Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 578

1.

The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation.

Batki J, Schnabl J, Wang J, Handler D, Andreev VI, Stieger CE, Novatchkova M, Lampersberger L, Kauneckaite K, Xie W, Mechtler K, Patel DJ, Brennecke J.

Nat Struct Mol Biol. 2019 Aug;26(8):720-731. doi: 10.1038/s41594-019-0270-6. Epub 2019 Aug 5.

PMID:
31384064
2.

CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4 Cleavage with ApA>p Formation Terminating RNase Activity.

Jia N, Jones R, Yang G, Ouerfelli O, Patel DJ.

Mol Cell. 2019 Jun 28. pii: S1097-2765(19)30447-2. doi: 10.1016/j.molcel.2019.06.014. [Epub ahead of print]

PMID:
31326273
3.

Second Messenger cA4 Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path.

Jia N, Jones R, Sukenick G, Patel DJ.

Mol Cell. 2019 Jun 28. pii: S1097-2765(19)30446-0. doi: 10.1016/j.molcel.2019.06.013. [Epub ahead of print]

PMID:
31326272
4.

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.

Minuesa G, Albanese SK, Xie W, Kazansky Y, Worroll D, Chow A, Schurer A, Park SM, Rotsides CZ, Taggart J, Rizzi A, Naden LN, Chou T, Gourkanti S, Cappel D, Passarelli MC, Fairchild L, Adura C, Glickman JF, Schulman J, Famulare C, Patel M, Eibl JK, Ross GM, Bhattacharya S, Tan DS, Leslie CS, Beuming T, Patel DJ, Goldgur Y, Chodera JD, Kharas MG.

Nat Commun. 2019 Jun 19;10(1):2691. doi: 10.1038/s41467-019-10523-3.

5.

Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.

Xie W, Lama L, Adura C, Tomita D, Glickman JF, Tuschl T, Patel DJ.

Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11946-11955. doi: 10.1073/pnas.1905013116. Epub 2019 May 29.

PMID:
31142647
6.

Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.

Lama L, Adura C, Xie W, Tomita D, Kamei T, Kuryavyi V, Gogakos T, Steinberg JI, Miller M, Ramos-Espiritu L, Asano Y, Hashizume S, Aida J, Imaeda T, Okamoto R, Jennings AJ, Michino M, Kuroita T, Stamford A, Gao P, Meinke P, Glickman JF, Patel DJ, Tuschl T.

Nat Commun. 2019 May 21;10(1):2261. doi: 10.1038/s41467-019-08620-4.

7.

Hatchet ribozyme structure and implications for cleavage mechanism.

Zheng L, Falschlunger C, Huang K, Mairhofer E, Yuan S, Wang J, Patel DJ, Micura R, Ren A.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):10783-10791. doi: 10.1073/pnas.1902413116. Epub 2019 May 14.

8.

Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase A2α.

Hirano Y, Gao YG, Stephenson DJ, Vu NT, Malinina L, Simanshu DK, Chalfant CE, Patel DJ, Brown RE.

Elife. 2019 May 3;8. pii: e44760. doi: 10.7554/eLife.44760.

9.

REC114 Partner ANKRD31 Controls Number, Timing, and Location of Meiotic DNA Breaks.

Boekhout M, Karasu ME, Wang J, Acquaviva L, Pratto F, Brick K, Eng DY, Xu J, Camerini-Otero RD, Patel DJ, Keeney S.

Mol Cell. 2019 Jun 6;74(5):1053-1068.e8. doi: 10.1016/j.molcel.2019.03.023. Epub 2019 Apr 16.

PMID:
31003867
10.

CasX: a new and small CRISPR gene-editing protein.

Yang H, Patel DJ.

Cell Res. 2019 May;29(5):345-346. doi: 10.1038/s41422-019-0165-4. No abstract available.

PMID:
30992542
11.

Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.

Jia N, Mo CY, Wang C, Eng ET, Marraffini LA, Patel DJ.

