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OSC1: Assessment of Cytotoxicity of Microcrystalline Cellulose Reinforced Denture Base Resin.

Rahaman Ali AAA, May LW, Paterson IC, John J.

J Indian Prosthodont Soc. 2018 Oct;18(Suppl 1):S7. doi: 10.4103/0972-4052.244589. No abstract available.


Correction: Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT2 and α1 receptor antagonists.

Heng HL, Chee CF, Chin SP, Ouyang Y, Wang H, Buckle MJC, Herr DR, Paterson IC, Doughty SW, Abd Rahman N, Chung LY.

Medchemcomm. 2018 Mar 7;9(3):593-594. doi: 10.1039/c8md90012d. eCollection 2018 Mar 1.


In vitro functional evaluation of isolaureline, dicentrine and glaucine enantiomers at 5-HT2 and α1 receptors.

Heng HL, Chee CF, Thy CK, Tee JT, Chin SP, Herr DR, Buckle MJC, Paterson IC, Doughty SW, Abd Rahman N, Chung LY.

Chem Biol Drug Des. 2018 Sep 14. doi: 10.1111/cbdd.13390. [Epub ahead of print]


Toward the total synthesis of patellazole B: synthesis of an advanced C1-C25 fragment corresponding to the macrocyclic skeleton.

Phillips AW, Anketell MJ, Balan T, Lam NYS, Williams S, Paterson I.

Org Biomol Chem. 2018 Sep 26;16(37):8286-8291. doi: 10.1039/c8ob01621f.


Environmental extremes drive population structure at the northern range limit of Atlantic salmon in North America.

Sylvester EVA, Beiko RG, Bentzen P, Paterson I, Horne JB, Watson B, Lehnert S, Duffy S, Clément M, Robertson MJ, Bradbury IR.

Mol Ecol. 2018 Oct;27(20):4026-4040. doi: 10.1111/mec.14849. Epub 2018 Sep 17.


Testing the Enemy Release Hypothesis on tall-statured grasses in South Africa, using Arundo donax, Phragmites australis, and Phragmites mauritianus as models.

Canavan K, Paterson ID, Hill MP, Dudley TL.

Bull Entomol Res. 2018 Aug 17:1-14. doi: 10.1017/S0007485318000627. [Epub ahead of print]


Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT2 and α1 receptor antagonists.

Heng HL, Chee CF, Chin SP, Ouyang Y, Wang H, Buckle MJC, Herr DR, Paterson IC, Doughty SW, Abd Rahman N, Chung LY.

Medchemcomm. 2018 Feb 26;9(3):576-582. doi: 10.1039/c7md00629b. eCollection 2018 Mar 1. Erratum in: Medchemcomm. 2018 Mar 7;9(3):593-594.


The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers.

Velapasamy S, Dawson CW, Young LS, Paterson IC, Yap LF.

Cancers (Basel). 2018 Jul 27;10(8). pii: E247. doi: 10.3390/cancers10080247. Review.


Corrigendum: A miRNA-145/TGF-β1 negative feedback loop regulates the cancer-associated fibroblast phenotype.

Melling GE, Flannery SE, Abidin SA, Clemmens H, Prajapati P, Hinsley EE, Hunt S, Catto JWF, Coletta RD, Mellone M, Thomas GJ, Parkinson EK, Prime SS, Paterson IC, Buttle DJ, Lambert DW.

Carcinogenesis. 2018 Jul 4. doi: 10.1093/carcin/bgy083. [Epub ahead of print] No abstract available.


Clinico-pathological features of oropharyngeal squamous cell carcinomas in Malaysia with reference to HPV infection.

Yap LF, Lai SL, Rhodes A, Sathasivam HP, Abdullah MA, Pua KC, Rajadurai P, Cheah PL, Thavaraj S, Robinson M, Paterson IC.

Infect Agent Cancer. 2018 Jun 11;13:21. doi: 10.1186/s13027-018-0193-6. eCollection 2018.


