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Items: 1 to 50 of 343

1.

Streptococcus pneumoniae potently induces cell death in mesothelial cells.

Rashwan R, Varano Della Vergiliana JF, Lansley SM, Cheah HM, Popowicz N, Paton JC, Waterer GW, Townsend T, Kay I, Brown JS, Lee YCG.

PLoS One. 2018 Jul 30;13(7):e0201530. doi: 10.1371/journal.pone.0201530. eCollection 2018.

2.

Arachidonic Acid Stress Impacts Pneumococcal Fatty Acid Homeostasis.

Eijkelkamp BA, Begg SL, Pederick VG, Trapetti C, Gregory MK, Whittall JJ, Paton JC, McDevitt CA.

Front Microbiol. 2018 May 11;9:813. doi: 10.3389/fmicb.2018.00813. eCollection 2018.

3.

Structural characterisation of the HT3 motif of the polyhistidine triad protein D from Streptococcus pneumoniae.

Luo Z, Pederick VG, Paton JC, McDevitt CA, Kobe B.

FEBS Lett. 2018 Jul;592(13):2341-2350. doi: 10.1002/1873-3468.13122. Epub 2018 Jun 14.

PMID:
29856892
4.

Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier.

Haßdenteufel S, Johnson N, Paton AW, Paton JC, High S, Zimmermann R.

Cell Rep. 2018 May 1;23(5):1373-1386. doi: 10.1016/j.celrep.2018.03.122.

5.

Specificity and utility of SubB2M, a new N-glycolylneuraminic acid lectin.

Wang J, Shewell LK, Paton AW, Paton JC, Day CJ, Jennings MP.

Biochem Biophys Res Commun. 2018 Jun 7;500(3):765-771. doi: 10.1016/j.bbrc.2018.04.151. Epub 2018 Apr 26.

6.

Glycointeractions in bacterial pathogenesis.

Poole J, Day CJ, von Itzstein M, Paton JC, Jennings MP.

Nat Rev Microbiol. 2018 Jul;16(7):440-452. doi: 10.1038/s41579-018-0007-2. Review.

PMID:
29674747
7.

Streptococcus pneumoniae: transmission, colonization and invasion.

Weiser JN, Ferreira DM, Paton JC.

Nat Rev Microbiol. 2018 Jun;16(6):355-367. doi: 10.1038/s41579-018-0001-8. Review.

PMID:
29599457
8.

Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization.

Tang CH, Chang S, Paton AW, Paton JC, Gabrilovich DI, Ploegh HL, Del Valle JR, Hu CC.

J Cell Biol. 2018 May 7;217(5):1739-1755. doi: 10.1083/jcb.201709137. Epub 2018 Mar 6.

9.

The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones.

Sowers CR, Wang R, Bourne RA, McGrath BC, Hu J, Bevilacqua SC, Paton JC, Paton AW, Collardeau-Frachon S, Nicolino M, Cavener DR.

J Biol Chem. 2018 Apr 6;293(14):5134-5149. doi: 10.1074/jbc.M117.813790. Epub 2018 Feb 14.

PMID:
29444822
10.

Role of Streptococcus pneumoniae OM001 operon in capsular polysaccharide production, virulence and survival in human saliva.

Ahmad Z, Harvey RM, Paton JC, Standish AJ, Morona R.

PLoS One. 2018 Jan 2;13(1):e0190402. doi: 10.1371/journal.pone.0190402. eCollection 2018.

11.

Lectin activity of the pneumococcal pilin proteins.

Day CJ, Paton AW, Harvey RM, Hartley-Tassell LE, Seib KL, Tiralongo J, Bovin N, Savino S, Masignani V, Paton JC, Jennings MP.

Sci Rep. 2017 Dec 19;7(1):17784. doi: 10.1038/s41598-017-17850-9.

12.

Human pleural fluid is a potent growth medium for Streptococcus pneumoniae.

