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Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution.

Okerblom J, Fletes W, Patel HH, Schenk S, Varki A, Breen EC.

Proc Biol Sci. 2018 Sep 12;285(1886). pii: 20181656. doi: 10.1098/rspb.2018.1656.


Atorvastatin, but not pravastatin, inhibits cardiac Akt/mTOR signaling and disturbs mitochondrial ultrastructure in cardiac myocytes.

Godoy JC, Niesman IR, Busija AR, Kassan A, Schilling JM, Schwarz A, Alvarez EA, Dalton ND, Drummond JC, Roth DM, Kararigas G, Patel HH, Zemljic-Harpf AE.

FASEB J. 2018 Aug 31:fj201800876R. doi: 10.1096/fj.201800876R. [Epub ahead of print]



Bryant SM, Kong CHT, Watson JJ, Gadeberg HC, Roth DM, Patel HH, Cannell MB, James AF, Orchard CH.

Am J Physiol Heart Circ Physiol. 2018 Jul 20. doi: 10.1152/ajpheart.00209.2018. [Epub ahead of print]


Not all fiber is good for you: Targeting fibroblast activation to improve cardiac function in heart failure.

Haushalter KJ, Patel HH.

Am J Physiol Heart Circ Physiol. 2018 Jul 13. doi: 10.1152/ajpheart.00386.2018. [Epub ahead of print] No abstract available.


Natural experiment examining the longitudinal association between change in residential segregation and youth cardiovascular health across race/ethnicity and gender in the USA.

D'Agostino EM, Patel HH, Ahmed Z, Hansen E, Mathew MS, Nardi MI, Messiah SE.

J Epidemiol Community Health. 2018 Jul;72(7):595-604. doi: 10.1136/jech-2018-210592. Epub 2018 May 10. Review.


Impact of change in neighborhood racial/ethnic segregation on cardiovascular health in minority youth attending a park-based afterschool program.

D'Agostino EM, Patel HH, Ahmed Z, Hansen E, Sunil Mathew M, Nardi MI, Messiah SE.

Soc Sci Med. 2018 May;205:116-129. doi: 10.1016/j.socscimed.2018.03.038. Epub 2018 Mar 27.


Sex differences in fitness outcomes among minority youth after participation in a park-based after-school program.

Messiah SE, D'Agostino EM, Patel HH, Hansen E, Mathew MS, Arheart KL.

Ann Epidemiol. 2018 Jul;28(7):432-439. doi: 10.1016/j.annepidem.2018.03.020. Epub 2018 Apr 12.


Formation of Chiral Allylic Ethers via an Enantioselective Palladium-Catalyzed Alkenylation of Acyclic Enol Ethers.

Patel HH, Prater MB, Squire SO Jr, Sigman MS.

J Am Chem Soc. 2018 May 9;140(18):5895-5898. doi: 10.1021/jacs.8b02751. Epub 2018 Apr 27.


Pulmonary Effective Arterial Elastance as a Measure of Right Ventricular Afterload and Its Prognostic Value in Pulmonary Hypertension Due to Left Heart Disease.

Tampakakis E, Shah SJ, Borlaug BA, Leary PJ, Patel HH, Miller WL, Kelemen BW, Houston BA, Kolb TM, Damico R, Mathai SC, Kasper EK, Hassoun PM, Kass DA, Tedford RJ.

Circ Heart Fail. 2018 Apr;11(4):e004436. doi: 10.1161/CIRCHEARTFAILURE.117.004436.


Effect of participation in a park-based afterschool program on cardiovascular disease risk among severely obese youth.

D'Agostino EM, Patel HH, Hansen E, Mathew MS, Nardi MI, Messiah SE.

Public Health. 2018 Jun;159:137-143. doi: 10.1016/j.puhe.2018.02.025. Epub 2018 Mar 27.


Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits.

Pearn ML, Schilling JM, Jian M, Egawa J, Wu C, Mandyam CD, Fannon-Pavlich MJ, Nguyen U, Bertoglio J, Kodama M, Mahata SK, DerMardirossian C, Lemkuil BP, Han R, Mobley WC, Patel HH, Patel PM, Head BP.

Br J Anaesth. 2018 Apr;120(4):745-760. doi: 10.1016/j.bja.2017.12.033. Epub 2018 Feb 15.


Isoflurane Impacts Murine Melanoma Growth in a Sex-Specific, Immune-Dependent Manner: A Brief Report.

Meier A, Gross ETE, Schilling JM, Seelige R, Jung Y, Santosa E, Searles S, Lin T, Tu XM, Patel HH, Bui JD.

Anesth Analg. 2018 Jun;126(6):1910-1913. doi: 10.1213/ANE.0000000000002902.


