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Tropomodulin's Actin-Binding Abilities Are Required to Modulate Dendrite Development.

Gray KT, Stefen H, Ly TNA, Keller CJ, Colpan M, Wayman GA, Pate E, Fath T, Kostyukova AS.

Front Mol Neurosci. 2018 Oct 9;11:357. doi: 10.3389/fnmol.2018.00357. eCollection 2018.


Piperine's mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle.

Nogara L, Naber N, Pate E, Canton M, Reggiani C, Cooke R.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13009-13014. Epub 2016 Oct 31.


Spectroscopic Studies of the Super Relaxed State of Skeletal Muscle.

Nogara L, Naber N, Pate E, Canton M, Reggiani C, Cooke R.

PLoS One. 2016 Aug 1;11(8):e0160100. doi: 10.1371/journal.pone.0160100. eCollection 2016.


The myosin inhibitor blebbistatin stabilizes the super-relaxed state in skeletal muscle.

Wilson C, Naber N, Pate E, Cooke R.

Biophys J. 2014 Oct 7;107(7):1637-46. doi: 10.1016/j.bpj.2014.07.075.


Role of tropomodulin's leucine rich repeat domain in the formation of neurite-like processes.

Guillaud L, Gray KT, Moroz N, Pantazis C, Pate E, Kostyukova AS.

Biochemistry. 2014 Apr 29;53(16):2689-700. doi: 10.1021/bi401431k. Epub 2014 Apr 18.


The histone H4 tail regulates the conformation of the ATP-binding pocket in the SNF2h chromatin remodeling enzyme.

Racki LR, Naber N, Pate E, Leonard JD, Cooke R, Narlikar GJ.

J Mol Biol. 2014 May 15;426(10):2034-44. doi: 10.1016/j.jmb.2014.02.021. Epub 2014 Mar 4.


A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly.

Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina DB, Garcia JF, Madhani HD, Cooke R, Schuck P, Cheng Y, Narlikar GJ.

Nature. 2013 Apr 18;496(7445):377-81. doi: 10.1038/nature12032. Epub 2013 Mar 13.


Conformational changes at the nucleotide site in the presence of bound ADP do not set the velocity of fast Drosophila myosins.

Eldred CC, Naber N, Pate E, Cooke R, Swank DM.

J Muscle Res Cell Motil. 2013 Feb;34(1):35-42. doi: 10.1007/s10974-012-9331-8. Epub 2012 Dec 1.


The loop 5 element structurally and kinetically coordinates dimers of the human kinesin-5, Eg5.

Waitzman JS, Larson AG, Cochran JC, Naber N, Cooke R, Jon Kull F, Pate E, Rice SE.

Biophys J. 2011 Dec 7;101(11):2760-9. doi: 10.1016/j.bpj.2011.10.032.


Analysis of the interaction of the Eg5 Loop5 with the nucleotide site.

Harrington TD, Naber N, Larson AG, Cooke R, Rice SE, Pate E.

J Theor Biol. 2011 Nov 21;289:107-15. doi: 10.1016/j.jtbi.2011.08.017. Epub 2011 Aug 23.


Slow myosin ATP turnover in the super-relaxed state in tarantula muscle.

Naber N, Cooke R, Pate E.

J Mol Biol. 2011 Sep 2;411(5):943-50. doi: 10.1016/j.jmb.2011.06.051. Epub 2011 Jul 12.


EPR spectra and molecular dynamics agree that the nucleotide pocket of myosin V is closed and that it opens on binding actin.

Purcell TJ, Naber N, Sutton S, Cooke R, Pate E.

J Mol Biol. 2011 Aug 5;411(1):16-26. doi: 10.1016/j.jmb.2011.05.019. Epub 2011 May 27.


Multiple conformations of the nucleotide site of Kinesin family motors in the triphosphate state.

Naber N, Larson A, Rice S, Cooke R, Pate E.

J Mol Biol. 2011 May 13;408(4):628-42. doi: 10.1016/j.jmb.2011.01.001. Epub 2011 Jan 26.


Nucleotide pocket thermodynamics measured by EPR reveal how energy partitioning relates myosin speed to efficiency.

Purcell TJ, Naber N, Franks-Skiba K, Dunn AR, Eldred CC, Berger CL, Málnási-Csizmadia A, Spudich JA, Swank DM, Pate E, Cooke R.