Popowicz ND, Lansley SM, Cheah HM, Kay ID, Carson CF, Waterer GW, Paton JC, Brown JS, Lee YCG.

PLoS One. 2017 Nov 30;12(11):e0188833. doi: 10.1371/journal.pone.0188833. eCollection 2017.

13.

Evaluation of robenidine analog NCL195 as a novel broad-spectrum antibacterial agent.

Ogunniyi AD, Khazandi M, Stevens AJ, Sims SK, Page SW, Garg S, Venter H, Powell A, White K, Petrovski KR, Laven-Law G, Tótoli EG, Salgado HR, Pi H, Coombs GW, Shinabarger DL, Turnidge JD, Paton JC, McCluskey A, Trott DJ.

PLoS One. 2017 Sep 5;12(9):e0183457. doi: 10.1371/journal.pone.0183457. eCollection 2017.

14.

Ouabain Protects Human Renal Cells against the Cytotoxic Effects of Shiga Toxin Type 2 and Subtilase Cytotoxin.

Amaral MM, Girard MC, Álvarez RS, Paton AW, Paton JC, Repetto HA, Sacerdoti F, Ibarra CA.

Toxins (Basel). 2017 Jul 18;9(7). pii: E226. doi: 10.3390/toxins9070226.

15.

Pneumolysin-induced autophagy contributes to inhibition of osteoblast differentiation through downregulation of Sp1 in human osteosarcoma cells.

Kim J, Lee HW, Rhee DK, Paton JC, Pyo S.

Biochim Biophys Acta Gen Subj. 2017 Nov;1861(11 Pt A):2663-2673. doi: 10.1016/j.bbagen.2017.07.008. Epub 2017 Jul 14.

PMID:
28713020
16.

Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins.

Littler DR, Ang SY, Moriel DG, Kocan M, Kleifeld O, Johnson MD, Tran MT, Paton AW, Paton JC, Summers RJ, Schembri MA, Rossjohn J, Beddoe T.

J Biol Chem. 2017 Sep 8;292(36):15143-15158. doi: 10.1074/jbc.M117.796094. Epub 2017 Jun 29.

17.

IL-17-producing γδ T cells switch migratory patterns between resting and activated states.

McKenzie DR, Kara EE, Bastow CR, Tyllis TS, Fenix KA, Gregor CE, Wilson JJ, Babb R, Paton JC, Kallies A, Nutt SL, Brüstle A, Mack M, Comerford I, McColl SR.

Nat Commun. 2017 Jun 5;8:15632. doi: 10.1038/ncomms15632.

18.

Proteomic comparisons of opaque and transparent variants of Streptococcus pneumoniae by two dimensional-differential gel electrophoresis.

Chai MH, Weiland F, Harvey RM, Hoffmann P, Ogunniyi AD, Paton JC.

Sci Rep. 2017 May 26;7(1):2453. doi: 10.1038/s41598-017-02465-x.

19.

Vacuolation Activity and Intracellular Trafficking of ArtB, the Binding Subunit of an AB5 Toxin Produced by Salmonella enterica Serovar Typhi.

Herdman BP, Paton JC, Wang H, Beddoe T, Paton AW.

Infect Immun. 2017 Jul 19;85(8). pii: e00214-17. doi: 10.1128/IAI.00214-17. Print 2017 Aug.

20.

Structure aided design of a Neu5Gc specific lectin.

Day CJ, Paton AW, Higgins MA, Shewell LK, Jen FE, Schulz BL, Herdman BP, Paton JC, Jennings MP.

Sci Rep. 2017 May 4;7(1):1495. doi: 10.1038/s41598-017-01522-9.

21.

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis.

Glab JA, Doerflinger M, Nedeva C, Jose I, Mbogo GW, Paton JC, Paton AW, Kueh AJ, Herold MJ, Huang DC, Segal D, Brumatti G, Puthalakath H.

Cell Death Differ. 2017 May;24(5):944-950. doi: 10.1038/cdd.2017.53. Epub 2017 Apr 14.

