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Items: 40

1.

Immunohisto(cyto)chemistry: an old time classic tool driving modern oncological therapies.

Cooks T, Theodorou SD, Paparouna E, Rizou SV, Myrianthopoulos V, Gorgoulis VG, Pateras IS.

Histol Histopathol. 2018 Nov 27:18069. doi: 10.14670/HH-18-069. [Epub ahead of print] Review.

PMID:
30480312
2.

LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state.

Furth N, Pateras IS, Rotkopf R, Vlachou V, Rivkin I, Schmitt I, Bakaev D, Gershoni A, Ainbinder E, Leshkowitz D, Johnson RL, Gorgoulis VG, Oren M, Aylon Y.

Life Sci Alliance. 2018 Oct 30;1(5):e201800171. doi: 10.26508/lsa.201800171. eCollection 2018 Oct.

3.

Ex Vivo Culture of Cells Derived From Circulating Tumour Cell Xenograft to support Small Cell Lung Cancer Research and Experimental Therapeutics.

Lallo A, Gulati S, Schenk MW, Khandelwal G, Berglund UW, Pateras IS, Chester CPE, Pham TM, Kalderen C, Frese KK, Gorgoulis VG, Miller C, Blackhall F, Helleday T, Dive C.

Br J Pharmacol. 2018 Nov 14. doi: 10.1111/bph.14542. [Epub ahead of print]

PMID:
30427531
4.

Geminin ablation in vivo enhances tumorigenesis through increased genomic instability.

Champeris Tsaniras S, Villiou M, Giannou AD, Nikou S, Petropoulos M, Pateras IS, Tserou P, Karousi F, Lalioti ME, Gorgoulis VG, Patmanidi AL, Stathopoulos GT, Bravou V, Lygerou Z, Taraviras S.

J Pathol. 2018 Oct;246(2):134-140. doi: 10.1002/path.5128. Epub 2018 Aug 21.

PMID:
29952003
5.

Targeting Tie-2/angiopoietin axis in experimental mesothelioma confers differential responses and raises predictive implications.

Magkouta S, Pappas A, Pateras IS, Kollintza A, Moschos C, Vazakidou ME, Karavana V, Gorgoulis VG, Kalomenidis I.

Oncotarget. 2018 Apr 24;9(31):21783-21796. doi: 10.18632/oncotarget.25004. eCollection 2018 Apr 24.

6.

Integrating the DNA damage and protein stress responses during cancer development and treatment.

Gorgoulis VG, Pefani DE, Pateras IS, Trougakos IP.

J Pathol. 2018 Sep;246(1):12-40. doi: 10.1002/path.5097. Epub 2018 Jul 19. Review.

7.

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.

Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis NN, Glytsou C, Pateras IS, Swain U, Souliotis VL, Georgakilas AG, Geacintov N, Scorrano L, Lukas C, Lukas J, Livneh Z, Lygerou Z, Chowdhury D, Sørensen CS, Bartek J, Gorgoulis VG.

Genome Biol. 2018 Mar 16;19(1):37. doi: 10.1186/s13059-018-1401-9.

8.

In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution.

Barbouti A, Evangelou K, Pateras IS, Papoudou-Bai A, Patereli A, Stefanaki K, Rontogianni D, Muñoz-Espín D, Kanavaros P, Gorgoulis VG.

Mech Ageing Dev. 2018 Feb 25. pii: S0047-6374(17)30300-7. doi: 10.1016/j.mad.2018.02.005. [Epub ahead of print]

PMID:
29490231
9.

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246.

Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC.

Nat Commun. 2018 Feb 22;9(1):771. doi: 10.1038/s41467-018-03224-w.

10.

Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers.

Solomon H, Dinowitz N, Pateras IS, Cooks T, Shetzer Y, Molchadsky A, Charni M, Rabani S, Koifman G, Tarcic O, Porat Z, Kogan-Sakin I, Goldfinger N, Oren M, Harris CC, Gorgoulis VG, Rotter V.

Oncogene. 2018 Mar;37(12):1669-1684. doi: 10.1038/s41388-017-0060-8. Epub 2018 Jan 18.

PMID:
29343849
11.

A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence.

Komseli ES, Pateras IS, Krejsgaard T, Stawiski K, Rizou SV, Polyzos A, Roumelioti FM, Chiourea M, Mourkioti I, Paparouna E, Zampetidis CP, Gumeni S, Trougakos IP, Pefani DE, O'Neill E, Gagos S, Eliopoulos AG, Fendler W, Chowdhury D, Bartek J, Gorgoulis VG.

BMC Genomics. 2018 Jan 10;19(1):37. doi: 10.1186/s12864-017-4375-1.

12.

