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Correction: Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT2 and α1 receptor antagonists.

Heng HL, Chee CF, Chin SP, Ouyang Y, Wang H, Buckle MJC, Herr DR, Paterson IC, Doughty SW, Abd Rahman N, Chung LY.

Medchemcomm. 2018 Mar 7;9(3):593-594. doi: 10.1039/c8md90012d. eCollection 2018 Mar 1.


In vitro functional evaluation of isolaureline, dicentrine and glaucine enantiomers at 5-HT2 and α1 receptors.

Heng HL, Chee CF, Thy CK, Tee JT, Chin SP, Herr DR, Buckle MJC, Paterson IC, Doughty SW, Abd Rahman N, Chung LY.

Chem Biol Drug Des. 2018 Sep 14. doi: 10.1111/cbdd.13390. [Epub ahead of print]


Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT2 and α1 receptor antagonists.

Heng HL, Chee CF, Chin SP, Ouyang Y, Wang H, Buckle MJC, Herr DR, Paterson IC, Doughty SW, Abd Rahman N, Chung LY.

Medchemcomm. 2018 Feb 26;9(3):576-582. doi: 10.1039/c7md00629b. eCollection 2018 Mar 1. Erratum in: Medchemcomm. 2018 Mar 7;9(3):593-594.


The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers.

Velapasamy S, Dawson CW, Young LS, Paterson IC, Yap LF.

Cancers (Basel). 2018 Jul 27;10(8). pii: E247. doi: 10.3390/cancers10080247. Review.


Corrigendum: A miRNA-145/TGF-β1 negative feedback loop regulates the cancer-associated fibroblast phenotype.

Melling GE, Flannery SE, Abidin SA, Clemmens H, Prajapati P, Hinsley EE, Hunt S, Catto JWF, Coletta RD, Mellone M, Thomas GJ, Parkinson EK, Prime SS, Paterson IC, Buttle DJ, Lambert DW.

Carcinogenesis. 2018 Jul 4. doi: 10.1093/carcin/bgy083. [Epub ahead of print] No abstract available.


Clinico-pathological features of oropharyngeal squamous cell carcinomas in Malaysia with reference to HPV infection.

Yap LF, Lai SL, Rhodes A, Sathasivam HP, Abdullah MA, Pua KC, Rajadurai P, Cheah PL, Thavaraj S, Robinson M, Paterson IC.

Infect Agent Cancer. 2018 Jun 11;13:21. doi: 10.1186/s13027-018-0193-6. eCollection 2018.


A miRNA-145/TGF-β1 negative feedback loop regulates the cancer-associated fibroblast phenotype.

Melling GE, Flannery SE, Abidin SA, Clemmens H, Prajapati P, Hinsley EE, Hunt S, Catto JWF, Coletta RD, Mellone M, Thomas GJ, Parkinson EK, Prime SS, Paterson IC, Buttle DJ, Lambert DW.

Carcinogenesis. 2018 May 28;39(6):798-807. doi: 10.1093/carcin/bgy032.


Distinct Biological Potential of Streptococcus gordonii and Streptococcus sanguinis Revealed by Comparative Genome Analysis.

Zheng W, Tan MF, Old LA, Paterson IC, Jakubovics NS, Choo SW.

Sci Rep. 2017 Jun 7;7(1):2949. doi: 10.1038/s41598-017-02399-4.


Synthesis and biological evaluation of indole core-based derivatives with potent antibacterial activity against resistant bacterial pathogens.

Hong W, Li J, Chang Z, Tan X, Yang H, Ouyang Y, Yang Y, Kaur S, Paterson IC, Ngeow YF, Wang H.

J Antibiot (Tokyo). 2017 Jul;70(7):832-844. doi: 10.1038/ja.2017.55. Epub 2017 May 3.


Susceptibility of Human Oral Squamous Cell Carcinoma (OSCC) H103 and H376 cell lines to Retroviral OSKM mediated reprogramming.

Verusingam ND, Yeap SK, Ky H, Paterson IC, Khoo SP, Cheong SK, Ong AHK, Kamarul T.

PeerJ. 2017 Apr 13;5:e3174. doi: 10.7717/peerj.3174. eCollection 2017.


Mechanisms of sphingosine 1-phosphate receptor signalling in cancer.

Patmanathan SN, Wang W, Yap LF, Herr DR, Paterson IC.

