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Treatment of a first patient with FLASH-radiotherapy.

Bourhis J, Sozzi WJ, Jorge PG, Gaide O, Bailat C, Duclos F, Patin D, Ozsahin M, Bochud F, Germond JF, Moeckli R, Vozenin MC.

Radiother Oncol. 2019 Jul 11. pii: S0167-8140(19)32959-7. doi: 10.1016/j.radonc.2019.06.019. [Epub ahead of print]


Septic shock secondary to an acute necrotizing community-acquired pneumonia with bacteremia due to Pseudomonas aeruginosa.

Riviere P, Patin D, Delaporte E, Mahfoudi H, Lecailtel S, Poher F, Villette P, Duclaux J, Jouault P, Brunin G.

IDCases. 2019 May 16;17:e00563. doi: 10.1016/j.idcr.2019.e00563. eCollection 2019.


Evaluation of the published kinase inhibitor set to identify multiple inhibitors of bacterial ATP-dependent mur ligases.

Hrast M, Rožman K, Ogris I, Škedelj V, Patin D, Sova M, Barreteau H, Gobec S, Grdadolnik SG, Zega A.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):1010-1017. doi: 10.1080/14756366.2019.1608981.


Impact of FiuA Outer Membrane Receptor Polymorphism on the Resistance of Pseudomonas aeruginosa toward Peptidoglycan Lipid II-Targeting PaeM Pyocins.

Latino L, Patin D, Chérier D, Touzé T, Pourcel C, Barreteau H, Mengin-Lecreulx D.

J Bacteriol. 2019 Jun 10;201(13). pii: e00164-19. doi: 10.1128/JB.00164-19. Print 2019 Jul 1.


Chemical Delivery System of MIBG to the Central Nervous System: Synthesis, 11C-Radiosynthesis, and in Vivo Evaluation.

Gourand F, Patin D, Henry A, Ibazizène M, Dhilly M, Fillesoye F, Tirel O, Tintas ML, Papamicaël C, Levacher V, Barré L.

ACS Med Chem Lett. 2019 Feb 15;10(3):352-357. doi: 10.1021/acsmedchemlett.8b00642. eCollection 2019 Mar 14.


The MurG glycosyltransferase provides an oligomeric scaffold for the cytoplasmic steps of peptidoglycan biosynthesis in the human pathogen Bordetella pertussis.

Laddomada F, Miyachiro MM, Jessop M, Patin D, Job V, Mengin-Lecreulx D, Le Roy A, Ebel C, Breyton C, Gutsche I, Dessen A.

Sci Rep. 2019 Mar 15;9(1):4656. doi: 10.1038/s41598-019-40966-z.


Lausanne checklist for safe stereotactic radiosurgery.

Tuleasca C, Zeverino M, Patin D, Marguet M, Lopes NR, Vallet V, Moeckli R, Levivier M.

Acta Neurochir (Wien). 2019 Apr;161(4):721-727. doi: 10.1007/s00701-019-03843-2. Epub 2019 Feb 21.


Inhibition of the Staphylococcus aureus c-di-AMP cyclase DacA by direct interaction with the phosphoglucosamine mutase GlmM.

Tosi T, Hoshiga F, Millership C, Singh R, Eldrid C, Patin D, Mengin-Lecreulx D, Thalassinos K, Freemont P, Gründling A.

PLoS Pathog. 2019 Jan 22;15(1):e1007537. doi: 10.1371/journal.ppat.1007537. eCollection 2019 Jan.


Gamma Knife radiosurgery for intravestibular and intracochlear schwannomas.

Tuleasca C, George M, Schiappacasse L, Patin D, Fenu J, Maire R, Levivier M.

Acta Neurochir (Wien). 2019 Jan;161(1):63-67. doi: 10.1007/s00701-018-3762-y. Epub 2018 Dec 8.


Letter to the Editor. Gamma Knife surgery for trigeminal pain due to benign and malignant skull base tumors.

Tuleasca C, Patin D, Levivier M.

J Neurosurg. 2018 Sep 1:1-3. doi: 10.3171/2018.5.JNS181298. [Epub ahead of print] No abstract available.


X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice.

Montay-Gruel P, Bouchet A, Jaccard M, Patin D, Serduc R, Aim W, Petersson K, Petit B, Bailat C, Bourhis J, Bräuer-Krisch E, Vozenin MC.

