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Items: 1 to 50 of 153

1.

SMRT sequencing reveals differential patterns of methylation in two O111:H- STEC isolates from a hemolytic uremic syndrome outbreak in Australia.

Forde BM, McAllister LJ, Paton JC, Paton AW, Beatson SA.

Sci Rep. 2019 Jul 1;9(1):9436. doi: 10.1038/s41598-019-45760-5.

2.

Clustering of IRE1α depends on sensing ER stress but not on its RNase activity.

Ricci D, Marrocco I, Blumenthal D, Dibos M, Eletto D, Vargas J, Boyle S, Iwamoto Y, Chomistek S, Paton JC, Paton AW, Argon Y.

FASEB J. 2019 Jun 14:fj201801240RR. doi: 10.1096/fj.201801240RR. [Epub ahead of print]

PMID:
31199681
3.

Proinsulin misfolding is an early event in the progression to type 2 diabetes.

Arunagiri A, Haataja L, Pottekat A, Pamenan F, Kim S, Zeltser LM, Paton AW, Paton JC, Tsai B, Itkin-Ansari P, Kaufman RJ, Liu M, Arvan P.

Elife. 2019 Jun 11;8. pii: e44532. doi: 10.7554/eLife.44532.

4.

Cell surface expression of 78-kDa glucose-regulated protein (GRP78) mediates diabetic nephropathy.

Van Krieken R, Mehta N, Wang T, Zheng M, Li R, Gao B, Ayaub E, Ask K, Paton JC, Paton AW, Austin RC, Krepinsky JC.

J Biol Chem. 2019 May 10;294(19):7755-7768. doi: 10.1074/jbc.RA118.006939. Epub 2019 Mar 26.

PMID:
30914477
5.

Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury.

Leonard A, Grose V, Paton AW, Paton JC, Yule DI, Rahman A, Fazal F.

Sci Rep. 2019 Feb 14;9(1):2096. doi: 10.1038/s41598-018-38312-w.

6.

The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating.

Ziska A, Tatzelt J, Dudek J, Paton AW, Paton JC, Zimmermann R, Haßdenteufel S.

Biol Open. 2019 Mar 5;8(3). pii: bio040691. doi: 10.1242/bio.040691.

7.

Long Interleukin-22 Binding Protein Isoform-1 Is an Intracellular Activator of the Unfolded Protein Response.

Gómez-Fernández P, Urtasun A, Paton AW, Paton JC, Borrego F, Dersh D, Argon Y, Alloza I, Vandenbroeck K.

Front Immunol. 2018 Dec 14;9:2934. doi: 10.3389/fimmu.2018.02934. eCollection 2018.

8.

Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na+-Taurocholate Cotransporting Polypeptide.

Robin MJD, Appelman MD, Vos HR, van Es RM, Paton JC, Paton AW, Burgering B, Fickert P, Heijmans J, van de Graaf SFJ.

Hepatol Commun. 2018 Oct 23;2(12):1550-1566. doi: 10.1002/hep4.1262. eCollection 2018 Dec.

9.

Detection of N-glycolylneuraminic acid biomarkers in sera from patients with ovarian cancer using an engineered N-glycolylneuraminic acid-specific lectin SubB2M.

Shewell LK, Wang JJ, Paton JC, Paton AW, Day CJ, Jennings MP.

Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):173-177. doi: 10.1016/j.bbrc.2018.11.001. Epub 2018 Nov 8.

10.

Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier.

Haßdenteufel S, Johnson N, Paton AW, Paton JC, High S, Zimmermann R.

Cell Rep. 2018 May 1;23(5):1373-1386. doi: 10.1016/j.celrep.2018.03.122.

11.

Specificity and utility of SubB2M, a new N-glycolylneuraminic acid lectin.

Wang J, Shewell LK, Paton AW, Paton JC, Day CJ, Jennings MP.

Biochem Biophys Res Commun. 2018 Jun 7;500(3):765-771. doi: 10.1016/j.bbrc.2018.04.151. Epub 2018 Apr 26.

12.

Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization.

Tang CH, Chang S, Paton AW, Paton JC, Gabrilovich DI, Ploegh HL, Del Valle JR, Hu CC.

J Cell Biol. 2018 May 7;217(5):1739-1755. doi: 10.1083/jcb.201709137. Epub 2018 Mar 6.

13.

The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones.

Sowers CR, Wang R, Bourne RA, McGrath BC, Hu J, Bevilacqua SC, Paton JC, Paton AW, Collardeau-Frachon S, Nicolino M, Cavener DR.

J Biol Chem. 2018 Apr 6;293(14):5134-5149. doi: 10.1074/jbc.M117.813790. Epub 2018 Feb 14.

14.

Lectin activity of the pneumococcal pilin proteins.