Cell Signal. 2017 Jun;34:66-75. doi: 10.1016/j.cellsig.2017.03.002. Epub 2017 Mar 14. Review.


Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3.

Lee HM, Lo KW, Wei W, Tsao SW, Chung GTY, Ibrahim MH, Dawson CW, Murray PG, Paterson IC, Yap LF.

J Pathol. 2017 May;242(1):62-72. doi: 10.1002/path.4879. Epub 2017 Mar 15.


HOPX functions as a tumour suppressor in head and neck cancer.

Yap LF, Lai SL, Patmanathan SN, Gokulan R, Robinson CM, White JB, Chai SJ, Rajadurai P, Prepageran N, Liew YT, Lopes V, Wei W, Hollows RJ, Murray PG, Lambert DW, Hunter KD, Paterson IC.

Sci Rep. 2016 Dec 9;6:38758. doi: 10.1038/srep38758.


PGD: a pangolin genome hub for the research community.

Tan TK, Tan KY, Hari R, Mohamed Yusoff A, Wong GJ, Siow CC, Mutha NV, Rayko M, Komissarov A, Dobrynin P, Krasheninnikova K, Tamazian G, Paterson IC, Warren WC, Johnson WE, O'Brien SJ, Choo SW.

Database (Oxford). 2016 Sep 11;2016. pii: baw063. doi: 10.1093/database/baw063. Print 2016.


Comparative Genome Analysis of Fusobacterium nucleatum.

Ang MY, Dutta A, Wee WY, Dymock D, Paterson IC, Choo SW.

Genome Biol Evol. 2016 Oct 5;8(9):2928-2938.


Pangolin genomes and the evolution of mammalian scales and immunity.

Choo SW, Rayko M, Tan TK, Hari R, Komissarov A, Wee WY, Yurchenko AA, Kliver S, Tamazian G, Antunes A, Wilson RK, Warren WC, Koepfli KP, Minx P, Krasheninnikova K, Kotze A, Dalton DL, Vermaak E, Paterson IC, Dobrynin P, Sitam FT, Rovie-Ryan JJ, Johnson WE, Yusoff AM, Luo SJ, Karuppannan KV, Fang G, Zheng D, Gerstein MB, Lipovich L, O'Brien SJ, Wong GJ.

Genome Res. 2016 Oct;26(10):1312-1322. Epub 2016 Aug 10.


A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts.

Kabir TD, Leigh RJ, Tasena H, Mellone M, Coletta RD, Parkinson EK, Prime SS, Thomas GJ, Paterson IC, Zhou D, McCall J, Speight PM, Lambert DW.

Aging (Albany NY). 2016 Aug;8(8):1608-35. doi: 10.18632/aging.100987.


Fibroblast activation and senescence in oral cancer.

Prime SS, Cirillo N, Hassona Y, Lambert DW, Paterson IC, Mellone M, Thomas GJ, James EN, Parkinson EK.

J Oral Pathol Med. 2017 Feb;46(2):82-88. doi: 10.1111/jop.12456. Epub 2016 May 30. Review.


Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2.

Patmanathan SN, Johnson SP, Lai SL, Panja Bernam S, Lopes V, Wei W, Ibrahim MH, Torta F, Narayanaswamy P, Wenk MR, Herr DR, Murray PG, Yap LF, Paterson IC.

Sci Rep. 2016 May 10;6:25650. doi: 10.1038/srep25650.


StreptoBase: An Oral Streptococcus mitis Group Genomic Resource and Analysis Platform.

Zheng W, Tan TK, Paterson IC, Mutha NV, Siow CC, Tan SY, Old LA, Jakubovics NS, Choo SW.

PLoS One. 2016 May 3;11(5):e0151908. doi: 10.1371/journal.pone.0151908. eCollection 2016.


Sphingosine 1-phosphate receptor 2 (S1P2) attenuates reactive oxygen species formation and inhibits cell death: implications for otoprotective therapy.

Herr DR, Reolo MJ, Peh YX, Wang W, Lee CW, Rivera R, Paterson IC, Chun J.

Sci Rep. 2016 Apr 15;6:24541. doi: 10.1038/srep24541.


The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling.

Hong W, Wang Y, Chang Z, Yang Y, Pu J, Sun T, Kaur S, Sacchettini JC, Jung H, Lin Wong W, Fah Yap L, Fong Ngeow Y, Paterson IC, Wang H.

Sci Rep. 2015 Oct 16;5:15328. doi: 10.1038/srep15328.


