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Update of the European paediatric respiratory medicine syllabus.

Primhak R, Tabin N, Beydon N, Bhatt J, Eber E, Hammer J, Martinez-Gimeno A, Midulla F, Nenna R, Paton J, Ross Russell R.

Breathe (Sheff). 2019 Sep;15(3):173-180. doi: 10.1183/20734735.0188-2019. Review.


Hypertensive Response to Ischemic Stroke in the Normotensive Wistar Rat.

Thakkar P, McGregor A, Barber PA, Paton JFR, Barrett C, McBryde F.

Stroke. 2019 Sep;50(9):2522-2530. doi: 10.1161/STROKEAHA.119.026459. Epub 2019 Aug 6.


Dietary zinc and the control of Streptococcus pneumoniae infection.

Eijkelkamp BA, Morey JR, Neville SL, Tan A, Pederick VG, Cole N, Singh PP, Ong CY, Gonzalez de Vega R, Clases D, Cunningham BA, Hughes CE, Comerford I, Brazel EB, Whittall JJ, Plumptre CD, McColl SR, Paton JC, McEwan AG, Doble PA, McDevitt CA.

PLoS Pathog. 2019 Aug 22;15(8):e1007957. doi: 10.1371/journal.ppat.1007957. eCollection 2019 Aug.


Centrally acting adrenomedullin in the long-term potentiation of sympathetic vasoconstrictor activity induced by intermittent hypoxia in rats.

Zoccal DB, Colombari DSA, Colombari E, Flor KC, da Silva MP, Costa-Silva JH, Machado BH, Moraes DJA, Murphy D, Paton JFR.

Exp Physiol. 2019 Sep;104(9):1371-1383. doi: 10.1113/EP087613. Epub 2019 Aug 5.


Denervated or Not? That Remains the Question for Renal Denervation.

Paton JFR.

Hypertension. 2019 Sep;74(3):493-494. doi: 10.1161/HYPERTENSIONAHA.119.12779. Epub 2019 Jul 22. No abstract available.


Textured shoe insoles to improve balance performance in adults with diabetic peripheral neuropathy: study protocol for a randomised controlled trial.

Hatton AL, Gane EM, Maharaj JN, Burns J, Paton J, Kerr G, Rome K.

BMJ Open. 2019 Jul 17;9(7):e026240. doi: 10.1136/bmjopen-2018-026240.


Heart failure developed after myocardial infarction does not affect gut microbiota composition in the rat.

Lataro RM, Imori PFM, Santos ES, Silva LEV, Duarte RTD, Silva CAA, Falcão JP, Paton JFR, Salgado HC.

Am J Physiol Gastrointest Liver Physiol. 2019 Sep 1;317(3):G342-G348. doi: 10.1152/ajpgi.00018.2019. Epub 2019 Jul 17.


SMRT sequencing reveals differential patterns of methylation in two O111:H- STEC isolates from a hemolytic uremic syndrome outbreak in Australia.

Forde BM, McAllister LJ, Paton JC, Paton AW, Beatson SA.

Sci Rep. 2019 Jul 1;9(1):9436. doi: 10.1038/s41598-019-45760-5.


Clustering of IRE1α depends on sensing ER stress but not on its RNase activity.

Ricci D, Marrocco I, Blumenthal D, Dibos M, Eletto D, Vargas J, Boyle S, Iwamoto Y, Chomistek S, Paton JC, Paton AW, Argon Y.

FASEB J. 2019 Sep;33(9):9811-9827. doi: 10.1096/fj.201801240RR. Epub 2019 Jun 14.


Renal Denervation Update From the International Sympathetic Nervous System Summit: JACC State-of-the-Art Review.

Kiuchi MG, Esler MD, Fink GD, Osborn JW, Banek CT, Böhm M, Denton KM, DiBona GF, Everett TH 4th, Grassi G, Katholi RE, Knuepfer MM, Kopp UC, Lefer DJ, Lohmeier TE, May CN, Mahfoud F, Paton JFR, Schmieder RE, Pellegrino PR, Sharabi Y, Schlaich MP.

J Am Coll Cardiol. 2019 Jun 18;73(23):3006-3017. doi: 10.1016/j.jacc.2019.04.015. Review.


Proinsulin misfolding is an early event in the progression to type 2 diabetes.

Arunagiri A, Haataja L, Pottekat A, Pamenan F, Kim S, Zeltser LM, Paton AW, Paton JC, Tsai B, Itkin-Ansari P, Kaufman RJ, Liu M, Arvan P.