Development of a University Campus Healthy Sleep Promotion Program.

McCabe BE, Troy AS, Patel HH, Halstead V, Arana M.

Issues Ment Health Nurs. 2018 Mar;39(3):264-268. doi: 10.1080/01612840.2017.1397231. Epub 2018 Feb 13.


Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells.

Haushalter KJ, Casteel DE, Raffeiner A, Stefan E, Patel HH, Taylor SS.

J Biol Chem. 2018 Mar 23;293(12):4411-4421. doi: 10.1074/jbc.M117.809988. Epub 2018 Jan 29.


Caveolins as Regulators of Stress Adaptation.

Schilling JM, Head BP, Patel HH.

Mol Pharmacol. 2018 Apr;93(4):277-285. doi: 10.1124/mol.117.111237. Epub 2018 Jan 22.


No pain, no gain: balancing central versus peripheral benefits of analgesics in the age of the opioid crisis.

Patel HH, Roth DM.

Br J Pharmacol. 2018 Mar;175(5):855-856. doi: 10.1111/bph.14130. Epub 2018 Jan 17. No abstract available.


The Effects of Aging on the Regulation of T-Tubular ICa by Caveolin in Mouse Ventricular Myocytes.

Kong CHT, Bryant SM, Watson JJ, Gadeberg HC, Roth DM, Patel HH, Cannell MB, Orchard CH, James AF.

J Gerontol A Biol Sci Med Sci. 2018 May 9;73(6):711-719. doi: 10.1093/gerona/glx242.


Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection.

Russell J, Du Toit EF, Peart JN, Patel HH, Headrick JP.

Cardiovasc Diabetol. 2017 Dec 4;16(1):155. doi: 10.1186/s12933-017-0638-z. Review.


Longitudinal analysis of cardiovascular disease risk profile in neighbourhood poverty subgroups: 5-year results from an afterschool fitness programme in the USA.

D'Agostino EM, Patel HH, Hansen E, Mathew MS, Nardi M, Messiah SE.

J Epidemiol Community Health. 2018 Mar;72(3):193-201. doi: 10.1136/jech-2017-209333. Epub 2017 Nov 24.


Neuron-Targeted Caveolin-1 Promotes Ultrastructural and Functional Hippocampal Synaptic Plasticity.

Egawa J, Zemljic-Harpf A, Mandyam CD, Niesman IR, Lysenko LV, Kleschevnikov AM, Roth DM, Patel HH, Patel PM, Head BP.

Cereb Cortex. 2018 Sep 1;28(9):3255-3266. doi: 10.1093/cercor/bhx196.


Inhibition of p75 neurotrophin receptor does not rescue cognitive impairment in adulthood after isoflurane exposure in neonatal mice.

Schilling JM, Kassan A, Mandyam C, Pearn ML, Voong A, Grogman GG, Risbrough VB, Niesman IR, Patel HH, Patel PM, Head BP.

Br J Anaesth. 2017 Sep 1;119(3):465-471. doi: 10.1093/bja/aew299.


Altered Penile Caveolin Expression in Diabetes: Potential Role in Erectile Dysfunction.

Parikh J, Zemljic-Harpf A, Fu J, Giamouridis D, Hsieh TC, Kassan A, Murthy KS, Bhargava V, Patel HH, Rajasekaran MR.

J Sex Med. 2017 Oct;14(10):1177-1186. doi: 10.1016/j.jsxm.2017.08.006.


Association between ABO blood type and live-birth outcomes in single-embryo transfer cycles.

Pereira N, Patel HH, Stone LD, Christos PJ, Elias RT, Spandorfer SD, Rosenwaks Z.

Fertil Steril. 2017 Nov;108(5):791-797. doi: 10.1016/j.fertnstert.2017.08.019. Epub 2017 Sep 15.


Determination of Degradation Kinetics and Effect of Anion Exchange Resin on Dissolution of Novel Anticancer Drug Rigosertib in Acidic Conditions.

Patel HH, Maniar M, Ren C, Dave RH.

AAPS PharmSciTech. 2018 Jan;19(1):93-100. doi: 10.1208/s12249-017-0820-3. Epub 2017 Jun 9.


Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits.

Ichikawa Y, Zemljic-Harpf AE, Zhang Z, McKirnan MD, Manso AM, Ross RS, Hammond HK, Patel HH, Roth DM.

PLoS One. 2017 May 12;12(5):e0177660. doi: 10.1371/journal.pone.0177660. eCollection 2017.


Neuron-specific caveolin-1 overexpression improves motor function and preserves memory in mice subjected to brain trauma.