J Mol Biol. 2011 Mar 18;407(1):79-91. doi: 10.1016/j.jmb.2010.11.053. Epub 2010 Dec 23.


The conserved L5 loop establishes the pre-powerstroke conformation of the Kinesin-5 motor, eg5.

Larson AG, Naber N, Cooke R, Pate E, Rice SE.

Biophys J. 2010 Jun 2;98(11):2619-27. doi: 10.1016/j.bpj.2010.03.014.


Combining EPR with fluorescence spectroscopy to monitor conformational changes at the myosin nucleotide pocket.

Naber N, Málnási-Csizmadia A, Purcell TJ, Cooke R, Pate E.

J Mol Biol. 2010 Mar 5;396(4):937-48. doi: 10.1016/j.jmb.2009.12.035. Epub 2009 Dec 28.


Analysis of the interaction of the nucleotide base with myosin and the effect on substrate efficacy.

Hyatt D, Cooke R, Pate E.

Biophys J. 2009 Oct 7;97(7):1952-60. doi: 10.1016/j.bpj.2009.07.022.


Dynamics of the nucleotide pocket of myosin measured by spin-labeled nucleotides.

Naber N, Purcell TJ, Pate E, Cooke R.

Biophys J. 2007 Jan 1;92(1):172-84. Epub 2006 Oct 6.


The open nucleotide pocket of the profilin/actin x-ray structure is unstable and closes in the absence of profilin.

Minehardt TJ, Kollman PA, Cooke R, Pate E.

Biophys J. 2006 Apr 1;90(7):2445-9. Epub 2006 Jan 20.


Molecular dynamics analysis of structural factors influencing back door pi release in myosin.

Lawson JD, Pate E, Rayment I, Yount RG.

Biophys J. 2004 Jun;86(6):3794-803.


Adolescent health in the Caribbean: a regional portrait.

Halcón L, Blum RW, Beuhring T, Pate E, Campbell-Forrester S, Venema A.

Am J Public Health. 2003 Nov;93(11):1851-7.


A cohort study of health effects of human T-cell lymphotropic virus type I infection in Jamaican children.

Maloney EM, Wiktor SZ, Palmer P, Cranston B, Pate EJ, Cohn S, Kim N, Miley W, Thomas TL, Blattner WA, Hanchard B.

Pediatrics. 2003 Aug;112(2):e136-42.


Closing of the nucleotide pocket of kinesin-family motors upon binding to microtubules.

Naber N, Minehardt TJ, Rice S, Chen X, Grammer J, Matuska M, Vale RD, Kollman PA, Car R, Yount RG, Cooke R, Pate E.

Science. 2003 May 2;300(5620):798-801.


EPR spectroscopy shows a microtubule-dependent conformational change in the kinesin switch 1 domain.

Naber N, Rice S, Matuska M, Vale RD, Cooke R, Pate E.

Biophys J. 2003 May;84(5):3190-6.


Adolescent health in the Caribbean: risk and protective factors.

Blum RW, Halcón L, Beuhring T, Pate E, Campell-Forrester S, Venema A.

Am J Public Health. 2003 Mar;93(3):456-60.


A classical and ab initio study of the interaction of the myosin triphosphate binding domain with ATP.

Minehardt TJ, Marzari N, Cooke R, Pate E, Kollman PA, Car R.

Biophys J. 2002 Feb;82(2):660-75.


Synthesis and characterization of novel spin-labeled photoaffinity nonnucleoside analogues of ATP as structural and EPR probes for myosin.

Chen X, Grammer J, Cooke R, Pate E, Yount RG.

Bioconjug Chem. 2000 Sep-Oct;11(5):725-33.


Human T cell lymphotropic virus type I-associated infective dermatitis in Jamaica: a case report of clinical and biologic correlates.

Maloney EM, Hisada M, Palmer P, Brooks K, Pate E, Wiktor SZ, Lagrenade L, Manns A.

Pediatr Infect Dis J. 2000 Jun;19(6):560-5. No abstract available.


Synthesis of a spin-labeled photoaffinity ATP analogue, and its use to specifically photolabel myosin cross-bridges in skeletal muscle fibers.

Wang D, Luo Y, Cooke R, Grammer J, Pate E, Yount RG.

J Muscle Res Cell Motil. 1999 Nov;20(8):743-53.


A structural change in the kinesin motor protein that drives motility.