Localized Synchrotron Irradiation of Mouse Skin Induces Persistent Systemic Genotoxic and Immune Responses.

Ventura J, Lobachevsky PN, Palazzolo JS, Forrester H, Haynes NM, Ivashkevich A, Stevenson AW, Hall CJ, Ntargaras A, Kotsaris V, Pollakis GC, Potsi G, Skordylis K, Terzoudi G, Pateras IS, Gorgoulis VG, Georgakilas AG, Sprung CN, Martin OA.

Cancer Res. 2017 Nov 15;77(22):6389-6399. doi: 10.1158/0008-5472.CAN-17-1066. Epub 2017 Nov 7.

13.

Evaluation of the impact of tumor HPV status on outcome in patients with locally advanced unresectable head and neck squamous cell carcinoma (HNSCC) receiving cisplatin, 5-fluorouracil with or without docetaxel: a subset analysis of EORTC 24971 study.

Psyrri A, Fortpied C, Koutsodontis G, Avgeris M, Kroupis C, Goutas N, Menis J, Herman L, Giurgea L, Remenár É, Degardin M, Pateras IS, Langendijk JA, van Herpen CML, Awada A, Germà-Lluch JR, Kienzer HR, Licitra L, Vermorken JB.

Ann Oncol. 2017 Sep 1;28(9):2213-2218. doi: 10.1093/annonc/mdx320.

PMID:
28651338
14.

Genetic Variability as a Regulator of TLR4 and NOD Signaling in Response to Bacterial Driven DNA Damage Response (DDR) and Inflammation: Focus on the Gastrointestinal (GI) Tract.

Spanou E, Kalisperati P, Pateras IS, Papalampros A, Barbouti A, Tzioufas AG, Kotsinas A, Sougioultzis S.

Front Genet. 2017 May 29;8:65. doi: 10.3389/fgene.2017.00065. eCollection 2017. Review.

15.

MiR-signing gastrointestinal (con-)tract cancer.

Gorgoulis VG, Pateras IS, Kotsinas A.

Oncotarget. 2017 May 2;8(18):29536-29537. doi: 10.18632/oncotarget.15701. No abstract available.

16.

Applying Broadband Dielectric Spectroscopy (BDS) for the Biophysical Characterization of Mammalian Tissues under a Variety of Cellular Stresses.

Souli MP, Klonos P, Fragopoulou AF, Mavragani IV, Pateras IS, Kostomitsopoulos N, Margaritis LH, Zoumpoulis P, Kaklamanis L, Kletsas D, Gorgoulis VG, Kyritsis A, Pissis P, Georgakilas AG.

Int J Mol Sci. 2017 Apr 15;18(4). pii: E838. doi: 10.3390/ijms18040838.

17.

Inflammation, DNA Damage, Helicobacter pylori and Gastric Tumorigenesis.

Kalisperati P, Spanou E, Pateras IS, Korkolopoulou P, Varvarigou A, Karavokyros I, Gorgoulis VG, Vlachoyiannopoulos PG, Sougioultzis S.

Front Genet. 2017 Feb 27;8:20. doi: 10.3389/fgene.2017.00020. eCollection 2017. Review.

18.

RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer.

Tarcic O, Granit RZ, Pateras IS, Masury H, Maly B, Zwang Y, Yarden Y, Gorgoulis VG, Pikarsky E, Ben-Porath I, Oren M.

Cell Death Differ. 2017 Apr;24(4):694-704. doi: 10.1038/cdd.2016.126. Epub 2017 Feb 3.

19.

Validation and development of MTH1 inhibitors for treatment of cancer.

Warpman Berglund U, Sanjiv K, Gad H, Kalderén C, Koolmeister T, Pham T, Gokturk C, Jafari R, Maddalo G, Seashore-Ludlow B, Chernobrovkin A, Manoilov A, Pateras IS, Rasti A, Jemth AS, Almlöf I, Loseva O, Visnes T, Einarsdottir BO, Gaugaz FZ, Saleh A, Platzack B, Wallner OA, Vallin KS, Henriksson M, Wakchaure P, Borhade S, Herr P, Kallberg Y, Baranczewski P, Homan EJ, Wiita E, Nagpal V, Meijer T, Schipper N, Rudd SG, Bräutigam L, Lindqvist A, Filppula A, Lee TC, Artursson P, Nilsson JA, Gorgoulis VG, Lehtiö J, Zubarev RA, Scobie M, Helleday T.

Ann Oncol. 2016 Dec;27(12):2275-2283. doi: 10.1093/annonc/mdw429. Epub 2016 Nov 8.

PMID:
27827301
20.

The Typhoid Toxin Promotes Host Survival and the Establishment of a Persistent Asymptomatic Infection.