Elife. 2019 Jun 11;8. pii: e44532. doi: 10.7554/eLife.44532.


The Logic of Carotid Body Connectivity to the Brain.

Zera T, Moraes DJA, da Silva MP, Fisher JP, Paton JFR.

Physiology (Bethesda). 2019 Jul 1;34(4):264-282. doi: 10.1152/physiol.00057.2018.


Direct interaction of whole-inactivated influenza A and pneumococcal vaccines enhances influenza-specific immunity.

David SC, Norton T, Tyllis T, Wilson JJ, Singleton EV, Laan Z, Davies J, Hirst TR, Comerford I, McColl SR, Paton JC, Alsharifi M.

Nat Microbiol. 2019 Aug;4(8):1316-1327. doi: 10.1038/s41564-019-0443-4. Epub 2019 May 20.


Intermittent Exposure to Chlorpyrifos Differentially Impacts Neuroreflex Control of Cardiorespiratory Function in Rats.

Batista TJ, Minassa VS, Aitken AV, Jara BT, Felippe ISA, Beijamini V, Paton JFR, Dos Santos L, Sampaio KN.

Cardiovasc Toxicol. 2019 May 16. doi: 10.1007/s12012-019-09528-7. [Epub ahead of print]


Shift of leading pacemaker site during reflex vagal stimulation and altered electrical source-to-sink balance.

Ashton JL, Trew ML, LeGrice IJ, Paterson DJ, Paton JF, Gillis AM, Smaill BH.

J Physiol. 2019 Jul;597(13):3297-3313. doi: 10.1113/JP276876. Epub 2019 May 26.


On the presence and functional significance of sympathetic premotor neurons with collateralized spinal axons in the rat.

Farmer DGS, Pracejus N, Dempsey B, Turner A, Bokiniec P, Paton JFR, Pickering AE, Burguet J, Andrey P, Goodchild AK, McAllen RM, McMullan S.

J Physiol. 2019 Jul;597(13):3407-3423. doi: 10.1113/JP277661. Epub 2019 Jun 2.


Enhanced safety and immunogenicity of a pneumococcal surface antigen A mutant whole-cell inactivated pneumococcal vaccine.

David SC, Laan Z, Minhas V, Chen AY, Davies J, Hirst TR, McColl SR, Alsharifi M, Paton JC.

Immunol Cell Biol. 2019 Sep;97(8):726-739. doi: 10.1111/imcb.12257. Epub 2019 May 23.


Streptococcus pneumoniae Capsular Polysaccharide.

Paton JC, Trappetti C.

Microbiol Spectr. 2019 Mar;7(2). doi: 10.1128/microbiolspec.GPP3-0019-2018. Review.


Two Sides of the Same Coin?-Treatment of Chronic Asthma in Children and Adults.

Chung LP, Paton JY.

Front Pediatr. 2019 Mar 11;7:62. doi: 10.3389/fped.2019.00062. eCollection 2019. Review.


Cell surface expression of 78-kDa glucose-regulated protein (GRP78) mediates diabetic nephropathy.

Van Krieken R, Mehta N, Wang T, Zheng M, Li R, Gao B, Ayaub E, Ask K, Paton JC, Paton AW, Austin RC, Krepinsky JC.

J Biol Chem. 2019 May 10;294(19):7755-7768. doi: 10.1074/jbc.RA118.006939. Epub 2019 Mar 26.


Biologics for paediatric severe asthma: trick or TREAT?

Saglani S, Bush A, Carroll W, Cunningham S, Fleming L, Gaillard E, Gupta A, Murray C, Nagakumar P, Paton J, Roberts G, Seddon P, Sinha I.

Lancet Respir Med. 2019 Apr;7(4):294-296. doi: 10.1016/S2213-2600(19)30045-1. Epub 2019 Feb 26. No abstract available.


Mepolizumab in adolescents with severe eosinophilic asthma not eligible for omalizumab: one center's early clinical experience.

Weir E, Paton J.

J Asthma. 2019 Feb 22:1-4. doi: 10.1080/02770903.2019.1579833. [Epub ahead of print] No abstract available.


Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury.

Leonard A, Grose V, Paton AW, Paton JC, Yule DI, Rahman A, Fazal F.

Sci Rep. 2019 Feb 14;9(1):2096. doi: 10.1038/s41598-018-38312-w.


The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating.

Ziska A, Tatzelt J, Dudek J, Paton AW, Paton JC, Zimmermann R, Haßdenteufel S.

Biol Open. 2019 Mar 5;8(3). pii: bio040691. doi: 10.1242/bio.040691.