Mol Cell. 2019 Jan 17;73(2):264-277.e5. doi: 10.1016/j.molcel.2018.11.007. Epub 2018 Nov 29.

PMID:
30503773
12.

Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016-40 for 195 countries and territories.

Foreman KJ, Marquez N, Dolgert A, Fukutaki K, Fullman N, McGaughey M, Pletcher MA, Smith AE, Tang K, Yuan CW, Brown JC, Friedman J, He J, Heuton KR, Holmberg M, Patel DJ, Reidy P, Carter A, Cercy K, Chapin A, Douwes-Schultz D, Frank T, Goettsch F, Liu PY, Nandakumar V, Reitsma MB, Reuter V, Sadat N, Sorensen RJD, Srinivasan V, Updike RL, York H, Lopez AD, Lozano R, Lim SS, Mokdad AH, Vollset SE, Murray CJL.

Lancet. 2018 Nov 10;392(10159):2052-2090. doi: 10.1016/S0140-6736(18)31694-5. Epub 2018 Oct 16.

13.

Transcriptional elongation factor Paf1 core complex adopts a spirally wrapped solenoidal topology.

Deng P, Zhou Y, Jiang J, Li H, Tian W, Cao Y, Qin Y, Kim J, Roeder RG, Patel DJ, Wang Z.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):9998-10003. doi: 10.1073/pnas.1812256115. Epub 2018 Sep 17.

14.

Structural analyses of 4-phosphate adaptor protein 2 yield mechanistic insights into sphingolipid recognition by the glycolipid transfer protein family.

Ochoa-Lizarralde B, Gao YG, Popov AN, Samygina VR, Zhai X, Mishra SK, Boldyrev IA, Molotkovsky JG, Simanshu DK, Patel DJ, Brown RE, Malinina L.

J Biol Chem. 2018 Oct 26;293(43):16709-16723. doi: 10.1074/jbc.RA117.000733. Epub 2018 Sep 11.

PMID:
30206120
15.

Anatomic Medial Patellofemoral Ligament Reconstruction Without Bone Tunnels or Anchors in the Patella.

Bedeir YH, Summers MA, Patel DJ, Grawe BM, Colosimo AJ.

Arthrosc Tech. 2018 May 14;7(6):e611-e615. doi: 10.1016/j.eats.2018.02.008. eCollection 2018 Jun.

16.

Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA.

Liu Y, Esyunina D, Olovnikov I, Teplova M, Kulbachinskiy A, Aravin AA, Patel DJ.

Cell Rep. 2018 Jul 10;24(2):453-462. doi: 10.1016/j.celrep.2018.06.021.

17.

Correction to: Behaviour and risk assessment of fluopyram and its metabolite in cucumber (Cucumis sativus) fruit and in soil.

Chawla S, Patel DJ, Patel SH, Kalasariya RL, Shah PG.

Environ Sci Pollut Res Int. 2018 Apr;25(12):11635. doi: 10.1007/s11356-018-1603-4.

PMID:
29488198
18.

Behaviour and risk assessment of fluopyram and its metabolite in cucumber (Cucumis sativus) fruit and in soil.

Chawla S, Patel DJ, Patel SH, Kalasariya RL, Shah PG.

Environ Sci Pollut Res Int. 2018 Apr;25(12):11626-11634. doi: 10.1007/s11356-018-1439-y. Epub 2018 Feb 10. Erratum in: Environ Sci Pollut Res Int. 2018 Feb 27;:.

PMID:
29429109
19.

Engineering of a Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs.

Noh KM, Wang H, Kim HR, Wenderski W, Fang F, Li CH, Dewell S, Hughes SH, Melnick AM, Patel DJ, Li H, Allis CD.

Mol Cell. 2018 Feb 1;69(3):533. doi: 10.1016/j.molcel.2018.01.014. No abstract available.

20.

