. eCollection 2020 Mar.


Factor VIII exhibits chaperone-dependent and glucose-regulated reversible amyloid formation in the endoplasmic reticulum.

Poothong J, Pottekat A, Siriin M, Campos AR, Paton AW, Paton JC, Lagunas-Acosta J, Chen Z, Swift M, Volkmann N, Hanein D, Yong J, Kaufman RJ.

Blood. 2020 Mar 3. pii: blood.2019002867. doi: 10.1182/blood.2019002867. [Epub ahead of print]


IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress.

Grey MJ, Cloots E, Simpson MS, LeDuc N, Serebrenik YV, De Luca H, De Sutter D, Luong P, Thiagarajah JR, Paton AW, Paton JC, Seeliger MA, Eyckerman S, Janssens S, Lencer WI.

J Cell Biol. 2020 Feb 3;219(2). pii: e201904048. doi: 10.1083/jcb.201904048.


Calcium Influx Caused by ER Stress Inducers Enhances Oncolytic Adenovirus Enadenotucirev Replication and Killing through PKCα Activation.

Taverner WK, Jacobus EJ, Christianson J, Champion B, Paton AW, Paton JC, Su W, Cawood R, Seymour LW, Lei-Rossmann J.

Mol Ther Oncolytics. 2019 Sep 28;15:117-130. doi: 10.1016/j.omto.2019.09.003. eCollection 2019 Dec 20.


Pneumococcal Vaccines.

Briles DE, Paton JC, Mukerji R, Swiatlo E, Crain MJ.

Microbiol Spectr. 2019 Nov;7(6). doi: 10.1128/microbiolspec.GPP3-0028-2018. Review.


Crosstalk between Human Microvascular Endothelial Cells and Tubular Epithelial Cells Modulates Pro-Inflammatory Responses Induced by Shiga Toxin Type 2 and Subtilase Cytotoxin.

Álvarez RS, Jancic C, Garimano N, Sacerdoti F, Paton AW, Paton JC, Ibarra C, Amaral MM.

Toxins (Basel). 2019 Nov 7;11(11). pii: E648. doi: 10.3390/toxins11110648.


The Role of Zinc Efflux during Acinetobacter baumannii Infection.

Alquethamy SF, Adams FG, Naidu V, Khorvash M, Pederick VG, Zang M, Paton JC, Paulsen IT, Hassan KA, Cain AK, McDevitt CA, Eijkelkamp BA.

ACS Infect Dis. 2020 Jan 10;6(1):150-158. doi: 10.1021/acsinfecdis.9b00351. Epub 2019 Nov 8.


9-Azido Analogues of Three Sialic Acid Forms for Metabolic Remodeling of Cell-Surface Sialoglycans.

Cheng B, Dong L, Zhu Y, Huang R, Sun Y, You Q, Song Q, Paton JC, Paton AW, Chen X.

ACS Chem Biol. 2019 Oct 18;14(10):2141-2147. doi: 10.1021/acschembio.9b00556. Epub 2019 Oct 4.


Dietary zinc and the control of Streptococcus pneumoniae infection.

Eijkelkamp BA, Morey JR, Neville SL, Tan A, Pederick VG, Cole N, Singh PP, Ong CY, Gonzalez de Vega R, Clases D, Cunningham BA, Hughes CE, Comerford I, Brazel EB, Whittall JJ, Plumptre CD, McColl SR, Paton JC, McEwan AG, Doble PA, McDevitt CA.

PLoS Pathog. 2019 Aug 22;15(8):e1007957. doi: 10.1371/journal.ppat.1007957. eCollection 2019 Aug.


SMRT sequencing reveals differential patterns of methylation in two O111:H- STEC isolates from a hemolytic uremic syndrome outbreak in Australia.

Forde BM, McAllister LJ, Paton JC, Paton AW, Beatson SA.

Sci Rep. 2019 Jul 1;9(1):9436. doi: 10.1038/s41598-019-45760-5.


Clustering of IRE1α depends on sensing ER stress but not on its RNase activity.

Ricci D, Marrocco I, Blumenthal D, Dibos M, Eletto D, Vargas J, Boyle S, Iwamoto Y, Chomistek S, Paton JC, Paton AW, Argon Y.

FASEB J. 2019 Sep;33(9):9811-9827. doi: 10.1096/fj.201801240RR. Epub 2019 Jun 14.


Proinsulin misfolding is an early event in the progression to type 2 diabetes.