Radiother Oncol. 2018 Dec;129(3):582-588. doi: 10.1016/j.radonc.2018.08.016. Epub 2018 Aug 31.


Synthesis of Lipid-Carbohydrate-Peptidyl-RNA Conjugates to Explore the Limits Imposed by the Substrate Specificity of Cell Wall Enzymes on the Acquisition of Drug Resistance.

Fonvielle M, Bouhss A, Hoareau C, Patin D, Mengin-Lecreulx D, Iannazzo L, Sakkas N, El Sagheer A, Brown T, Ethève-Quelquejeu M, Arthur M.

Chemistry. 2018 Oct 9;24(56):14911-14915. doi: 10.1002/chem.201802360. Epub 2018 Sep 6.


The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients.

Vozenin MC, De Fornel P, Petersson K, Favaudon V, Jaccard M, Germond JF, Petit B, Burki M, Ferrand G, Patin D, Bouchaab H, Ozsahin M, Bochud F, Bailat C, Devauchelle P, Bourhis J.

Clin Cancer Res. 2019 Jan 1;25(1):35-42. doi: 10.1158/1078-0432.CCR-17-3375. Epub 2018 Jun 6.


Spinal bromodomain-containing protein 4 contributes to neuropathic pain induced by HIV glycoprotein 120 with morphine in rats.

Takahashi K, Yi H, Liu CH, Liu S, Kashiwagi Y, Patin DJ, Hao S.

Neuroreport. 2018 Apr 11;29(6):441-446. doi: 10.1097/WNR.0000000000000992.


Critical Impact of Peptidoglycan Precursor Amidation on the Activity of l,d-Transpeptidases from Enterococcus faecium and Mycobacterium tuberculosis.

Ngadjeua F, Braud E, Saidjalolov S, Iannazzo L, Schnappinger D, Ehrt S, Hugonnet JE, Mengin-Lecreulx D, Patin D, Ethève-Quelquejeu M, Fonvielle M, Arthur M.

Chemistry. 2018 Apr 17;24(22):5743-5747. doi: 10.1002/chem.201706082. Epub 2018 Feb 21.


In silico identification, synthesis and biological evaluation of novel tetrazole inhibitors of MurB.

Hrast M, Jukič M, Patin D, Tod J, Dowson CG, Roper DI, Barreteau H, Gobec S.

Chem Biol Drug Des. 2018 Jun;91(6):1101-1112. doi: 10.1111/cbdd.13172. Epub 2018 Feb 12.


Noninvasive Electrical Stimulation for the Treatment of Chronic Ocular Pain and Photophobia.

Sivanesan E, Levitt RC, Sarantopoulos CD, Patin D, Galor A.

Neuromodulation. 2018 Dec;21(8):727-734. doi: 10.1111/ner.12742. Epub 2017 Dec 28.


Evidence that Dry Eye Represents a Chronic Overlapping Pain Condition.

Levitt AE, Galor A, Chowdhury AR, Felix ER, Sarantopoulos CD, Zhuang GY, Patin D, Maixner W, Smith SB, Martin ER, Levitt RC.

Mol Pain. 2017 Jan-Dec;13:1744806917729306. doi: 10.1177/1744806917729306. Review.


Synthesis and structure-activity relationship study of novel quinazolinone-based inhibitors of MurA.

Hrast M, Rožman K, Jukič M, Patin D, Gobec S, Sova M.

Bioorg Med Chem Lett. 2017 Aug 1;27(15):3529-3533. doi: 10.1016/j.bmcl.2017.05.064. Epub 2017 May 22.


Commissioning of the Leksell Gamma Knife® Icon™.

Zeverino M, Jaccard M, Patin D, Ryckx N, Marguet M, Tuleasca C, Schiappacasse L, Bourhis J, Levivier M, Bochud FO, Moeckli R.

Med Phys. 2017 Feb;44(2):355-363. doi: 10.1002/mp.12052. Epub 2017 Jan 30.


Discovery of new MurA inhibitors using induced-fit simulation and docking.

Rožman K, Lešnik S, Brus B, Hrast M, Sova M, Patin D, Barreteau H, Konc J, Janežič D, Gobec S.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):944-949. doi: 10.1016/j.bmcl.2016.12.082. Epub 2016 Dec 31.


The Polyanalgesic Consensus Conference (PACC): Recommendations on Intrathecal Drug Infusion Systems Best Practices and Guidelines.