Day CJ, Paton AW, Harvey RM, Hartley-Tassell LE, Seib KL, Tiralongo J, Bovin N, Savino S, Masignani V, Paton JC, Jennings MP.

Sci Rep. 2017 Dec 19;7(1):17784. doi: 10.1038/s41598-017-17850-9.

15.

Ouabain Protects Human Renal Cells against the Cytotoxic Effects of Shiga Toxin Type 2 and Subtilase Cytotoxin.

Amaral MM, Girard MC, Álvarez RS, Paton AW, Paton JC, Repetto HA, Sacerdoti F, Ibarra CA.

Toxins (Basel). 2017 Jul 18;9(7). pii: E226. doi: 10.3390/toxins9070226.

16.

Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins.

Littler DR, Ang SY, Moriel DG, Kocan M, Kleifeld O, Johnson MD, Tran MT, Paton AW, Paton JC, Summers RJ, Schembri MA, Rossjohn J, Beddoe T.

J Biol Chem. 2017 Sep 8;292(36):15143-15158. doi: 10.1074/jbc.M117.796094. Epub 2017 Jun 29.

17.

Vacuolation Activity and Intracellular Trafficking of ArtB, the Binding Subunit of an AB5 Toxin Produced by Salmonella enterica Serovar Typhi.

Herdman BP, Paton JC, Wang H, Beddoe T, Paton AW.

Infect Immun. 2017 Jul 19;85(8). pii: e00214-17. doi: 10.1128/IAI.00214-17. Print 2017 Aug.

18.

Structure aided design of a Neu5Gc specific lectin.

Day CJ, Paton AW, Higgins MA, Shewell LK, Jen FE, Schulz BL, Herdman BP, Paton JC, Jennings MP.

Sci Rep. 2017 May 4;7(1):1495. doi: 10.1038/s41598-017-01522-9.

19.

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis.

Glab JA, Doerflinger M, Nedeva C, Jose I, Mbogo GW, Paton JC, Paton AW, Kueh AJ, Herold MJ, Huang DC, Segal D, Brumatti G, Puthalakath H.

Cell Death Differ. 2017 May;24(5):944-950. doi: 10.1038/cdd.2017.53. Epub 2017 Apr 14.

20.

The Pneumococcal Alpha-Glycerophosphate Oxidase Enhances Nasopharyngeal Colonization through Binding to Host Glycoconjugates.

Mahdi LK, Higgins MA, Day CJ, Tiralongo J, Hartley-Tassell LE, Jennings MP, Gordon DL, Paton AW, Paton JC, Ogunniyi AD.

EBioMedicine. 2017 Apr;18:236-243. doi: 10.1016/j.ebiom.2017.03.002. Epub 2017 Mar 3.

21.

Autoinducer 2 Signaling via the Phosphotransferase FruA Drives Galactose Utilization by Streptococcus pneumoniae, Resulting in Hypervirulence.

Trappetti C, McAllister LJ, Chen A, Wang H, Paton AW, Oggioni MR, McDevitt CA, Paton JC.

MBio. 2017 Jan 24;8(1). pii: e02269-16. doi: 10.1128/mBio.02269-16.

22.

Systemic effects of Subtilase cytotoxin produced by Escherichia coli O113:H21.

Seyahian EA, Oltra G, Ochoa F, Melendi S, Hermes R, Paton JC, Paton AW, Lago N, Castro Parodi M, Damiano A, Ibarra C, Zotta E.

Toxicon. 2017 Mar 1;127:49-55. doi: 10.1016/j.toxicon.2016.12.014. Epub 2017 Jan 3.

PMID:
28057514
23.

GRP78 Is an Important Host Factor for Japanese Encephalitis Virus Entry and Replication in Mammalian Cells.

Nain M, Mukherjee S, Karmakar SP, Paton AW, Paton JC, Abdin MZ, Basu A, Kalia M, Vrati S.

J Virol. 2017 Feb 28;91(6). pii: e02274-16. doi: 10.1128/JVI.02274-16. Print 2017 Mar 15.

24.

Physiological Exploration of the Long Term Evolutionary Selection against Expression of N-Glycolylneuraminic Acid in the Brain.

Naito-Matsui Y, Davies LR, Takematsu H, Chou HH, Tangvoranuntakul P, Carlin AF, Verhagen A, Heyser CJ, Yoo SW, Choudhury B, Paton JC, Paton AW, Varki NM, Schnaar RL, Varki A.

J Biol Chem. 2017 Feb 17;292(7):2557-2570. doi: 10.1074/jbc.M116.768531. Epub 2017 Jan 3.

25.

Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion.

Cunningham CN, He K, Arunagiri A, Paton AW, Paton JC, Arvan P, Tsai B.