Identification of Novel Acinetobacter baumannii Host Fatty Acid Stress Adaptation Strategies.

Jiang JH, Hassan KA, Begg SL, Rupasinghe TWT, Naidu V, Pederick VG, Khorvash M, Whittall JJ, Paton JC, Paulsen IT, McDevitt CA, Peleg AY, Eijkelkamp BA.

MBio. 2019 Feb 5;10(1). pii: e02056-18. doi: 10.1128/mBio.02056-18.


The Role of the CopA Copper Efflux System in Acinetobacter baumannii Virulence.

Alquethamy SF, Khorvash M, Pederick VG, Whittall JJ, Paton JC, Paulsen IT, Hassan KA, McDevitt CA, Eijkelkamp BA.

Int J Mol Sci. 2019 Jan 29;20(3). pii: E575. doi: 10.3390/ijms20030575.


Capacity To Utilize Raffinose Dictates Pneumococcal Disease Phenotype.

Minhas V, Harvey RM, McAllister LJ, Seemann T, Syme AE, Baines SL, Paton JC, Trappetti C.

MBio. 2019 Jan 15;10(1). pii: e02596-18. doi: 10.1128/mBio.02596-18.


Long Interleukin-22 Binding Protein Isoform-1 Is an Intracellular Activator of the Unfolded Protein Response.

Gómez-Fernández P, Urtasun A, Paton AW, Paton JC, Borrego F, Dersh D, Argon Y, Alloza I, Vandenbroeck K.

Front Immunol. 2018 Dec 14;9:2934. doi: 10.3389/fimmu.2018.02934. eCollection 2018.


Matched cohort study of therapeutic strategies to prevent preschool wheezing/asthma attacks.

Grigg J, Nibber A, Paton JY, Chisholm A, Guilbert TW, Kaplan A, Turner S, Roche N, Hillyer EV, Price DB; Respiratory Effectiveness Group.

J Asthma Allergy. 2018 Dec 11;11:309-321. doi: 10.2147/JAA.S178531. eCollection 2018.


Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na+-Taurocholate Cotransporting Polypeptide.

Robin MJD, Appelman MD, Vos HR, van Es RM, Paton JC, Paton AW, Burgering B, Fickert P, Heijmans J, van de Graaf SFJ.

Hepatol Commun. 2018 Oct 23;2(12):1550-1566. doi: 10.1002/hep4.1262. eCollection 2018 Dec.


Stand by to repel boarders.

Paton JC, Trappetti C.

Nat Microbiol. 2019 Jan;4(1):8-9. doi: 10.1038/s41564-018-0324-2. No abstract available.


Blockade of Rostral Ventrolateral Medulla Apelin Receptors Does Not Attenuate Arterial Pressure in SHR and L-NAME-Induced Hypertensive Rats.

Griffiths PR, Lolait SJ, Pearce LE, McBryde FD, Paton JFR, O'Carroll AM.

Front Physiol. 2018 Oct 24;9:1488. doi: 10.3389/fphys.2018.01488. eCollection 2018.


Detection of N-glycolylneuraminic acid biomarkers in sera from patients with ovarian cancer using an engineered N-glycolylneuraminic acid-specific lectin SubB2M.

Shewell LK, Wang JJ, Paton JC, Paton AW, Day CJ, Jennings MP.

Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):173-177. doi: 10.1016/j.bbrc.2018.11.001. Epub 2018 Nov 8.


A recombinant conjugated pneumococcal vaccine that protects against murine infections with a similar efficacy to Prevnar-13.

Reglinski M, Ercoli G, Plumptre C, Kay E, Petersen FC, Paton JC, Wren BW, Brown JS.

NPJ Vaccines. 2018 Oct 31;3:53. doi: 10.1038/s41541-018-0090-4. eCollection 2018.


Locus Coeruleus as a vigilance centre for active inspiration and expiration in rats.

Magalhães KS, Spiller PF, da Silva MP, Kuntze LB, Paton JFR, Machado BH, Moraes DJA.

Sci Rep. 2018 Oct 23;8(1):15654. doi: 10.1038/s41598-018-34047-w.


Th17 responses to pneumococcus in blood and adenoidal cells in children.

Oliver E, Pope C, Clarke E, Langton Hewer C, Ogunniyi AD, Paton JC, Mitchell T, Malley R, Finn A.

Clin Exp Immunol. 2019 Feb;195(2):213-225. doi: 10.1111/cei.13225. Epub 2018 Oct 31.