Genotyping-by-sequencing of genome-wide microsatellite loci reveals fine-scale harvest composition in a coastal Atlantic salmon fishery.

Bradbury IR, Wringe BF, Watson B, Paterson I, Horne J, Beiko R, Lehnert SJ, Clément M, Anderson EC, Jeffery NW, Duffy S, Sylvester E, Robertson M, Bentzen P.

Evol Appl. 2018 Mar 11;11(6):918-930. doi: 10.1111/eva.12606. eCollection 2018 Jul.


Comparison of epicardial adipose tissue radiodensity threshold between contrast and non-contrast enhanced computed tomography scans: A cohort study of derivation and validation.

Xu L, Xu Y, Coulden R, Sonnex E, Hrybouski S, Paterson I, Butler C.

Atherosclerosis. 2018 Aug;275:74-79. doi: 10.1016/j.atherosclerosis.2018.05.013. Epub 2018 May 11.


A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.

Menchon G, Prota AE, Lucena-Agell D, Bucher P, Jansen R, Irschik H, Müller R, Paterson I, Díaz JF, Altmann KH, Steinmetz MO.

Nat Commun. 2018 May 29;9(1):2106. doi: 10.1038/s41467-018-04535-8.


What is the minimum change in left ventricular ejection fraction, which can be measured with contrast echocardiography?

Suwatanaviroj T, He W, Pituskin E, Paterson I, Choy J, Becher H.

Echo Res Pract. 2018 Jun;5(2):71-77. doi: 10.1530/ERP-18-0003. Epub 2018 Apr 11.


Expansive reed populations-alien invasion or disturbed wetlands?

Canavan K, Paterson ID, Lambertini C, Hill MP.

AoB Plants. 2018 Feb 23;10(2):ply014. doi: 10.1093/aobpla/ply014. eCollection 2018 Mar.


A synthesis-enabled relative stereochemical assignment of the C1-C28 region of hemicalide.

Han BY, Lam NYS, MacGregor CI, Goodman JM, Paterson I.

Chem Commun (Camb). 2018 Mar 27;54(26):3247-3250. doi: 10.1039/c8cc00933c.


A miRNA-145/TGF-β1 negative feedback loop regulates the cancer-associated fibroblast phenotype.

Melling GE, Flannery SE, Abidin SA, Clemmens H, Prajapati P, Hinsley EE, Hunt S, Catto JWF, Coletta RD, Mellone M, Thomas GJ, Parkinson EK, Prime SS, Paterson IC, Buttle DJ, Lambert DW.

Carcinogenesis. 2018 May 28;39(6):798-807. doi: 10.1093/carcin/bgy032.


Chloroquine-induced cardiomyopathy: a reversible cause of heart failure.

Yogasundaram H, Hung W, Paterson ID, Sergi C, Oudit GY.

ESC Heart Fail. 2018 Jun;5(3):372-375. doi: 10.1002/ehf2.12276. Epub 2018 Feb 20.


Toward aplyronine payloads for antibody-drug conjugates: total synthesis of aplyronines A and D.

AnŽiček N, Williams S, Housden MP, Paterson I.

Org Biomol Chem. 2018 Feb 21;16(8):1343-1350. doi: 10.1039/c7ob03204h.


Home Exercise Training Improves Exercise Capacity in Cirrhosis Patients: Role of Exercise Adherence.

Kruger C, McNeely ML, Bailey RJ, Yavari M, Abraldes JG, Carbonneau M, Newnham K, DenHeyer V, Ma M, Thompson R, Paterson I, Haykowsky MJ, Tandon P.

Sci Rep. 2018 Jan 8;8(1):99. doi: 10.1038/s41598-017-18320-y.


Variability of left ventricular volume and ejection fraction measurements using contrast echocardiography: The influence of the left ventricular length measurements in a large cohort of patients during monitoring cardiotoxic effects of chemotherapy.