Deer TR, Pope JE, Hayek SM, Bux A, Buchser E, Eldabe S, De Andrés JA, Erdek M, Patin D, Grider JS, Doleys DM, Jacobs MS, Yaksh TL, Poree L, Wallace MS, Prager J, Rauck R, DeLeon O, Diwan S, Falowski SM, Gazelka HM, Kim P, Leong M, Levy RM, McDowell G II, McRoberts P, Naidu R, Narouze S, Perruchoud C, Rosen SM, Rosenberg WS, Saulino M, Staats P, Stearns LJ, Willis D, Krames E, Huntoon M, Mekhail N.

Neuromodulation. 2017 Feb;20(2):96-132. doi: 10.1111/ner.12538. Epub 2017 Jan 2. Review. Erratum in: Neuromodulation. 2017 Jun;20(4):405-406.


Pectocin M1 (PcaM1) Inhibits Escherichia coli Cell Growth and Peptidoglycan Biosynthesis through Periplasmic Expression.

Chérier D, Giacomucci S, Patin D, Bouhss A, Touzé T, Blanot D, Mengin-Lecreulx D, Barreteau H.

Antibiotics (Basel). 2016 Oct 8;5(4). pii: E36.


Electrophilic RNA for Peptidyl-RNA Synthesis and Site-Specific Cross-Linking with tRNA-Binding Enzymes.

Fonvielle M, Sakkas N, Iannazzo L, Le Fournis C, Patin D, Mengin-Lecreulx D, El-Sagheer A, Braud E, Cardon S, Brown T, Arthur M, Etheve-Quelquejeu M.

Angew Chem Int Ed Engl. 2016 Oct 17;55(43):13553-13557. doi: 10.1002/anie.201606843. Epub 2016 Sep 26.


Identification and Partial Characterization of a Novel UDP-N-Acetylenolpyruvoylglucosamine Reductase/UDP-N-Acetylmuramate:l-Alanine Ligase Fusion Enzyme from Verrucomicrobium spinosum DSM 4136(T).

Naqvi KF, Patin D, Wheatley MS, Savka MA, Dobson RC, Gan HM, Barreteau H, Blanot D, Mengin-Lecreulx D, Hudson AO.

Front Microbiol. 2016 Mar 23;7:362. doi: 10.3389/fmicb.2016.00362. eCollection 2016.


Unusual substrate specificity of the peptidoglycan MurE ligase from Erysipelothrix rhusiopathiae.

Patin D, Turk S, Barreteau H, Mainardi JL, Arthur M, Gobec S, Mengin-Lecreulx D, Blanot D.

Biochimie. 2016 Feb;121:209-18. doi: 10.1016/j.biochi.2015.12.006. Epub 2015 Dec 14.


Neuropathic Ocular Pain due to Dry Eye is Associated with Multiple Comorbid Chronic Pain Syndromes.

Galor A, Covington D, Levitt AE, McManus KT, Seiden B, Felix ER, Kalangara J, Feuer W, Patin DJ, Martin ER, Sarantopoulos KD, Levitt RC.

J Pain. 2016 Mar;17(3):310-8. doi: 10.1016/j.jpain.2015.10.019. Epub 2015 Dec 1.


Insights into Substrate Specificity of NlpC/P60 Cell Wall Hydrolases Containing Bacterial SH3 Domains.

Xu Q, Mengin-Lecreulx D, Liu XW, Patin D, Farr CL, Grant JC, Chiu HJ, Jaroszewski L, Knuth MW, Godzik A, Lesley SA, Elsliger MA, Deacon AM, Wilson IA.

MBio. 2015 Sep 15;6(5):e02327-14. doi: 10.1128/mBio.02327-14.


Evaluation of the specificity of [(18)F]fludarabine PET/CT in a xenograft model of follicular lymphoma: comparison with [(18)F]FDG and impact of rituximab therapy.

Hovhannisyan N, Guillouet S, Fillesoye F, Dhilly M, Patin D, Galateau F, Leporrier M, Barré L.

EJNMMI Res. 2015 Apr 14;5:23. doi: 10.1186/s13550-015-0101-7. eCollection 2015.


Chronic dry eye symptoms after LASIK: parallels and lessons to be learned from other persistent post-operative pain disorders.