Arunagiri A, Haataja L, Pottekat A, Pamenan F, Kim S, Zeltser LM, Paton AW, Paton JC, Tsai B, Itkin-Ansari P, Kaufman RJ, Liu M, Arvan P.

Elife. 2019 Jun 11;8. pii: e44532. doi: 10.7554/eLife.44532.


Direct interaction of whole-inactivated influenza A and pneumococcal vaccines enhances influenza-specific immunity.

David SC, Norton T, Tyllis T, Wilson JJ, Singleton EV, Laan Z, Davies J, Hirst TR, Comerford I, McColl SR, Paton JC, Alsharifi M.

Nat Microbiol. 2019 Aug;4(8):1316-1327. doi: 10.1038/s41564-019-0443-4. Epub 2019 May 20.


Enhanced safety and immunogenicity of a pneumococcal surface antigen A mutant whole-cell inactivated pneumococcal vaccine.

David SC, Laan Z, Minhas V, Chen AY, Davies J, Hirst TR, McColl SR, Alsharifi M, Paton JC.

Immunol Cell Biol. 2019 Sep;97(8):726-739. doi: 10.1111/imcb.12257. Epub 2019 May 23.


Streptococcus pneumoniae Capsular Polysaccharide.

Paton JC, Trappetti C.

Microbiol Spectr. 2019 Mar;7(2). doi: 10.1128/microbiolspec.GPP3-0019-2018. Review.


Cell surface expression of 78-kDa glucose-regulated protein (GRP78) mediates diabetic nephropathy.

Van Krieken R, Mehta N, Wang T, Zheng M, Li R, Gao B, Ayaub E, Ask K, Paton JC, Paton AW, Austin RC, Krepinsky JC.

J Biol Chem. 2019 May 10;294(19):7755-7768. doi: 10.1074/jbc.RA118.006939. Epub 2019 Mar 26.


Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury.

Leonard A, Grose V, Paton AW, Paton JC, Yule DI, Rahman A, Fazal F.

Sci Rep. 2019 Feb 14;9(1):2096. doi: 10.1038/s41598-018-38312-w.


The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating.

Ziska A, Tatzelt J, Dudek J, Paton AW, Paton JC, Zimmermann R, Haßdenteufel S.

Biol Open. 2019 Mar 5;8(3). pii: bio040691. doi: 10.1242/bio.040691.


Identification of Novel Acinetobacter baumannii Host Fatty Acid Stress Adaptation Strategies.

Jiang JH, Hassan KA, Begg SL, Rupasinghe TWT, Naidu V, Pederick VG, Khorvash M, Whittall JJ, Paton JC, Paulsen IT, McDevitt CA, Peleg AY, Eijkelkamp BA.

mBio. 2019 Feb 5;10(1). pii: e02056-18. doi: 10.1128/mBio.02056-18.


The Role of the CopA Copper Efflux System in Acinetobacter baumannii Virulence.

Alquethamy SF, Khorvash M, Pederick VG, Whittall JJ, Paton JC, Paulsen IT, Hassan KA, McDevitt CA, Eijkelkamp BA.

Int J Mol Sci. 2019 Jan 29;20(3). pii: E575. doi: 10.3390/ijms20030575.


Capacity To Utilize Raffinose Dictates Pneumococcal Disease Phenotype.

Minhas V, Harvey RM, McAllister LJ, Seemann T, Syme AE, Baines SL, Paton JC, Trappetti C.

mBio. 2019 Jan 15;10(1). pii: e02596-18. doi: 10.1128/mBio.02596-18.


Long Interleukin-22 Binding Protein Isoform-1 Is an Intracellular Activator of the Unfolded Protein Response.

Gómez-Fernández P, Urtasun A, Paton AW, Paton JC, Borrego F, Dersh D, Argon Y, Alloza I, Vandenbroeck K.

Front Immunol. 2018 Dec 14;9:2934. doi: 10.3389/fimmu.2018.02934. eCollection 2018.


Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na+-Taurocholate Cotransporting Polypeptide.

Robin MJD, Appelman MD, Vos HR, van Es RM, Paton JC, Paton AW, Burgering B, Fickert P, Heijmans J, van de Graaf SFJ.

Hepatol Commun. 2018 Oct 23;2(12):1550-1566. doi: 10.1002/hep4.1262. eCollection 2018 Dec.


Stand by to repel boarders.

Paton JC, Trappetti C.

Nat Microbiol. 2019 Jan;4(1):8-9. doi: 10.1038/s41564-018-0324-2. No abstract available.


Detection of N-glycolylneuraminic acid biomarkers in sera from patients with ovarian cancer using an engineered N-glycolylneuraminic acid-specific lectin SubB2M.