Del Bel Belluz L, Guidi R, Pateras IS, Levi L, Mihaljevic B, Rouf SF, Wrande M, Candela M, Turroni S, Nastasi C, Consolandi C, Peano C, Tebaldi T, Viero G, Gorgoulis VG, Krejsgaard T, Rhen M, Frisan T.

PLoS Pathog. 2016 Apr 7;12(4):e1005528. doi: 10.1371/journal.ppat.1005528. eCollection 2016 Apr.

21.

RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer.

Tarcic O, Pateras IS, Cooks T, Shema E, Kanterman J, Ashkenazi H, Boocholez H, Hubert A, Rotkopf R, Baniyash M, Pikarsky E, Gorgoulis VG, Oren M.

Cell Rep. 2016 Feb 16;14(6):1462-1476. doi: 10.1016/j.celrep.2016.01.020. Epub 2016 Feb 4.

22.

Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy.

Golomb L, Sagiv A, Pateras IS, Maly A, Krizhanovsky V, Gorgoulis VG, Oren M, Ben-Yehuda A.

Cell Death Differ. 2015 Nov;22(11):1764-74. doi: 10.1038/cdd.2015.21. Epub 2015 Mar 20.

23.

IL-15 suppresses colitis-associated colon carcinogenesis by inducing antitumor immunity.

Bahri R, Pateras IS, D'Orlando O, Goyeneche-Patino DA, Campbell M, Polansky JK, Sandig H, Papaioannou M, Evangelou K, Foukas PG, Gorgoulis VG, Bulfone-Paus S.

Oncoimmunology. 2015 Jan 22;4(9):e1002721. eCollection 2015 Sep.

24.

The DNA damage response and immune signaling alliance: Is it good or bad? Nature decides when and where.

Pateras IS, Havaki S, Nikitopoulou X, Vougas K, Townsend PA, Panayiotidis MI, Georgakilas AG, Gorgoulis VG.

Pharmacol Ther. 2015 Oct;154:36-56. doi: 10.1016/j.pharmthera.2015.06.011. Epub 2015 Jul 3. Review.

PMID:
26145166
25.

Dual function of p38α MAPK in colon cancer: suppression of colitis-associated tumor initiation but requirement for cancer cell survival.

Gupta J, del Barco Barrantes I, Igea A, Sakellariou S, Pateras IS, Gorgoulis VG, Nebreda AR.

Cancer Cell. 2014 Apr 14;25(4):484-500. doi: 10.1016/j.ccr.2014.02.019. Epub 2014 Mar 27.

26.

The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis.

Evangelou K, Bartkova J, Kotsinas A, Pateras IS, Liontos M, Velimezi G, Kosar M, Liloglou T, Trougakos IP, Dyrskjot L, Andersen CL, Papaioannou M, Drosos Y, Papafotiou G, Hodny Z, Sosa-Pineda B, Wu XR, Klinakis A, Ørntoft T, Lukas J, Bartek J, Gorgoulis VG.

Cell Death Differ. 2013 Nov;20(11):1485-97. doi: 10.1038/cdd.2013.76. Epub 2013 Jul 12.

27.

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer.

Velimezi G, Liontos M, Vougas K, Roumeliotis T, Bartkova J, Sideridou M, Dereli-Oz A, Kocylowski M, Pateras IS, Evangelou K, Kotsinas A, Orsolic I, Bursac S, Cokaric-Brdovcak M, Zoumpourlis V, Kletsas D, Papafotiou G, Klinakis A, Volarevic S, Gu W, Bartek J, Halazonetis TD, Gorgoulis VG.

Nat Cell Biol. 2013 Aug;15(8):967-77. doi: 10.1038/ncb2795. Epub 2013 Jul 14. Erratum in: Nat Cell Biol. 2013 Oct;15(10):1260.

PMID:
23851489
28.

Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.

Cooks T, Pateras IS, Tarcic O, Solomon H, Schetter AJ, Wilder S, Lozano G, Pikarsky E, Forshew T, Rosenfeld N, Harpaz N, Itzkowitz S, Harris CC, Rotter V, Gorgoulis VG, Oren M.

Cancer Cell. 2013 May 13;23(5):634-46. doi: 10.1016/j.ccr.2013.03.022. Erratum in: Cancer Cell. 2013 Aug 12;24(2):272. Rozenfeld, Nitzan [corrected to Rosenfeld, Nitzan].

29.

A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas.

Nikolaev SI, Sotiriou SK, Pateras IS, Santoni F, Sougioultzis S, Edgren H, Almusa H, Robyr D, Guipponi M, Saarela J, Gorgoulis VG, Antonarakis SE, Halazonetis TD.