22.

The Pneumococcal Alpha-Glycerophosphate Oxidase Enhances Nasopharyngeal Colonization through Binding to Host Glycoconjugates.

Mahdi LK, Higgins MA, Day CJ, Tiralongo J, Hartley-Tassell LE, Jennings MP, Gordon DL, Paton AW, Paton JC, Ogunniyi AD.

EBioMedicine. 2017 Apr;18:236-243. doi: 10.1016/j.ebiom.2017.03.002. Epub 2017 Mar 3.

23.

Zinc stress induces copper depletion in Acinetobacter baumannii.

Hassan KA, Pederick VG, Elbourne LD, Paulsen IT, Paton JC, McDevitt CA, Eijkelkamp BA.

BMC Microbiol. 2017 Mar 11;17(1):59. doi: 10.1186/s12866-017-0965-y.

24.

Autoinducer 2 Signaling via the Phosphotransferase FruA Drives Galactose Utilization by Streptococcus pneumoniae, Resulting in Hypervirulence.

Trappetti C, McAllister LJ, Chen A, Wang H, Paton AW, Oggioni MR, McDevitt CA, Paton JC.

MBio. 2017 Jan 24;8(1). pii: e02269-16. doi: 10.1128/mBio.02269-16.

25.

The effect of gamma-irradiation conditions on the immunogenicity of whole-inactivated Influenza A virus vaccine.

David SC, Lau J, Singleton EV, Babb R, Davies J, Hirst TR, McColl SR, Paton JC, Alsharifi M.

Vaccine. 2017 Feb 15;35(7):1071-1079. doi: 10.1016/j.vaccine.2016.12.044. Epub 2017 Jan 18.

PMID:
28109709
26.

Host-to-Host Transmission of the Pneumococcus-New Victims of a Toxic Relationship.

Trappetti C, Paton JC.

Cell Host Microbe. 2017 Jan 11;21(1):5-6. doi: 10.1016/j.chom.2016.12.011.

27.

Systemic effects of Subtilase cytotoxin produced by Escherichia coli O113:H21.

Seyahian EA, Oltra G, Ochoa F, Melendi S, Hermes R, Paton JC, Paton AW, Lago N, Castro Parodi M, Damiano A, Ibarra C, Zotta E.

Toxicon. 2017 Mar 1;127:49-55. doi: 10.1016/j.toxicon.2016.12.014. Epub 2017 Jan 3.

PMID:
28057514
28.

GRP78 Is an Important Host Factor for Japanese Encephalitis Virus Entry and Replication in Mammalian Cells.

Nain M, Mukherjee S, Karmakar SP, Paton AW, Paton JC, Abdin MZ, Basu A, Kalia M, Vrati S.

J Virol. 2017 Feb 28;91(6). pii: e02274-16. doi: 10.1128/JVI.02274-16. Print 2017 Mar 15.

29.

Physiological Exploration of the Long Term Evolutionary Selection against Expression of N-Glycolylneuraminic Acid in the Brain.

Naito-Matsui Y, Davies LR, Takematsu H, Chou HH, Tangvoranuntakul P, Carlin AF, Verhagen A, Heyser CJ, Yoo SW, Choudhury B, Paton JC, Paton AW, Varki NM, Schnaar RL, Varki A.

J Biol Chem. 2017 Feb 17;292(7):2557-2570. doi: 10.1074/jbc.M116.768531. Epub 2017 Jan 3.

30.

Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion.

Cunningham CN, He K, Arunagiri A, Paton AW, Paton JC, Arvan P, Tsai B.

Diabetes. 2017 Mar;66(3):741-753. doi: 10.2337/db16-1338. Epub 2016 Dec 27.

31.

Enhanced protective responses to a serotype-independent pneumococcal vaccine when combined with an inactivated influenza vaccine.

Babb R, Chen A, Ogunniyi AD, Hirst TR, Kara EE, McColl SR, Alsharifi M, Paton JC.