Shewell LK, Wang JJ, Paton JC, Paton AW, Day CJ, Jennings MP.

Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):173-177. doi: 10.1016/j.bbrc.2018.11.001. Epub 2018 Nov 8.


A recombinant conjugated pneumococcal vaccine that protects against murine infections with a similar efficacy to Prevnar-13.

Reglinski M, Ercoli G, Plumptre C, Kay E, Petersen FC, Paton JC, Wren BW, Brown JS.

NPJ Vaccines. 2018 Oct 31;3:53. doi: 10.1038/s41541-018-0090-4. eCollection 2018.


Th17 responses to pneumococcus in blood and adenoidal cells in children.

Oliver E, Pope C, Clarke E, Langton Hewer C, Ogunniyi AD, Paton JC, Mitchell T, Malley R, Finn A.

Clin Exp Immunol. 2019 Feb;195(2):213-225. doi: 10.1111/cei.13225. Epub 2018 Oct 31.


Specific growth conditions induce a Streptococcus pneumoniae non-mucoidal, small colony variant and determine the outcome of its co-culture with Haemophilus influenzae.

Tikhomirova A, Trappetti C, Standish AJ, Zhou Y, Breen J, Pederson S, Zilm PS, Paton JC, Kidd SP.

Pathog Dis. 2018 Oct 1;76(7). doi: 10.1093/femspd/fty074.


Streptococcus pneumoniae potently induces cell death in mesothelial cells.

Rashwan R, Varano Della Vergiliana JF, Lansley SM, Cheah HM, Popowicz N, Paton JC, Waterer GW, Townsend T, Kay I, Brown JS, Lee YCG.

PLoS One. 2018 Jul 30;13(7):e0201530. doi: 10.1371/journal.pone.0201530. eCollection 2018.


Arachidonic Acid Stress Impacts Pneumococcal Fatty Acid Homeostasis.

Eijkelkamp BA, Begg SL, Pederick VG, Trapetti C, Gregory MK, Whittall JJ, Paton JC, McDevitt CA.

Front Microbiol. 2018 May 11;9:813. doi: 10.3389/fmicb.2018.00813. eCollection 2018.


Structural characterisation of the HT3 motif of the polyhistidine triad protein D from Streptococcus pneumoniae.

Luo Z, Pederick VG, Paton JC, McDevitt CA, Kobe B.

FEBS Lett. 2018 Jul;592(13):2341-2350. doi: 10.1002/1873-3468.13122. Epub 2018 Jun 14.


Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier.

Haßdenteufel S, Johnson N, Paton AW, Paton JC, High S, Zimmermann R.

Cell Rep. 2018 May 1;23(5):1373-1386. doi: 10.1016/j.celrep.2018.03.122.


Specificity and utility of SubB2M, a new N-glycolylneuraminic acid lectin.

Wang J, Shewell LK, Paton AW, Paton JC, Day CJ, Jennings MP.

Biochem Biophys Res Commun. 2018 Jun 7;500(3):765-771. doi: 10.1016/j.bbrc.2018.04.151. Epub 2018 Apr 26.


Glycointeractions in bacterial pathogenesis.

Poole J, Day CJ, von Itzstein M, Paton JC, Jennings MP.

Nat Rev Microbiol. 2018 Jul;16(7):440-452. doi: 10.1038/s41579-018-0007-2. Review.


Streptococcus pneumoniae: transmission, colonization and invasion.

Weiser JN, Ferreira DM, Paton JC.

Nat Rev Microbiol. 2018 Jun;16(6):355-367. doi: 10.1038/s41579-018-0001-8. Review.


Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization.

Tang CH, Chang S, Paton AW, Paton JC, Gabrilovich DI, Ploegh HL, Del Valle JR, Hu CC.

J Cell Biol. 2018 May 7;217(5):1739-1755. doi: 10.1083/jcb.201709137. Epub 2018 Mar 6.


The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones.

Sowers CR, Wang R, Bourne RA, McGrath BC, Hu J, Bevilacqua SC, Paton JC, Paton AW, Collardeau-Frachon S, Nicolino M, Cavener DR.

J Biol Chem. 2018 Apr 6;293(14):5134-5149. doi: 10.1074/jbc.M117.813790. Epub 2018 Feb 14.


Role of Streptococcus pneumoniae OM001 operon in capsular polysaccharide production, virulence and survival in human saliva.

Ahmad Z, Harvey RM, Paton JC, Standish AJ, Morona R.