Suwatanaviroj T, He W, Mirhadi E, Paakanen R, Pituskin E, Paterson I, Choy J, Becher H.

Echocardiography. 2018 Mar;35(3):322-328. doi: 10.1111/echo.13783. Epub 2017 Dec 22.


Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients.

Michelakis ED, Gurtu V, Webster L, Barnes G, Watson G, Howard L, Cupitt J, Paterson I, Thompson RB, Chow K, O'Regan DP, Zhao L, Wharton J, Kiely DG, Kinnaird A, Boukouris AE, White C, Nagendran J, Freed DH, Wort SJ, Gibbs JSR, Wilkins MR.

Sci Transl Med. 2017 Oct 25;9(413). pii: eaao4583. doi: 10.1126/scitranslmed.aao4583.


Challenges and discoveries in the total synthesis of complex polyketide natural products.

Paterson I, Lam NYS.

J Antibiot (Tokyo). 2018 Feb;71(2):215-233. doi: 10.1038/ja.2017.111. Epub 2017 Oct 25. Review.


Subclinical Pulmonary Edema Is Associated With Reduced Exercise Capacity in HFpEF and HFrEF.

Thompson RB, Pagano JJ, Chow K, Sekowski V, Paterson I, Ezekowitz J, Anderson T, Dyck JRB, Haykowsky MJ; Alberta HEART investigators.

J Am Coll Cardiol. 2017 Oct 3;70(14):1827-1828. doi: 10.1016/j.jacc.2017.07.787. No abstract available.


The Role of Cardio-Oncology in the Interprofessional Care of Adult Patients Receiving Cancer Therapy.

Pituskin E, Paterson I, Cox-Kennett N, Rothe D, Perri M, Becher H.

Semin Oncol Nurs. 2017 Nov;33(4):384-392. doi: 10.1016/j.soncn.2017.08.010. Epub 2017 Sep 21. Review.


A prospective evaluation of the established criteria for heart failure with preserved ejection fraction using the Alberta HEART cohort.

Ezekowitz JA, McAlister FA, Howlett J, Alemayehu W, Paterson I, Belenkie I, Oudit GY, Kaul P, Dyck JR, Anderson T; Alberta HEART Investigators.

ESC Heart Fail. 2018 Feb;5(1):19-26. doi: 10.1002/ehf2.12200. Epub 2017 Jul 25.


Induction of accelerated senescence by the microtubule-stabilizing agent peloruside A.

Chan A, Gilfillan C, Templeton N, Paterson I, Northcote PT, Miller JH.

Invest New Drugs. 2017 Dec;35(6):706-717. doi: 10.1007/s10637-017-0493-5. Epub 2017 Jul 22.


Distinct Biological Potential of Streptococcus gordonii and Streptococcus sanguinis Revealed by Comparative Genome Analysis.

Zheng W, Tan MF, Old LA, Paterson IC, Jakubovics NS, Choo SW.

Sci Rep. 2017 Jun 7;7(1):2949. doi: 10.1038/s41598-017-02399-4.


Beta blockers and improved progression-free survival in patients with advanced HER2 negative breast cancer: a retrospective analysis of the ROSE/TRIO-012 study.

Spera G, Fresco R, Fung H, Dyck JRB, Pituskin E, Paterson I, Mackey JR.

Ann Oncol. 2017 Aug 1;28(8):1836-1841. doi: 10.1093/annonc/mdx264.


Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration.

Field JJ, Northcote PT, Paterson I, Altmann KH, Díaz JF, Miller JH.

Int J Mol Sci. 2017 May 3;18(5). pii: E971. doi: 10.3390/ijms18050971.


Synthesis and biological evaluation of indole core-based derivatives with potent antibacterial activity against resistant bacterial pathogens.