Egawa J, Schilling JM, Cui W, Posadas E, Sawada A, Alas B, Zemljic-Harpf AE, Fannon-Pavlich MJ, Mandyam CD, Roth DM, Patel HH, Patel PM, Head BP.

FASEB J. 2017 Aug;31(8):3403-3411. doi: 10.1096/fj.201601288RRR. Epub 2017 Apr 27.


Corrigendum: Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress.

Kassan M, Vikram A, Kim YR, Li Q, Kassan A, Patel HH, Kumar S, Gabani M, Liu J, Jacobs JS, Irani K.

Sci Rep. 2017 Apr 10;7:46123. doi: 10.1038/srep46123. No abstract available.


Hypoxia-inducible factor-1α activation improves renal oxygenation and mitochondrial function in early chronic kidney disease.

Thomas JL, Pham H, Li Y, Hall E, Perkins GA, Ali SS, Patel HH, Singh P.

Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F282-F290. doi: 10.1152/ajprenal.00579.2016. Epub 2017 Mar 22.


Delta Opioid Receptors and Cardioprotection.

See Hoe L, Patel HH, Peart JN.

Handb Exp Pharmacol. 2017 Feb 26. doi: 10.1007/164_2017_6. [Epub ahead of print]


Temporal trends in minimally invasive myomectomy before and after the US Food and Drug Administration recommendation against electric morcellation.

Pereira N, Frankel WC, Hutchinson AP, Patel HH, Mostisser C, Elias RT.

Int J Gynaecol Obstet. 2017 Jun;137(3):295-300. doi: 10.1002/ijgo.12128. Epub 2017 Mar 16.


Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress.

Kassan M, Vikram A, Kim YR, Li Q, Kassan A, Patel HH, Kumar S, Gabani M, Liu J, Jacobs JS, Irani K.

Sci Rep. 2017 Feb 9;7:42265. doi: 10.1038/srep42265.


Thy-1 interaction with Fas in lipid rafts regulates fibroblast apoptosis and lung injury resolution.

Liu X, Wong SS, Taype CA, Kim J, Shentu TP, Espinoza CR, Finley JC, Bradley JE, Head BP, Patel HH, Mah EJ, Hagood JS.

Lab Invest. 2017 Mar;97(3):256-267. doi: 10.1038/labinvest.2016.145. Epub 2017 Feb 6.


Caveolins and cavins in the trafficking, maturation, and degradation of caveolae: implications for cell physiology.

Busija AR, Patel HH, Insel PA.

Am J Physiol Cell Physiol. 2017 Apr 1;312(4):C459-C477. doi: 10.1152/ajpcell.00355.2016. Epub 2017 Jan 25. Review.


Enlarged vestibular aqueducts and other inner-ear abnormalities in patients with Down syndrome.

Clark CM, Patel HH, Kanekar SG, Isildak H.

J Laryngol Otol. 2017 Apr;131(4):298-302. doi: 10.1017/S0022215116009786. Epub 2016 Dec 28.


Caveolin-1 regulation of disrupted-in-schizophrenia-1 as a potential therapeutic target for schizophrenia.

Kassan A, Egawa J, Zhang Z, Almenar-Queralt A, Nguyen QM, Lajevardi Y, Kim K, Posadas E, Jeste DV, Roth DM, Patel PM, Patel HH, Head BP.

J Neurophysiol. 2017 Jan 1;117(1):436-444. doi: 10.1152/jn.00481.2016. Epub 2016 Nov 2.


Enantioselective Palladium-Catalyzed Alkenylation of Trisubstituted Alkenols To Form Allylic Quaternary Centers.

Patel HH, Sigman MS.

J Am Chem Soc. 2016 Nov 2;138(43):14226-14229. Epub 2016 Oct 25.


Helium postconditioning regulates expression of caveolin-1 and -3 and induces RISK pathway activation after ischaemia/reperfusion in cardiac tissue of rats.

Flick M, Albrecht M, Oei GTML, Steenstra R, Kerindongo RP, Zuurbier CJ, Patel HH, Hollmann MW, Preckel B, Weber NC.

Eur J Pharmacol. 2016 Nov 15;791:718-725. doi: 10.1016/j.ejphar.2016.10.012. Epub 2016 Oct 11.


Caveolin-3 plays a critical role in autophagy after ischemia-reperfusion.

Kassan A, Pham U, Nguyen Q, Reichelt ME, Cho E, Patel PM, Roth DM, Head BP, Patel HH.

Am J Physiol Cell Physiol. 2016 Dec 1;311(6):C854-C865. doi: 10.1152/ajpcell.00147.2016. Epub 2016 Oct 5.


Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure.