Specific growth conditions induce a Streptococcus pneumoniae non-mucoidal, small colony variant and determine the outcome of its co-culture with Haemophilus influenzae.

Tikhomirova A, Trappetti C, Standish AJ, Zhou Y, Breen J, Pederson S, Zilm PS, Paton JC, Kidd SP.

Pathog Dis. 2018 Oct 1;76(7). doi: 10.1093/femspd/fty074.


Left ventricular extracellular volume fraction and atrioventricular interaction in hypertension.

Rodrigues JCL, Erdei T, Dastidar AG, Szantho G, Burchell AE, Ratcliffe LEK, Hart EC, Nightingale AK, Paton JFR, Manghat NE, Hamilton MCK.

Eur Radiol. 2019 Mar;29(3):1574-1585. doi: 10.1007/s00330-018-5700-z. Epub 2018 Sep 19.


Acute hydrocortisone administration reduces cardiovagal baroreflex sensitivity and heart rate variability in young men.

Adlan AM, Veldhuijzen van Zanten JJCS, Lip GYH, Paton JFR, Kitas GD, Fisher JP.

J Physiol. 2018 Oct;596(20):4847-4861. doi: 10.1113/JP276644. Epub 2018 Sep 12.


Streptococcus pneumoniae potently induces cell death in mesothelial cells.

Rashwan R, Varano Della Vergiliana JF, Lansley SM, Cheah HM, Popowicz N, Paton JC, Waterer GW, Townsend T, Kay I, Brown JS, Lee YCG.

PLoS One. 2018 Jul 30;13(7):e0201530. doi: 10.1371/journal.pone.0201530. eCollection 2018.


Purinergic plasticity within petrosal neurons in hypertension.

Moraes DJA, da Silva MP, Spiller PF, Machado BH, Paton JFR.

Am J Physiol Regul Integr Comp Physiol. 2018 Nov 1;315(5):R963-R971. doi: 10.1152/ajpregu.00142.2018. Epub 2018 Jun 27.


Antihypertensive Treatment Fails to Control Blood Pressure During Exercise.

Chant B, Bakali M, Hinton T, Burchell AE, Nightingale AK, Paton JFR, Hart EC.

Hypertension. 2018 Jul;72(1):102-109. doi: 10.1161/HYPERTENSIONAHA.118.11076.


At-risk children with asthma (ARC): a systematic review.

Buelo A, McLean S, Julious S, Flores-Kim J, Bush A, Henderson J, Paton JY, Sheikh A, Shields M, Pinnock H; ARC Group.

Thorax. 2018 Sep;73(9):813-824. doi: 10.1136/thoraxjnl-2017-210939. Epub 2018 Jun 5.


Arachidonic Acid Stress Impacts Pneumococcal Fatty Acid Homeostasis.

Eijkelkamp BA, Begg SL, Pederick VG, Trapetti C, Gregory MK, Whittall JJ, Paton JC, McDevitt CA.

Front Microbiol. 2018 May 11;9:813. doi: 10.3389/fmicb.2018.00813. eCollection 2018.


Structural characterisation of the HT3 motif of the polyhistidine triad protein D from Streptococcus pneumoniae.

Luo Z, Pederick VG, Paton JC, McDevitt CA, Kobe B.

FEBS Lett. 2018 Jul;592(13):2341-2350. doi: 10.1002/1873-3468.13122. Epub 2018 Jun 14.


Differences in autonomic innervation to the vertebrobasilar arteries in spontaneously hypertensive and Wistar rats.

Roloff EVL, Walas D, Moraes DJA, Kasparov S, Paton JFR.

J Physiol. 2018 Aug;596(16):3505-3529. doi: 10.1113/JP275973. Epub 2018 Jul 19.


The Neural Basis of Timing: Distributed Mechanisms for Diverse Functions.

Paton JJ, Buonomano DV.

Neuron. 2018 May 16;98(4):687-705. doi: 10.1016/j.neuron.2018.03.045. Review.


The prevalence, distribution, and functional importance of lower limb somatosensory impairments in chronic stroke survivors: a cross sectional observational study.

Gorst T, Rogers A, Morrison SC, Cramp M, Paton J, Freeman J, Marsden J.

Disabil Rehabil. 2019 Oct;41(20):2443-2450. doi: 10.1080/09638288.2018.1468932. Epub 2018 May 4.


Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier.

Haßdenteufel S, Johnson N, Paton AW, Paton JC, High S, Zimmermann R.

Cell Rep. 2018 May 1;23(5):1373-1386. doi: 10.1016/j.celrep.2018.03.122.

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