Hong W, Li J, Chang Z, Tan X, Yang H, Ouyang Y, Yang Y, Kaur S, Paterson IC, Ngeow YF, Wang H.

J Antibiot (Tokyo). 2017 Jul;70(7):832-844. doi: 10.1038/ja.2017.55. Epub 2017 May 3.


Susceptibility of Human Oral Squamous Cell Carcinoma (OSCC) H103 and H376 cell lines to Retroviral OSKM mediated reprogramming.

Verusingam ND, Yeap SK, Ky H, Paterson IC, Khoo SP, Cheong SK, Ong AHK, Kamarul T.

PeerJ. 2017 Apr 13;5:e3174. doi: 10.7717/peerj.3174. eCollection 2017.


Mechanisms of sphingosine 1-phosphate receptor signalling in cancer.

Patmanathan SN, Wang W, Yap LF, Herr DR, Paterson IC.

Cell Signal. 2017 Jun;34:66-75. doi: 10.1016/j.cellsig.2017.03.002. Epub 2017 Mar 14. Review.


Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3.

Lee HM, Lo KW, Wei W, Tsao SW, Chung GTY, Ibrahim MH, Dawson CW, Murray PG, Paterson IC, Yap LF.

J Pathol. 2017 May;242(1):62-72. doi: 10.1002/path.4879. Epub 2017 Mar 15.


Structural Basis of Microtubule Stabilization by Discodermolide.

Prota AE, Bargsten K, Redondo-Horcajo M, Smith AB 3rd, Yang CH, McDaid HM, Paterson I, Horwitz SB, Fernando Díaz J, Steinmetz MO.

Chembiochem. 2017 May 18;18(10):905-909. doi: 10.1002/cbic.201600696. Epub 2017 Mar 27.


Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells.

Trigili C, Barasoain I, Sánchez-Murcia PA, Bargsten K, Redondo-Horcajo M, Nogales A, Gardner NM, Meyer A, Naylor GJ, Gómez-Rubio E, Gago F, Steinmetz MO, Paterson I, Prota AE, Díaz JF.

ACS Omega. 2016 Dec 31;1(6):1192-1204. doi: 10.1021/acsomega.6b00317. Epub 2016 Dec 13.


HOPX functions as a tumour suppressor in head and neck cancer.

Yap LF, Lai SL, Patmanathan SN, Gokulan R, Robinson CM, White JB, Chai SJ, Rajadurai P, Prepageran N, Liew YT, Lopes V, Wei W, Hollows RJ, Murray PG, Lambert DW, Hunter KD, Paterson IC.

Sci Rep. 2016 Dec 9;6:38758. doi: 10.1038/srep38758.


An Expedient Total Synthesis of Chivosazole F: an Actin-Binding Antimitotic Macrolide from the Myxobacterium Sorangium Cellulosum.

Williams S, Jin J, Kan SB, Li M, Gibson LJ, Paterson I.

Angew Chem Int Ed Engl. 2017 Jan 9;56(2):645-649. doi: 10.1002/anie.201610636. Epub 2016 Nov 29.


Optimising Antibiotic Usage to Treat Bacterial Infections.

Paterson IK, Hoyle A, Ochoa G, Baker-Austin C, Taylor NG.

Sci Rep. 2016 Nov 28;6:37853. doi: 10.1038/srep37853.


Influenza H1N1 Infection Leading To Cardiac Tamponade in a Previously Healthy Patient: A Case Report.

Sidhu RS, Sharma A, Paterson ID, Bainey KR.

Res Cardiovasc Med. 2016 Jul 16;5(3):e31546. eCollection 2016 Aug.


Differential Responses of Post-Exercise Recovery of Leg Blood Flow and Oxygen Uptake Kinetics in HFpEF versus HFrEF.

Thompson RB, Pagano JJ, Mathewson KW, Paterson I, Dyck JR, Kitzman DW, Haykowsky MJ.