Rice S, Lin AW, Safer D, Hart CL, Naber N, Carragher BO, Cain SM, Pechatnikova E, Wilson-Kubalek EM, Whittaker M, Pate E, Cooke R, Taylor EW, Milligan RA, Vale RD.

Nature. 1999 Dec 16;402(6763):778-84.


X-ray structures of the Dictyostelium discoideum myosin motor domain with six non-nucleotide analogs.

Gulick AM, Bauer CB, Thoden JB, Pate E, Yount RG, Rayment I.

J Biol Chem. 2000 Jan 7;275(1):398-408.


Estimating the time of HTLV-I infection following mother-to-child transmission in a breast-feeding population in Jamaica.

Furnia A, Lal R, Maloney E, Wiktor S, Pate E, Rudolph D, Waters D, Blattner W, Manns A.

J Med Virol. 1999 Dec;59(4):541-6.


Low incidence of human papillomavirus type 16 antibody seroconversion in young children.

Manns A, Strickler HD, Wikktor SZ, Pate EJ, Gray R, Waters D.

Pediatr Infect Dis J. 1999 Sep;18(9):833-5. No abstract available.


Mother-to-child transmission of human T-cell lymphotropic virus type I associated with prolonged breast-feeding.

Wiktor SZ, Pate EJ, Rosenberg PS, Barnett M, Palmer P, Medeiros D, Maloney EM, Blattner WA.

J Hum Virol. 1997 Nov-Dec;1(1):37-44.


Relationship between unsupplemented vitamin A serum concentrations and measles vaccine response in Jamaican children.

Willy ME, Hoover DR, Halsey NA, Maloney EM, Pate EJ, Wiktor SZ, Blattner WA, Manns A.

Pediatr Infect Dis J. 1998 Jun;17(6):526-8. No abstract available.


Opening of the myosin nucleotide triphosphate binding domain during the ATPase cycle.

Pate E, Naber N, Matuska M, Franks-Skiba K, Cooke R.

Biochemistry. 1997 Oct 7;36(40):12155-66.


Urinary 5-L-oxoproline (pyroglutamic acid) excretion is greater in infants in Jamaica than in infants in England.

Persaud C, Pate E, Forrester T, Jackson AA.

Eur J Clin Nutr. 1997 Aug;51(8):510-3.


In vitro actin filament sliding velocities produced by mixtures of different types of myosin.

Cuda G, Pate E, Cooke R, Sellers JR.

Biophys J. 1997 Apr;72(4):1767-79.


HLA DRB1*DQB1* haplotype in HTLV-I-associated familial infective dermatitis may predict development of HTLV-I-associated myelopathy/tropical spastic paraparesis.

LaGrenade L, Sonoda S, Miller W, Pate E, Rodgers-Johnson P, Hanchard B, Cranston B, Fujiyoshi T, Yashiki S, Blank M, Gibbs CJ, Manns A.

Am J Med Genet. 1996 Jan 2;61(1):37-41.


Comparison of HHV-6 antibody titers in West Africa and the Caribbean.

Cleghorn FR, Maybank KA, Jack N, Pate E, Mingle J, Levine PH, Manns A.

Ann Epidemiol. 1995 Nov;5(6):497-500.


A novel adenosine triphosphate analog with a heavy atom to target the nucleotide binding site of proteins.

Naber N, Matuska M, Sablin EP, Pate E, Cooke R.

Protein Sci. 1995 Sep;4(9):1824-31.


The myosin catalytic domain does not rotate during the working power stroke.

Zhao L, Pate E, Baker AJ, Cooke R.

Biophys J. 1995 Sep;69(3):994-9.


The relative distribution of T cell subsets is altered in Jamaican children infected with human T cell lymphotropic virus type I.

Maloney EM, Pate E, Wiktor SZ, Morais P, Mann D, Gray R, Manns A, Blattner WA.

J Infect Dis. 1995 Sep;172(3):867-70.


Reduced effect of pH on skinned rabbit psoas muscle mechanics at high temperatures: implications for fatigue.

Pate E, Bhimani M, Franks-Skiba K, Cooke R.

J Physiol. 1995 Aug 1;486 ( Pt 3):689-94.


Photoaffinity ADP analogs as covalently attached reporter groups of the active site of myosin subfragment 1.

Luo Y, Wang D, Cremo CR, Pate E, Cooke R, Yount RG.

Biochemistry. 1995 Feb 14;34(6):1978-87.


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