Levitt AE, Galor A, Weiss JS, Felix ER, Martin ER, Patin DJ, Sarantopoulos KD, Levitt RC.

Mol Pain. 2015 Apr 21;11:21. doi: 10.1186/s12990-015-0020-7. Review.


Diaminopimelic Acid Amidation in Corynebacteriales: NEW INSIGHTS INTO THE ROLE OF LtsA IN PEPTIDOGLYCAN MODIFICATION.

Levefaudes M, Patin D, de Sousa-d'Auria C, Chami M, Blanot D, Hervé M, Arthur M, Houssin C, Mengin-Lecreulx D.

J Biol Chem. 2015 May 22;290(21):13079-94. doi: 10.1074/jbc.M115.642843. Epub 2015 Apr 6.


Structure-guided functional characterization of DUF1460 reveals a highly specific NlpC/P60 amidase family.

Xu Q, Mengin-Lecreulx D, Patin D, Grant JC, Chiu HJ, Jaroszewski L, Knuth MW, Godzik A, Lesley SA, Elsliger MA, Deacon AM, Wilson IA.

Structure. 2014 Dec 2;22(12):1799-1809. doi: 10.1016/j.str.2014.09.018. Epub 2014 Nov 20.


MurD enzymes: some recent developments.

Šink R, Barreteau H, Patin D, Mengin-Lecreulx D, Gobec S, Blanot D.

Biomol Concepts. 2013 Dec;4(6):539-56. doi: 10.1515/bmc-2013-0024. Review.


Purification and biochemical characterisation of GlmU from Yersinia pestis.

Patin D, Bayliss M, Mengin-Lecreulx D, Oyston P, Blanot D.

Arch Microbiol. 2015 Apr;197(3):371-8. doi: 10.1007/s00203-014-1065-0. Epub 2014 Nov 23.


2-[18F]fludarabine, a novel positron emission tomography (PET) tracer for imaging lymphoma: a micro-PET study in murine models.

Dhilly M, Guillouet S, Patin D, Fillesoye F, Abbas A, Gourand F, Tirel O, Galateau F, MacKenzie ET, Dumontet C, Leporrier M, Barré L.

Mol Imaging Biol. 2014 Feb;16(1):118-26. doi: 10.1007/s11307-013-0659-2.


Fully automated radiosynthesis of 2-[18F]fludarabine for PET imaging of low-grade lymphoma.

Guillouet S, Patin D, Tirel O, Delamare J, Gourand F, Deloye JB, Leporrier M, Barré L.

Mol Imaging Biol. 2014 Feb;16(1):28-35. doi: 10.1007/s11307-013-0657-4.


Biochemical characterization of UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-2,6-diaminopimelate ligase (MurE) from Verrucomicrobium spinosum DSM 4136(T.).

McGroty SE, Pattaniyil DT, Patin D, Blanot D, Ravichandran AC, Suzuki H, Dobson RC, Savka MA, Hudson AO.

PLoS One. 2013 Jun 13;8(6):e66458. doi: 10.1371/journal.pone.0066458. Print 2013.


The functional vanGCd cluster of Clostridium difficile does not confer vancomycin resistance.

Ammam F, Meziane-Cherif D, Mengin-Lecreulx D, Blanot D, Patin D, Boneca IG, Courvalin P, Lambert T, Candela T.

Mol Microbiol. 2013 Aug;89(4):612-25. doi: 10.1111/mmi.12299. Epub 2013 Jul 12.


The structure of FemX(Wv) in complex with a peptidyl-RNA conjugate: mechanism of aminoacyl transfer from Ala-tRNA(Ala) to peptidoglycan precursors.

Fonvielle M, Li de La Sierra-Gallay I, El-Sagheer AH, Lecerf M, Patin D, Mellal D, Mayer C, Blanot D, Gale N, Brown T, van Tilbeurgh H, Ethève-Quelquejeu M, Arthur M.

Angew Chem Int Ed Engl. 2013 Jul 8;52(28):7278-81. doi: 10.1002/anie.201301411. Epub 2013 Jun 6. No abstract available.


Synthetic tripeptides as alternate substrates of murein peptide ligase (Mpl).

Hervé M, Kovač A, Cardoso C, Patin D, Brus B, Barreteau H, Mengin-Lecreulx D, Gobec S, Blanot D.

