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Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury.

Leonard A, Grose V, Paton AW, Paton JC, Yule DI, Rahman A, Fazal F.

Sci Rep. 2019 Feb 14;9(1):2096. doi: 10.1038/s41598-018-38312-w.


The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating.

Ziska A, Tatzelt J, Dudek J, Paton AW, Paton JC, Zimmermann R, Haßdenteufel S.

Biol Open. 2019 Feb 11. pii: bio.040691. doi: 10.1242/bio.040691. [Epub ahead of print]


Identification of Novel Acinetobacter baumannii Host Fatty Acid Stress Adaptation Strategies.

Jiang JH, Hassan KA, Begg SL, Rupasinghe TWT, Naidu V, Pederick VG, Khorvash M, Whittall JJ, Paton JC, Paulsen IT, McDevitt CA, Peleg AY, Eijkelkamp BA.

MBio. 2019 Feb 5;10(1). pii: e02056-18. doi: 10.1128/mBio.02056-18.


The Role of the CopA Copper Efflux System in Acinetobacter baumannii Virulence.

Alquethamy SF, Khorvash M, Pederick VG, Whittall JJ, Paton JC, Paulsen IT, Hassan KA, McDevitt CA, Eijkelkamp BA.

Int J Mol Sci. 2019 Jan 29;20(3). pii: E575. doi: 10.3390/ijms20030575.


Capacity To Utilize Raffinose Dictates Pneumococcal Disease Phenotype.

Minhas V, Harvey RM, McAllister LJ, Seemann T, Syme AE, Baines SL, Paton JC, Trappetti C.

MBio. 2019 Jan 15;10(1). pii: e02596-18. doi: 10.1128/mBio.02596-18.


Long Interleukin-22 Binding Protein Isoform-1 Is an Intracellular Activator of the Unfolded Protein Response.

Gómez-Fernández P, Urtasun A, Paton AW, Paton JC, Borrego F, Dersh D, Argon Y, Alloza I, Vandenbroeck K.

Front Immunol. 2018 Dec 14;9:2934. doi: 10.3389/fimmu.2018.02934. eCollection 2018.


Matched cohort study of therapeutic strategies to prevent preschool wheezing/asthma attacks.

Grigg J, Nibber A, Paton JY, Chisholm A, Guilbert TW, Kaplan A, Turner S, Roche N, Hillyer EV, Price DB; Respiratory Effectiveness Group.

J Asthma Allergy. 2018 Dec 11;11:309-321. doi: 10.2147/JAA.S178531. eCollection 2018.


Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na+-Taurocholate Cotransporting Polypeptide.

Robin MJD, Appelman MD, Vos HR, van Es RM, Paton JC, Paton AW, Burgering B, Fickert P, Heijmans J, van de Graaf SFJ.

Hepatol Commun. 2018 Oct 23;2(12):1550-1566. doi: 10.1002/hep4.1262. eCollection 2018 Dec.


Stand by to repel boarders.

Paton JC, Trappetti C.

Nat Microbiol. 2019 Jan;4(1):8-9. doi: 10.1038/s41564-018-0324-2. No abstract available.


Blockade of Rostral Ventrolateral Medulla Apelin Receptors Does Not Attenuate Arterial Pressure in SHR and L-NAME-Induced Hypertensive Rats.

Griffiths PR, Lolait SJ, Pearce LE, McBryde FD, Paton JFR, O'Carroll AM.

Front Physiol. 2018 Oct 24;9:1488. doi: 10.3389/fphys.2018.01488. eCollection 2018.


Detection of N-glycolylneuraminic acid biomarkers in sera from patients with ovarian cancer using an engineered N-glycolylneuraminic acid-specific lectin SubB2M.

Shewell LK, Wang JJ, Paton JC, Paton AW, Day CJ, Jennings MP.

Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):173-177. doi: 10.1016/j.bbrc.2018.11.001. Epub 2018 Nov 8.


A recombinant conjugated pneumococcal vaccine that protects against murine infections with a similar efficacy to Prevnar-13.

Reglinski M, Ercoli G, Plumptre C, Kay E, Petersen FC, Paton JC, Wren BW, Brown JS.

NPJ Vaccines. 2018 Oct 31;3:53. doi: 10.1038/s41541-018-0090-4. eCollection 2018.


Locus Coeruleus as a vigilance centre for active inspiration and expiration in rats.

Magalhães KS, Spiller PF, da Silva MP, Kuntze LB, Paton JFR, Machado BH, Moraes DJA.