Functional evaluation of tryptophans in glycolipid binding and membrane interaction by HET-C2, a fungal glycolipid transfer protein.

Kenoth R, Zou X, Simanshu DK, Pike HM, Malinina L, Patel DJ, Brown RE, Kamlekar RK.

Biochim Biophys Acta Biomembr. 2018 May;1860(5):1069-1076. doi: 10.1016/j.bbamem.2018.01.001. Epub 2018 Jan 3.

21.

Publisher Correction: Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.

Vincent J, Adura C, Gao P, Luz A, Lama L, Asano Y, Okamoto R, Imaeda T, Aida J, Rothamel K, Gogakos T, Steinberg J, Reasoner S, Aso K, Tuschl T, Patel DJ, Glickman JF, Ascano M.

Nat Commun. 2017 Nov 23;8(1):1827. doi: 10.1038/s41467-017-01770-3.

22.

Structure-based mechanistic insights into catalysis by small self-cleaving ribozymes.

Ren A, Micura R, Patel DJ.

Curr Opin Chem Biol. 2017 Dec;41:71-83. doi: 10.1016/j.cbpa.2017.09.017. Epub 2017 Nov 3. Review.

PMID:
29107885
23.

Atom-Specific Mutagenesis Reveals Structural and Catalytic Roles for an Active-Site Adenosine and Hydrated Mg2+ in Pistol Ribozymes.

Neuner S, Falschlunger C, Fuchs E, Himmelstoss M, Ren A, Patel DJ, Micura R.

Angew Chem Int Ed Engl. 2017 Dec 11;56(50):15954-15958. doi: 10.1002/anie.201708679. Epub 2017 Nov 15.

PMID:
29098759
24.

Electronic Cigarette Exposure: Calls to Wisconsin Poison Control Centers, 2010–2015.

Weiss D, Tomasallo CD, Meiman JG, Creswell PD, Melstrom PC, Gummin DD, Patel DJ, Michaud NT, Sebero HA, Anderson HA.

WMJ. 2016 Dec;115(6):306-10.

25.

Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX.

Hoelper D, Huang H, Jain AY, Patel DJ, Lewis PW.

Nat Commun. 2017 Oct 30;8(1):1193. doi: 10.1038/s41467-017-01206-y.

26.

Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme.

Zheng L, Mairhofer E, Teplova M, Zhang Y, Ma J, Patel DJ, Micura R, Ren A.

Nat Commun. 2017 Oct 30;8(1):1180. doi: 10.1038/s41467-017-01276-y.

27.

Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex.

Guo TW, Bartesaghi A, Yang H, Falconieri V, Rao P, Merk A, Eng ET, Raczkowski AM, Fox T, Earl LA, Patel DJ, Subramaniam S.

Cell. 2017 Oct 5;171(2):414-426.e12. doi: 10.1016/j.cell.2017.09.006.

28.

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.

Vincent J, Adura C, Gao P, Luz A, Lama L, Asano Y, Okamoto R, Imaeda T, Aida J, Rothamel K, Gogakos T, Steinberg J, Reasoner S, Aso K, Tuschl T, Patel DJ, Glickman JF, Ascano M.

Nat Commun. 2017 Sep 29;8(1):750. doi: 10.1038/s41467-017-00833-9. Erratum in: Nat Commun. 2017 Nov 23;8(1):1827.

29.

Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes.

Sheng G, Gogakos T, Wang J, Zhao H, Serganov A, Juranek S, Tuschl T, Patel DJ, Wang Y.

Nucleic Acids Res. 2017 Sep 6;45(15):9149-9163. doi: 10.1093/nar/gkx547.

30.

Polycomb-like proteins link the PRC2 complex to CpG islands.

Li H, Liefke R, Jiang J, Kurland JV, Tian W, Deng P, Zhang W, He Q, Patel DJ, Bulyk ML, Shi Y, Wang Z.