The antineoplastic properties of FTY720: evidence for the repurposing of fingolimod.

Patmanathan SN, Yap LF, Murray PG, Paterson IC.

J Cell Mol Med. 2015 Oct;19(10):2329-40. doi: 10.1111/jcmm.12635. Epub 2015 Jul 14. Review.


(6E,10E) Isopolycerasoidol and (6E,10E) Isopolycerasoidol Methyl Ester, Prenylated Benzopyran Derivatives from Pseuduvaria monticola Induce Mitochondrial-Mediated Apoptosis in Human Breast Adenocarcinoma Cells.

Taha H, Looi CY, Arya A, Wong WF, Yap LF, Hasanpourghadi M, Mohd MA, Paterson IC, Mohd Ali H.

PLoS One. 2015 May 6;10(5):e0126126. doi: 10.1371/journal.pone.0126126. eCollection 2015.


The opposing roles of NOTCH signalling in head and neck cancer: a mini review.

Yap LF, Lee D, Khairuddin A, Pairan MF, Puspita B, Siar CH, Paterson IC.

Oral Dis. 2015 Oct;21(7):850-7. doi: 10.1111/odi.12309. Epub 2015 Jan 29. Review.


Down-regulation of LPA receptor 5 contributes to aberrant LPA signalling in EBV-associated nasopharyngeal carcinoma.

Yap LF, Velapasamy S, Lee HM, Thavaraj S, Rajadurai P, Wei W, Vrzalikova K, Ibrahim MH, Khoo AS, Tsao SW, Paterson IC, Taylor GS, Dawson CW, Murray PG.

J Pathol. 2015 Feb;235(3):456-65. doi: 10.1002/path.4460. Epub 2014 Dec 18.


Nickel(II) complex of polyhydroxybenzaldehyde N4-thiosemicarbazone exhibits anti-inflammatory activity by inhibiting NF-κB transactivation.

Shawish HB, Wong WY, Wong YL, Loh SW, Looi CY, Hassandarvish P, Phan AY, Wong WF, Wang H, Paterson IC, Ea CK, Mustafa MR, Maah MJ.

PLoS One. 2014 Jun 30;9(6):e100933. doi: 10.1371/journal.pone.0100933. eCollection 2014.


Investigating the binding preferences of small molecule inhibitors of human protein arginine methyltransferase 1 using molecular modelling.

Hong W, Li J, Laughton CA, Yap LF, Paterson IC, Wang H.

J Mol Graph Model. 2014 Jun;51:193-202. doi: 10.1016/j.jmgm.2014.05.010. Epub 2014 Jun 4.


Genome Sequence of Fusobacterium nucleatum Strain W1481, a Possible New Subspecies Isolated from a Periodontal Pocket.

Ang MY, Dymock D, Tan JL, Thong MH, Tan QK, Wong GJ, Paterson IC, Choo SW.

Genome Announc. 2014 Feb 13;2(1). pii: e00009-14. doi: 10.1128/genomeA.00009-14.


Genome Sequence of Parvimonas micra Strain A293, Isolated from an Abdominal Abscess from a Patient in the United Kingdom.

Ang MY, Dymock D, Tan JL, Thong MH, Tan QK, Wong GJ, Paterson IC, Choo SW.

Genome Announc. 2013 Dec 5;1(6). pii: e01025-13. doi: 10.1128/genomeA.01025-13.


The study of interactions between DNA and PcrA DNA helicase by using targeted molecular dynamic simulations.

Wang H, Cui J, Hong W, Paterson IC, Laughton CA.

J Mol Model. 2013 Nov;19(11):4997-5006. doi: 10.1007/s00894-013-2008-4. Epub 2013 Sep 26.


Identification of novel small molecule TGF-β antagonists using structure-based drug design.

Wang H, Sessions RB, Prime SS, Shoemark DK, Allen SJ, Hong W, Narayanan S, Paterson IC.

J Comput Aided Mol Des. 2013 Apr;27(4):365-72. doi: 10.1007/s10822-013-9651-9. Epub 2013 Apr 27.


Transforming growth factor-β enhances invasion and metastasis in Ras-transfected human malignant epidermal keratinocytes.

Davies M, Prime SS, Eveson JW, Price N, Ganapathy A, D'Mello A, Paterson IC.

Int J Exp Pathol. 2012 Apr;93(2):148-56. doi: 10.1111/j.1365-2613.2011.00806.x.


