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Items: 17


Commentary: Thyrotropin Stimulates Differentiation Not Proliferation of Normal Human Thyrocytes in Culture.

Kyrilli A, Paternot S, Miot F, Corvilain B, Vassart G, Roger PP, Dumont JE.

Front Endocrinol (Lausanne). 2017 Aug 25;8:214. doi: 10.3389/fendo.2017.00214. eCollection 2017. No abstract available.


CDK4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclib.

Raspé E, Coulonval K, Pita JM, Paternot S, Rothé F, Twyffels L, Brohée S, Craciun L, Larsimont D, Kruys V, Sandras F, Salmon I, Van Laere S, Piccart M, Ignatiadis M, Sotiriou C, Roger PP.

EMBO Mol Med. 2017 Aug;9(8):1052-1066. doi: 10.15252/emmm.201607084.


JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21.

Colleoni B, Paternot S, Pita JM, Bisteau X, Coulonval K, Davis RJ, Raspé E, Roger PP.

Oncogene. 2017 Jul 27;36(30):4349-4361. doi: 10.1038/onc.2017.7. Epub 2017 Apr 3.


The CDK4/CDK6 inhibitor PD0332991 paradoxically stabilizes activated cyclin D3-CDK4/6 complexes.

Paternot S, Colleoni B, Bisteau X, Roger PP.

Cell Cycle. 2014;13(18):2879-88. doi: 10.4161/15384101.2014.946841.


CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point.

Bisteau X, Paternot S, Colleoni B, Ecker K, Coulonval K, De Groote P, Declercq W, Hengst L, Roger PP.

PLoS Genet. 2013 May;9(5):e1003546. doi: 10.1371/journal.pgen.1003546. Epub 2013 May 30.


cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4.

Blancquaert S, Wang L, Paternot S, Coulonval K, Dumont JE, Harris TE, Roger PP.

Mol Endocrinol. 2010 Jul;24(7):1453-68. doi: 10.1210/me.2010-0087. Epub 2010 May 19.


Rb inactivation in cell cycle and cancer: the puzzle of highly regulated activating phosphorylation of CDK4 versus constitutively active CDK-activating kinase.

Paternot S, Bockstaele L, Bisteau X, Kooken H, Coulonval K, Roger PP.

Cell Cycle. 2010 Feb 15;9(4):689-99. Epub 2010 Feb 12. Review.


Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation.

Bockstaele L, Bisteau X, Paternot S, Roger PP.

Mol Cell Biol. 2009 Aug;29(15):4188-200. doi: 10.1128/MCB.01823-08. Epub 2009 Jun 1.


Cyclic AMP inhibits the proliferation of thyroid carcinoma cell lines through regulation of CDK4 phosphorylation.

Rocha AS, Paternot S, Coulonval K, Dumont JE, Soares P, Roger PP.

Mol Biol Cell. 2008 Nov;19(11):4814-25. doi: 10.1091/mbc.E08-06-0617. Epub 2008 Sep 17.


Regulation of CDK4.

Bockstaele L, Coulonval K, Kooken H, Paternot S, Roger PP.

Cell Div. 2006 Nov 8;1:25.


Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors".

Bockstaele L, Kooken H, Libert F, Paternot S, Dumont JE, de Launoit Y, Roger PP, Coulonval K.

Mol Cell Biol. 2006 Jul;26(13):5070-85.


Distinct specificities of pRb phosphorylation by CDK4 activated by cyclin D1 or cyclin D3: differential involvement in the distinct mitogenic modes of thyroid epithelial cells.

Paternot S, Arsenijevic T, Coulonval K, Bockstaele L, Dumont JE, Roger PP.

Cell Cycle. 2006 Jan;5(1):61-70. Epub 2006 Jan 18.


Phosphorylations of cyclin-dependent kinase 2 revisited using two-dimensional gel electrophoresis.

Coulonval K, Bockstaele L, Paternot S, Roger PP.

J Biol Chem. 2003 Dec 26;278(52):52052-60. Epub 2003 Oct 9.


Cyclic AMP-dependent phosphorylation of cyclin D3-bound CDK4 determines the passage through the cell cycle restriction point in thyroid epithelial cells.

Paternot S, Coulonval K, Dumont JE, Roger PP.

J Biol Chem. 2003 Jul 18;278(29):26533-40. Epub 2003 Apr 30.

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