Diabetes. 2017 Mar;66(3):741-753. doi: 10.2337/db16-1338. Epub 2016 Dec 27.

26.

Induction of endoplasmic reticulum stress by deletion of Grp78 depletes Apc mutant intestinal epithelial stem cells.

van Lidth de Jeude JF, Meijer BJ, Wielenga MCB, Spaan CN, Baan B, Rosekrans SL, Meisner S, Shen YH, Lee AS, Paton JC, Paton AW, Muncan V, van den Brink GR, Heijmans J.

Oncogene. 2017 Jun 15;36(24):3397-3405. doi: 10.1038/onc.2016.326. Epub 2016 Nov 7.

PMID:
27819675
27.

Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma.

Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):9015-20. doi: 10.1073/pnas.1603883113. Epub 2016 Jul 22.

28.

Comparative Characterization of Shiga Toxin Type 2 and Subtilase Cytotoxin Effects on Human Renal Epithelial and Endothelial Cells Grown in Monolayer and Bilayer Conditions.

Álvarez RS, Sacerdoti F, Jancic C, Paton AW, Paton JC, Ibarra C, Amaral MM.

PLoS One. 2016 Jun 23;11(6):e0158180. doi: 10.1371/journal.pone.0158180. eCollection 2016.

29.

The Variable Region of Pneumococcal Pathogenicity Island 1 Is Responsible for Unusually High Virulence of a Serotype 1 Isolate.

Harvey RM, Trappetti C, Mahdi LK, Wang H, McAllister LJ, Scalvini A, Paton AW, Paton JC.

Infect Immun. 2016 Jan 11;84(3):822-32. doi: 10.1128/IAI.01454-15.

30.

Genomic Comparison of Two O111:H- Enterohemorrhagic Escherichia coli Isolates from a Historic Hemolytic-Uremic Syndrome Outbreak in Australia.

McAllister LJ, Bent SJ, Petty NK, Skippington E, Beatson SA, Paton JC, Paton AW.

Infect Immun. 2016 Jan 4;84(3):775-81. doi: 10.1128/IAI.01229-15.

31.

IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation.

Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, Ma H, Inoue T, Gao B, Kim H, Bu P, Guber RD, Shen X, Lee AH, Iwawaki T, Paton AW, Paton JC, Fang D, Tsai B, Yates JR 3rd, Wu H, Kersten S, Long Q, Duhamel GE, Simpson KW, Qi L.

Nat Cell Biol. 2015 Dec;17(12):1546-55. doi: 10.1038/ncb3266. Epub 2015 Nov 9.

32.

ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy.

Wielenga MCB, Colak S, Heijmans J, van Lidth de Jeude JF, Rodermond HM, Paton JC, Paton AW, Vermeulen L, Medema JP, van den Brink GR.

Cell Rep. 2015 Oct 20;13(3):489-494. doi: 10.1016/j.celrep.2015.09.016. Epub 2015 Oct 8.

33.

Isolation site influences virulence phenotype of serotype 14 Streptococcus pneumoniae strains belonging to multilocus sequence type 15.

Amin Z, Harvey RM, Wang H, Hughes CE, Paton AW, Paton JC, Trappetti C.

Infect Immun. 2015 Dec;83(12):4781-90. doi: 10.1128/IAI.01081-15. Epub 2015 Sep 28.

34.

Protection against Shiga-Toxigenic Escherichia coli by Non-Genetically Modified Organism Receptor Mimic Bacterial Ghosts.

Paton AW, Chen AY, Wang H, McAllister LJ, Höggerl F, Mayr UB, Shewell LK, Jennings MP, Morona R, Lubitz W, Paton JC.

Infect Immun. 2015 Sep;83(9):3526-33. doi: 10.1128/IAI.00669-15. Epub 2015 Jun 22.

35.

Identification of markers that functionally define a quiescent multiple myeloma cell sub-population surviving bortezomib treatment.

Adomako A, Calvo V, Biran N, Osman K, Chari A, Paton JC, Paton AW, Moore K, Schewe DM, Aguirre-Ghiso JA.

BMC Cancer. 2015 May 30;15:444. doi: 10.1186/s12885-015-1460-1.

36.

Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors.

Ng PS, Böhm R, Hartley-Tassell LE, Steen JA, Wang H, Lukowski SW, Hawthorne PL, Trezise AE, Coloe PJ, Grimmond SM, Haselhorst T, von Itzstein M, Paton AW, Paton JC, Jennings MP.

Nat Commun. 2014 Dec 17;5:5750. doi: 10.1038/ncomms6750.

37.

The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity.

Shewell LK, Harvey RM, Higgins MA, Day CJ, Hartley-Tassell LE, Chen AY, Gillen CM, James DB, Alonzo F 3rd, Torres VJ, Walker MJ, Paton AW, Paton JC, Jennings MP.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):E5312-20. doi: 10.1073/pnas.1412703111. Epub 2014 Nov 24.