Lysophosphatidic acid and calcitriol co-operate to promote human osteoblastogenesis: requirement of albumin-bound LPA.

Mansell JP, Nowghani M, Pabbruwe M, Paterson IC, Smith AJ, Blom AW.

Prostaglandins Other Lipid Mediat. 2011 Aug;95(1-4):45-52. doi: 10.1016/j.prostaglandins.2011.05.002. Epub 2011 May 31.


TGF-β inhibits metastasis in late stage human squamous cell carcinoma of the skin by a mechanism that does not involve Id1.

Ganapathy A, Paterson IC, Prime SS, Eveson JW, Pring M, Price N, Threadgold SP, Davies M.

Cancer Lett. 2010 Dec 1;298(1):107-18. doi: 10.1016/j.canlet.2010.06.008.


Upregulation of Eps8 in oral squamous cell carcinoma promotes cell migration and invasion through integrin-dependent Rac1 activation.

Yap LF, Jenei V, Robinson CM, Moutasim K, Benn TM, Threadgold SP, Lopes V, Wei W, Thomas GJ, Paterson IC.

Oncogene. 2009 Jul 9;28(27):2524-34. doi: 10.1038/onc.2009.105. Epub 2009 May 18.


Investigating the Conformational Preferences of Transforming Growth Factor-β Isoforms using Targeted Molecular Dynamics Simulations.

Warner DJ, Paterson IC, Sessions RB.

J Chem Theory Comput. 2009 Mar 10;5(3):482-90. doi: 10.1021/ct800483q.


Spindle assembly checkpoint and centrosome abnormalities in oral cancer.

Thirthagiri E, Robinson CM, Huntley S, Davies M, Yap LF, Prime SS, Paterson IC.

Cancer Lett. 2007 Dec 18;258(2):276-85. Epub 2007 Oct 23.


Expression of Ki-67 and p53 in cutaneous free flaps used to reconstruct soft tissue defects following resection of oral squamous cell carcinoma.

Max Robinson C, Prime SS, Paterson IC, Guest PG, Eveson JW.

Oral Oncol. 2007 Mar;43(3):263-71. Epub 2006 Aug 22.


The role of TGF-beta in epithelial malignancy and its relevance to the pathogenesis of oral cancer (part II).

Prime SS, Davies M, Pring M, Paterson IC.

Crit Rev Oral Biol Med. 2004 Nov 1;15(6):337-47. Review.


TGF-beta signal transduction in oro-facial health and non-malignant disease (part I).

Prime SS, Pring M, Davies M, Paterson IC.

Crit Rev Oral Biol Med. 2004 Nov 1;15(6):324-36. Review.


Metastatic dissemination of human malignant oral keratinocyte cell lines following orthotopic transplantation reflects response to TGF-beta 1.

Prime SS, Eveson JW, Stone AM, Huntley SP, Davies M, Paterson IC, Robinson CM.

J Pathol. 2004 Aug;203(4):927-32.


Attenuated type II TGF-beta receptor signalling in human malignant oral keratinocytes induces a less differentiated and more aggressive phenotype that is associated with metastatic dissemination.

Huntley SP, Davies M, Matthews JB, Thomas G, Marshall J, Robinson CM, Eveson JW, Paterson IC, Prime SS.

Int J Cancer. 2004 Jun 10;110(2):170-6.


Functional significance of MMP-2 and MMP-9 expression by human malignant oral keratinocyte cell lines.

Robinson CM, Stone AM, Shields JD, Huntley S, Paterson IC, Prime SS.

Arch Oral Biol. 2003 Nov;48(11):779-86.


Effect of deprivation on survival of patients with head and neck cancer: a study of 20,131 cases.

Paterson IC, John G, Adams Jones D.

Clin Oncol (R Coll Radiol). 2002 Dec;14(6):455-8.


Homeopathy: what is it and is it of value in the care of patients with cancer?

Paterson IC.

Clin Oncol (R Coll Radiol). 2002 Jun;14(3):250-3. Review.


TGF-beta1 acts as a tumor suppressor of human malignant keratinocytes independently of Smad 4 expression and ligand-induced G(1) arrest.

Paterson IC, Davies M, Stone A, Huntley S, Smith E, Pring M, Eveson JW, Robinson CM, Parkinson EK, Prime SS.

Oncogene. 2002 Feb 28;21(10):1616-24.

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