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Items: 7

1.

Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities.

Zhang D, Hop CE, Patilea-Vrana G, Gampa G, Seneviratne HK, Unadkat JD, Kenny JR, Nagapudi K, Di L, Zhou L, Zak M, Wright MR, Bumpus NN, Zang R, Liu X, Lai Y, Khojasteh SC.

Drug Metab Dispos. 2019 Jul 2. pii: dmd.119.086744. doi: 10.1124/dmd.119.086744. [Epub ahead of print]

2.

A marijuana-drug interaction primer: Precipitants, pharmacology, and pharmacokinetics.

Cox EJ, Maharao N, Patilea-Vrana G, Unadkat JD, Rettie AE, McCune JS, Paine MF.

Pharmacol Ther. 2019 May 6. pii: S0163-7258(19)30075-0. doi: 10.1016/j.pharmthera.2019.05.001. [Epub ahead of print] Review.

PMID:
31071346
3.

Quantifying Hepatic Enzyme Kinetics of (-)-∆9-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC, through In Vitro Modeling.

Patilea-Vrana GI, Unadkat JD.

Drug Metab Dispos. 2019 Jul;47(7):743-752. doi: 10.1124/dmd.119.086470. Epub 2019 May 2.

PMID:
31048453
4.

Hepatic Enzymes Relevant to the Disposition of (-)-∆9-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC.

Patilea-Vrana GI, Anoshchenko O, Unadkat JD.

Drug Metab Dispos. 2019 Mar;47(3):249-256. doi: 10.1124/dmd.118.085548. Epub 2018 Dec 19.

PMID:
30567877
5.

When Does the Rate-Determining Step in the Hepatic Clearance of a Drug Switch from Sinusoidal Uptake to All Hepatobiliary Clearances? Implications for Predicting Drug-Drug Interactions.

Patilea-Vrana GI, Unadkat JD.

Drug Metab Dispos. 2018 Nov;46(11):1487-1496. doi: 10.1124/dmd.118.081307. Epub 2018 Aug 16.

PMID:
30115647
6.

Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model I: Insights into Factors that Determine Fetal Drug Exposure through Simulations and Sensitivity Analyses.

Zhang Z, Imperial MZ, Patilea-Vrana GI, Wedagedera J, Gaohua L, Unadkat JD.

Drug Metab Dispos. 2017 Aug;45(8):920-938. doi: 10.1124/dmd.117.075192. Epub 2017 Jun 6.

7.

Transport vs. Metabolism: What Determines the Pharmacokinetics and Pharmacodynamics of Drugs? Insights From the Extended Clearance Model.

Patilea-Vrana G, Unadkat JD.

Clin Pharmacol Ther. 2016 Nov;100(5):413-418. doi: 10.1002/cpt.437. Epub 2016 Aug 27.

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