Clin Sci (Lond). 2017 Jan 1;131(2):169-180. doi: 10.1042/CS20160475. Epub 2016 Nov 24.

PMID:
27885052
32.

Induction of endoplasmic reticulum stress by deletion of Grp78 depletes Apc mutant intestinal epithelial stem cells.

van Lidth de Jeude JF, Meijer BJ, Wielenga MCB, Spaan CN, Baan B, Rosekrans SL, Meisner S, Shen YH, Lee AS, Paton JC, Paton AW, Muncan V, van den Brink GR, Heijmans J.

Oncogene. 2017 Jun 15;36(24):3397-3405. doi: 10.1038/onc.2016.326. Epub 2016 Nov 7.

PMID:
27819675
33.

Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma.

Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):9015-20. doi: 10.1073/pnas.1603883113. Epub 2016 Jul 22.

34.

Comparative Characterization of Shiga Toxin Type 2 and Subtilase Cytotoxin Effects on Human Renal Epithelial and Endothelial Cells Grown in Monolayer and Bilayer Conditions.

Álvarez RS, Sacerdoti F, Jancic C, Paton AW, Paton JC, Ibarra C, Amaral MM.

PLoS One. 2016 Jun 23;11(6):e0158180. doi: 10.1371/journal.pone.0158180. eCollection 2016.

35.

A dynamic relationship between mucosal T helper type 17 and regulatory T-cell populations in nasopharynx evolves with age and associates with the clearance of pneumococcal carriage in humans.

Mubarak A, Ahmed MS, Upile N, Vaughan C, Xie C, Sharma R, Acar P, McCormick MS, Paton JC, Mitchell T, Cunliffe N, Zhang Q.

Clin Microbiol Infect. 2016 Aug;22(8):736.e1-7. doi: 10.1016/j.cmi.2016.05.017. Epub 2016 May 30.

36.

Intranasal vaccination with γ-irradiated Streptococcus pneumoniae whole-cell vaccine provides serotype-independent protection mediated by B-cells and innate IL-17 responses.

Babb R, Chen A, Hirst TR, Kara EE, McColl SR, Ogunniyi AD, Paton JC, Alsharifi M.

Clin Sci (Lond). 2016 May;130(9):697-710. doi: 10.1042/CS20150699. Epub 2016 Feb 1.

PMID:
26831937
37.

The Variable Region of Pneumococcal Pathogenicity Island 1 Is Responsible for Unusually High Virulence of a Serotype 1 Isolate.

Harvey RM, Trappetti C, Mahdi LK, Wang H, McAllister LJ, Scalvini A, Paton AW, Paton JC.

Infect Immun. 2016 Jan 11;84(3):822-32. doi: 10.1128/IAI.01454-15.

38.

Genomic Comparison of Two O111:H- Enterohemorrhagic Escherichia coli Isolates from a Historic Hemolytic-Uremic Syndrome Outbreak in Australia.

McAllister LJ, Bent SJ, Petty NK, Skippington E, Beatson SA, Paton JC, Paton AW.

Infect Immun. 2016 Jan 4;84(3):775-81. doi: 10.1128/IAI.01229-15.

39.

Streptococcus pneumoniae induces pyroptosis through the regulation of autophagy in murine microglia.

Kim JY, Paton JC, Briles DE, Rhee DK, Pyo S.

Oncotarget. 2015 Dec 29;6(42):44161-78. doi: 10.18632/oncotarget.6592.

40.

The First Histidine Triad Motif of PhtD Is Critical for Zinc Homeostasis in Streptococcus pneumoniae.

Eijkelkamp BA, Pederick VG, Plumptre CD, Harvey RM, Hughes CE, Paton JC, McDevitt CA.

Infect Immun. 2015 Nov 16;84(2):407-15. doi: 10.1128/IAI.01082-15. Print 2016 Feb.

41.

IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation.

Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, Ma H, Inoue T, Gao B, Kim H, Bu P, Guber RD, Shen X, Lee AH, Iwawaki T, Paton AW, Paton JC, Fang D, Tsai B, Yates JR 3rd, Wu H, Kersten S, Long Q, Duhamel GE, Simpson KW, Qi L.

Nat Cell Biol. 2015 Dec;17(12):1546-55. doi: 10.1038/ncb3266. Epub 2015 Nov 9.

42.

Characterization of Pneumococcal Genes Involved in Bloodstream Invasion in a Mouse Model.

Mahdi LK, Van der Hoek MB, Ebrahimie E, Paton JC, Ogunniyi AD.

PLoS One. 2015 Nov 5;10(11):e0141816. doi: 10.1371/journal.pone.0141816. eCollection 2015.

43.

CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells.

Kara EE, McKenzie DR, Bastow CR, Gregor CE, Fenix KA, Ogunniyi AD, Paton JC, Mack M, Pombal DR, Seillet C, Dubois B, Liston A, MacDonald KP, Belz GT, Smyth MJ, Hill GR, Comerford I, McColl SR.

Nat Commun. 2015 Oct 29;6:8644. doi: 10.1038/ncomms9644.

44.

A Second β-Hexosaminidase Encoded in the Streptococcus pneumoniae Genome Provides an Expanded Biochemical Ability to Degrade Host Glycans.

Robb M, Robb CS, Higgins MA, Hobbs JK, Paton JC, Boraston AB.

J Biol Chem. 2015 Dec 25;290(52):30888-900. doi: 10.1074/jbc.M115.688630. Epub 2015 Oct 21.

45.

The outcome of H. influenzae and S. pneumoniae inter-species interactions depends on pH, nutrient availability and growth phase.

Tikhomirova A, Trappetti C, Paton JC, Kidd SP.

Int J Med Microbiol. 2015 Dec;305(8):881-92. doi: 10.1016/j.ijmm.2015.09.003. Epub 2015 Sep 14.

PMID:
26481153
46.

ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy.

Wielenga MCB, Colak S, Heijmans J, van Lidth de Jeude JF, Rodermond HM, Paton JC, Paton AW, Vermeulen L, Medema JP, van den Brink GR.

Cell Rep. 2015 Oct 20;13(3):489-494. doi: 10.1016/j.celrep.2015.09.016. Epub 2015 Oct 8.

47.

Streptococcal toxins: role in pathogenesis and disease.

Barnett TC, Cole JN, Rivera-Hernandez T, Henningham A, Paton JC, Nizet V, Walker MJ.

Cell Microbiol. 2015 Dec;17(12):1721-41. doi: 10.1111/cmi.12531. Epub 2015 Nov 17. Review.

PMID:
26433203
48.

Isolation site influences virulence phenotype of serotype 14 Streptococcus pneumoniae strains belonging to multilocus sequence type 15.

Amin Z, Harvey RM, Wang H, Hughes CE, Paton AW, Paton JC, Trappetti C.

Infect Immun. 2015 Dec;83(12):4781-90. doi: 10.1128/IAI.01081-15. Epub 2015 Sep 28.

49.

Characterizing the conformational dynamics of metal-free PsaA using molecular dynamics simulations and electron paramagnetic resonance spectroscopy.

Deplazes E, Begg SL, van Wonderen JH, Campbell R, Kobe B, Paton JC, MacMillan F, McDevitt CA, O'Mara ML.

Biophys Chem. 2015 Dec;207:51-60. doi: 10.1016/j.bpc.2015.08.004. Epub 2015 Sep 3.

PMID:
26379256
50.

ZnuA and zinc homeostasis in Pseudomonas aeruginosa.

Pederick VG, Eijkelkamp BA, Begg SL, Ween MP, McAllister LJ, Paton JC, McDevitt CA.

Sci Rep. 2015 Aug 20;5:13139. doi: 10.1038/srep13139.

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