Sci Rep. 2018 Oct 23;8(1):15654. doi: 10.1038/s41598-018-34047-w.


Th17 responses to pneumococcus in blood and adenoidal cells in children.

Oliver E, Pope C, Clarke E, Langton Hewer C, Ogunniyi AD, Paton JC, Mitchell T, Malley R, Finn A.

Clin Exp Immunol. 2019 Feb;195(2):213-225. doi: 10.1111/cei.13225. Epub 2018 Oct 31.


Specific growth conditions induce a Streptococcus pneumoniae non-mucoidal, small colony variant and determine the outcome of its co-culture with Haemophilus influenzae.

Tikhomirova A, Trappetti C, Standish AJ, Zhou Y, Breen J, Pederson S, Zilm PS, Paton JC, Kidd SP.

Pathog Dis. 2018 Oct 1;76(7). doi: 10.1093/femspd/fty074.


Left ventricular extracellular volume fraction and atrioventricular interaction in hypertension.

Rodrigues JCL, Erdei T, Dastidar AG, Szantho G, Burchell AE, Ratcliffe LEK, Hart EC, Nightingale AK, Paton JFR, Manghat NE, Hamilton MCK.

Eur Radiol. 2019 Mar;29(3):1574-1585. doi: 10.1007/s00330-018-5700-z. Epub 2018 Sep 19.


Acute hydrocortisone administration reduces cardiovagal baroreflex sensitivity and heart rate variability in young men.

Adlan AM, Veldhuijzen van Zanten JJCS, Lip GYH, Paton JFR, Kitas GD, Fisher JP.

J Physiol. 2018 Oct;596(20):4847-4861. doi: 10.1113/JP276644. Epub 2018 Sep 12.


Streptococcus pneumoniae potently induces cell death in mesothelial cells.

Rashwan R, Varano Della Vergiliana JF, Lansley SM, Cheah HM, Popowicz N, Paton JC, Waterer GW, Townsend T, Kay I, Brown JS, Lee YCG.

PLoS One. 2018 Jul 30;13(7):e0201530. doi: 10.1371/journal.pone.0201530. eCollection 2018.


Purinergic plasticity within petrosal neurons in hypertension.

Moraes DJA, da Silva MP, Spiller PF, Machado BH, Paton JFR.

Am J Physiol Regul Integr Comp Physiol. 2018 Nov 1;315(5):R963-R971. doi: 10.1152/ajpregu.00142.2018. Epub 2018 Jun 27.


Antihypertensive Treatment Fails to Control Blood Pressure During Exercise.

Chant B, Bakali M, Hinton T, Burchell AE, Nightingale AK, Paton JFR, Hart EC.

Hypertension. 2018 Jul;72(1):102-109. doi: 10.1161/HYPERTENSIONAHA.118.11076.


At-risk children with asthma (ARC): a systematic review.

Buelo A, McLean S, Julious S, Flores-Kim J, Bush A, Henderson J, Paton JY, Sheikh A, Shields M, Pinnock H; ARC Group.

Thorax. 2018 Sep;73(9):813-824. doi: 10.1136/thoraxjnl-2017-210939. Epub 2018 Jun 5.


Arachidonic Acid Stress Impacts Pneumococcal Fatty Acid Homeostasis.

Eijkelkamp BA, Begg SL, Pederick VG, Trapetti C, Gregory MK, Whittall JJ, Paton JC, McDevitt CA.

Front Microbiol. 2018 May 11;9:813. doi: 10.3389/fmicb.2018.00813. eCollection 2018.


Structural characterisation of the HT3 motif of the polyhistidine triad protein D from Streptococcus pneumoniae.

Luo Z, Pederick VG, Paton JC, McDevitt CA, Kobe B.

FEBS Lett. 2018 Jul;592(13):2341-2350. doi: 10.1002/1873-3468.13122. Epub 2018 Jun 14.


Differences in autonomic innervation to the vertebrobasilar arteries in spontaneously hypertensive and Wistar rats.

Roloff EVL, Walas D, Moraes DJA, Kasparov S, Paton JFR.

J Physiol. 2018 Aug;596(16):3505-3529. doi: 10.1113/JP275973. Epub 2018 Jul 19.


The Neural Basis of Timing: Distributed Mechanisms for Diverse Functions.

Paton JJ, Buonomano DV.

Neuron. 2018 May 16;98(4):687-705. doi: 10.1016/j.neuron.2018.03.045. Review.