38.

Preconditioning with endoplasmic reticulum stress ameliorates endothelial cell inflammation.

Leonard A, Paton AW, El-Quadi M, Paton JC, Fazal F.

PLoS One. 2014 Oct 30;9(10):e110949. doi: 10.1371/journal.pone.0110949. eCollection 2014.

39.

The impact of pneumolysin on the macrophage response to Streptococcus pneumoniae is strain-dependent.

Harvey RM, Hughes CE, Paton AW, Trappetti C, Tweten RK, Paton JC.

PLoS One. 2014 Aug 8;9(8):e103625. doi: 10.1371/journal.pone.0103625. eCollection 2014.

40.

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis.

Lu M, Lawrence DA, Marsters S, Acosta-Alvear D, Kimmig P, Mendez AS, Paton AW, Paton JC, Walter P, Ashkenazi A.

Science. 2014 Jul 4;345(6192):98-101. doi: 10.1126/science.1254312.

41.

ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis.

Fucho R, Martínez L, Baulies A, Torres S, Tarrats N, Fernandez A, Ribas V, Astudillo AM, Balsinde J, Garcia-Rovés P, Elena M, Bergheim I, Lotersztajn S, Trautwein C, Appelqvist H, Paton AW, Paton JC, Czaja MJ, Kaplowitz N, Fernandez-Checa JC, García-Ruiz C.

J Hepatol. 2014 Nov;61(5):1126-34. doi: 10.1016/j.jhep.2014.06.009. Epub 2014 Jun 16.

43.

Therapeutic use of a receptor mimic probiotic reduces intestinal Shiga toxin levels in a piglet model of hemolytic uremic syndrome.

Hostetter SJ, Helgerson AF, Paton JC, Paton AW, Cornick NA.

BMC Res Notes. 2014 Jun 2;7:331. doi: 10.1186/1756-0500-7-331.

44.

Genetic diversity and virulence potential of shiga toxin-producing Escherichia coli O113:H21 strains isolated from clinical, environmental, and food sources.

Feng PC, Delannoy S, Lacher DW, Dos Santos LF, Beutin L, Fach P, Rivas M, Hartland EL, Paton AW, Guth BE.

Appl Environ Microbiol. 2014 Aug;80(15):4757-63. doi: 10.1128/AEM.01182-14. Epub 2014 May 23.

45.

The BiP molecular chaperone plays multiple roles during the biogenesis of torsinA, an AAA+ ATPase associated with the neurological disease early-onset torsion dystonia.

Zacchi LF, Wu HC, Bell SL, Millen L, Paton AW, Paton JC, Thomas PJ, Zolkiewski M, Brodsky JL.

J Biol Chem. 2014 May 2;289(18):12727-47. doi: 10.1074/jbc.M113.529123. Epub 2014 Mar 13.

46.

Effects of Escherichia coli subtilase cytotoxin and Shiga toxin 2 on primary cultures of human renal tubular epithelial cells.

Márquez LB, Velázquez N, Repetto HA, Paton AW, Paton JC, Ibarra C, Silberstein C.

PLoS One. 2014 Jan 21;9(1):e87022. doi: 10.1371/journal.pone.0087022. eCollection 2014.

47.

The signal sequence influences post-translational ER translocation at distinct stages.

Johnson N, Haßdenteufel S, Theis M, Paton AW, Paton JC, Zimmermann R, High S.

PLoS One. 2013 Oct 9;8(10):e75394. doi: 10.1371/journal.pone.0075394. eCollection 2013.

48.

EcxAB is a founding member of a new family of metalloprotease AB5 toxins with a hybrid cholera-like B subunit.

Ng NM, Littler DR, Paton AW, Le Nours J, Rossjohn J, Paton JC, Beddoe T.

Structure. 2013 Nov 5;21(11):2003-13. doi: 10.1016/j.str.2013.08.024. Epub 2013 Oct 3.

49.

Action of shiga toxin type-2 and subtilase cytotoxin on human microvascular endothelial cells.

Amaral MM, Sacerdoti F, Jancic C, Repetto HA, Paton AW, Paton JC, Ibarra C.

PLoS One. 2013 Jul 30;8(7):e70431. doi: 10.1371/journal.pone.0070431. Print 2013.

50.

Structural basis of subtilase cytotoxin SubAB assembly.

Le Nours J, Paton AW, Byres E, Troy S, Herdman BP, Johnson MD, Paton JC, Rossjohn J, Beddoe T.

J Biol Chem. 2013 Sep 20;288(38):27505-16. doi: 10.1074/jbc.M113.462622. Epub 2013 Aug 6.

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