Nature. 2017 Sep 14;549(7671):287-291. doi: 10.1038/nature23881. Epub 2017 Sep 6.

31.

TRF2 binds branched DNA to safeguard telomere integrity.

Schmutz I, Timashev L, Xie W, Patel DJ, de Lange T.

Nat Struct Mol Biol. 2017 Sep;24(9):734-742. doi: 10.1038/nsmb.3451. Epub 2017 Aug 14.

PMID:
28805810
32.

Inhibition Mechanism of an Anti-CRISPR Suppressor AcrIIA4 Targeting SpyCas9.

Yang H, Patel DJ.

Mol Cell. 2017 Jul 6;67(1):117-127.e5. doi: 10.1016/j.molcel.2017.05.024. Epub 2017 Jun 9.

33.

How α-Helical Motifs Form Functionally Diverse Lipid-Binding Compartments.

Malinina L, Patel DJ, Brown RE.

Annu Rev Biochem. 2017 Jun 20;86:609-636. doi: 10.1146/annurev-biochem-061516-044445. Epub 2017 Mar 30. Review.

PMID:
28375742
34.

New CRISPR-Cas systems discovered.

Yang H, Patel DJ.

Cell Res. 2017 Mar;27(3):313-314. doi: 10.1038/cr.2017.21. Epub 2017 Feb 21.

35.

Corrigendum: SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation.

Johnson LM, Du J, Hale CJ, Bischof S, Feng S, Chodavarapu RK, Zhong X, Marson G, Pellegrini M, Segal DJ, Patel DJ, Jacobsen SE.

Nature. 2017 Mar 2;543(7643):136. doi: 10.1038/nature21398. Epub 2017 Feb 8. No abstract available.

PMID:
28178234
36.

RNA-Puzzles Round III: 3D RNA structure prediction of five riboswitches and one ribozyme.

Miao Z, Adamiak RW, Antczak M, Batey RT, Becka AJ, Biesiada M, Boniecki MJ, Bujnicki JM, Chen SJ, Cheng CY, Chou FC, Ferré-D'Amaré AR, Das R, Dawson WK, Ding F, Dokholyan NV, Dunin-Horkawicz S, Geniesse C, Kappel K, Kladwang W, Krokhotin A, Łach GE, Major F, Mann TH, Magnus M, Pachulska-Wieczorek K, Patel DJ, Piccirilli JA, Popenda M, Purzycka KJ, Ren A, Rice GM, Santalucia J Jr, Sarzynska J, Szachniuk M, Tandon A, Trausch JJ, Tian S, Wang J, Weeks KM, Williams B 2nd, Xiao Y, Xu X, Zhang D, Zok T, Westhof E.

RNA. 2017 May;23(5):655-672. doi: 10.1261/rna.060368.116. Epub 2017 Jan 30.

37.

Histone chaperone networks shaping chromatin function.

Hammond CM, Strømme CB, Huang H, Patel DJ, Groth A.

Nat Rev Mol Cell Biol. 2017 Mar;18(3):141-158. doi: 10.1038/nrm.2016.159. Epub 2017 Jan 5. Review.

38.

Circulatory collapse, right ventricular dilatation, and alveolar dead space: A triad for the rapid diagnosis of massive pulmonary embolism.

Gazmuri RJ, Patel DJ, Stevens R, Smith S.

Am J Emerg Med. 2017 Jun;35(6):936.e1-936.e4. doi: 10.1016/j.ajem.2016.12.039. Epub 2016 Dec 16.

PMID:
28040384
39.

Phosphatidylserine Stimulates Ceramide 1-Phosphate (C1P) Intermembrane Transfer by C1P Transfer Proteins.

Zhai X, Gao YG, Mishra SK, Simanshu DK, Boldyrev IA, Benson LM, Bergen HR 3rd, Malinina L, Mundy J, Molotkovsky JG, Patel DJ, Brown RE.