The prevalence, distribution, and functional importance of lower limb somatosensory impairments in chronic stroke survivors: a cross sectional observational study.

Gorst T, Rogers A, Morrison SC, Cramp M, Paton J, Freeman J, Marsden J.

Disabil Rehabil. 2018 May 4:1-8. doi: 10.1080/09638288.2018.1468932. [Epub ahead of print]


Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier.

Haßdenteufel S, Johnson N, Paton AW, Paton JC, High S, Zimmermann R.

Cell Rep. 2018 May 1;23(5):1373-1386. doi: 10.1016/j.celrep.2018.03.122.


Specificity and utility of SubB2M, a new N-glycolylneuraminic acid lectin.

Wang J, Shewell LK, Paton AW, Paton JC, Day CJ, Jennings MP.

Biochem Biophys Res Commun. 2018 Jun 7;500(3):765-771. doi: 10.1016/j.bbrc.2018.04.151. Epub 2018 Apr 26.


Glycointeractions in bacterial pathogenesis.

Poole J, Day CJ, von Itzstein M, Paton JC, Jennings MP.

Nat Rev Microbiol. 2018 Jul;16(7):440-452. doi: 10.1038/s41579-018-0007-2. Review.


Inflammatory pathways are central to posterior cerebrovascular artery remodelling prior to the onset of congenital hypertension.

Walas D, Nowicki-Osuch K, Alibhai D, von Linstow Roloff E, Coghill J, Waterfall C, Paton JF.

J Cereb Blood Flow Metab. 2018 Apr 13:271678X18769180. doi: 10.1177/0271678X18769180. [Epub ahead of print]


Streptococcus pneumoniae: transmission, colonization and invasion.

Weiser JN, Ferreira DM, Paton JC.

Nat Rev Microbiol. 2018 Jun;16(6):355-367. doi: 10.1038/s41579-018-0001-8. Review.


Comparison of accelerometer measured levels of physical activity and sedentary time between obese and non-obese children and adolescents: a systematic review.

Elmesmari R, Martin A, Reilly JJ, Paton JY.

BMC Pediatr. 2018 Mar 9;18(1):106. doi: 10.1186/s12887-018-1031-0. Review.


Noctural dipping status and left ventricular hypertrophy: A cardiac magnetic resonance imaging study.

Rodrigues JCL, Amadu AM, Ghosh Dastidar A, Harries I, Burchell AE, Ratcliffe LEK, Hart EC, Hamilton MCK, Paton JFR, Nightingale AK, Manghat NE.

J Clin Hypertens (Greenwich). 2018 Apr;20(4):784-793. doi: 10.1111/jch.13235. Epub 2018 Mar 8.


Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization.

Tang CH, Chang S, Paton AW, Paton JC, Gabrilovich DI, Ploegh HL, Del Valle JR, Hu CC.

J Cell Biol. 2018 May 7;217(5):1739-1755. doi: 10.1083/jcb.201709137. Epub 2018 Mar 6.


The effects of aging on biosynthetic processes in the rat hypothalamic osmoregulatory neuroendocrine system.

Greenwood MP, Greenwood M, Romanova EV, Mecawi AS, Paterson A, Sarenac O, Japundžić-Žigon N, Antunes-Rodrigues J, Paton JFR, Sweedler JV, Murphy D.

Neurobiol Aging. 2018 May;65:178-191. doi: 10.1016/j.neurobiolaging.2018.01.008. Epub 2018 Jan 31.


Neuroreflex control of cardiovascular function is impaired after acute poisoning with chlorpyrifos, an organophosphorus insecticide: Possible short and long term clinical implications.

Cunha AF, Felippe ISA, Ferreira-Junior NC, Resstel LBM, Guimarães DAM, Beijamini V, Paton JFR, Sampaio KN.

Toxicology. 2018 Apr 1;398-399:13-22. doi: 10.1016/j.tox.2018.02.005. Epub 2018 Feb 19.


The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones.

Sowers CR, Wang R, Bourne RA, McGrath BC, Hu J, Bevilacqua SC, Paton JC, Paton AW, Collardeau-Frachon S, Nicolino M, Cavener DR.

J Biol Chem. 2018 Apr 6;293(14):5134-5149. doi: 10.1074/jbc.M117.813790. Epub 2018 Feb 14.


Variable role of carotid bodies in cardiovascular responses to exercise, hypoxia and hypercapnia in spontaneously hypertensive rats.

Pijacka W, Katayama PL, Salgado HC, Lincevicius GS, Campos RR, McBryde FD, Paton JFR.