PLoS One. 2018 Jan 2;13(1):e0190402. doi: 10.1371/journal.pone.0190402. eCollection 2018.


Lectin activity of the pneumococcal pilin proteins.

Day CJ, Paton AW, Harvey RM, Hartley-Tassell LE, Seib KL, Tiralongo J, Bovin N, Savino S, Masignani V, Paton JC, Jennings MP.

Sci Rep. 2017 Dec 19;7(1):17784. doi: 10.1038/s41598-017-17850-9.


Human pleural fluid is a potent growth medium for Streptococcus pneumoniae.

Popowicz ND, Lansley SM, Cheah HM, Kay ID, Carson CF, Waterer GW, Paton JC, Brown JS, Lee YCG.

PLoS One. 2017 Nov 30;12(11):e0188833. doi: 10.1371/journal.pone.0188833. eCollection 2017.


Evaluation of robenidine analog NCL195 as a novel broad-spectrum antibacterial agent.

Ogunniyi AD, Khazandi M, Stevens AJ, Sims SK, Page SW, Garg S, Venter H, Powell A, White K, Petrovski KR, Laven-Law G, Tótoli EG, Salgado HR, Pi H, Coombs GW, Shinabarger DL, Turnidge JD, Paton JC, McCluskey A, Trott DJ.

PLoS One. 2017 Sep 5;12(9):e0183457. doi: 10.1371/journal.pone.0183457. eCollection 2017.


Ouabain Protects Human Renal Cells against the Cytotoxic Effects of Shiga Toxin Type 2 and Subtilase Cytotoxin.

Amaral MM, Girard MC, Álvarez RS, Paton AW, Paton JC, Repetto HA, Sacerdoti F, Ibarra CA.

Toxins (Basel). 2017 Jul 18;9(7). pii: E226. doi: 10.3390/toxins9070226.


Pneumolysin-induced autophagy contributes to inhibition of osteoblast differentiation through downregulation of Sp1 in human osteosarcoma cells.

Kim J, Lee HW, Rhee DK, Paton JC, Pyo S.

Biochim Biophys Acta Gen Subj. 2017 Nov;1861(11 Pt A):2663-2673. doi: 10.1016/j.bbagen.2017.07.008. Epub 2017 Jul 14.


Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins.

Littler DR, Ang SY, Moriel DG, Kocan M, Kleifeld O, Johnson MD, Tran MT, Paton AW, Paton JC, Summers RJ, Schembri MA, Rossjohn J, Beddoe T.

J Biol Chem. 2017 Sep 8;292(36):15143-15158. doi: 10.1074/jbc.M117.796094. Epub 2017 Jun 29.


IL-17-producing γδ T cells switch migratory patterns between resting and activated states.

McKenzie DR, Kara EE, Bastow CR, Tyllis TS, Fenix KA, Gregor CE, Wilson JJ, Babb R, Paton JC, Kallies A, Nutt SL, Brüstle A, Mack M, Comerford I, McColl SR.

Nat Commun. 2017 Jun 5;8:15632. doi: 10.1038/ncomms15632.


Proteomic comparisons of opaque and transparent variants of Streptococcus pneumoniae by two dimensional-differential gel electrophoresis.

Chai MH, Weiland F, Harvey RM, Hoffmann P, Ogunniyi AD, Paton JC.

Sci Rep. 2017 May 26;7(1):2453. doi: 10.1038/s41598-017-02465-x.


Vacuolation Activity and Intracellular Trafficking of ArtB, the Binding Subunit of an AB5 Toxin Produced by Salmonella enterica Serovar Typhi.

Herdman BP, Paton JC, Wang H, Beddoe T, Paton AW.

Infect Immun. 2017 Jul 19;85(8). pii: e00214-17. doi: 10.1128/IAI.00214-17. Print 2017 Aug.


Structure aided design of a Neu5Gc specific lectin.

Day CJ, Paton AW, Higgins MA, Shewell LK, Jen FE, Schulz BL, Herdman BP, Paton JC, Jennings MP.

Sci Rep. 2017 May 4;7(1):1495. doi: 10.1038/s41598-017-01522-9.


DR5 and caspase-8 are dispensable in ER stress-induced apoptosis.

Glab JA, Doerflinger M, Nedeva C, Jose I, Mbogo GW, Paton JC, Paton AW, Kueh AJ, Herold MJ, Huang DC, Segal D, Brumatti G, Puthalakath H.

Cell Death Differ. 2017 May;24(5):944-950. doi: 10.1038/cdd.2017.53. Epub 2017 Apr 14.

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