J Biol Chem. 2017 Feb 10;292(6):2531-2541. doi: 10.1074/jbc.M116.760256. Epub 2016 Dec 23.

40.

PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease.

Yang H, Gao P, Rajashankar KR, Patel DJ.

Cell. 2016 Dec 15;167(7):1814-1828.e12. doi: 10.1016/j.cell.2016.11.053.

41.

Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function.

Robbins N, Spitzer M, Wang W, Waglechner N, Patel DJ, O'Brien JS, Ejim L, Ejim O, Tyers M, Wright GD.

Cell Chem Biol. 2016 Nov 17;23(11):1383-1394. doi: 10.1016/j.chembiol.2016.08.015. Epub 2016 Oct 13.

42.

Structural basis underlying viral hijacking of a histone chaperone complex.

Huang H, Deng Z, Vladimirova O, Wiedmer A, Lu F, Lieberman PM, Patel DJ.

Nat Commun. 2016 Sep 1;7:12707. doi: 10.1038/ncomms12707.

43.

Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin.

Li S, Yen L, Pastor WA, Johnston JB, Du J, Shew CJ, Liu W, Ho J, Stender B, Clark AT, Burlingame AL, Daxinger L, Patel DJ, Jacobsen SE.

Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5108-16. doi: 10.1073/pnas.1609709113. Epub 2016 Aug 15.

44.

Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition.

Gao P, Yang H, Rajashankar KR, Huang Z, Patel DJ.

Cell Res. 2016 Aug;26(8):901-13. doi: 10.1038/cr.2016.88. Epub 2016 Jul 22.

45.

Structure and function of the bacterial decapping enzyme NudC.

Höfer K, Li S, Abele F, Frindert J, Schlotthauer J, Grawenhoff J, Du J, Patel DJ, Jäschke A.

Nat Chem Biol. 2016 Sep;12(9):730-4. doi: 10.1038/nchembio.2132. Epub 2016 Jul 18.

46.

Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage.

Ren A, Vušurović N, Gebetsberger J, Gao P, Juen M, Kreutz C, Micura R, Patel DJ.

Nat Chem Biol. 2016 Sep;12(9):702-8. doi: 10.1038/nchembio.2125. Epub 2016 Jul 11.

47.

H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex.

Saredi G, Huang H, Hammond CM, Alabert C, Bekker-Jensen S, Forne I, Reverón-Gómez N, Foster BM, Mlejnkova L, Bartke T, Cejka P, Mailand N, Imhof A, Patel DJ, Groth A.

Nature. 2016 Jun 30;534(7609):714-718. doi: 10.1038/nature18312. Epub 2016 Jun 22.

48.

Cutoff Suppresses RNA Polymerase II Termination to Ensure Expression of piRNA Precursors.

Chen YA, Stuwe E, Luo Y, Ninova M, Le Thomas A, Rozhavskaya E, Li S, Vempati S, Laver JD, Patel DJ, Smibert CA, Lipshitz HD, Toth KF, Aravin AA.

Mol Cell. 2016 Jul 7;63(1):97-109. doi: 10.1016/j.molcel.2016.05.010. Epub 2016 Jun 9.

49.

The CENP-T/-W complex is a binding partner of the histone chaperone FACT.

Prendergast L, Müller S, Liu Y, Huang H, Dingli F, Loew D, Vassias I, Patel DJ, Sullivan KF, Almouzni G.

Genes Dev. 2016 Jun 1;30(11):1313-26. doi: 10.1101/gad.275073.115. Epub 2016 Jun 9.

50.

Validation of a QuEChERS-based gas chromatographic method for analysis of pesticide residues in Cassia angustifolia (senna).

Tripathy V, Saha A, Patel DJ, Basak BB, Shah PG, Kumar J.

J Environ Sci Health B. 2016 Aug 2;51(8):508-18. doi: 10.1080/03601234.2016.1170544. Epub 2016 May 6.

PMID:
27153296

Supplemental Content

Loading ...
Support Center