J Physiol. 2018 Aug;596(15):3201-3216. doi: 10.1113/JP275487. Epub 2018 Feb 12.


Role of Streptococcus pneumoniae OM001 operon in capsular polysaccharide production, virulence and survival in human saliva.

Ahmad Z, Harvey RM, Paton JC, Standish AJ, Morona R.

PLoS One. 2018 Jan 2;13(1):e0190402. doi: 10.1371/journal.pone.0190402. eCollection 2018.


Lectin activity of the pneumococcal pilin proteins.

Day CJ, Paton AW, Harvey RM, Hartley-Tassell LE, Seib KL, Tiralongo J, Bovin N, Savino S, Masignani V, Paton JC, Jennings MP.

Sci Rep. 2017 Dec 19;7(1):17784. doi: 10.1038/s41598-017-17850-9.


Hypothalamic paraventricular nucleus neuronal nitric oxide synthase activity is a major determinant of renal sympathetic discharge in conscious Wistar rats.

McBryde FD, Liu BH, Roloff EV, Kasparov S, Paton JFR.

Exp Physiol. 2018 Mar 1;103(3):419-428. doi: 10.1113/EP086744. Epub 2018 Jan 19.


Role of ventral medullary catecholaminergic neurons for respiratory modulation of sympathetic outflow in rats.

Moraes DJA, Bonagamba LGH, da Silva MP, Paton JFR, Machado BH.

Sci Rep. 2017 Dec 4;7(1):16883. doi: 10.1038/s41598-017-17113-7.


Human pleural fluid is a potent growth medium for Streptococcus pneumoniae.

Popowicz ND, Lansley SM, Cheah HM, Kay ID, Carson CF, Waterer GW, Paton JC, Brown JS, Lee YCG.

PLoS One. 2017 Nov 30;12(11):e0188833. doi: 10.1371/journal.pone.0188833. eCollection 2017.


Evaluating UK National Guidance for Screening of Children for Tuberculosis. A Prospective Multicenter Study.

Kampmann B, Seddon JA, Paton J, Nademi Z, Keane D, Williams B, Williams A, Liebeschutz S, Riddell A, Bernatoniene J, Patel S, Martinez N, McMaster P, Basu-Roy R, Welch SB.

Am J Respir Crit Care Med. 2018 Apr 15;197(8):1058-1064. doi: 10.1164/rccm.201707-1487OC.


The Kölliker-Fuse nucleus orchestrates the timing of expiratory abdominal nerve bursting.

Barnett WH, Jenkin SEM, Milsom WK, Paton JFR, Abdala AP, Molkov YI, Zoccal DB.

J Neurophysiol. 2018 Feb 1;119(2):401-412. doi: 10.1152/jn.00499.2017. Epub 2017 Oct 25.


Cooperative Oxygen Sensing by the Kidney and Carotid Body in Blood Pressure Control.

Patinha D, Pijacka W, Paton JFR, Koeners MP.

Front Physiol. 2017 Oct 4;8:752. doi: 10.3389/fphys.2017.00752. eCollection 2017.


Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension.

da Silva Gonçalves Bos D, Happé C, Schalij I, Pijacka W, Paton JFR, Guignabert C, Tu L, Thuillet R, Bogaard HJ, van Rossum AC, Vonk-Noordegraaf A, de Man FS, Handoko ML.

JACC Basic Transl Sci. 2017 Feb 1;2(1):22-35. doi: 10.1016/j.jacbts.2016.09.007. eCollection 2017 Feb.


The many worlds hypothesis of dopamine prediction error: implications of a parallel circuit architecture in the basal ganglia.

Lau B, Monteiro T, Paton JJ.

Curr Opin Neurobiol. 2017 Oct;46:241-247. doi: 10.1016/j.conb.2017.08.015. Epub 2017 Oct 3. Review.


Experiencing recovery: findings from a qualitative study into mental illness, self and place.

Horsfall D, Paton J, Carrington A.

J Ment Health. 2018 Aug;27(4):307-313. doi: 10.1080/09638237.2017.1385736. Epub 2017 Oct 5.


Cardiovascular autonomic regulation, inflammation and pain in rheumatoid arthritis.

Adlan AM, Veldhuijzen van Zanten JJCS, Lip GYH, Paton JFR, Kitas GD, Fisher JP.

Auton Neurosci. 2017 Dec;208:137-145. doi: 10.1016/j.autneu.2017.09.003. Epub 2017 Sep 13.

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