PLoS One. 2016 Oct 4;11(10):e0163513. doi: 10.1371/journal.pone.0163513. eCollection 2016.


Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy.

Makani V, Zhang B, Han H, Yao Y, Lassalas P, Lou K, Paterson I, Lee VM, Trojanowski JQ, Ballatore C, Smith AB 3rd, Brunden KR.

Acta Neuropathol Commun. 2016 Sep 29;4(1):106.


Two in one: cryptic species discovered in biological control agent populations using molecular data and crossbreeding experiments.

Paterson ID, Mangan R, Downie DA, Coetzee JA, Hill MP, Burke AM, Downey PO, Henry TJ, Compton SG.

Ecol Evol. 2016 Jul 30;6(17):6139-50. doi: 10.1002/ece3.2297. eCollection 2016 Sep.


Rationale and design of the multidisciplinary team IntervenTion in cArdio-oNcology study (TITAN).

Pituskin E, Haykowsky M, McNeely M, Mackey J, Chua N, Paterson I.

BMC Cancer. 2016 Sep 15;16(1):733. doi: 10.1186/s12885-016-2761-8.


PGD: a pangolin genome hub for the research community.

Tan TK, Tan KY, Hari R, Mohamed Yusoff A, Wong GJ, Siow CC, Mutha NV, Rayko M, Komissarov A, Dobrynin P, Krasheninnikova K, Tamazian G, Paterson IC, Warren WC, Johnson WE, O'Brien SJ, Choo SW.

Database (Oxford). 2016 Sep 11;2016. pii: baw063. doi: 10.1093/database/baw063. Print 2016.


Comparative Genome Analysis of Fusobacterium nucleatum.

Ang MY, Dutta A, Wee WY, Dymock D, Paterson IC, Choo SW.

Genome Biol Evol. 2016 Oct 5;8(9):2928-2938.


Pangolin genomes and the evolution of mammalian scales and immunity.

Choo SW, Rayko M, Tan TK, Hari R, Komissarov A, Wee WY, Yurchenko AA, Kliver S, Tamazian G, Antunes A, Wilson RK, Warren WC, Koepfli KP, Minx P, Krasheninnikova K, Kotze A, Dalton DL, Vermaak E, Paterson IC, Dobrynin P, Sitam FT, Rovie-Ryan JJ, Johnson WE, Yusoff AM, Luo SJ, Karuppannan KV, Fang G, Zheng D, Gerstein MB, Lipovich L, O'Brien SJ, Wong GJ.

Genome Res. 2016 Oct;26(10):1312-1322. Epub 2016 Aug 10.


Glycogen Storage Disease Because of a PRKAG2 Mutation Causing Severe Biventricular Hypertrophy and High-Grade Atrio-Ventricular Block.

Yogasundaram H, Paterson ID, Graham M, Sergi C, Oudit GY.

Circ Heart Fail. 2016 Aug;9(8). pii: e003367. doi: 10.1161/CIRCHEARTFAILURE.116.003367. No abstract available.


A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts.

Kabir TD, Leigh RJ, Tasena H, Mellone M, Coletta RD, Parkinson EK, Prime SS, Thomas GJ, Paterson IC, Zhou D, McCall J, Speight PM, Lambert DW.

Aging (Albany NY). 2016 Aug;8(8):1608-35. doi: 10.18632/aging.100987.


Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy.

Virani SA, Dent S, Brezden-Masley C, Clarke B, Davis MK, Jassal DS, Johnson C, Lemieux J, Paterson I, Sebag IA, Simmons C, Sulpher J, Thain K, Thavendiranathan P, Wentzell JR, Wurtele N, Côté MA, Fine NM, Haddad H, Hayley BD, Hopkins S, Joy AA, Rayson D, Stadnick E, Straatman L.

Can J Cardiol. 2016 Jul;32(7):831-41. doi: 10.1016/j.cjca.2016.02.078. Epub 2016 Apr 7. Review.


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