Cancer Res. 2012 Dec 1;72(23):6279-89. doi: 10.1158/0008-5472.CAN-12-3869. Erratum in: Cancer Res. 2014 Jan 15;74(2):636.

30.

How do cytokines trigger genomic instability?

Aivaliotis IL, Pateras IS, Papaioannou M, Glytsou C, Kontzoglou K, Johnson EO, Zoumpourlis V.

J Biomed Biotechnol. 2012;2012:536761. doi: 10.1155/2012/536761. Epub 2012 Jun 17. Review.

31.

The single nucleotide polymorphism g.1548A >G (K469E) of the ICAM-1 gene is associated with worse prognosis in non-small cell lung cancer.

Thanopoulou E, Kotzamanis G, Pateras IS, Ziras N, Papalambros A, Mariolis-Sapsakos T, Sigala F, Johnson E, Kotsinas A, Scorilas A, Gorgoulis VG.

Tumour Biol. 2012 Oct;33(5):1429-36. doi: 10.1007/s13277-012-0393-4. Epub 2012 May 6.

PMID:
22562265
32.

Detection of herplex simplex virus-1 and -2 in cardiac myxomas.

Pateras IS, Evangelou K, Tsimaratou K, Liontos M, Sakellariou S, Barlogiannis T, Karakitsos P, Papalois A, Kotsinas A, Gorgoulis VG.

J Biomed Biotechnol. 2012;2012:823949. doi: 10.1155/2012/823949. Epub 2012 Feb 28.

33.

The tumor suppressor gene ARF as a sensor of oxidative stress.

Liontos M, Pateras IS, Evangelou K, Gorgoulis VG.

Curr Mol Med. 2012 Jul 1;12(6):704-15. Review.

PMID:
22292438
34.

The roles of p27(Kip1) and DNA damage signalling in the chemotherapy-induced delayed cell cycle checkpoint.

Liontos M, Velimezi G, Pateras IS, Angelopoulou R, Papavassiliou AG, Bartek J, Gorgoulis VG.

J Cell Mol Med. 2010 Sep;14(9):2264-7. doi: 10.1111/j.1582-4934.2010.01145.x. Epub 2010 Oct 11.

35.

Why is p53-inducible gene 3 rarely affected in cancer?

Kotsinas A, Pateras IS, Galanos PS, Karamouzis MV, Sfikakis PP, Gorgoulis VG.

Oncogene. 2010 Sep 16;29(37):5220. doi: 10.1038/onc.2010.263. Epub 2010 Jul 5. No abstract available.

PMID:
20603616
36.

Increased expression of bFGF is associated with carotid atherosclerotic plaques instability engaging the NF-κB pathway.

Sigala F, Savvari P, Liontos M, Sigalas P, Pateras IS, Papalampros A, Basdra EK, Kolettas E, Papavassiliou AG, Gorgoulis VG.

J Cell Mol Med. 2010 Sep;14(9):2273-80. doi: 10.1111/j.1582-4934.2010.01082.x.

37.

p57KIP2: "Kip"ing the cell under control.

Pateras IS, Apostolopoulou K, Niforou K, Kotsinas A, Gorgoulis VG.

Mol Cancer Res. 2009 Dec;7(12):1902-19. doi: 10.1158/1541-7786.MCR-09-0317. Epub 2009 Nov 24. Review.

38.

Gene amplification is a relatively frequent event leading to ZBTB7A (Pokemon) overexpression in non-small cell lung cancer.

Apostolopoulou K, Pateras IS, Evangelou K, Tsantoulis PK, Liontos M, Kittas C, Tiniakos DG, Kotsinas A, Cordon-Cardo C, Gorgoulis VG.

J Pathol. 2007 Nov;213(3):294-302.

PMID:
17907153
39.

Downregulation of the KIP family members p27(KIP1) and p57(KIP2) by SKP2 and the role of methylation in p57(KIP2) inactivation in nonsmall cell lung cancer.

Pateras IS, Apostolopoulou K, Koutsami M, Evangelou K, Tsantoulis P, Liloglou T, Nikolaidis G, Sigala F, Kittas C, Field JK, Kotsinas A, Gorgoulis VG.

Int J Cancer. 2006 Dec 1;119(11):2546-56.

40.

Centrosome abnormalities are frequently observed in non-small-cell lung cancer and are associated with aneuploidy and cyclin E overexpression.

Koutsami MK, Tsantoulis PK, Kouloukoussa M, Apostolopoulou K, Pateras IS, Spartinou Z, Drougou A, Evangelou K, Kittas C, Bartkova J, Bartek J, Gorgoulis VG.

J Pathol. 2006 Aug;209(4):512-21.

PMID:
16739112

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