Biochimie. 2013 Jun;95(6):1120-6. doi: 10.1016/j.biochi.2012.12.011. Epub 2012 Dec 25.


Efficient access to peptidyl-RNA conjugates for picomolar inhibition of non-ribosomal FemX(Wv) aminoacyl transferase.

Fonvielle M, Mellal D, Patin D, Lecerf M, Blanot D, Bouhss A, Santarem M, Mengin-Lecreulx D, Sollogoub M, Arthur M, Ethève-Quelquejeu M.

Chemistry. 2013 Jan 21;19(4):1357-63. doi: 10.1002/chem.201201999. Epub 2012 Nov 29.


Colicin M, a peptidoglycan lipid-II-degrading enzyme: potential use for antibacterial means?

Touzé T, Barreteau H, El Ghachi M, Bouhss A, Barnéoud-Arnoulet A, Patin D, Sacco E, Blanot D, Arthur M, Duché D, Lloubès R, Mengin-Lecreulx D.

Biochem Soc Trans. 2012 Dec 1;40(6):1522-7. doi: 10.1042/BST20120189.


Functional and structural characterization of PaeM, a colicin M-like bacteriocin produced by Pseudomonas aeruginosa.

Barreteau H, Tiouajni M, Graille M, Josseaume N, Bouhss A, Patin D, Blanot D, Fourgeaud M, Mainardi JL, Arthur M, van Tilbeurgh H, Mengin-Lecreulx D, Touzé T.

J Biol Chem. 2012 Oct 26;287(44):37395-405. doi: 10.1074/jbc.M112.406439. Epub 2012 Sep 12.


Dual Inhibitor of MurD and MurE Ligases from Escherichia coli and Staphylococcus aureus.

Tomašić T, Sink R, Zidar N, Fic A, Contreras-Martel C, Dessen A, Patin D, Blanot D, Müller-Premru M, Gobec S, Zega A, Kikelj D, Mašič LP.

ACS Med Chem Lett. 2012 Jun 27;3(8):626-30. doi: 10.1021/ml300047h. eCollection 2012 Aug 9.


Characterization of colicin M and its orthologs targeting bacterial cell wall peptidoglycan biosynthesis.

Barreteau H, El Ghachi M, Barnéoud-Arnoulet A, Sacco E, Touzé T, Duché D, Gérard F, Brooks M, Patin D, Bouhss A, Blanot D, van Tilbeurgh H, Arthur M, Lloubès R, Mengin-Lecreulx D.

Microb Drug Resist. 2012 Jun;18(3):222-9. doi: 10.1089/mdr.2011.0230. Epub 2012 Mar 20. Review.


Biochemical characterisation of the chlamydial MurF ligase, and possible sequence of the chlamydial peptidoglycan pentapeptide stem.

Patin D, Bostock J, Chopra I, Mengin-Lecreulx D, Blanot D.

Arch Microbiol. 2012 Jun;194(6):505-12. doi: 10.1007/s00203-011-0784-8. Epub 2012 Jan 10.


Colicin M hydrolyses branched lipids II from Gram-positive bacteria.

Patin D, Barreteau H, Auger G, Magnet S, Crouvoisier M, Bouhss A, Touzé T, Arthur M, Mengin-Lecreulx D, Blanot D.

Biochimie. 2012 Apr;94(4):985-90. doi: 10.1016/j.biochi.2011.12.019. Epub 2011 Dec 26.


New 5-benzylidenethiazolidin-4-one inhibitors of bacterial MurD ligase: design, synthesis, crystal structures, and biological evaluation.

Zidar N, Tomašić T, Šink R, Kovač A, Patin D, Blanot D, Contreras-Martel C, Dessen A, Premru MM, Zega A, Gobec S, Mašič LP, Kikelj D.

Eur J Med Chem. 2011 Nov;46(11):5512-23. doi: 10.1016/j.ejmech.2011.09.017. Epub 2011 Sep 17.


Discovery of novel 5-benzylidenerhodanine and 5-benzylidenethiazolidine-2,4-dione inhibitors of MurD ligase.

Zidar N, Tomasić T, Sink R, Rupnik V, Kovac A, Turk S, Patin D, Blanot D, Contreras Martel C, Dessen A, Müller Premru M, Zega A, Gobec S, Peterlin Masic L, Kikelj D.

J Med Chem. 2010 Sep 23;53(18):6584-94. doi: 10.1021/jm100285g.


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