Barbagallo F, Xu B, Reddy GR, West T, Wang Q, Fu Q, Li M, Shi Q, Ginsburg KS, Ferrier W, Isidori AM, Naro F, Patel HH, Bossuyt J, Bers D, Xiang YK.

Circ Res. 2016 Sep 30;119(8):931-43. doi: 10.1161/CIRCRESAHA.116.308964. Epub 2016 Aug 30.


Chronic β1-adrenoceptor blockade impairs ischaemic tolerance and preconditioning in murine myocardium.

See Hoe LE, Schilling JM, Busija AR, Haushalter KJ, Ozberk V, Keshwani MM, Roth DM, Toit ED, Headrick JP, Patel HH, Peart JN.

Eur J Pharmacol. 2016 Oct 15;789:1-7. doi: 10.1016/j.ejphar.2016.06.054. Epub 2016 Jun 30.


Electrophysiology and metabolism of caveolin-3-overexpressing mice.

Schilling JM, Horikawa YT, Zemljic-Harpf AE, Vincent KP, Tyan L, Yu JK, McCulloch AD, Balijepalli RC, Patel HH, Roth DM.

Basic Res Cardiol. 2016 May;111(3):28. doi: 10.1007/s00395-016-0542-9. Epub 2016 Mar 29.


Hydrogen Sulfide--Mechanisms of Toxicity and Development of an Antidote.

Jiang J, Chan A, Ali S, Saha A, Haushalter KJ, Lam WL, Glasheen M, Parker J, Brenner M, Mahon SB, Patel HH, Ambasudhan R, Lipton SA, Pilz RB, Boss GR.

Sci Rep. 2016 Feb 15;6:20831. doi: 10.1038/srep20831.


A Slick Way Volatile Anesthetics Reduce Myocardial Injury.

Wagner NM, Gross ER, Patel HH.

Anesthesiology. 2016 May;124(5):986-8. doi: 10.1097/ALN.0000000000001047. No abstract available.


Evaluation of [11C]TAZA for amyloid β plaque imaging in postmortem human Alzheimer's disease brain region and whole body distribution in rodent PET/CT.

Pan ML, Mukherjee MT, Patel HH, Patel B, Constantinescu CC, Mirbolooki MR, Liang C, Mukherjee J.

Synapse. 2016 Apr;70(4):163-76. doi: 10.1002/syn.21893. Epub 2016 Feb 11.


The plasma membrane as a capacitor for energy and metabolism.

Ray S, Kassan A, Busija AR, Rangamani P, Patel HH.

Am J Physiol Cell Physiol. 2016 Feb 1;310(3):C181-92. doi: 10.1152/ajpcell.00087.2015. Epub 2015 Nov 25. Review.


Neuron-Targeted Caveolin-1 Improves Molecular Signaling, Plasticity, and Behavior Dependent on the Hippocampus in Adult and Aged Mice.

Mandyam CD, Schilling JM, Cui W, Egawa J, Niesman IR, Kellerhals SE, Staples MC, Busija AR, Risbrough VB, Posadas E, Grogman GC, Chang JW, Roth DM, Patel PM, Patel HH, Head BP.

Biol Psychiatry. 2017 Jan 15;81(2):101-110. doi: 10.1016/j.biopsych.2015.09.020. Epub 2015 Oct 8.


Estrogen receptor beta signaling alters cellular inflammasomes activity after global cerebral ischemia in reproductively senescence female rats.

de Rivero Vaccari JP, Patel HH, Brand FJ 3rd, Perez-Pinzon MA, Bramlett HM, Raval AP.

J Neurochem. 2016 Feb;136(3):492-6. doi: 10.1111/jnc.13404. Epub 2015 Nov 13.


Non-canonical roles for caveolin in regulation of membrane repair and mitochondria: implications for stress adaptation with age.

Schilling JM, Patel HH.

J Physiol. 2016 Aug 15;594(16):4581-9. doi: 10.1113/JP270591. Epub 2015 Oct 14. Review.


Epigenetics: The Epicenter for Future Anesthesia Research?

Stary CM, Patel HH, Roth DM.

Anesthesiology. 2015 Oct;123(4):743-4. doi: 10.1097/ALN.0000000000000808. No abstract available.


Caveolin-3 Overexpression Attenuates Cardiac Hypertrophy via Inhibition of T-type Ca2+ Current Modulated by Protein Kinase Cα in Cardiomyocytes.

Markandeya YS, Phelan LJ, Woon MT, Keefe AM, Reynolds CR, August BK, Hacker TA, Roth DM, Patel HH, Balijepalli RC.

J Biol Chem. 2015 Sep 4;290(36):22085-100. doi: 10.1074/jbc.M115.674945. Epub 2015 Jul 13.

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